公开(公告)号：AU729610B2

公开(公告)日：2001-02-08

申请号：AU1858997

申请日：1997-02-10

Applicant: BAXTER INT

Inventor： BISCHOF DANIEL F

IPC: A61K35/14 ,  A61M1/36 ,  A61M35/00

Abstract: Blood processing systems and methods establish on line communication between a container and a source of blood containing leukocytes and platelets, such as a human donor. The systems and methods create a centrifugal field between the source of blood and the container that separates from the blood an unfinished suspension of platelets having a first physiologic characteristic different than the desired physiologic characteristic. The systems and methods pump the unfinished platelet suspension outside the centrifugal field through a finishing device. The finishing device changes the first physiologic characteristic to the desired physiological characteristic, thereby creating the finished platelet suspension. The systems and methods convey the finished platelet suspension from the finishing device directly into the container. The systems and methods function without interrupting the on line communication between the container and the source of blood.

公开(公告)号：BR9806231A

公开(公告)日：2000-03-21

申请号：BR9806231

申请日：1998-06-22

Applicant: BAXTER INT

Inventor： MIN KYUNGYOON ,  BROWN RICHARD I ,  CANTU ROBERT J ,  BISCHOF DANIEL F ,  CORK WILLIAM H

IPC: A61M1/30 ,  A61M1/36 ,  B04B5/04 ,  B04B13/00 ,  B01D21/26 ,  B04B11/04

Abstract: Blood separation systems and methods employ a rotating chamber. The chamber includes an inlet region where whole blood enters for centrifugal separation into packed red blood cells, a plasma constituent, and an interface carrying mononuclear cells between the packed red blood cells and the plasma constituent. The packed red blood cells in the chamber have a hematocrit value HPRBC. A controller operates in a first mode to convey whole blood into the inlet region while removing packed red blood cells and the plasma constituent from the chamber and while maintaining the interface within the chamber. The controller also operates in the first mode to maintain a set HPRBC by conveying packed red blood cells into the inlet region.

公开(公告)号：NO992162D0

公开(公告)日：1999-05-04

申请号：NO992162

申请日：1999-05-04

Applicant: PALL CORP ,  BAXTER INT

Inventor： SUTTER MARK A ,  BORTON NOEL T ,  BISCHOF DANIEL F ,  CHAPMAN JOHN ,  HERMAN ROBERT E ,  SUN CHONG-SON

IPC: A61M1/02 ,  A61K35/14 ,  A61M1/36 ,  B01D61/18 ,  B01D63/08 ,  B01D69/12 ,  A61M

公开(公告)号：NO982981L

公开(公告)日：1998-06-26

申请号：NO982981

申请日：1998-06-26

Applicant: BAXTER INT

Inventor： HERMAN ROBERT E ,  CHAPMAN JOHN ,  CHONG-SON SUN ,  MATHIAS JEAN M ,  MAYAUDON VURONIQUE ,  GHELDERE SERGE DE ,  BISCHOF DANIEL F

IPC: C12N5/06 ,  A61J3/00 ,  A61K35/16 ,  A61L2/00 ,  A61M1/36 ,  C12N7/00 ,  C12N

Abstract: Systems and methods treat plasma carrying contaminants and cellular matter that are capable of entraining contaminants. The systems and methods separate cellular matter from the plasma by filtration, thereby removing contaminants entrained within the cellular matter. The system and methods add to the plasma a photoactive material. The systems and methods emit radiation at a selected wavelength into the plasma to activate the photoactive material and thereby eradicate the contaminant that is free of entrainment by cellular matter.

