公开(公告)号：US11690847B2

公开(公告)日：2023-07-04

申请号：US16465500

申请日：2017-11-30

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Sanford Markowitz ,  Won Jin Ho ,  Stephen P. Fink ,  Vinay Varadan

IPC: A61K31/5377 ,  A61P1/00 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/573 ,  A61K31/56

CPC classification number: A61K31/5377 ,  A61K31/421 ,  A61K31/426 ,  A61K31/437 ,  A61K31/4365 ,  A61K31/4439 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/56 ,  A61K31/573 ,  A61P1/00

Abstract: A method of treating intestinal gastrointestinal, or bowel disorders in a subject in need thereof includes administering to the subject a therapeutically effective amount of 15-PGDH inhibitor alone or in combination with a corticosteroid and/or TNF alpha antagonist.

公开(公告)号：US20200061073A1

公开(公告)日：2020-02-27

申请号：US16465500

申请日：2017-11-30

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Sanford Markowitz ,  Won Jin Ho ,  Stephen P. Fink ,  Vinay Varadan

IPC: A61K31/5377 ,  A61K31/4439 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4985 ,  A61K31/4365 ,  A61K31/519 ,  A61K31/437 ,  A61K31/573 ,  A61P1/00

Abstract: A method of treating intestinal gastrointestinal, or bowel disorders in a subject in need thereof includes administering to the subject a therapeutically effective amount of 15-PGDH inhibitor alone or in combination with a corticosteroid and/or TNF alpha antagonist.

公开(公告)号：US10055842B2

公开(公告)日：2018-08-21

申请号：US15397266

申请日：2017-01-03

Applicant: Case Western Reserve University

Inventor： Prateek Prasanna ,  Nathaniel Braman ,  Anant Madabhushi ,  Vinay Varadan ,  Lyndsay Harris ,  Salendra Singh

IPC: G06K9/00 ,  G06T7/00 ,  G06T7/11

CPC classification number: G06T7/0012 ,  A61B5/055 ,  A61B5/4312 ,  G06T7/11 ,  G06T7/44 ,  G06T7/45 ,  G06T2207/10088 ,  G06T2207/10096 ,  G06T2207/30061 ,  G06T2207/30068 ,  G06T2207/30081

Abstract: Methods, apparatus, and other embodiments distinguish disease phenotypes and mutational status using co-occurrence of local anisotropic gradient orientations (CoLIAGe) and Laws features. One example apparatus includes a set of circuits that acquires a radiologic image (e.g., MRI image) of a region of tissue demonstrating breast cancer, computes a gradient orientation for a pixel in the MRI image, computes a significant orientation for the pixel based on the gradient orientation, constructs a feature vector that captures a discretized entropy distribution for the image based on the significant orientation, extracts a set of texture features from the MRI image, and classifies the phenotype of the breast cancer based on the feature vector and the set of texture features. Embodiments of example apparatus may generate and display a heatmap of entropy values for the image. Example methods and apparatus may operate substantially in real-time, or may operate in two, three, or more dimensions.

公开(公告)号：US20180033138A1

公开(公告)日：2018-02-01

申请号：US15397266

申请日：2017-01-03

Applicant: Case Western Reserve University

Inventor： Prateek Prasanna ,  Nathaniel Braman ,  Anant Madabhushi ,  Vinay Varadan ,  Lyndsay Harris ,  Salendra Singh

IPC: G06T7/00 ,  G06T7/11

CPC classification number: G06T7/0012 ,  A61B5/055 ,  A61B5/4312 ,  G06T7/11 ,  G06T7/44 ,  G06T7/45 ,  G06T2207/10088 ,  G06T2207/10096 ,  G06T2207/30061 ,  G06T2207/30068 ,  G06T2207/30081

