公开(公告)号：ZA989571B

公开(公告)日：2000-04-25

申请号：ZA989571

申请日：1998-10-21

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  STEINER GERD ,  BACH ALFRED ,  EMLING FRANZ ,  GARCIA-LADONA XAVIER ,  TESCHENDORF HANS JUERGEN ,  WICKE KARSTEN

IPC: A61K31/428 ,  A61P25/24 ,  A61P43/00 ,  C07D275/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D ,  A61K

Abstract: where the substituents have the meanings indicated in the description, their preparation and use as serotonin antagonists.

公开(公告)号：ZA9809664B

公开(公告)日：2000-04-25

申请号：ZA9809664

申请日：1998-10-23

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  STEINER GERD ,  BACH ALFRED ,  EMLING FRANZ ,  GARCIA-LADONA XAVIER ,  TESCHENDORF HANS JUERGEN ,  WICKE KARSTEN

IPC: A61K31/519 ,  A61P1/00 ,  A61P1/14 ,  A61P3/04 ,  A61P5/00 ,  A61P9/12 ,  A61P15/00 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D471/04 ,  C07D ,  A61K

CPC classification number: C07D471/04

公开(公告)号：CZ448399A3

公开(公告)日：2000-04-12

申请号：CZ448399

申请日：1998-05-29

Applicant: BASF AG

Inventor： STEINER GERD ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  BACH ALFRED ,  WICKE KARSTEN ,  TESCHENDORF HANS-JUERGEN ,  GARCIA-LADONA FRANCISCO-JAVIER ,  EMLING FRANZ

IPC: A61K31/505 ,  C07D221/00 ,  C07D239/00 ,  C07D333/00 ,  C07D495/14

公开(公告)号：NZ310444A

公开(公告)日：1999-11-29

申请号：NZ31044496

申请日：1996-06-03

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  EMLING FRANZ ,  ROMERDAHL CYNTHIA A

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/04 ,  C07K5/103 ,  C07K7/06

Abstract: A method for the preparation of novel peptides (Formula I) and their use in pharmaceutical compositions. Such compositions containing said peptides offer improved therapeutic potential for the treatment of neoplastic disease. Peptides of Formula I have the general formula: R1R2N-CHX-CO-A-B-D-E-(F)t-K Where: R1 is methyl, ethyl, or isopropyl; R2 is hydrogen, methyl, or ethyl; R1-N-R2 together may be a pyrrollidine ring; A is a valyl, isoleucyl, leucyl, 2-tert-butylglycyl, 2-ethylglycyl, norleucyl or norvalyl residue B is a N-methyl-valyl, -leucyl, -isoleucyl, -norvalyl, -norleucyl, -2-tert-butylglycyl, -3-tert-butylalanyl, or -2-ethylglycyl residue; B is a prolyl, 3,4-dehydroprolyl, 4-fluoroprolyl, 4,4-difluoroprolyl, azetidine-2-carbonyl, homoprolyl, 3-methylprolyl, 4-methylprolyl, 5-methylprolyl, or thiazolidine-4-carbonyl residue; E is a 3,4-dehydroprolyl, 4-fluoroprolyl, 3-methylprolyl, 4-methylprolyl, azetidine-2-carbonyl, or 4,4-difluoroprolyl residue; F is a valyl, 2-tert-butylglycyl, isoleucyl, leucyl, 2-cyclohexylglycyl, norleucyl, norvalyl, neopentylglycyl, alanyl, b-alanyl, or aminoisobutyroyl residue; X is alkyl (preferably C2-5), cyclopropyl, or cyclopentyl; T is 0 or 1 K is alkoxy (preferably C1-4), benzyloxy or an optionally substituted amino moiety.

公开(公告)号：SK23099A3

公开(公告)日：1999-08-06

申请号：SK23099

申请日：1997-08-22

Applicant: BASF AG

Inventor： STEINER GERD ,  LUBISCH WILFRIED ,  BACH ALFRED ,  EMLING FRANZ ,  WICKE KARSTEN ,  TESCHENDORF HANS-JURGEN ,  BEHL BERTHOLD ,  KERRRIGAN FRANK ,  CHEETHAM SHARON

IPC: A61K31/435 ,  A61K31/519 ,  A61P25/24 ,  A61P43/00 ,  C07D211/00 ,  C07D239/00 ,  C07D333/00 ,  C07D495/14

Abstract: The invention concerns 3-substituted 3,4,5,6,7,8-hexahydro- pyrid3':4,5]thieno-[2,3-d]pyrimidine derivatives of formula (I), their physiologically acceptable salts and use in the therapy.

公开(公告)号：AU9748498A

公开(公告)日：1999-05-17

申请号：AU9748498

申请日：1998-10-05

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  STEINER GERD ,  BACH ALFRED ,  EMLING FRANZ ,  GARCIA-LADONA XAVIER ,  TESCHENDORF HANS-JURGEN ,  WICKE KARSTEN

IPC: A61K31/519 ,  A61P1/00 ,  A61P1/14 ,  A61P3/04 ,  A61P5/00 ,  A61P9/12 ,  A61P15/00 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D471/00 ,  C07D471/04

Abstract: 3-substituted tetrahydropyridopyrimidinone derivatives of the formula (I) wherein the radicals have the meanings given in the Description, to a method for producing said derivatives and, to their use for producing active ingredients for drugs.

