公开(公告)号：CZ9801846A3

公开(公告)日：1998-09-16

申请号：CZ184698

申请日：1996-12-11

Applicant: BASF AG

Inventor： AMBERG WILHELM DR ,  BARLOZZARI TERESA ,  BERNARD HARALD DR ,  BUSCHMANN ERNST DR ,  HAUPT ANDREAS DR ,  HEGE HANS-GUENTHER DR ,  JANSSEN BERND DR ,  KLING ANDREAS DR ,  LIETZ HELMUT ,  RITTER KURT DR ,  ULRICH MARTINA DR ,  WEYMANN JURGEN DR ,  ZIERKE THOMAS DR

IPC: A61K38/00 ,  A61K31/00 ,  A61K38/08 ,  A61P35/00 ,  A61P35/02 ,  C07K1/00 ,  C07K7/06

CPC classification number: A61K38/08

公开(公告)号：CZ9701132A3

公开(公告)日：1998-03-18

申请号：CZ113297

申请日：1995-10-07

Applicant: BASF AG

Inventor： RIECHERS HARTMUT DR ,  KLINGE DAGMAR DR ,  AMBERG WILHELM DR ,  KLING ANDREAS DR ,  MULLER STEFAN DR ,  BAUMANN ERNST DR ,  RHEINHEIMER JOACHIM DR ,  VOGELBACHER JOSEF UWE DR ,  WERNET WOLFGANG DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR

IPC: C07D251/30 ,  A61K31/505 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  C07D239/00 ,  C07D239/26 ,  C07D239/28 ,  C07D239/34 ,  C07D239/38 ,  C07D239/60 ,  C07D239/70 ,  C07D239/96 ,  C07D251/12 ,  C07D251/52 ,  C07D257/02 ,  C07D309/00 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D491/048 ,  A61K31/495

CPC classification number: C07D495/04 ,  C07D239/34 ,  C07D239/48 ,  C07D239/52 ,  C07D239/60 ,  C07D239/70 ,  C07D239/96 ,  C07D251/20 ,  C07D251/26 ,  C07D251/52 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D487/04 ,  C07D491/04 ,  C07D491/048

公开(公告)号：DE19614533A1

公开(公告)日：1997-10-16

申请号：DE19614533

申请日：1996-04-12

Applicant: BASF AG

Inventor： KLINGE DAGMAR DR ,  AMBERG WILHELM DR ,  BAUMANN ERNST DR ,  KLING ANDREAS DR ,  RIECHERS HARTMUT DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR ,  HERGENROEDER STEFAN ,  SCHULT SABINE DR

IPC: A61K31/00 ,  A61K31/505 ,  A61K31/517 ,  A61P5/42 ,  A61P9/10 ,  A61P13/00 ,  A61P13/12 ,  C07D217/22 ,  C07D239/34 ,  C07D239/48 ,  C07D239/52 ,  C07D239/56 ,  C07D239/60 ,  C07D239/70 ,  C07D239/80 ,  C07D239/96 ,  C07D251/20 ,  C07D251/22 ,  C07D251/30 ,  C07D251/38 ,  C07D251/52 ,  C07D403/12 ,  C07D405/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D239/32 ,  A61K31/53 ,  A61K31/44 ,  A61K31/47

Abstract: The present invention relates to carboxylic acid derivatives of the formula (I) in which the radicals have the meaning given in the description, the production of these compounds and their use as medicaments.

公开(公告)号：DE4120917A1

公开(公告)日：1993-01-07

申请号：DE4120917

申请日：1991-06-25

Applicant: BASF AG

Inventor： BOCKSTIEGEL BERNHARD DR ,  EMLING FRANZ DR ,  KLING ANDREAS DR ,  JESSEL BARBARA DR ,  JANSSEN BERND DR

IPC: C07C219/06

Abstract: Described is the use, for the treatment of illnesses, of esters of fatty acids with amino alcohols of the formula I, in which R to R are as defined in the description.

公开(公告)号：HU0203338A2

公开(公告)日：2003-03-28

申请号：HU0203338

申请日：2000-03-29

Applicant: BASF AG

Inventor： GENESTE HERVE ,  GRAEF CLAUDIA ISABELLA ,  HORNBERGER WILFRIED DR ,  KLING ANDREAS DR ,  LANGE UDO ,  LAUTERBACH ARNULF ,  SADOWSKI JENS ,  SUBKOWSKI THOMAS ,  ZECHEL JOHANN-CHRISTIAN

IPC: C07D239/36 ,  A61K31/505 ,  A61K45/00 ,  A61K45/06 ,  A61P3/14 ,  A61P7/02 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P17/02 ,  A61P17/06 ,  A61P19/08 ,  A61P19/10 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  C07D239/34 ,  C07D239/60 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14

Abstract: The invention relates to novel compounds which bind to integrin receptors, to their preparation, to their use as integrin receptor ligands and for treating diseases, to pharmaceutical preparations comprising these compounds, and to pharmaceutical preparations comprising at least one other active compound.

