公开(公告)号：DE19614542A1

公开(公告)日：1997-10-16

申请号：DE19614542

申请日：1996-04-12

Applicant: BASF AG

Inventor： AMBERG WILHELM DR ,  KLING ANDREAS DR ,  KLINGE DAGMAR DR ,  RIECHERS HARTMUT DR ,  BAUMANN ERNST DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR ,  HERGENROEDER STEFAN ,  SCHULT SABINE DR

IPC: A61K31/00 ,  A61K31/47 ,  A61K31/505 ,  A61P9/00 ,  A61P9/12 ,  A61P13/00 ,  A61P13/12 ,  C07D215/22 ,  C07D215/227 ,  C07D239/34 ,  C07D239/60 ,  C07D401/12 ,  C07D403/12 ,  C07D239/32 ,  C07D213/60 ,  C07C215/16 ,  C07C217/22 ,  C07D227/08 ,  C07D247/02 ,  A61K31/44

Abstract: The present invention relates to carboxylic acid derivatives of formula (I) in which the radicals have the meaning given in the description, and the production of these substances and their use as medicaments.

公开(公告)号：CZ287396A3

公开(公告)日：1997-04-16

申请号：CZ287396

申请日：1995-03-23

Applicant: BASF AG

Inventor： BAUMANN ERNST DR ,  VOGELBACHER UWE JOSEF DR ,  RHEINHEIMER JOACHIM DR ,  KLINGE DAGMAR DR ,  RIECHERS HARTMUT DR ,  KROGER BURKHARD DR ,  BIALOJAN SIEGFRIED DR ,  BOLLSCHWEILER CLAUS DR ,  WERNER VOLFGANG DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR

IPC: C07D251/26 ,  A61K31/00 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I

公开(公告)号：DE4411225A1

公开(公告)日：1995-10-05

申请号：DE4411225

申请日：1994-03-31

Applicant: BASF AG

Inventor： BAUMANN ERNST DR ,  VOGELBACHER UWE JOSEF DR ,  RHEINHEIMER JOACHM DR ,  KLINGE DAGMAR DR ,  RIECHERS HARTMUT DR ,  KROEGER BURKHARD DR ,  BIALOJAN SIEGFRIED DR ,  BOLLSCHWEILER CLAUS DR ,  WERNET WOLFGANG DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR

IPC: C07D251/26 ,  A61K31/00 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: The invention concerns the use of carboxylic acid derivatives of formula I (I) in which R means a formyl group, a CO2H group or a residue which can be hydrolysed to form COOH; X means nitrogen or CR , wherein R means hydrogen or, together with R , forms a 3- to 4-member alkylene or alkenylene chain in each of which a methyl group can be replaced by oxygen; Y means sulphur or oxygen or a single bond; Z means sulphur or oxygen; and the other substituents have the meanings given in the description. These derivatives can be used for preparing medicaments.

公开(公告)号：DE59106082D1

公开(公告)日：1995-08-31

申请号：DE59106082

申请日：1991-10-02

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BINDER RUDOLF DR ,  RASCHACK MANFRED DR ,  REINHARDT ROLAND DR ,  SEEMANN DIETMAR DR

IPC: A61K31/445 ,  A61K31/4468 ,  A61P9/00 ,  C07D211/58

Abstract: Phenylpiperidinylamines of the formula I I where R1 is -NHSO2R4 or R2 and R3 are each, independently of one another, H or C1-C4-alkyl or together are a (CH2)n chain with n=4 or 5, and R4 is C1-C4-alkyl or phenyl, and the physiologically tolerated salts thereof, and pharmaceutical compositions containing these are described.

公开(公告)号：AT125531T

公开(公告)日：1995-08-15

申请号：AT91116812

申请日：1991-10-02

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BINDER RUDOLF DR ,  RASCHACK MANFRED DR ,  REINHARDT ROLAND DR ,  SEEMANN DIETMAR DR

IPC: A61K31/445 ,  A61K31/4468 ,  A61P9/00 ,  C07D211/58

Abstract: Phenylpiperidinylamines of the formula I I where R1 is -NHSO2R4 or R2 and R3 are each, independently of one another, H or C1-C4-alkyl or together are a (CH2)n chain with n=4 or 5, and R4 is C1-C4-alkyl or phenyl, and the physiologically tolerated salts thereof, and pharmaceutical compositions containing these are described.