公开(公告)号：CA2305258A1

公开(公告)日：1999-05-06

申请号：CA2305258

申请日：1998-10-05

Applicant: BASF AG

Inventor： STEINER GERD ,  STARCK DOROTHEA ,  DULLWEBER UTA ,  BACH ALFRED ,  LUBISCH WILFRIED ,  EMLING FRANZ ,  GARCIA-LADONA XAVIER ,  TESCHENDORF HANS-JURGEN ,  WICKE KARSTEN

IPC: A61K31/519 ,  A61P1/00 ,  A61P1/14 ,  A61P3/04 ,  A61P5/00 ,  A61P9/12 ,  A61P15/00 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D471/00 ,  C07D471/04

Abstract: The invention relates to 3-substituted tetrahydropyridopyrimidinone derivatives of formula (I) wherein the radicals have the meanings given in the Description, to a method for producing said derivatives, and to their use as selective 5HT1B-and 5HT1A antagonists.

公开(公告)号：DE19734444A1

公开(公告)日：1999-02-11

申请号：DE19734444

申请日：1997-08-08

Applicant: BASF AG

Inventor： STEINER GERD ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  BACH ALFRED ,  WICKE KARSTEN ,  TESCHENDORF HANS-JUERGEN ,  GARCIA-LADONA FRANCISCO-JAVI ,  EMLING FRANZ

IPC: A61K31/435 ,  A61P25/24 ,  C07D495/14 ,  A61K31/505

Abstract: 3-substituted 3,4,5,7-tetrahydro-pyrrolo3',4':4,5 thieno2,3-Dpyrimidine derivatives of formula (I), in which the substituents have the meaning given in the description, their preparation and their use as medicaments.

公开(公告)号：CO4700527A1

公开(公告)日：1998-12-29

申请号：CO96029751

申请日：1996-06-07

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  EMLING FRANZ ,  ROMERDAHL CYNTHIA A

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/04 ,  C07K5/103 ,  C07K7/06

Abstract: Péptidos novedosos de la fórmula IR1 R2 N-CHX-CO-A-B-D-E-(F)t-K I en donde R1 es metilo, etilo o isopropilo; R2 es hidrógeno, metilo o etileno; R1 -N-R2 juntos pueden ser un anillo de pirrolidina; A es un residuo de valil, isoleucil, leucil, 2-tert-butilglicil, 2-etilglicil-norleucil o norvalil; B es un residuo de N-metil-valil, -leucil,-isoleucil, norvalil, norleucil, 2-tert-butilglicil, -3-tert-butilalamil, o 2-etilglicil; D es un residuo 3,4-de hidroprolil, 4-fluoroprolil, 4,4-difluoroprolil, azetidina-2-carbonil, 3-metilprolil, 4-metilprolil, o 5-metilpropil; E es un residuo propil, homopropil,hidroxipropil o tiazolidina-4-carbonil;F es un residuo de valil, 2-tert-butilglicil- isoleucil, leucil, 2-ciclohexilglicil, norleucil, norvalil, neopentilglicil, alanil, ß-alanil o aminoisobutiroil;X es alkilo (preferiblemente C2-5 ), ciclopropil, o ciclopentilo; t es 0 o 1; y K es alkoxi (preferiblemente C1-4 ), benxiloxi o una traza amino substituida o no substituida; y las sales de los mismos con ácido tolerados fisiológicamente.

公开(公告)号：CO4700526A1

公开(公告)日：1998-12-29

申请号：CO96029749

申请日：1996-06-07

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  EMLING FRANZ ,  ROMERDAHL CYNTHIA A

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/04 ,  C07K5/103 ,  C07K7/06

Abstract: Péptidos novedosos de la fórmula I:R1 R2 N-CHX-CO-A-B-D-E-(F)t-K en donde R1 es metilo, etilo o isopropilo; R2 es hidrógeno, metilo o etileno; R1 -N-R2 juntos pueden ser un anillo de pirrolidina; A es un residuo de valil, isoleucil, leucil, 2-tert-butilglicil, 2-etilglicil-norleucil o norvalil; B es un residuo de N-metil-valil, -leucil, -isoleucil, norvalil, norleucil, 2-tert-butilglicil, -3-tert-butilalamil, o 2-etilglicil; D es un residuo 3,4-de hidroprolil, 4-fluoroprolil, 4,4-difluoroprolil,azetidina-2-carbonil, 3-metilprolil, 4-metilprolil, o 5-metilpropil; E es un residuo propil, homopropil, hidroxipropil o tiazolidina-4-carbonil;F es un residuo de valil, 2-tert-butilglicil-isoleucil, leucil 2-ciclohexilglicil, norleucil, norvalil, neopentilglicil, alanil, ß-alanil o aminoisobutiroil;X es alkilo (preferiblemente C2-5 ), ciclopropil, o ciclopentilo; t es 0 ó 1; yK es alkoxi (Preferiblemente C1-4 ), benxiloxi o una traza amino substituida o no substituida;y las sales de los mismos con ácido tolerados fisiológicamente.