公开(公告)号：CZ9800641A3

公开(公告)日：1998-09-16

申请号：CZ64198

申请日：1996-08-29

Applicant: BASF AG

Inventor： AMBERG WILHELM DR ,  KLING ANDREAS DR ,  KLINGE DAGMAR DR ,  REICHERS HARTMUT DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR ,  HERGENRODER STEFAN ,  ELGER BERND ,  SCHULT SABINE DR

IPC: C07D317/02 ,  A61K31/00 ,  A61K31/19 ,  A61K31/192 ,  A61K31/34 ,  A61K31/341 ,  A61K31/343 ,  A61K31/35 ,  A61K31/352 ,  A61K31/357 ,  A61K31/36 ,  A61K31/435 ,  A61K31/44 ,  A61K31/505 ,  A61P9/00 ,  A61P9/08 ,  C07C53/134 ,  C07C57/30 ,  C07C57/32 ,  C07C57/38 ,  C07C59/64 ,  C07C69/616 ,  C07C69/734 ,  C07C255/00 ,  C07D213/55 ,  C07D213/64 ,  C07D221/04 ,  C07D239/26 ,  C07D239/34 ,  C07D239/52 ,  C07D239/70 ,  C07D257/04 ,  C07D307/79 ,  C07D317/50 ,  C07D317/60 ,  C07D319/02 ,  C07D319/18

CPC classification number: C07D213/64 ,  C07C57/30 ,  C07C57/38 ,  C07C59/64 ,  C07C69/616 ,  C07C69/734 ,  C07D213/55 ,  C07D221/04 ,  C07D239/26 ,  C07D239/34 ,  C07D239/52 ,  C07D239/70 ,  C07D307/79 ,  C07D317/60 ,  C07D319/18

公开(公告)号：CZ64198A3

公开(公告)日：1998-09-16

申请号：CZ64198

申请日：1996-08-29

Applicant: BASF AG

Inventor： AMBERG WILHELM DR ,  KLING ANDREAS DR ,  KLINGE DAGMAR DR ,  REICHERS HARTMUT DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR ,  HERGENRODER STEFAN ,  ELGER BERND ,  SCHULT SABINE DR

IPC: C07D317/02 ,  A61K31/00 ,  A61K31/19 ,  A61K31/192 ,  A61K31/34 ,  A61K31/341 ,  A61K31/343 ,  A61K31/35 ,  A61K31/352 ,  A61K31/357 ,  A61K31/36 ,  A61K31/435 ,  A61K31/44 ,  A61K31/505 ,  A61P9/00 ,  A61P9/08 ,  C07C53/134 ,  C07C57/30 ,  C07C57/32 ,  C07C57/38 ,  C07C59/64 ,  C07C69/616 ,  C07C69/734 ,  C07C255/00 ,  C07D213/55 ,  C07D213/64 ,  C07D221/04 ,  C07D239/26 ,  C07D239/34 ,  C07D239/52 ,  C07D239/70 ,  C07D257/04 ,  C07D307/79 ,  C07D317/50 ,  C07D317/60 ,  C07D319/02 ,  C07D319/18

Abstract: PCT No. PCT/EP96/03793 Sec. 371 Date Feb. 24, 1998 Sec. 102(e) Date Feb. 24, 1998 PCT Filed Aug. 29, 1996 PCT Pub. No. WO97/09294 PCT Pub. Date Mar. 13, 1997Carboxylic acid derivatives of the formula I here R1 is a tetrazole [sic], nitrile [sic], a group COOH or a radical which can be hydrolyzed to COOH, and the other substituents have the meaning explained in the description.

公开(公告)号：DE19745151A1

公开(公告)日：1999-04-15

申请号：DE19745151

申请日：1997-10-14

Applicant: BASF AG

Inventor： PUHL MICHAEL DR ,  AMBERG WILHELM DR ,  HILLEN HEINZ DR ,  KLING ANDREAS DR ,  HERGENROEDER STEFAN DR ,  MARKERT CLAUS OTTO DR

IPC: A61K38/00 ,  A61P1/00 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P13/08 ,  A61P13/12 ,  A61P25/06 ,  A61P35/00 ,  A61P43/00 ,  C07K1/06 ,  C07K5/065 ,  C07K5/078 ,  A61K38/05

Abstract: N-2-Mercapto-3-phenylpropionyl dipeptides of formula (I) and their salts are new. R1 = H or optionally substituted 1-8C alkyl, aryl(1-8C)alkyl, heteroaryl(1-8C)alkyl, aryl or heteroaryl; R2 = optionally substituted 2-thienylmethyl, 2-naphthylmethyl or N-Boc-3-indolylmethyl; and R3 = H or optionally substituted acyl.

