公开(公告)号：WO1996018292A1

公开(公告)日：1996-06-20

申请号：PCT/US1995010705

申请日：1995-08-22

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  GRODE, Gerald, A. ,  STEWART, Mary, A.

IPC: A01N01/02

CPC classification number: A61K35/14

Abstract: A new citrate-based anticoagulant for donor whole blood provides good platelet yield and cell morphology at a significantly reduced risk of donor paresthesia during apheresis procedures. The primary citrate anticoagulant compositions include a citric acid to total citrate ration greater than about 30 %. The anticoagulants are mixed with whole blood to provide an anticoagulated blood mixture which contains a citric acid concentration of greater than about 5.0 mM, a total citrate concentration of less than about 20 mM, and an initial blood pH of less than about 6.75. The platelet rich products including PRP and PC prepared from blood collected in accordance with the invention exhibit better platelet yields and better platelet morphology on storage.

Abstract translation: 用于供体全血的新的基于柠檬酸盐的抗凝剂在分离术期间以显着降低的供体感觉异常风险提供良好的血小板产生和细胞形态。 主要的柠檬酸盐抗凝剂组合物包括柠檬酸至总柠檬酸盐比例大于约30％。 将抗凝剂与全血混合以提供含有大于约5.0mM的柠檬酸浓度，小于约20mM的总柠檬酸盐浓度和小于约6.75的初始血液pH的抗凝血液混合物。 包含根据本发明收集的血液制备的包含PRP和PC的富血小板产品在储存时表现出更好的血小板产量和更好的血小板形态。

公开(公告)号：WO1996015805A1

公开(公告)日：1996-05-30

申请号：PCT/US1995014111

申请日：1995-10-30

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  BLUE, John ,  GARBER, Jan, W. ,  GONDER, Janet, C. ,  MARCHAND, Gary, R. ,  PRZYBELSKI, Robert, J. ,  STERN, Kathleen, N.

IPC: A61K38/42

CPC classification number: A61K38/42

Abstract: Low doses of stroma-free diaspirin cross-linked hemoglobin are administered to patients undergoing hemodialysis, to achieve hemostabilization and avoid hypotensive episodes in susceptible patients. Hemoglobin therapy when implemented prophylactically in hemodialysis also partially obviates the need for further interventions to control circulatory system instability.

Abstract translation: 向患有血液透析的患者施用低剂量的无间质的diaspirin交联血红蛋白，以实现稳定化并避免易感患者的低血压发作。 在血液透析中预防性地实施血红蛋白治疗也部分地消除了进一步干预以控制循环系统不稳定性的需要。

公开(公告)号：WO1996015757A1

公开(公告)日：1996-05-30

申请号：PCT/US1995010706

申请日：1995-08-22

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  PATEL, Indrajit, T.

IPC: A61J01/05

CPC classification number: B32B1/02 ,  A61J1/10 ,  B29C47/00 ,  B29C47/0009 ,  B29C49/04 ,  B29L2031/7148 ,  B32B27/08 ,  B32B27/306 ,  B32B27/32 ,  B32B2250/24 ,  B32B2270/00 ,  B32B2323/046 ,  B32B2331/04 ,  B32B2439/00 ,  B32B2535/00 ,  C08L23/0815 ,  C08L23/0853 ,  C08L53/025 ,  C08L2203/02 ,  C08L2205/03 ,  Y10T428/1334 ,  Y10T428/1345 ,  Y10T428/1352 ,  Y10T428/1386 ,  Y10T428/31909 ,  Y10T428/31913 ,  Y10T428/31917 ,  Y10T428/31924 ,  Y10T428/31928 ,  Y10T428/31931 ,  Y10T428/31935 ,  Y10T428/31938 ,  C08L2666/02 ,  C08L2666/04

Abstract: The invention provides a flexible plastic formulation capable of being extruded, blow-molded, ethylene oxide and radiation sterilized. The plastic formulation of the invention comprises: a) from about 60 to about 94 percent by weight of a copolymer consisting essentially of ethylene and vinyl acetate units; b) from about 5 to about 25 percent by weight of a block copolymer, the block copolymer consisting essentially of a central block copolymer molecule including generally equal proportions of ethylene and butylene units, and terminal blocks of polystyrene; and c) from about 1 to about 15 percent by weight of an ultra-low density polyethylene material. The plastic formulations of the invention are useful in the manufacture of blood bags, tubing and the like.

