-
公开(公告)号：CZ9803262A3
公开(公告)日：2000-01-12
申请号：CZ326298
申请日：1997-04-04
Applicant: BASF AG
Inventor： AMBERG WILHEM , KLING ANDREAS , KLINGE DAGMAR , RIECHERS HARTMUT , BAUMANN ERNST , UNGER LILIANE , RASCHACK MANFRED , HERGENROEDER STEFAN , SCHULT SABINE
IPC: A61K31/505 , A61P9/00 , A61P13/08 , A61P13/12 , C07D215/22 , C07D239/34 , C07D239/60
-
公开(公告)号：NO996268L
公开(公告)日：1999-12-17
申请号：NO996268
申请日：1999-12-17
Applicant: BASF AG
Inventor： AMBERG WILHELM , KLING ANDREAS , KLINGE DAGMAR , RIECHERS HARTMUT , HERGENROEDER STEFAN , RASCHACK MANFRED , UNGER LILIANE
IPC: C07D251/16 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K31/517 , A61K31/519 , A61K31/53 , A61P7/02 , A61P9/02 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/08 , A61P13/12 , A61P25/06 , A61P35/00 , A61P35/04 , A61P43/00 , C07C247/12 , C07D213/68 , C07D237/14 , C07D237/16 , C07D239/34 , C07D239/52 , C07D239/56 , C07D239/60 , C07D239/70 , C07D239/80 , C07D239/95 , C07D241/18 , C07D251/22 , C07D251/34 , C07D251/52 , C07D253/06 , C07D403/12 , C07D491/048
Abstract: The invention relates to carboxylic acid derivatives of formula (I) wherein the constituents have the meaning given in the description. The invention also relates to the production of said derivatives, and to their use as endothelin receptor antagonists.
-
公开(公告)号：DE19806438A1
公开(公告)日：1999-08-19
申请号：DE19806438
申请日：1998-02-17
Applicant: BASF AG
Inventor： AMBERG WILHELM , JANSEN ROLF , KLING ANDREAS , KLINGE DAGMAR , RIECHERS HARTMUT , HERGENROEDER STEFAN , RASCHACK MANFRED , UNGER LILIANE
IPC: A61K31/505 , A61K31/506 , A61P5/14 , A61P9/02 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/12 , A61P35/00 , A61P43/00 , C07D239/34 , C07D239/46 , C07D239/52 , C07D239/60 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
Abstract: Pyrimidinyloxy-propionic acid derivatives (I) are new. Also new are combinations of (I) with inhibitors of the renin-angiotensin system, beta -blockers, diuretics, calcium antagonists and VEGF blockers. (Pyrimidin-2-yloxy)-propionic acid derivatives of formula (I) and their salts are new: R = tetrazolyl or C(O)R; R = OR , N-bonded heteroaryl optionally substituted with halo, alkyl or alkoxy, -O-(CH2)p-S(O)k-R or -NH-SO2-R ; R = H, an alkali or alkaline earth cation, NH4 , an organic ammonium ion, cycloalkyl, alkyl, optionally substituted benzyl, optionally halogenated alkenyl or alkynyl or optionally substituted phenyl; R = alkyl, cycloalkyl, alkenyl, alkynyl or optionally substituted phenyl; k = 0-2; p = 1-4; R = optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl or phenyl; R = H, OH, NH2, NH(alkyl), N(alkyl)2, halo, alkyl, alkenyl, alkynyl, hydroxyalkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio or morpholinyl; X = halo, haloalkyl or OH; R = H, OH, NH2, NH(alkyl), N(alkyl)2, halo, alkyl, alkenyl, alkynyl, hydroxyalkyl, haloalkyl, alkoxy, haloalkoxy, -NH-O-alkyl or alkylthio; R , R = optionally substituted phenyl or naphthyl; phenyl or naphthyl ortho-linked with one another via a bond, methylene, ethylene, ethenylene, O, S, SO2, NH or N(alkyl); optionally substituted heteroaryl; or cycloalkyl; Z' = S, O, or a single bond; and R = H (when Z = S or O), optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, naphthyl or heteroaryl. The full definitions are given in the DEFINITIONS (Full Definitions) Field. An Independent claim is also included for combinations of (I) with inhibitors of the renin-angiotensin system, beta -blockers, diuretics, calcium antagonists and VEGF blockers.
