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公开(公告)号：HUT38360A
公开(公告)日：1986-05-28
申请号：HU281785
申请日：1985-07-24
Applicant: CIBA GEIGY AG
Inventor： BASCHANG GERHARD , FECHTIG BRUNO , HARTMANN ALBERT , LUKAS BOHUMIR
Abstract: Described are phosphatidyl compounds of the formula I (I) in which R1 represents C3-14-alkanoyl, benzoyl, the acyl radical of an alpha -aminocarboxylic acid that is other than glycine, L-alanine and derivatives thereof having a substituted amino group, and of which the alpha -amino group may be substituted by lower alkanoyl, lower alkoxycarbonyl or by benzyloxycarbonyl, or the acyl radical of a beta -aminocarboxylic acid or an alpha - or beta -hydroxycarboxylic acid, T represents a group NH that is unsubstituted or is substituted by lower alkyl, or oxygen, Y represents dimethylene that is unsubstituted or is substituted by free, etherified or amidated carboxy, W represents hydrogen, and Z represents a 1,2-dihydroxyethyl, 2-hydroxyethyl or hydroxymethyl group, in which at least one of the hydroxy groups is esterified by an aliphatic C8-30-carboxylic acid or is etherified by an aliphatic C8-30-alcohol, or each of W and Z represents a hydroxymethyl group that is esterified by an aliphatic C8-30-carboxylic acid or is etherified by an aliphatic C8-30-alcohol, and their salts, and processes for their manufacture. The mentioned novel compounds, and structurally related compounds that are likewise described and that belong to the state of the art, are used for the propylaxis and treatment of viral infections.
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公开(公告)号：DK77286D0
公开(公告)日：1986-02-19
申请号：DK77286
申请日：1986-02-19
Applicant: CIBA GEIGY AG
Inventor： BASCHANG GERHARD , HARTMANN ALBERT , STANEK JAROSLAV , WACKER OSKAR
Abstract: The derivatives have the formula I in which the hexose moiety is derived from D-glucose, D-mannose or D-galactose, n is 0 or 1, and R is lower alkanoyl or benzoyl, R is lower alkyl or phenyl, R , R and R are, independently of one another, hydrogen or lower alkyl, or R and R together are trimethylene and R is hydrogen, R and R are, independently of one another, hydrogen, lower alkanoyl or benzoyl, R is hydrogen or unsubstituted or phenyl-, hydroxyl-, mercapto- or lower alkylthio-substituted lower alkyl, R and R are, independently of one another, hydroxyl, amino or lower alkoxy, R is hydrogen, carboxyl or lower alkoxycarbonyl and R is hydrogen or unsubstituted or amino-, lower alkanoylamino-, hydroxyl-, guanidino-, lower alkanoyloxy-, 2-benzyloxycarbonylamino- ethylsulphinyl-, 2-benzyloxycarbonylaminoethylsulphonyl-, 2-lower- alkoxycarbonylaminoethylsulphinyl- or 2-lower-alkoxycarbonylamino- ethylsulphonyl-substituted lower alkyl, with the proviso that in the compounds in which the pyranose moiety is derived from D-glucose and, at the same time, n is 0, R , R and R are hydrogen, R is methyl, R is amino and R is hydroxyl, and in which the radicals R , R and R all have the same meaning, R , R and R are different from acetyl and butyryl when R is phenyl and, at the same time, R is hydrogen, and that R , R and R are different from acetyl when R and R are both methyl, and these compounds and salts thereof where appropriate have an antiviral action in vivo.
