公开(公告)号：DE4313232A1

公开(公告)日：1994-10-27

申请号：DE4313232

申请日：1993-04-22

Applicant: BASF AG

Inventor： ECKARD PETER ,  HILLEN HEINZ DR ,  OTTER RAINER DR ,  SCHMIDT MARTIN DR ,  SUBKOWSKI THOMAS DR ,  ZECHEL JOHANN-CHRISTIAN DR

IPC: C07K14/575 ,  C12Q1/37 ,  C07K7/08 ,  G01N33/68

Abstract: The present invention relates to an assay method for identifying inhibitors of endothelin converting enzyme (ECE) and to substrates for use in this assay method.

公开(公告)号：DE19534164A1

公开(公告)日：1996-04-25

申请号：DE19534164

申请日：1995-09-15

Applicant: BASF AG

Inventor： ALBRECHT HANS-PETER ,  BOEHM HANS-JOACHIM ,  BRADY KENNETH DALE ,  ECKARD PETER ,  KARDORFF UWE ,  MEYER NORBERT ,  SCHIRMER ULRICH ,  TALANIAN ROBERT VINCENT ,  WALKER NIGEL P C

IPC: A61K31/53 ,  A61K31/5377 ,  C07D487/04

Abstract: Pyrimido(5,4-e)-as-triazine-5,7(6H,8H)-dione derivs. of formula (I) and their acid addn. salts are claimed for use in combatting diseases. R , R = H, alkyl, 3-6C cycloalkyl, 2-8C alkenyl, phenyl or benzyl; R = H, halogen or NO2; 1-8C alkyl (opt. substd. by 1-3 of OH, halogen, alkoxy, alkyl, (1-4C)alkoxy(1-4C)alkoxy, 2-6C alkenyl, alkylthio, phenyl and benzyl); 2-6C alkenyl or -phenylalkenyl; 3-6C cycloalkyl (opt. substd. by one to three 1-4C alkyl gps.); 5- or 6-membered heterocycle contg. 1 or 2 of O, S, NR and N as ring members; COR or COOR ; phenyl or monocyclic heteroaryl (both opt. substd. by 1-3 of halogen, NO2, alkyl, 2-6C alkenyl, alkoxy and NR R ); or -ZR ; R , R = H or alkyl; Z = O, S or NR ; R = H or alkyl; or phenyl or benzyl (both opt. ring-substd. by 1-3 of alkyl, alkoxy and halogen); R = H or alkyl; or NR R = 5- or 6-membered ring (opt. interrupted by O); n = 0 or 1; alkyl moieties have 1-6C unless specified otherwise. (I) are known cpds., described in EP407888.