公开(公告)号：EP0984800A4

公开(公告)日：2003-03-26

申请号：EP98918867

申请日：1998-04-29

Applicant: BAXTER INT

Inventor： CHAPMAN JOHN ,  FISHER JERRY

IPC: A61L2/00 ,  A61M1/02 ,  B01D21/26 ,  B01D61/14 ,  A61M1/00 ,  A61M1/34

CPC classification number: A61M1/02 ,  A61L2/0017 ,  A61M2202/0439 ,  B01D21/262 ,  B01D61/147 ,  B01D2221/10 ,  A61M2202/0035 ,  A61M2202/0042

Abstract: A method for at least reducing the potential risk for the transmission of transmissible spongiform encephalopathy through blood products comprising the step of removing, intact, substantially all leukocytes that are present in the blood product or an intermediate of the blood product, prior to administering the blood product to a patient.

公开(公告)号：EP0809433A4

公开(公告)日：2001-01-10

申请号：EP96941472

申请日：1996-11-26

Applicant: BAXTER INT

Inventor： SUN CHONG-SON ,  CHAPMAN JOHN ,  BISCHOF DANIEL F

IPC: A61K35/14 ,  A61L2/00 ,  A61M1/02 ,  A61M1/36 ,  B01J19/12 ,  A01N1/02 ,  A61B19/00 ,  A61M37/00

CPC classification number: A61K35/16 ,  A61L2/0011 ,  A61L2/0017 ,  A61L2/08 ,  A61M1/0218 ,  A61M1/3633 ,  A61M1/3679 ,  A61M1/3681 ,  A61M1/3683 ,  A61M2202/0439 ,  B01J19/122 ,  A61M2202/0057

Abstract: Systems and methods treat plasma carrying contaminants and leukocytes that are capable of entraining contaminants. The systems and methods separate leukocytes from the plasma by filtration, thereby removing contaminants entrained within leukocytes. The systems and methods also add to the plasma a photoactive material and emit radiation at a selected wavelength into the plasma to activate the photoactive material and thereby eradicate the contaminant that is free of entrainment by leukocytes.

公开(公告)号：EP0900371A4

公开(公告)日：2000-12-13

申请号：EP97950881

申请日：1997-12-09

Applicant: BAXTER INT

Inventor： CHAPMAN JOHN ,  MATHIAS JEAN-MARIE

IPC: A61M1/36 ,  A61K31/00 ,  A61K31/54 ,  A61K31/5415 ,  A61K41/00 ,  A61P31/00 ,  A61P31/12 ,  G01N21/75 ,  G01N21/78 ,  A61L2/00

CPC classification number: A61K41/0019 ,  Y10S436/904 ,  Y10S436/905

Abstract: Systems and methods are disclosed for treating biological fluids carrying contaminants by photoactivating materials mixed with the fluids. The system (10) comprises a vessel (12) having a transparent region and containing a solution (14) comprising a photoactive material which undergoes reduction oxidation in response to exposure to a prescribed light energy, and a reducing agent mixed with the photoactive material.

Abstract translation: 公开了用于通过与流体混合的光活化材料处理携带污染物的生物流体的系统和方法。 系统（10）包括具有透明区域并容纳包含光敏材料的溶液（14）的容器（12），所述光敏材料响应于暴露于规定光能而进行还原氧化，还包括与光敏材料混合的还原剂。

公开(公告)号：EP0684763A4

公开(公告)日：1996-06-26

申请号：EP95904869

申请日：1994-12-09

Applicant: BAXTER INT

Inventor： FOLEY JOHN T ,  CHAPMAN JOHN ,  WOLF LUDWIG JR

IPC: G01N33/48 ,  A01N1/02 ,  A61K35/14 ,  A61K38/00 ,  A61L2/00 ,  A61M1/02 ,  A61M1/36 ,  B01D15/08 ,  B01D61/00 ,  A61K39/12 ,  A61M5/14 ,  A61M37/00 ,  B01D15/04

CPC classification number: A61M1/0209 ,  A61L2/0088 ,  A61M1/0218 ,  A61M1/3686 ,  A61M1/3687

Abstract: A method for treating a body fluid to at least substantially inactivate viral contaminants that may be present therein comprising the steps of: providing a body fluid; adding to the body fluid a viral inactivating agent to create a resultant product; and passing the resultant product through a column including material having an affinity for the viral inactivating agent.

公开(公告)号：EP0870013A4

公开(公告)日：2003-02-05

申请号：EP97911624

申请日：1997-10-03

Applicant: BAXTER INT

Inventor： HERMAN ROBERT E ,  CHAPMAN JOHN ,  CHONG-SON SUN ,  MATHIAS JEAN M ,  MAYAUDON VERONIQUE ,  DE GHELDERE SERGE ,  BISCHOF DANIEL F

IPC: C12N5/06 ,  A61J3/00 ,  A61K35/16 ,  A61L2/00 ,  A61M1/36 ,  C12N7/00 ,  C12N7/06

CPC classification number: A61L2/0011 ,  A61K35/16 ,  A61L2/022 ,  A61L2/08 ,  Y10S435/975

Abstract: Systems and methods treat plasma carrying contaminants and cellular matter that are capable of entraining contaminants. The systems and methods separate cellular matter from the plasma by filtration, thereby removing contaminants entrained within the cellular matter. The system and methods add to the plasma a photoactive material. The systems and methods emit radiation at a selected wavelength into the plasma to activate the photoactive material and thereby eradicate the contaminant that is free of entrainment by cellular matter.