公开(公告)号：NO973790D0

公开(公告)日：1997-08-18

申请号：NO973790

申请日：1997-08-18

Applicant: BAXTER INT

Inventor： SUN CHONG-SON ,  CHAPMAN JOHN ,  BISCHOF DANIEL F

IPC: A61K35/14 ,  A61K35/16 ,  A61L2/00 ,  A61M1/02 ,  A61M1/36 ,  B01J19/12 ,  A61M

公开(公告)号：CA2208051A1

公开(公告)日：1997-06-26

申请号：CA2208051

申请日：1996-11-26

Applicant: BAXTER INT

Inventor： CHAPMAN JOHN ,  BISCHOF DANIEL F ,  SUN CHONG-SON

IPC: A61K35/14 ,  A61K35/16 ,  A61L2/00 ,  A61M1/02 ,  A61M1/36 ,  B01J19/12 ,  A61M1/34 ,  A01N1/02 ,  A61L2/08 ,  C12N7/04

Abstract: Systems and methods treat plasma carrying contaminants and leukocytes that are capable of entraining contaminants. The systems and methods separate leukocytes from the plasma by filtration, thereby removing contaminants entrained within leukocytes. The systems and methods also add to the plasma a photoactive material and emit radiation at a selected wavelength into the plasma to activate the photoactive material and thereby eradicate the contaminant that is free of entrainment by leukocytes.

公开(公告)号：AU648631B2

公开(公告)日：1994-04-28

申请号：AU9179991

申请日：1991-12-20

Applicant: BAXTER INT

Inventor： BISCHOF DANIEL F

IPC: A61K35/14 ,  A61L2/00 ,  A61M1/02 ,  A61M1/36 ,  B01J19/12 ,  A61L2/08

Abstract: Systems and methods remove a contaminant from a fluid like blood, regardless of whether the contaminant is carried free within the fluid or entrained within cellular matter carried within the fluid. The systems and methods rely upon photodynamic processes to remove free contaminants from the fluid. The systems and methods rely upon separation processes to remove the cellular matter and, with it, the contaminants it entrains from the fluid.

公开(公告)号：CA2500738C

公开(公告)日：2014-02-18

申请号：CA2500738

申请日：2003-09-24

Applicant: BAXTER INT ,  CERUS CORP

Inventor： METZEL PEYTON S ,  BISCHOF DANIEL F ,  MOORE JOSEPH S ,  DING YUANPANG SAMUEL ,  HERMAN ROBERT E ,  MAYAUDON VERONIQUE ,  SOUDANT GREGORY ,  LECOUR DANIEL ,  BRIERE YVON ,  CIMINO GEORGE D ,  HEI DEREK J ,  LAIRD JAMES ,  MOHIUDDIN MAHMOOD

IPC: A61B19/00 ,  A61J1/00 ,  A61J1/05 ,  A61L2/00 ,  A61M1/02 ,  A61M1/36 ,  B01D15/00

Abstract: Apparatus, systems and methods are disclosed for treating a biological fluid with light. A disposable fluid processing set (200) including integrally connected containers (202, 206, 210, 214) and tubing (203, 205, 208, 211, 219) and a holder (260) or organizer (500) for receiving at least one of the containers, or for providing a rounded surface over which at least one of the containers is folded.

公开(公告)号：CA2469364C

公开(公告)日：2013-04-09

申请号：CA2469364

申请日：2002-11-22

Applicant: BAXTER INT

Inventor： BISCHOF DANIEL F ,  LO YING-CHENG

IPC: A61J3/00 ,  A61K35/14 ,  A01N1/02 ,  A61J1/05 ,  A61L2/00 ,  A61M1/02 ,  A61M1/36

Abstract: Methods and systems for preparing blood products that are ready for treatment in established pathogen inactivation procedures are disclosed. The methoids include providing a source of a blood component and combining the blood component with a synthetic medium in a selected ratio of the blood component to the synthetic media, whereby the resulting blood product is treatment-ready.

公开(公告)号：CA2434317C

公开(公告)日：2012-08-28

申请号：CA2434317

申请日：2002-11-22

Applicant: BAXTER INT

Inventor： BISCHOF DANIEL F ,  LO YING-CHENG ,  LYNN DANIEL ,  BLICKHAN BRYAN J

IPC: A61J1/05 ,  A61M1/36 ,  A01N1/02 ,  A61K35/14 ,  A61M1/02 ,  A61M1/34 ,  A61P7/04

Abstract: Systems and methods for manually process blood and blood components in sterile, closed environments, which further condition the blood components for subsequent pathogen inactivation processes. The systems and methods mate the manual collection of random donor platelet units with the creation of larger therapeutic doses of platelets targeted to undergo pathogen inactivation prior to long term storage and/or transfusion.