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    METODO PARA PREPARAR PARTICULAS PEQUENAS.
    22.
    发明专利
    METODO PARA PREPARAR PARTICULAS PEQUENAS. 未知

    公开(公告)号：MXPA05009936A

    公开(公告)日：2006-05-31

    申请号：MXPA05009936

    申请日：2004-02-25

    Applicant: BAXTER INT

    Inventor： BRYNJELSEN SEAN

    IPC: A61K31/496 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/55 ,  A61K31/573

    Abstract: La presente invencion se refiere a la formacion de particulas pequenas o compuestos organicos mediante precipitacion de los compuestos organicos en un medio acuoso a fin de formar una pre-suspension seguida por adicion de energia para estabilizar una cubierta de la particula o para alterar la estructura de reticula de la particula. El proceso incluye las etapas de: (i) disolver el compuesto organico en el primer solvente miscible en agua a fin de formar una solucion; (ii) mezclar la solucion con el segundo solvente para definir una pre-suspension de particulas; y (iii) agregar energia a la pre-suspension para formar una suspension de particulas que tienen un tamano de particula eficaz promedio de menos de aproximadamente 100 mum. El proceso se utiliza preferentemente para preparar una suspension de particulas pequenas de un compuesto farmaceuticamente activo, escasamente soluble en agua, para suministro in vivo mediante una ruta de administracion tal como parenteral, oral, pulmonar, nasal, bucal, topica, oftalmica, recta, vaginal, transdermica o lo similar.

    METHOD FOR PREPARING SMALL PARTICLES
    24.
    发明专利
    METHOD FOR PREPARING SMALL PARTICLES 未知

    公开(公告)号：CA2517589A1

    公开(公告)日：2004-09-30

    申请号：CA2517589

    申请日：2004-02-25

    Applicant: BAXTER INT

    Inventor： WONG JOSEPH CHUNG TAK ,  KIPP JAMES E ,  WERLING JANE ,  REBBECK CHRISTINE L ,  BRYNJELSEN SEAN ,  DOTY MARK J

    IPC: A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

    Abstract: The present invention is concerned with the formation of small particles or organic compounds by precipitating the organic compounds in an aqueous mediu m to form a pre-suspension followed by adding energy to stabilize a coating of the particle or to alter the lattice structure of the particle. The process includes the steps of: (i) dissolving the organic compound in the water- miscible first solvent to form a solution; (ii) mixing the solution with the second solvent to define a presuspension of particles; and (iii) adding ener gy to the presuspension to form a suspension of particles having an average effective particle size of less than about 100 .mu.m. The process is preferably used to prepare a suspension of small particles of a poorly water - soluble, pharmaceutically active compound suitable for in vivo delivery by a n administrate route such as parenteral, oral, pulmonary, nasal, buccal, topic al ophthalmic, rectal, vaginal, transdermal or the like.

    Method for preparing small particles
    25.
    发明专利
    Method for preparing small particles 未知

    公开(公告)号：AU2004222362A1

    公开(公告)日：2004-09-30

    申请号：AU2004222362

    申请日：2004-02-25

    Applicant: BAXTER INT

    Inventor： KIPP JAMES E ,  WONG JOSEPH CHUNG TAK ,  WERLING JANE ,  REBBECK CHRISTINE L ,  BRYNJELSEN SEAN

    IPC: A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

    Abstract: The present invention is concerned with the formation of small particles of organic compounds by precipitating the organic compounds in an aqueous medium to form a pre-suspension followed by adding energy to stabilize a coating of the particle or to alter the lattice structure of the particle. The process includes the steps of: (i) dissolving the organic compound in the water-miscible first solvent to form a solution; (ii) mixing the solution with the second solvent to define a presuspension of particles; and (iii) adding energy to the presuspension to form a suspension of particles having an average effective particle size of less than about 100 mum. The process is preferably used to prepare a suspension of small particles of a poorly water-soluble, pharmaceutically active compound suitable for in vivo delivery by an administrate route such as parenteral, oral, pulmonary, nasal, buccal, topical ophthalmic, rectal, vaginal, transdermal or the like.

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