-
公开(公告)号：CA2434483A1
公开(公告)日：2002-07-25
申请号：CA2434483
申请日：2002-01-19
Applicant: BASF AG
Inventor： BECK CHRISTINE , BALDENIUS KAI-UWE , YOCUM ROGERS R , PERO JANICE G , HERMANN THERON , PATTERSON THOMAS A
IPC: C12N15/09 , A61K31/7088 , A61P43/00 , C12N1/21 , C12N9/10 , C12P13/00 , C12P13/02 , C12P13/04 , C12R1/125 , C07C231/02 , C07C235/12 , C12P7/42 , C12N15/75
Abstract: The present invention features improved methods for producing pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. In particular, the invention features method s for reducing byproduct formation and increasing yields and purity of desired product. Recombinant microorganisms and conditions for culturing same are al so are featured. Also featured are compositions produced by such microorganisms .
-
公开(公告)号：NO20021382D0
公开(公告)日：2002-03-20
申请号：NO20021382
申请日：2002-03-20
Applicant: BASF AG
Inventor： YOCUM ROGERS R , PATTERSON THOMAS A , HERMANN THERON , PERO JANICE G
IPC: C12N15/09 , C12N1/21 , C12N9/02 , C12N9/12 , C12N9/88 , C12N15/52 , C12P13/02 , C12P13/04 , C12P13/06 , C12P17/04 , C12Q1/48 , C12R1/125 , C12N
Abstract: The present invention features methods of producing panto-compounds (e.g., pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzyme A biosynthetic pathway has been manipulated. Methods featuring ketopantoate reductase overexpressing microorganisms as well as aspartate ±-decarboxylase overexpressing microorganisms are provided. Methods of producing panto-compounds in a precursor-independent manner and in high yield are described. Recombinant microorganisms, vectors, isolated nucleic acid molecules, genes and gene products useful in practicing the above methodologies are also provided. The present invention also features a previously unidentified microbial pantothenate kinase gene, coaX , as well as methods of producing panto-compounds utilizing microorganisms having modified pantothenate kinase activity. Recombinant microorganisms, vectors, isolated coaX nucleic acid molecules and purified CoaX proteins are featured. Also featured are methods for identifying pantothenate kinase modulators utilizing the recombinant microorganisms and/or purified CoaX proteins of the present invention.
-
公开(公告)号：CA2385497A1
公开(公告)日：2001-03-29
申请号：CA2385497
申请日：2000-09-21
Applicant: BASF AG
Inventor： HERMANN THERON , PERO JANICE G , PATTERSON THOMAS A , YOCUM ROGERS R
IPC: C12N15/09 , C12N1/21 , C12N9/02 , C12N9/12 , C12N9/88 , C12N15/52 , C12P13/02 , C12P13/04 , C12P13/06 , C12P17/04 , C12Q1/48 , C12R1/125 , C12N9/00 , C12N9/10 , C12P7/42 , C12N15/53 , C12N15/54 , C12N15/60 , C12N15/75
Abstract: The present invention features methods of producing panto-compounds (e.g., pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzymeA biosynthetic pathway has been manipulated. Methods featuring ketopantoate reductase overexpressing microorganisms as well as aspartate g( a)- decarboxylase overexpressing microorganisms are provided. Methods of produci ng panto-compounds in a precursor-independent manner and in high yield are described. Recombinant microorganisms, vectors, isolated nucleic acid molecules, genes and gene products useful in practicing the above methodologies are also provided. The present invention also features a previously microbial pantothenate kinase gene, coaX, as well as methods of producing panto-compounds utilizing microorganisms having modified pantothenate kinase activity. Recombinant microorganisms, vectors, isolated coaXnucleic acid molecules and purified CoaX proteins are featured. Also featured are methods for identifying pantothenate kinase modulators utilizing the recombinant microorganisms and/or purified CoaX proteins of th e present invention.
-
公开(公告)号：HU230509B1
公开(公告)日：2016-09-28
申请号：HU0202705
申请日：2000-09-21
Applicant: BASF AG
Inventor： YOCUM ROGERS R , PATTERSON THOMAS A , HERMANN THERON , PERO JANICE G
-
公开(公告)号：IN1278CH2003A
公开(公告)日：2005-11-18
申请号：IN1278CH2003
申请日：2002-01-19
Applicant: BASF AG
Inventor： YOCUM R ROGERS , PATTERSON THOMAS A , PERO JANICE G , HERMANN THERON
IPC: C12N1/21 , C12N15/09 , C12N9/00 , C12N9/04 , C12N9/10 , C12N9/88 , C12P13/02 , C12P13/04 , C12R1/125
Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
-
Patent Agency Ranking
公开(公告)号：PL369009A1
公开(公告)日：2005-04-18
申请号：PL36900902
申请日：2002-01-18
Applicant: BASF AG
Inventor： YOCUM R ROGERS , PATTERSON THOMAS A , PERO JANICE G , HERMANN THERON
IPC: C12N1/21 , C12N9/00 , C12N9/04 , C12N9/10 , C12N15/09 , C12N9/88 , C12P13/02 , C12P13/04 , C12R1/125 , C12N15/03 , C07C235/12
Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
-
公开(公告)号：TR200200751T2
公开(公告)日：2004-08-23
申请号：TR200200751
申请日：2000-09-21
Applicant: BASF AG
Inventor： YOCUM ROGERS R , PATTERSON THOMAS A , HERMANN THERON , PERO JANICE G
IPC: C12N15/09 , C12N1/21 , C12N9/02 , C12N9/12 , C12N9/88 , C12N15/52 , C12P13/02 , C12P13/04 , C12P13/06 , C12P17/04 , C12Q1/48 , C12R1/125 , C12N15/60 , C12N15/75 , C12N9/00 , C12N8/02 , C12P7/42
Abstract: The present invention features methods of producing panto-compounds (e.g., pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzyme A biosynthetic pathway has been manipulated. Methods featuring ketopantoate reductase overexpressing microorganisms as well as aspartate ±-decarboxylase overexpressing microorganisms are provided. Methods of producing panto-compounds in a precursor-independent manner and in high yield are described. Recombinant microorganisms, vectors, isolated nucleic acid molecules, genes and gene products useful in practicing the above methodologies are also provided. The present invention also features a previously unidentified microbial pantothenate kinase gene, coaX , as well as methods of producing panto-compounds utilizing microorganisms having modified pantothenate kinase activity. Recombinant microorganisms, vectors, isolated coaX nucleic acid molecules and purified CoaX proteins are featured. Also featured are methods for identifying pantothenate kinase modulators utilizing the recombinant microorganisms and/or purified CoaX proteins of the present invention.