Abstract translation: 本发明提供一种能够被挤出，吹塑，环氧乙烷和辐射灭菌的柔性塑料制剂。 本发明的塑料制剂包含：a）约60-约94重量％的基本上由乙烯和乙酸乙烯酯单元组成的共聚物; b）约5至约25重量％的嵌段共聚物，所述嵌段共聚物基本上由包含通常相等比例的乙烯和丁烯单元的中心嵌段共聚物分子和聚苯乙烯的端基组成; 和c）约1至约15重量％的超低密度聚乙烯材料。 本发明的塑料制剂可用于制造血袋，管等。

公开(公告)号：WO1996015153A1

公开(公告)日：1996-05-23

申请号：PCT/US1995014869

申请日：1995-11-15

Applicant: BAXTER INTERNATIONAL INC. ,  ARIZONA BOARD OF REGENTS, UNIVERSITY OF ARIZONA

Inventor： BAXTER INTERNATIONAL INC. ,  ARIZONA BOARD OF REGENTS, UNIVERSITY OF ARIZONA ,  LANDSPERGER, William, J. ,  MARCHALONIS, John, J. ,  LAKE, Douglas, F.

IPC: C07K16/28

CPC classification number: C07K16/065 ,  A61K38/00 ,  C07K16/2809

Abstract: Human antibody preparations enriched for antibodies that bind to human T-cell receptor peptide or conformational determinants are disclosed. Also disclosed are methods for making such antibody preparations from human plasma Cohn fractions by immunoaffinity purification using either recombinant Tcr protein or Tcr variable region peptides. Purification of Tcr antibodies from human or animal antibody mixtures is accomplished by immunoaffinity procedures using recombinant human T-cell receptor proteins. The affinity purified antibodies can bind to intact membrane-bound Tcr using fluorescence activated cell sorting (FACS) and can inhibit T-cell proliferation following stimulation by mitogen. Affinity purified human polyclonal antibodies can inhibit lytic activity of natural killer cells on a monoclonal T-cell line. The antibody preparations can be used for diagnosis, monitoring and therapy of various autoimmune-related syndromes.

Abstract translation: 公开了富含结合人T细胞受体肽或构象决定簇的抗体的人抗体制剂。 还公开了通过使用重组Tcr蛋白或Tcr可变区肽的免疫亲和纯化从人血浆Cohn级分制备这种抗体制剂的方法。 来自人或动物抗体混合物的Tcr抗体的纯化通过使用重组人T细胞受体蛋白质的免疫亲和方法完成。 亲和纯化的抗体可以使用荧光激活细胞分选（FACS）结合完整的膜结合的Tcr，并且可以抑制丝裂原刺激后的T细胞增殖。 亲和纯化的人多克隆抗体可以抑制单克隆T细胞系上天然杀伤细胞的裂解活性。 抗体制剂可用于各种自身免疫相关综合征的诊断，监测和治疗。

公开(公告)号：WO1996005960A1

公开(公告)日：1996-02-29

申请号：PCT/US1995008729

申请日：1995-07-12

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  SERVERS, Dale, R. ,  FRANKENBERGER, David ,  WILLIAMS, Richard ,  KEMP, Michael

IPC: B31B23/00

CPC classification number: B29C66/8511 ,  B29C65/78 ,  B29C66/1122 ,  B29C66/133 ,  B29C66/24221 ,  B29C66/53262 ,  B29C66/71 ,  B29C66/723 ,  B29L2031/7148 ,  B31B70/00 ,  B31B2155/00 ,  B31B2155/002 ,  B31B2160/10 ,  B65H20/00 ,  B65H37/04 ,  B29K2023/06 ,  B29K2023/12 ,  B29K2027/06 ,  B29K2077/00

Abstract: An apparatus (31) and a method are disclosed for performing an operation upon multiple webs (51, 53), including the feeding of multiple webs (51, 53), the provision of a carrier (65) for assisting in moving the webs (51, 53) along a predetermined path (83), the performance of an operation (69) upon the webs, the insertion of a carrier (65) between the webs (51, 53), and the provision of a sealing device (71) for sealing the webs together to form a sealed portion (75) to cooperate with the carrier (65) for assisting in moving the webs (51, 53). The carriers (65) are mounted on a conveyor (83) and each carrier (65) pushes against the sealed portion (75) to pull the webs (51, 53), and the packages (41) formed therefrom in the direction of conveyor travel. The preferred carrier (65) has a shaped head on the end of a flat plastic blade. The shaped head may have an opening (81) therein of a smaller size than the sealer (188) inserted into the opening such that the fused plastic may extrude outwardly to abut the edge (79) of the carrier defining the opening.