公开(公告)号：EP0683626A4

公开(公告)日：1996-03-27

申请号：EP94916492

申请日：1994-02-17

Applicant: BAXTER INT

Inventor： MARTINSON JEFFREY ,  BRATTEN WILLIAM ,  WANG LI MING ,  CHAPMAN JOHN

IPC: G01N33/48 ,  A01N1/02 ,  A61B5/15 ,  B01D17/02 ,  B01D17/038 ,  B01D21/24 ,  B01D21/26 ,  C12Q1/68 ,  C12Q1/70 ,  G01N1/40 ,  G01N33/49 ,  G01N33/50 ,  G01N33/569 ,  C12P19/34

CPC classification number: G01N33/56983 ,  B01D17/0217 ,  B01D21/2405 ,  B01D21/2444 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D2221/10 ,  C12Q1/6806 ,  C12Q1/70 ,  G01N1/40 ,  G01N33/491 ,  G01N33/5091 ,  G01N33/5094 ,  G01N33/56972

Abstract: A method and apparatus for creating a leukocyte rich sample from a mixed population of blood cells. The method comprises the steps of: separating an amount of blood into layers that include a buffy coat layer having a mixed population of blood cells including plasma and red blood cells; providing a chamber having an opening for receiving a fluid; causing the buffy coat layer to enter the chamber; centrifuging the chamber to separate the buffy coat layer into at least a plasma containing layer, a leukocyte containing layer, and a red blood cell containing layer; and separating the leukocyte containing layer from the other layers in the chamber.

公开(公告)号：DE69633439T2

公开(公告)日：2005-09-22

申请号：DE69633439

申请日：1996-11-26

Applicant: BAXTER INT

Inventor： SUN CHONG-SON ,  CHAPMAN JOHN ,  BISCHOF F

IPC: A61K35/14 ,  A61K35/16 ,  A61L2/00 ,  A61M1/02 ,  A61M1/36 ,  B01J19/12 ,  A01N1/02 ,  A61B19/00 ,  A61M37/00

公开(公告)号：AT276655T

公开(公告)日：2004-10-15

申请号：AT96941472

申请日：1996-11-26

Applicant: BAXTER INT

Inventor： SUN CHONG-SON ,  CHAPMAN JOHN ,  BISCHOF DANIEL F

IPC: A61K35/14 ,  A61K35/16 ,  A61L2/00 ,  A61M1/02 ,  A61M1/36 ,  B01J19/12 ,  A01N1/02 ,  A61B19/00 ,  A61M37/00

公开(公告)号：AT220498T

公开(公告)日：2002-08-15

申请号：AT95904869

申请日：1994-12-09

Applicant: BAXTER INT

Inventor： FOLEY JOHN T ,  CHAPMAN JOHN ,  WOLF LUDWIG JR

IPC: G01N33/48 ,  A01N1/02 ,  A61K35/14 ,  A61K38/00 ,  A61L2/00 ,  A61M1/02 ,  A61M1/36 ,  B01D15/08 ,  B01D61/00 ,  A61K39/12 ,  A61M37/00 ,  A61M5/14 ,  B01D15/04 ,  A61L2/08

Abstract: A method for treating a body fluid to at least substantially inactivate viral contaminants that may be present therein is provided. The method includes the steps of: providing a body fluid; adding to the body fluid a viral inactivating agent to create a resultant product; and passing the resultant product through a column including material having an affinity for the viral inactivating agent.

公开(公告)号：AU735878B2

公开(公告)日：2001-07-19

申请号：AU4894897

申请日：1997-10-03

Applicant: BAXTER INT

Inventor： HERMAN ROBERT E ,  CHAPMAN JOHN ,  CHONG-SON SUN ,  MATHIAS JEAN M ,  MAYAUDON VERONIQUE ,  GHELDERE SERGE DE ,  BISCHOF DANIEL F

IPC: C12N5/06 ,  A61J3/00 ,  A61K35/16 ,  A61L2/00 ,  A61M1/36 ,  C12N7/00 ,  C12N7/04 ,  C12N7/06

Abstract: Systems and methods treat plasma carrying contaminants and cellular matter that are capable of entraining contaminants. The systems and methods separate cellular matter from the plasma by filtration, thereby removing contaminants entrained within the cellular matter. The system and methods add to the plasma a photoactive material. The systems and methods emit radiation at a selected wavelength into the plasma to activate the photoactive material and thereby eradicate the contaminant that is free of entrainment by cellular matter.