公开(公告)号：ES2054650T3

公开(公告)日：1994-08-16

申请号：ES87117946

申请日：1987-12-04

Applicant: BASF AG

Inventor： SEITZ WERNER DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR ,  BALDINGER VERENA DR ,  RUEBSAMEN KLAUS DR ,  GRIES JOSEF DR

IPC: A61K31/275 ,  A61K31/335 ,  A61K31/357 ,  A61K31/36 ,  A61P1/04 ,  A61P3/00 ,  A61P9/00 ,  A61P11/00 ,  A61P43/00 ,  C07C67/00 ,  C07C253/00 ,  C07C253/30 ,  C07C255/32 ,  C07C255/33 ,  C07C255/35 ,  C07C255/37 ,  C07C255/42 ,  C07C255/53 ,  C07C255/58 ,  C07D317/50 ,  C07D317/60 ,  C07D319/08 ,  C07D319/18 ,  C07D321/00

Abstract: Basic-substituted phenylacetonitriles of the formula I … … in which… R to R and n have the meaning given in the description, are suitable for combating diseases.

公开(公告)号：DE4032767A1

公开(公告)日：1992-04-30

申请号：DE4032767

申请日：1990-10-16

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BINDER RUDOLF DR ,  RASCHACK MANFRED DR ,  REINHARDT ROLAND DR ,  SEEMANN DIETMAR DR

IPC: A61K31/445 ,  A61K31/4468 ,  A61P9/00 ,  C07D211/58

Abstract: Phenylpiperidinylamines of the formula I I where R1 is -NHSO2R4 or R2 and R3 are each, independently of one another, H or C1-C4-alkyl or together are a (CH2)n chain with n=4 or 5, and R4 is C1-C4-alkyl or phenyl, and the physiologically tolerated salts thereof, and pharmaceutical compositions containing these are described.

公开(公告)号：DE3831993A1

公开(公告)日：1990-03-29

申请号：DE3831993

申请日：1988-09-21

Applicant: BASF AG

Inventor： TREIBER HANS-JOERG DR ,  HOFMANN HANS PETER DR ,  SZABO LASZLO DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR

IPC: C07D243/08 ,  A61K31/495 ,  A61K31/55 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  C07D295/08 ,  C07D295/084 ,  C07D295/092

Abstract: 2-hydroxy-3-phenoxy-propyl-substituted piperazines or homopiperazines of formula (I), in which R to R , Y, m and n have the meaning given in the description, and their manufacture are described. The new compounds are useful for treating diseases.

公开(公告)号：DE3603032A1

公开(公告)日：1987-08-06

申请号：DE3603032

申请日：1986-01-31

Applicant: BASF AG

Inventor： UNGER LILIANE DR ,  RASCHACK MANFRED DR ,  BALDINGER VERENA DR ,  DENGEL FERDINAND DR ,  EHRMANN OSKAR DR ,  TREIBER HANS-JOERG DR ,  SEITZ WERNER DR

IPC: A61K31/275 ,  A61K31/335 ,  A61K31/357 ,  A61P7/02 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07C67/00 ,  C07C253/00 ,  C07C255/32 ,  C07C255/42 ,  C07C255/43 ,  C07C255/53 ,  C07C255/58 ,  C07D317/58 ,  C07D319/08 ,  C07D319/18 ,  C07D321/12 ,  C07D325/00 ,  C07C121/66 ,  C07C121/75 ,  C07D317/50 ,  C07D317/52 ,  C07D317/62 ,  C07D317/64

公开(公告)号：DE3262516D1

公开(公告)日：1985-04-18

申请号：DE3262516

申请日：1982-03-31

Applicant: BASF AG

Inventor： EHRMANN OSKAR DR ,  RASCHACK MANFRED DR ,  GRIES JOSEF DR ,  KRETZSCHMAR ROLF DR ,  LEHMANN HANS DIETER DR ,  FRIEDRICH LUDWIG DR ,  WUPPERMANN DIRK DR ,  ZIMMERMANN FRANK DR ,  SEITZ WERNER DR ,  TREIBER HANS JOERG DR ,  DENGEL FERDINAND DR ,  FRANK WOLFRAM DR ,  KURBJUWEIT HANS-GEORG DR ,  MUELLER CLAUS D DR

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C121/75 ,  C07C121/66 ,  C07C149/42