Abstract translation: 公开了一种用于对多个腹板（51,53）进行操作的装置（31）和方法，包括多个腹板（51,53）的进给，提供用于辅助腹板移动的载体（65） 沿着预定路径（83），在腹板上执行操作（69），在腹板（51,53）之间插入载体（65），并且设置密封装置（71） ），用于将腹板密封在一起以形成密封部分（75），以与托架（65）配合以协助移动腹板（51,53）。 载体（65）安装在输送机（83）上，每个载体（65）推压密封部分（75）以将腹板（51,53）和由其形成的包装（41）沿输送方向 旅行。 优选的载体（65）在扁平塑料叶片的端部上具有成形头部。 成形头部可以在其中具有比插入到开口中的密封剂（188）更小的尺寸的开口（81），使得熔融塑料可以向外挤出以邻接限定开口的载体的边缘（79）。

公开(公告)号：WO1996003938A1

公开(公告)日：1996-02-15

申请号：PCT/US1995008419

申请日：1995-07-05

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  CARPENTIER, Alexandre ,  CARPENTIER, Alain, F.

IPC: A61F02/24

CPC classification number: A61F2/2448 ,  A61F2250/0004 ,  A61F2250/0082

Abstract: The distensible annuloplasty ring which may be enlarged, in situ, by application of dilaroty pressure by way of a balloon or other dilating apparatus. The distensible annuloplasty ring of the invention is usable in pediatric patients whose growth, subsequent to surgical implantation of the ring, will necessitate subsequent enlargement of the ring to accommodate growth of the annulus. The invention includes a transluminal and/or transeptal method for post-implantation enlargement of the annuloplasty ring via catheter.

Abstract translation: 可扩张的瓣环成形术环，可以通过使用气囊或其它扩张装置施加压力的压力原位放大。 本发明的可扩张瓣环成形术环可用于儿科患者，其生长在环的手术植入之后将需要随后的扩大环以适应环的生长。 本发明包括用于通过导管进行的瓣膜成形术环的植入后扩大的经腔和/或跨膜方法。

公开(公告)号：WO1996001611A1

公开(公告)日：1996-01-25

申请号：PCT/US1995008151

申请日：1995-06-29

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  GELLER, Robin, Lee ,  BRAUKER, James, H. ,  JOHNSTON, William, D. ,  LEVON, Steven, A. ,  MARYANOV, David, A.

IPC: A61J09/00

CPC classification number: A61K9/0024 ,  A61K35/13 ,  A61K38/19 ,  A61K39/0011 ,  A61K2039/5152 ,  A61K2300/00

Abstract: An implantable device for the prevention or treatment of cancer comprising an implantable chamber containing tumor cells, or somatic cells engineered to express at least one antigen corresponding to antigen of a patient's tumor; the chamber having a porous wall to provide, in use, a porous boundary between the patient's immune cells and the contained cells; the porosity of the boundary being sufficient to permit subcellular antigenic material to pass through the boundary, while preventing the contained cells and patient immune cells from passing through the boundary.

Abstract translation: 一种用于预防或治疗癌症的可植入装置，包括含有肿瘤细胞的植入式腔室，或被改造以表达至少一种与患者肿瘤抗原相对应的抗原的体细胞; 该室具有多孔壁，在使用中提供患者的免疫细胞和所含细胞之间的多孔边界; 边界的孔隙度足以允许亚细胞抗原物质通过边界，同时防止含有细胞和患者免疫细胞通过边界。

公开(公告)号：WO1995024229A3

公开(公告)日：1995-09-14

申请号：PCT/US1995002545

申请日：1995-03-02

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  ANDERSON, Robert, L. ,  CASTLEBERRY, Jeffrey, P. ,  STRACENER, Steve, W.

IPC: F04B43/09

公开(公告)号：WO1995024229A2

公开(公告)日：1995-09-14

申请号：PCT/US1995002545

申请日：1995-03-02

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  ANDERSON, Robert, L. ,  CASTLEBERRY, Jeffrey, P. ,  STRACENER, Steve, W.

