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公开(公告)号：WO1992008349A1
公开(公告)日：1992-05-29
申请号：PCT/US1991008116
申请日：1991-10-30
Applicant: BAXTER INTERNATIONAL INC.
Inventor： BAXTER INTERNATIONAL INC. , GRODE, Gerald, A. , BISCHOF, Daniel , GOLDHABER, Richard
IPC: A01N01/02
CPC classification number: A61L2/0023 , A01N1/02 , A01N1/0226
Abstract: The present invention provides a blood component storage medium that can be sterilized, through autoclaving, and has improved shelf storage properties. The blood component storage medium comprises a first solution including at least one sugar and having a pH of less than 7. A second, distinct solution, including a bicarbonate buffer is provided having a pH greater than 7. The two solutions are stored separately and are mixed together prior to use as a storage medium.
Abstract translation: 本发明提供一种可通过高压灭菌消毒的血液成分储存介质，并具有改进的储存储存性能。 血液成分储存培养基包括含有至少一种糖并且pH小于7的第一溶液。提供pH值大于7的第二种不同的溶液，包括碳酸氢盐缓冲液。两种溶液分别储存， 在使用前作为储存介质混合在一起。
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Patent Agency Ranking
公开(公告)号：WO1996018292A1
公开(公告)日：1996-06-20
申请号：PCT/US1995010705
申请日：1995-08-22
Applicant: BAXTER INTERNATIONAL INC.
Inventor： BAXTER INTERNATIONAL INC. , GRODE, Gerald, A. , STEWART, Mary, A.
IPC: A01N01/02
CPC classification number: A61K35/14
Abstract: A new citrate-based anticoagulant for donor whole blood provides good platelet yield and cell morphology at a significantly reduced risk of donor paresthesia during apheresis procedures. The primary citrate anticoagulant compositions include a citric acid to total citrate ration greater than about 30 %. The anticoagulants are mixed with whole blood to provide an anticoagulated blood mixture which contains a citric acid concentration of greater than about 5.0 mM, a total citrate concentration of less than about 20 mM, and an initial blood pH of less than about 6.75. The platelet rich products including PRP and PC prepared from blood collected in accordance with the invention exhibit better platelet yields and better platelet morphology on storage.
Abstract translation: 用于供体全血的新的基于柠檬酸盐的抗凝剂在分离术期间以显着降低的供体感觉异常风险提供良好的血小板产生和细胞形态。 主要的柠檬酸盐抗凝剂组合物包括柠檬酸至总柠檬酸盐比例大于约30％。 将抗凝剂与全血混合以提供含有大于约5.0mM的柠檬酸浓度，小于约20mM的总柠檬酸盐浓度和小于约6.75的初始血液pH的抗凝血液混合物。 包含根据本发明收集的血液制备的包含PRP和PC的富血小板产品在储存时表现出更好的血小板产量和更好的血小板形态。
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公开(公告)号：EP0510185B1
公开(公告)日：1996-12-11
申请号：EP92902017.0
申请日：1991-10-30
Applicant: BAXTER INTERNATIONAL INC.
Inventor： GRODE, Gerald, A. , BISCHOF, Daniel , GOLDHABER, Richard
IPC: A01N1/02
CPC classification number: A61L2/0023 , A01N1/02 , A01N1/0226
Abstract: The present invention provides a blood component storage medium that can be sterilized, through autoclaving, and has improved shelf storage properties. The blood component storage medium comprises a first solution including at least one sugar and having a pH of less than 7. A second, distinct solution, including a bicarbonate buffer is provided having a pH greater than 7. The two solutions are stored separately and are mixed together prior to use as a storage medium.
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公开(公告)号：EP0510185A1
公开(公告)日：1992-10-28
申请号：EP92902017.0
申请日：1991-10-30
Applicant: BAXTER INTERNATIONAL INC.
Inventor： GRODE, Gerald, A. , BISCHOF, Daniel , GOLDHABER, Richard
CPC classification number: A61L2/0023 , A01N1/02 , A01N1/0226
Abstract: La présente invention décrit un milieu de stockage d'un constituant sanguin, qui peut être stérilisé dans un autoclave et qui présente des caractéristiques améliorées de conservation. Le milieu de stockage de constituant sanguin se compose d'une première solution comprenant au moins un sucre et présentant un pH inférieur à 7. Une seconde solution séparée est aussi comprise, laquelle contient un tampon de bicarbonate et présente un pH supérieur à 7. Les deux solutions sont séparément stockées et sont mélangées avant leur utilisation comme milieu de stockage.
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公开(公告)号：EP0744892B1
公开(公告)日：2003-12-03
申请号：EP95929639.3
申请日：1995-08-22
Applicant: BAXTER INTERNATIONAL INC.
Inventor： GRODE, Gerald, A. , STEWART, Mary, A.
CPC classification number: A61K35/14
Abstract: A new citrate-based anticoagulant for donor whole blood provides good platelet yield and cell morphology at a significantly reduced risk of donor paresthesia during apheresis procedures. The primary citrate anticoagulant compositions include a citric acid to total citrate ratio greater than about 30%. The anticoagulants are mixed with whole blood to provide an anticoagulated blood mixture which contains a citric acid concentration of greater than about 5.0 mM, a total citrate concentration of less than about 20 mM, and an initial blood pH of less than about 6.75. The platelet rich products including PRP and PC prepared from blood collected in accordance with the invention exhibit better platelet yields and better platelet morphology on storage.
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公开(公告)号：EP0744892A1
公开(公告)日：1996-12-04
申请号：EP95929639.0
申请日：1995-08-22
Applicant: BAXTER INTERNATIONAL INC.
Inventor： GRODE, Gerald, A. , STEWART, Mary, A.
CPC classification number: A61K35/14
Abstract: A new citrate-based anticoagulant for donor whole blood provides good platelet yield and cell morphology at a significantly reduced risk of donor paresthesia during apheresis procedures. The primary citrate anticoagulant compositions include a citric acid to total citrate ratio greater than about 30%. The anticoagulants are mixed with whole blood to provide an anticoagulated blood mixture which contains a citric acid concentration of greater than about 5.0 mM, a total citrate concentration of less than about 20 mM, and an initial blood pH of less than about 6.75. The platelet rich products including PRP and PC prepared from blood collected in accordance with the invention exhibit better platelet yields and better platelet morphology on storage.
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