-
公开(公告)号：HU9802329A2
公开(公告)日：1999-02-01
申请号：HU9802329
申请日：1996-08-29
Applicant: BASF AG
Inventor： AMBERG WILHELM , ELGER BERND , HERGENROEDER STEFAN , KLING ANDREAS , KLINGE DAGMAR , RASCHACK MANFRED , RIECHERS HARTMUT , SCHULT SABINE , UNGER LILIANE
IPC: A61K31/00 , A61K31/19 , A61K31/192 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/357 , C07D317/02 , A61K31/36 , A61K31/435 , A61K31/44 , A61K31/505 , A61P9/00 , A61P9/08 , C07C53/134 , C07C57/30 , C07C57/32 , C07C57/38 , C07C59/64 , C07C69/616 , C07C69/734 , C07C255/00 , C07D213/55 , C07D213/64 , C07D221/04 , C07D239/26 , C07D239/34 , C07D239/52 , C07D239/70 , C07D257/04 , C07D307/79 , C07D317/50 , C07D317/60 , C07D319/02 , C07D319/18 , A61K31/275 , A61K31/335 , A61K31/395
Abstract: PCT No. PCT/EP96/03793 Sec. 371 Date Feb. 24, 1998 Sec. 102(e) Date Feb. 24, 1998 PCT Filed Aug. 29, 1996 PCT Pub. No. WO97/09294 PCT Pub. Date Mar. 13, 1997Carboxylic acid derivatives of the formula I here R1 is a tetrazole [sic], nitrile [sic], a group COOH or a radical which can be hydrolyzed to COOH, and the other substituents have the meaning explained in the description.
-
公开(公告)号：PL325398A1
公开(公告)日：1998-07-20
申请号：PL32539896
申请日：1996-08-29
Applicant: BASF AG
Inventor： AMBERG WILHELM , KLING ANDREAS , KLINGE DAGMAR , RIECHERS HARTMUT , UNGER LILIANE , RASCHACK MANFRED , HERGENROEDER STEFAN , ELGER BERND , SCHULT SABINE
IPC: A61K31/00 , A61K31/19 , A61K31/192 , A61K31/34 , A61K31/341 , C07D317/02 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/357 , A61K31/36 , A61K31/435 , A61K31/44 , A61K31/505 , A61P9/00 , A61P9/08 , C07C53/134 , C07C57/30 , C07C57/32 , C07C57/38 , C07C59/64 , C07C69/616 , C07C69/734 , C07C255/00 , C07D213/55 , C07D213/64 , C07D221/04 , C07D239/26 , C07D239/34 , C07D239/52 , C07D239/70 , C07D257/04 , C07D307/79 , C07D317/50 , C07D317/60 , C07D319/02 , C07D319/18
Abstract: PCT No. PCT/EP96/03793 Sec. 371 Date Feb. 24, 1998 Sec. 102(e) Date Feb. 24, 1998 PCT Filed Aug. 29, 1996 PCT Pub. No. WO97/09294 PCT Pub. Date Mar. 13, 1997Carboxylic acid derivatives of the formula I here R1 is a tetrazole [sic], nitrile [sic], a group COOH or a radical which can be hydrolyzed to COOH, and the other substituents have the meaning explained in the description.
-
Patent Agency Ranking
公开(公告)号：HRP970198A2
公开(公告)日：1998-04-30
申请号：HRP970198
申请日：1997-04-11
Applicant: BASF AG
Inventor： KLINGE DAGMAR , AMBERG WILHELM , BAUMANN ERNST , KLING ANDREAS , RIECHERS HARTMUT , UNGER LILIANE , RASCHACK MANFRED , HERGENROEDER STEFAN , SCHULT SABINE
IPC: A61K31/00 , A61K31/505 , A61K31/517 , A61P5/42 , A61P9/10 , A61P13/00 , A61P13/12 , C07D217/22 , C07D239/34 , C07D239/48 , C07D239/52 , C07D239/56 , C07D239/60 , C07D239/70 , C07D239/80 , C07D239/96 , C07D251/20 , C07D251/22 , C07D251/30 , C07D251/38 , C07D251/52 , C07D403/12 , C07D405/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/044
Abstract: The present invention relates to carboxylic acid derivatives of the formulawhere the radicals have the meanings stated in the description, to the preparation of these compounds and to their use as drugs.