Abstract: Methods, apparatus, and other embodiments distinguish disease phenotypes and mutational status using co-occurrence of local anisotropic gradient orientations (CoLIAGe) and Laws features. One example apparatus includes a set of circuits that acquires a radiologic image (e.g., MRI image) of a region of tissue demonstrating breast cancer, computes a gradient orientation for a pixel in the MRI image, computes a significant orientation for the pixel based on the gradient orientation, constructs a feature vector that captures a discretized entropy distribution for the image based on the significant orientation, extracts a set of texture features from the MRI image, and classifies the phenotype of the breast cancer based on the feature vector and the set of texture features. Embodiments of example apparatus may generate and display a heatmap of entropy values for the image. Example methods and apparatus may operate substantially in real-time, or may operate in two, three, or more dimensions.

公开(公告)号：US20230355636A1

公开(公告)日：2023-11-09

申请号：US18144065

申请日：2023-05-05

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Sanford Markowitz ,  Won Jin Ho ,  Stephen P. Fink ,  Vinay Varadan

IPC: A61K31/5377 ,  A61P1/00 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/573 ,  A61K31/56

CPC classification number: A61K31/5377 ,  A61P1/00 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/573 ,  A61K31/56

Abstract: A method of treating intestinal, gastrointestinal, or bowel disorders in a subject in need thereof includes administering to the subject a therapeutically effective amount of 15-PGDH inhibitor alone or in combination with a corticosteroid and/or TNF alpha antagonist.

公开(公告)号：US20180247010A1

公开(公告)日：2018-08-30

申请号：US15755878

申请日：2016-08-26

Applicant: KONINKLIJKE PHILIPS N.V. ,  CASE WESTERN RESERVE UNIVERSITY (CWRU)

Inventor： Abolfazl Razi ,  Vinay Varadan ,  Nevenka Dimitrova ,  Nilanjana Banerjee

IPC: G06F19/12 ,  G06F19/18

CPC classification number: G16B5/00 ,  G06F17/18 ,  G16B20/00

Abstract: A system and method for determining the functional impact of somatic mutations and genomic aberrations on downstream cellular processes by integrating multi-omics measurements in cancer samples with community-curated biological pathways are disclosed. The method comprises the steps of extracting biological pathway information from well-curated biological pathway sources, using the pathway information to generate an upstream regulatory parent sub-network tree for each gene of interest, integrating measurement-based omic data for both cancer and normal samples to determine a nonlinear function for each gene expression level based on the gene's epigenetic information and regulatory network status, using the nonlinear function to predict gene expression levels and compare activation and consistency scores with inputted patient-specific gene expression data, and using the patient-specific gene expression predictions to identify significant deviations and inconsistencies in gene expression levels from expected levels in individual patient samples to identify potential biomarkers in providing predictive information in relation to cancer and cancer treatment.

公开(公告)号：US20160132637A1

公开(公告)日：2016-05-12

申请号：US14939363

申请日：2015-11-12

Applicant: Case Western Reserve University

Inventor： Vinay Varadan ,  Kishore Guda

IPC: G06F19/22 ,  G06F19/24

CPC classification number: G16B30/00 ,  G16B20/00 ,  G16B40/00

Abstract: This disclosure relates to systems and methods that employ a noise model generated from control samples to detect copy number alterations (CNA) in one or more test samples. The noise model can be generated to represent an indication of noise associated with chromosomes of control biological samples obtained via a common protocol. The indication can be determined by comparing chromosomes of the control biological samples. The noise model can be used to detect CNAs within the test sample by analyzing variability thereof with respect to the noise model.

Abstract translation: 本公开涉及使用由控制样本产生的噪声模型来检测一个或多个测试样本中的拷贝数变更（CNA）的系统和方法。 可以产生噪声模型以表示通过通用协议获得的对照生物样品的染色体相关噪声的指示。 可以通过比较对照生物样品的染色体来确定适应症。 噪声模型可用于通过分析与噪声模型相关的变异性来检测测试样本中的CNA。