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公开(公告)号:AT230990T
公开(公告)日:2003-02-15
申请号:AT93908327
申请日:1993-03-01
Applicant: CELL THERAPEUTICS INC
Inventor: BIANCO JAMES A , WOODSON PAUL , PORUBEK DAVID , SINGER JACK
IPC: C07D473/06 , A61K20060101 , A61K31/44 , A61K31/519 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/06 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P25/20 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P39/02 , A61P43/00 , C07D473/04 , C07D473/10 , C07D473/08 , A61P37/00
Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an omega -1 alcohol of a straight chain alkyl (C5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.
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公开(公告)号:CZ9402123A3
公开(公告)日:1995-09-13
申请号:CZ212394
申请日:1994-09-02
Applicant: CELL THERAPEUTICS INC
Inventor: BIANCO JAMES A , WOODSON PAUL , PORUBEK DAVID , SINGER JACK
IPC: C07D473/06 , A61K20060101 , A61K31/44 , A61K31/519 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/06 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P25/20 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P39/02 , A61P43/00 , C07D473/04 , C07D473/10
CPC classification number: A61K31/522 , A61K31/519 , A61K31/52 , C07D473/10 , Y02P20/582 , Y10S514/814 , Y10S514/866 , Y10S514/921
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公开(公告)号:NZ247038A
公开(公告)日:1995-02-24
申请号:NZ24703893
申请日:1993-03-02
Applicant: CELL THERAPEUTICS INC
Inventor: BIANCO JAMES A , PORUBEK DAVID , SINGER JACK , WOODSON PAUL
IPC: C07D473/06 , A61K20060101 , A61K31/44 , A61K31/519 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/06 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P25/20 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P39/02 , A61P43/00 , C07D473/04 , C07D473/10
Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an omega -1 alcohol of a straight chain alkyl (C5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.
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公开(公告)号:NO943263D0
公开(公告)日:1994-09-02
申请号:NO943263
申请日:1994-09-02
Applicant: CELL THERAPEUTICS INC
Inventor: BIANCO JAMES A , WOODSON PAUL , PORUBEK DAVID , SINGER JACK
IPC: C07D473/06 , A61K20060101 , A61K31/44 , A61K31/519 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/06 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P25/20 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P39/02 , A61P43/00 , C07D473/04 , C07D473/10 , A61K
Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an omega -1 alcohol of a straight chain alkyl (C5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.
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公开(公告)号:AU5671294A
公开(公告)日:1994-06-08
申请号:AU5671294
申请日:1993-11-16
Applicant: CELL THERAPEUTICS INC
Inventor: UNDERINER GAIL E , PORUBEK DAVID , KLEIN PETER J , WOODSON PAUL
IPC: A61K31/519 , C07C233/91 , C07C317/18 , C07D209/48 , C07D211/76 , C07D211/88 , C07D215/22 , C07D239/54 , C07D239/88 , C07D239/96 , C07D295/088 , C07D473/06 , C07D473/08 , C07D473/10 , C07D475/02 , A61K31/53 , A61K31/10 , A61K31/16 , A61K31/40 , A61K31/44 , A61K31/47 , A61K31/505 , A61K31/515 , A61K31/52 , C07D209/02 , C07D211/20 , C07D211/30 , C07D211/36 , C07D211/40 , C07D211/54 , C07D217/22 , C07D237/00 , C07D239/02 , C07D239/72 , C07D251/00 , C07D253/00 , C07D315/00 , C07D317/00 , C07D473/00 , C07D487/00
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公开(公告)号:CA2151617A1
公开(公告)日:1994-05-26
申请号:CA2151617
申请日:1993-11-16
Applicant: CELL THERAPEUTICS INC
Inventor: UNDERINER GAIL E , PORUBEK DAVID , KLEIN PETER J , WOODSON PAUL
IPC: A61K31/519 , C07C233/91 , C07C317/18 , C07D209/48 , C07D211/76 , C07D211/88 , C07D215/22 , C07D239/54 , C07D239/88 , C07D239/96 , C07D295/088 , C07D473/06 , C07D473/08 , C07D473/10 , C07D475/02 , A61K31/16 , A61K31/435 , A61K31/495
Abstract: Disclosed are therapeutic compounds having the formula: (R)j - (core moiety), including resolved enantiomers, diastereomers, hydrates, salts, solvates and mixtures thereof. j is an integer from one to three, the core moiety is either non-cyclic or comprises at least one five- to seven-membered ring structure, R may be selected from the group consisting of hydrogen, halogen, hydroxyl, amino, substituted or unsubstituted benzyl, C1-6 alkyl or C1-6 alkenyl, and at least one R has formula (I), wherein n is an integer from seven to twenty and at least one of X or Y is -OH. The other of X or Y, which is not -OH, is hydrogen, CH3-, CH3-CH2-, CH3-(CH2)2- or (CH3)2-CH2-, and each W1, W2, and W3 is independently hydrogen, CH3-, CH3-CH2-, CH3-(CH2)2- or (CH3)2-CH2-. The X, Y, W1, W2, or W3 alkyl groups may be unsubstituted or substituted by an hydroxyl, halo or dimethylamino group. The disclosed compounds and therapeutic compositions thereof are useful in treating individuals having a disease or treatment-induced toxicity, mediated by second messenger activity.
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公开(公告)号:AU3919093A
公开(公告)日:1993-10-05
申请号:AU3919093
申请日:1993-03-01
Applicant: CELL THERAPEUTICS INC
Inventor: BIANCO JAMES A , WOODSON PAUL , PORUBEK DAVID , SINGER JACK
IPC: C07D473/06 , A61K20060101 , A61K31/44 , A61K31/519 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/06 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P25/20 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P39/02 , A61P43/00 , C07D473/04 , C07D473/10
Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an omega -1 alcohol of a straight chain alkyl (C5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.
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公开(公告)号:ZA931542B
公开(公告)日:1993-09-27
申请号:ZA931542
申请日:1993-03-04
Applicant: CELL THERAPEUTICS INC
Inventor: BIANCO JAMES A , WOODSON PAUL , PORUBEK DAVID , SINGER JACK
IPC: A61K20060101 , C07D20060101 , A61K , C07D
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公开(公告)号:ZA9301542B
公开(公告)日:1993-09-27
申请号:ZA9301542
申请日:1993-03-04
Applicant: CELL THERAPEUTICS INC
Inventor: BIANCO JAMES A , WOODSON PAUL , PORUBEK DAVID , SINGER JACK
IPC: A61K20060101 , C07D20060101 , A61K , C07D
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