IPC: A61M00/00

CPC classification number: A61M5/16854 ,  A61M5/142 ,  A61M39/281 ,  A61M2005/1404

Abstract: A medical infusion pump (10) including an improved electric motor assembly (256). The medical infusion pump (10) includes a pumping mechanism (250) and a pump chamber (132) in an operative position with respect to the pumping mechanism (250), the pumping mechanism (250), manipulating the pump chamber (132) to pump liquid through the pump chamber. An electric motor (256) having a rotatable drive shaft (316) is operably linked to the pump driving mechanism (250), and the pump driving mechanism (250) pumps a select amount of liquid through the pump chamber (132) on each rotation of the electric motor drive shaft (316). The improved electric motor assembly (256) includes a motor having a portion of a drive shaft (388) extending therefrom. A magnet (392) is attached to the extending portion of the drive shaft for rotation with the drive shaft. A flux gatherer (396) is spaced from and magnetically coupled to the magnet (392) for biasing the poles of the magnet in a select orientation relative to the flux gatherer (396) so as to stop the pump driving mechanism (250) in a select position. A magnetic position detector (400) is spaced from and magnetically coupled to the magnet (392) for emitting an electrical signal each rotation of the drive shaft (388).

Abstract translation: 一种包括改进的电动机组件（256）的医用输液泵（10）。 医用输液泵（10）包括泵送机构（250）和相对于泵送机构（250）的操作位置的泵室（132），泵送机构（250）将泵室（132）操纵至 泵送液体通过泵室。 具有可旋转驱动轴（316）的电动机（256）可操作地连接到泵驱动机构（250），并且泵驱动机构（250）在每次旋转时泵送选择量的液体通过泵室（132） 的电动机驱动轴（316）。 改进的电动机组件（256）包括具有从其延伸的驱动轴（388）的一部分的电动机。 磁体（392）安装在驱动轴的延伸部分上，与驱动轴一起旋转。 磁通采集器（396）与磁体（392）隔开并磁耦合，用于相对于磁通采集器（396）以选择的方向偏压磁体的磁极，从而将泵驱动机构（250）停止在 选择位置 磁性位置检测器（400）与磁体（392）间隔开并磁耦合，用于发射驱动轴（388）的每个旋转的电信号。

公开(公告)号：WO1995021638A1

公开(公告)日：1995-08-17

申请号：PCT/US1995001724

申请日：1995-02-09

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  CHEN, Herbert ,  NESS, Ronald, A. ,  WOODARD, John, C.

IPC: A61M01/12

CPC classification number: A61M1/1055 ,  A61M1/1037 ,  A61M1/1046 ,  A61M1/1096 ,  A61M1/12 ,  A61M1/122 ,  Y10S128/03

Abstract: A pump system (110) is described which is particularly suited for use as a left ventricular assist device for internal use in humans. The pump system (110) generally includes a pump (100) having a deformable sac (111) formed in a seamless piece of flexible resilient material having: (i) a pair of opposite substantially planar walls (113, 114) and of substantially circular shape joined by an annular wall (112) of substantially semicircular cross section and (ii) inlet and outlet means (121, 123). The inlet means (121) have an asymmetric tapered section (125) positioned to direct the inlet flow toward the annular wall (112) of the sac (111) to produce a smooth circular flow within the sac (111) and minimize thrombus formation. A pair of pusher plates (134, 136) are disposed on opposite sides of the sac (111). Each of the pusher plates (134, 136) are engageable with a respective one of the planar walls (113, 114) of the sac (111) for displacing at least one of the planar walls toward the other to deform the sac. The pump system (110) also includes removable inlet and outlet conduit means (160, 161) with valve means (150, 151) for controlling inlet and outlet flow. Each of the conduit means (160, 161) include connecting means having sealing means (181, 182) for securing the inlet and outlet conduit means (160, 161) to the pump (100).

Abstract translation: 描述了一种泵系统（110），其尤其适合用作人体内部使用的左心室辅助装置。 泵系统（110）通常包括具有形成在柔性弹性材料的无缝件中的可变形囊（111）的泵（100），其具有：（i）一对相对的基本上平坦的壁（113,114） 形状由大致半圆形横截面的环形壁（112）连接，以及（ii）入口和出口装置（121,123）。 入口装置（121）具有非对称锥形部分（125），其定位成将入口流引向囊（111）的环形壁（112），以在囊（111）内产生平滑的圆形流动并使血栓形成最小化。 一对推动板（134,136）设置在囊（111）的相对侧上。 推动器板（134,136）中的每一个可与囊（111）的相应的一个平面壁（113,114）接合，用于将至少一个平面壁朝着另一个移动以使囊变形。 泵系统（110）还包括可移除的入口和出口管道装置（160,161），其具有用于控制入口和出口流量的阀装置（150,151）。 每个管道装置（160,161）包括具有密封装置（181,182）的连接装置，用于将入口和出口导管装置（160,161）固定到泵（100）。