-
公开(公告)号：SK5222002A3
公开(公告)日：2003-03-04
申请号：SK5222002
申请日：2000-09-21
Applicant: BASF AG
Inventor： YOCUM ROGERS R , PATTERSON THOMAS A , HERMANN THERON , PERO JANICE G
IPC: C12N15/09 , C12N1/21 , C12N9/02 , C12N9/12 , C12N9/88 , C12N15/52 , C12P13/02 , C12P13/04 , C12P13/06 , C12P17/04 , C12Q1/48 , C12R1/125 , C12N15/00
Abstract: The present invention features methods of producing panto-compounds (e.g., pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzyme A biosynthetic pathway has been manipulated. Methods featuring ketopantoate reductase overexpressing microorganisms as well as aspartate ±-decarboxylase overexpressing microorganisms are provided. Methods of producing panto-compounds in a precursor-independent manner and in high yield are described. Recombinant microorganisms, vectors, isolated nucleic acid molecules, genes and gene products useful in practicing the above methodologies are also provided. The present invention also features a previously unidentified microbial pantothenate kinase gene, coaX , as well as methods of producing panto-compounds utilizing microorganisms having modified pantothenate kinase activity. Recombinant microorganisms, vectors, isolated coaX nucleic acid molecules and purified CoaX proteins are featured. Also featured are methods for identifying pantothenate kinase modulators utilizing the recombinant microorganisms and/or purified CoaX proteins of the present invention.
-
公开(公告)号：BR0014115A
公开(公告)日：2002-05-21
申请号：BR0014115
申请日：2000-09-21
Applicant: BASF AG
Inventor： YOCUM ROGERS R , PATTERSON THOMAS A , HERMANN THERON , PERO JANICE G
IPC: C12N15/09 , C12N1/21 , C12N9/02 , C12N9/12 , C12N9/88 , C12N15/52 , C12P13/02 , C12P13/04 , C12P13/06 , C12P17/04 , C12Q1/48 , C12R1/125 , C12N9/00
Abstract: The present invention features methods of producing panto-compounds (e.g., pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzyme A biosynthetic pathway has been manipulated. Methods featuring ketopantoate reductase overexpressing microorganisms as well as aspartate ±-decarboxylase overexpressing microorganisms are provided. Methods of producing panto-compounds in a precursor-independent manner and in high yield are described. Recombinant microorganisms, vectors, isolated nucleic acid molecules, genes and gene products useful in practicing the above methodologies are also provided. The present invention also features a previously unidentified microbial pantothenate kinase gene, coaX , as well as methods of producing panto-compounds utilizing microorganisms having modified pantothenate kinase activity. Recombinant microorganisms, vectors, isolated coaX nucleic acid molecules and purified CoaX proteins are featured. Also featured are methods for identifying pantothenate kinase modulators utilizing the recombinant microorganisms and/or purified CoaX proteins of the present invention.
-
公开(公告)号：AU7708700A
公开(公告)日：2001-04-24
申请号：AU7708700
申请日：2000-09-21
Applicant: BASF AG
Inventor： YOCUM ROGERS R , PATTERSON THOMAS A , HERMANN THERON , PERO JANICE G
IPC: C12N15/09 , C12N1/21 , C12N9/02 , C12N9/12 , C12N9/88 , C12N15/52 , C12P13/02 , C12P13/04 , C12P13/06 , C12P17/04 , C12Q1/48 , C12R1/125 , C12N9/00
Abstract: The present invention features methods of producing panto-compounds (e.g., pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzyme A biosynthetic pathway has been manipulated. Methods featuring ketopantoate reductase overexpressing microorganisms as well as aspartate ±-decarboxylase overexpressing microorganisms are provided. Methods of producing panto-compounds in a precursor-independent manner and in high yield are described. Recombinant microorganisms, vectors, isolated nucleic acid molecules, genes and gene products useful in practicing the above methodologies are also provided. The present invention also features a previously unidentified microbial pantothenate kinase gene, coaX , as well as methods of producing panto-compounds utilizing microorganisms having modified pantothenate kinase activity. Recombinant microorganisms, vectors, isolated coaX nucleic acid molecules and purified CoaX proteins are featured. Also featured are methods for identifying pantothenate kinase modulators utilizing the recombinant microorganisms and/or purified CoaX proteins of the present invention.
-
-
-
-
-
-
-
-
-
Search Results
43
records
(took 0.022 seconds)