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公开(公告)号：FI860708A0
公开(公告)日：1986-02-17
申请号：FI860708
申请日：1986-02-17
Applicant: CIBA GEIGY AG
Inventor： WACKER OSKAR , HARTMANN ALBERT , STANEK JAROSLAV , FECHTIG BRUNO , BASCHANG GERHARD
Abstract: The derivatives have the formula I in which the hexose moiety is derived from D-glucose, D-mannose or D-galactose, n is 0 or 1, and R , R and R are, independently of one another, lower alkanoyl or benzoyl, R is lower alkyl or phenyl, R , R and R are, independently of one another, hydrogen or lower alkyl, or R and R together are trimethylene and R is hydrogen, R is hydrogen or unsubstituted or phenyl-, hydroxyl-, mercapto- or lower alkylthio-substituted lower alkyl, R and R are, independently of one another, hydroxyl, amino, C1-10-alkoxy, aryl-lower alkoxy, alkanoyloxy-lower alkoxy with up to 16 C atoms, aroyloxy-lower alkoxy, 3-cholesteryloxy or 2-trimethylammonioethyloxy, R is hydrogen, carboxyl, lower alkoxycarbonyl or aryl-lower alkoxycarbonyl and R is hydrogen or unsubstituted or amino-, hydroxyl-, lower alkanoylamino-, lower alkanoyloxy-, 2-benzyloxycarbonylaminoethylsulphinyl-, 2-benzyloxycarbonylaminoethylsulphonyl-, 2-lower-alkoxycarbonyl- aminoethylsulphinyl-, 2-lower-alkoxycarbonylaminoethylsulphonyl- or guanidino-substituted lower alkyl, with the proviso that at least one of the radicals R and R is different from hydroxyl, amino and C1-7-alkoxy or R is different from hydrogen, carboxyl and alkoxycarbonyl with up to 7 C atoms in the alkoxy moiety, and these compounds and salts thereof where appropriate can be used for the prophylaxis and therapy of viral infections.
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公开(公告)号：AU4537885A
公开(公告)日：1986-01-30
申请号：AU4537885
申请日：1985-07-25
Applicant: CIBA GEIGY AG
Inventor： BASCHANG GERHARD , FECHTIG BRUNO , HARTMANN ALBERT , LUKAS BOHUMIR , WACKER OSKAR
Abstract: Described are phosphatidyl compounds of the formula I (I) in which R1 represents C3-14-alkanoyl, benzoyl, the acyl radical of an alpha -aminocarboxylic acid that is other than glycine, L-alanine and derivatives thereof having a substituted amino group, and of which the alpha -amino group may be substituted by lower alkanoyl, lower alkoxycarbonyl or by benzyloxycarbonyl, or the acyl radical of a beta -aminocarboxylic acid or an alpha - or beta -hydroxycarboxylic acid, T represents a group NH that is unsubstituted or is substituted by lower alkyl, or oxygen, Y represents dimethylene that is unsubstituted or is substituted by free, etherified or amidated carboxy, W represents hydrogen, and Z represents a 1,2-dihydroxyethyl, 2-hydroxyethyl or hydroxymethyl group, in which at least one of the hydroxy groups is esterified by an aliphatic C8-30-carboxylic acid or is etherified by an aliphatic C8-30-alcohol, or each of W and Z represents a hydroxymethyl group that is esterified by an aliphatic C8-30-carboxylic acid or is etherified by an aliphatic C8-30-alcohol, and their salts, and processes for their manufacture. The mentioned novel compounds, and structurally related compounds that are likewise described and that belong to the state of the art, are used for the propylaxis and treatment of viral infections.