公开(公告)号：CZ104598A3

公开(公告)日：1998-09-16

申请号：CZ104598

申请日：1996-09-26

Applicant: BASF AG

Inventor： KLINGE DAGMAR DR ,  AMBERG WILHELM DR ,  KLING ANDREAS DR ,  RIECHERS HARTMUT DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR

IPC: A61K31/00 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/444 ,  A61K31/505 ,  A61K31/53 ,  A61P5/24 ,  A61P5/36 ,  A61P5/42 ,  A61P9/12 ,  C07D213/74 ,  C07D239/10 ,  C07D239/42 ,  C07D239/46 ,  C07D239/48 ,  C07D239/50 ,  C07D239/52 ,  C07D239/58 ,  C07D251/46 ,  C07D401/04 ,  C07D405/12 ,  C07D405/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052 ,  C07D491/056 ,  C07D239/70 ,  C07D487/02 ,  C07D251/42

Abstract: The invention relates to amino acid derivatives of the formula Iwhere the radicals have the meanings stated in the description, and to the use thereof as drugs.

公开(公告)号：CZ113297A3

公开(公告)日：1998-03-18

申请号：CZ113297

申请日：1995-10-07

Applicant: BASF AG

Inventor： RIECHERS HARTMUT DR ,  KLINGE DAGMAR DR ,  AMBERG WILHELM DR ,  KLING ANDREAS DR ,  MULLER STEFAN DR ,  BAUMANN ERNST DR ,  RHEINHEIMER JOACHIM DR ,  VOGELBACHER JOSEF UWE DR ,  WERNET WOLFGANG DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR

IPC: C07D251/30 ,  A61K31/505 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  C07D239/00 ,  C07D239/26 ,  C07D239/28 ,  C07D239/34 ,  C07D239/38 ,  C07D239/60 ,  C07D239/70 ,  C07D239/96 ,  C07D251/12 ,  C07D251/52 ,  C07D257/02 ,  C07D309/00 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D491/048 ,  A61K31/495

Abstract: Heterocyclyl-substd. propanoic acids and their derivs., of formula (I), are new. R = formyl, tetrazolyl, nitrile, COOH or a gp. that can be hydrolysed to COOH; X = N or CR14; R2 = H, OH, NH2, alkylamino, dialkylamino, halo, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; R14 = H or 1-5 C alkyl; R3 = R2 or alkoxyimino; or CR3 + CR14 = 5 or 6 membered alkylene or alkenyl ring (opt. substd. by 1-2 alkyl) in which a methylene can be replaced by O, S, NH or alkylamino; R4, R5 = phenyl or naphthyl (both opt. substd. by one or more halo, NO2, CN, OH, alkyl, haloalkyl, alkoxy, haloalkyloxy, phenoxy, alkylthio, NH2, alkylamine or dialkylamino) or 3-7 C cycloalkyl; or the phenyl or naphthyl gps. are opt. bonded at the O- position (by a bond, CH2, O, S, SO2, ethylene, ethenylene or opt. alkylated amino); R6 = H, 1-8 C alkyl, 2-6 C alkenyl, 3-6 C alkynyl, 3-8 C cycloalkyl (all opt. substd. by 1 or more halo, NO2, CN, alkoxy 3-6 C alkenyloxy, 3-6 C alkynyloxy, alkylthio, haloalkoxy, alkylcarbonyl, alkoxycarbonyl, 3-8 C alkylcarbonylalkyl, alkylamino, dialkylamino, phenyl, Ph or OPh), Ar or Het; Y = S, O or bond; Q = S, O, SO, SO2 or bond; Ph = substd. phenyl, where substits. are halo, NO2, CN, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; Ar = phenyl or naphthyl (both opt. substd. by 1 or more halo, NO2, CN, OH, NH2, alkylamino, dialkylamino or OCH2CH2O); Het = 5 or 6 membered heteroaromatic with 1-3 N atoms and/or one S or O (opt. substd. by 1-4 halo and/or 1 or 2 alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, phenyl, phenoxy or phenyl carbonyl (where the phenyl is opt. substd. by 1-5 halo and/or 1-3 alkyl, haloalkyl, alkoxy, haloalkoxy and/or alkylthio)); alkyl and alkoxy have 1-4 C unless otherwise stated; provided that R6 is not H when Q = bond.