公开(公告)号：US20230000474A1

公开(公告)日：2023-01-05

申请号：US17855515

申请日：2022-06-30

Applicant: Case Western Reserve University

Inventor： Sanford Markowitz ,  Amitabh Chak ,  Joseph Willis

IPC: A61B10/04 ,  A61B5/00

Abstract: Provided herein are methods and a device for collecting biological samples from a subject. In particular, the present disclosure relates to a device designed to specifically capture samples within the target areas of a patient for specific cell collection for particular diagnosis.

公开(公告)号：US11426420B2

公开(公告)日：2022-08-30

申请号：US16603544

申请日：2018-04-09

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  Board of Regents of the University of Texas System

Inventor： Sanford Markowitz ,  Won Jin Ho ,  Yiyuan Yuan ,  Mukesh Jain ,  Mohamed Sabeh ,  Joseph Ready ,  Noelle Williams

IPC: A61K31/704 ,  A61P9/00 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/7048 ,  C07K16/32

Abstract: A method of treating preventing, minimizing, and/or reversing congestive heart failure, cardiomyopathy, and/or reduction of cardiac ejection fraction in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.

公开(公告)号：US20220096063A1

公开(公告)日：2022-03-31

申请号：US17643335

申请日：2021-12-08

Applicant: Case Western Reserve University

Inventor： Sanford Markowitz ,  Amitabh Chak ,  Joseph Willis ,  Jeffrey Silver Taggart ,  Rebecca Blice ,  Dean Secrest ,  Dennis Siedlak

IPC: A61B10/02

Abstract: A device for collecting a biological sample in a patient includes a collection portion having a first axial end portion and a second axial end portion. The second axial end portion has a collapsed position and an expanded position. The second axial end portion moves in an axial direction relative to the first axial end portion when the second axial end portion moves between the collapsed position and the expanded position. The second axial end portion extends axially into the first axial end portion and has a concave shape when in the collapsed position. The second axial end portion is convex when in the expanded position.

公开(公告)号：US20220096061A1

公开(公告)日：2022-03-31

申请号：US17643320

申请日：2021-12-08

Applicant: Case Western Reserve University

Inventor： Sanford Markowitz ,  Amitabh Chak ,  Joseph Willis ,  Jeffrey Silver Taggart ,  Rebecca Blice ,  Dean Secrest ,  Dennis Siedlak

IPC: A61B10/02

Abstract: A device for collecting a biological sample in a patient includes a collection portion having a first axial end portion and a second axial end portion. The second axial end portion has a collapsed position and an expanded position. The second axial end portion moves in an axial direction relative to the first axial end portion when the second axial end portion moves between the collapsed position and the expanded position. The second axial end portion extends axially into the first axial end portion and has a concave shape when in the collapsed position. The second axial end portion is convex when in the expanded position.

公开(公告)号：US20220096060A1

公开(公告)日：2022-03-31

申请号：US17643299

申请日：2021-12-08

Applicant: Case Western Reserve University

Inventor： Sanford Markowitz ,  Amitabh Chak ,  Joseph Willis ,  Jeffrey Silver Taggart ,  Rebecca Blice ,  Dean Secrest ,  Dennis Siedlak

IPC: A61B10/02

Abstract: A device for collecting a biological sample in a patient includes a collection portion having a first axial end portion and a second axial end portion. The second axial end portion has a collapsed position and an expanded position. The second axial end portion moves in an axial direction relative to the first axial end portion when the second axial end portion moves between the collapsed position and the expanded position. The second axial end portion extends axially into the first axial end portion and has a concave shape when in the collapsed position. The second axial end portion is convex when in the expanded position.

公开(公告)号：US20200061073A1

公开(公告)日：2020-02-27

申请号：US16465500

申请日：2017-11-30

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Sanford Markowitz ,  Won Jin Ho ,  Stephen P. Fink ,  Vinay Varadan

IPC: A61K31/5377 ,  A61K31/4439 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4985 ,  A61K31/4365 ,  A61K31/519 ,  A61K31/437 ,  A61K31/573 ,  A61P1/00

Abstract: A method of treating intestinal gastrointestinal, or bowel disorders in a subject in need thereof includes administering to the subject a therapeutically effective amount of 15-PGDH inhibitor alone or in combination with a corticosteroid and/or TNF alpha antagonist.

公开(公告)号：US10301320B2

公开(公告)日：2019-05-28

申请号：US15359330

申请日：2016-11-22

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  Board of Regents of the University of Texas System ,  University of Kentucky Research Foundation

Inventor： Sanford Markowitz ,  James K. V. Willson ,  Bruce Posner ,  Joseph Ready ,  Youngyou Zhang ,  Hsin-Hsiung Tai ,  Monika Antczak ,  Stanton Gerson ,  KiBeom Bae ,  Sung Yeun Yang ,  Amar Desai

IPC: A61K31/4365 ,  C07D495/04 ,  C07D213/71 ,  C07D213/73 ,  C07D213/75 ,  C07D213/76 ,  C07D215/08 ,  C07D237/20 ,  C07D405/12 ,  C07D239/42 ,  C07D241/20 ,  C07D261/14 ,  C07D207/263 ,  C07D275/03 ,  C07D209/08 ,  C07D277/46 ,  C07D295/185 ,  C07C311/21 ,  A61K31/519

Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.

公开(公告)号：US09789116B2

公开(公告)日：2017-10-17

申请号：US15029943

申请日：2014-10-15

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Sanford Markowitz ,  James K. V. Willson ,  Bruce Posner ,  Joseph Ready ,  Monika Antczak ,  Yongyou Zhang ,  Amar Desai ,  Stanton Gerson ,  William Greenlee

IPC: A61K31/535 ,  A61K31/5377 ,  A61K31/4365 ,  A61K31/519 ,  A61K31/437 ,  A61K31/444 ,  A61K31/496

CPC classification number: A61K31/5377 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/444 ,  A61K31/496 ,  A61K31/519 ,  C07D495/04

Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.

公开(公告)号：US20170173028A1

公开(公告)日：2017-06-22

申请号：US15029943

申请日：2014-10-15

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Sanford Markowitz ,  James K.V. Willson ,  Bruce Posner ,  Joseph Ready ,  Monika Antczak ,  Youngyou Zhang ,  Amar Desai ,  Stanton Gerson ,  William Greenlee

IPC: A61K31/5377 ,  A61K31/496 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4365 ,  A61K31/519

CPC classification number: A61K31/5377 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/444 ,  A61K31/496 ,  A61K31/519 ,  C07D495/04

Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.

公开(公告)号：US20250161277A1

公开(公告)日：2025-05-22

申请号：US19029244

申请日：2025-01-17

Applicant: RODEO THERAPEUTICS CORPORATION ,  CASE WESTERN RESERVE UNIVERSITY ,  BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Sanford Markowitz ,  Joseph Ready ,  Stephen L. Gwaltney, II ,  Monika Antczak

IPC: A61K31/4365 ,  A61K31/437 ,  A61K31/501 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D495/04 ,  C07D519/00

Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.