-
公开(公告)号：NO981002D0
公开(公告)日：1998-03-06
申请号：NO981002
申请日：1998-03-06
Applicant: BASF AG
Inventor： AMBERG WILHELM , KLING ANDREAS , KLINGE DAGMAR , RIECHERS HARTMUT , UNGER LILIANE , RASCHACK MANFRED , HERGENROEDER STEFAN , ELGER BERND , SCHULT SABINE
IPC: A61K31/00 , A61K31/19 , C07D317/02 , A61K31/192 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/357 , A61K31/36 , A61K31/435 , A61K31/44 , A61K31/505 , A61P9/00 , A61P9/08 , C07C53/134 , C07C57/30 , C07C57/32 , C07C57/38 , C07C59/64 , C07C69/616 , C07C69/734 , C07C255/00 , C07D213/55 , C07D213/64 , C07D221/04 , C07D239/26 , C07D239/34 , C07D239/52 , C07D239/70 , C07D257/04 , C07D307/79 , C07D317/50 , C07D317/60 , C07D319/02 , C07D319/18
Abstract: PCT No. PCT/EP96/03793 Sec. 371 Date Feb. 24, 1998 Sec. 102(e) Date Feb. 24, 1998 PCT Filed Aug. 29, 1996 PCT Pub. No. WO97/09294 PCT Pub. Date Mar. 13, 1997Carboxylic acid derivatives of the formula I here R1 is a tetrazole [sic], nitrile [sic], a group COOH or a radical which can be hydrolyzed to COOH, and the other substituents have the meaning explained in the description.
-
公开(公告)号：DE19614542A1
公开(公告)日：1997-10-16
申请号：DE19614542
申请日：1996-04-12
Applicant: BASF AG
Inventor： AMBERG WILHELM DR , KLING ANDREAS DR , KLINGE DAGMAR DR , RIECHERS HARTMUT DR , BAUMANN ERNST DR , UNGER LILIANE DR , RASCHACK MANFRED DR , HERGENROEDER STEFAN , SCHULT SABINE DR
IPC: A61K31/00 , A61K31/47 , A61K31/505 , A61P9/00 , A61P9/12 , A61P13/00 , A61P13/12 , C07D215/22 , C07D215/227 , C07D239/34 , C07D239/60 , C07D401/12 , C07D403/12 , C07D239/32 , C07D213/60 , C07C215/16 , C07C217/22 , C07D227/08 , C07D247/02 , A61K31/44
Abstract: The present invention relates to carboxylic acid derivatives of formula (I) in which the radicals have the meaning given in the description, and the production of these substances and their use as medicaments.
-
公开(公告)号：NO311802B1
公开(公告)日：2002-01-28
申请号：NO984713
申请日：1998-10-09
Applicant: BASF AG
Inventor： AMBERG WILHELM , KLING ANDREAS , KLINGE DAGMAR , RIECHERS HARTMUT , BAUMANN ERNST , UNGER LILIANE , RASCHACK MANFRED , HERGENROEDER STEFAN , SCHULT SABINE
IPC: A61K31/00 , A61K31/47 , A61K31/505 , A61P9/00 , A61P9/12 , A61P13/00 , A61P13/12 , C07D215/22 , C07D215/227 , C07D239/34 , C07D239/60 , C07D401/12 , C07D403/12
Abstract: PCT No. PCT/EP97/01687 Sec. 371 Date Oct. 8, 1998 Sec. 102(e) Date Oct. 8, 1998 PCT Filed Apr. 4, 1997 PCT Pub. No. WO97/38982 PCT Pub. Date Oct. 23, 1997Carboxylic acid derivatives of the formula I where the radicals have the meanings stated in the description, and the preparation of these agreements [sic] and their use as drugs are described.
-
公开(公告)号：NO311801B1
公开(公告)日：2002-01-28
申请号：NO984717
申请日：1998-10-09
Applicant: BASF AG
Inventor： KLINGE DAGMAR , AMBERG WILHELM , BAUMANN ERNST , KLING ANDREAS , RIECHERS HARTMUT , UNGER LILIANE , RASCHACK MANNFRED , HERGENROEDER STEFAN , SCHULT SABINE
IPC: A61K31/00 , A61K31/505 , A61K31/517 , A61P5/42 , A61P9/10 , A61P13/00 , A61P13/12 , C07D217/22 , C07D239/34 , C07D239/48 , C07D239/52 , C07D239/56 , C07D239/60 , C07D239/70 , C07D239/80 , C07D239/96 , C07D251/20 , C07D251/22 , C07D251/30 , C07D251/38 , C07D251/52 , C07D403/12 , C07D405/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/044
Abstract: The present invention relates to carboxylic acid derivatives of the formulawhere the radicals have the meanings stated in the description, to the preparation of these compounds and to their use as drugs.
-
-
-
-
-
-
-
-
-
Search Results
161
records
(took 0.025 seconds)