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公开(公告)号：NO852953L
公开(公告)日：1986-01-27
申请号：NO852953
申请日：1985-07-24
Applicant: CIBA GEIGY AG
Inventor： BASCHANG GERHARD , FECHTIG BRUNO , HARTMANN ALBERT , LUKAS BOHUMIR , WACKER OSKAR
Abstract: Described are phosphatidyl compounds of the formula I (I) in which R1 represents C3-14-alkanoyl, benzoyl, the acyl radical of an alpha -aminocarboxylic acid that is other than glycine, L-alanine and derivatives thereof having a substituted amino group, and of which the alpha -amino group may be substituted by lower alkanoyl, lower alkoxycarbonyl or by benzyloxycarbonyl, or the acyl radical of a beta -aminocarboxylic acid or an alpha - or beta -hydroxycarboxylic acid, T represents a group NH that is unsubstituted or is substituted by lower alkyl, or oxygen, Y represents dimethylene that is unsubstituted or is substituted by free, etherified or amidated carboxy, W represents hydrogen, and Z represents a 1,2-dihydroxyethyl, 2-hydroxyethyl or hydroxymethyl group, in which at least one of the hydroxy groups is esterified by an aliphatic C8-30-carboxylic acid or is etherified by an aliphatic C8-30-alcohol, or each of W and Z represents a hydroxymethyl group that is esterified by an aliphatic C8-30-carboxylic acid or is etherified by an aliphatic C8-30-alcohol, and their salts, and processes for their manufacture. The mentioned novel compounds, and structurally related compounds that are likewise described and that belong to the state of the art, are used for the propylaxis and treatment of viral infections.
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Patent Agency Ranking
公开(公告)号：DK337485D0
公开(公告)日：1985-07-24
申请号：DK337485
申请日：1985-07-24
Applicant: CIBA GEIGY AG
Inventor： BASCHANG GERHARD , FECHTIG BRUNO , HARTMANN ALBERT , LUKAS BOHUMIR , WACKER OSKAR
Abstract: Described are phosphatidyl compounds of the formula I (I) in which R1 represents C3-14-alkanoyl, benzoyl, the acyl radical of an alpha -aminocarboxylic acid that is other than glycine, L-alanine and derivatives thereof having a substituted amino group, and of which the alpha -amino group may be substituted by lower alkanoyl, lower alkoxycarbonyl or by benzyloxycarbonyl, or the acyl radical of a beta -aminocarboxylic acid or an alpha - or beta -hydroxycarboxylic acid, T represents a group NH that is unsubstituted or is substituted by lower alkyl, or oxygen, Y represents dimethylene that is unsubstituted or is substituted by free, etherified or amidated carboxy, W represents hydrogen, and Z represents a 1,2-dihydroxyethyl, 2-hydroxyethyl or hydroxymethyl group, in which at least one of the hydroxy groups is esterified by an aliphatic C8-30-carboxylic acid or is etherified by an aliphatic C8-30-alcohol, or each of W and Z represents a hydroxymethyl group that is esterified by an aliphatic C8-30-carboxylic acid or is etherified by an aliphatic C8-30-alcohol, and their salts, and processes for their manufacture. The mentioned novel compounds, and structurally related compounds that are likewise described and that belong to the state of the art, are used for the propylaxis and treatment of viral infections.
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27.发明专利
公开(公告)号：CA1190221A
公开(公告)日：1985-07-09
申请号：CA394632
申请日：1982-01-21
Applicant: CIBA GEIGY AG
Inventor： BASCHANG GERHARD , HARTMANN ALBERT , WACKER OSKAR , TARCSAY LAJOS
IPC: A61K39/39 , A61P31/04 , A61P37/00 , C07K1/113 , C07K9/00 , C07K14/52 , C07K14/53 , C07K14/535 , C07C103/52
Abstract: Derivatives of D-glucose, D-galactose or D-mannose of the formula I (I) are immunostimulants and can be used e.g. as adjuvants or for the prophylaxis of infectious diseases. The characteristic feature is that at least one of the substituents R1, R2, R6, R12, R13 and, in certain cases R9 and R11, contains a phosphoryl substituent of formula Ib or Ic (Ib), (Ic) in which represents an aliphatic or cycloaliphatic radical having at least 7 carbon atoms, R16 represents hydrogen and R17 represents 2-hydroxyethyl or 1,2-dihydroxyethyl, wherein at least one hydroxy group is esterified or etherified by a radical having at least 7 carbon atoms, or wherein each of R16 and R17 independently of the other, represents esterified or etherified hydroxymethyl, the esterifying or etherifying radicals having at least 7 carbon atoms.
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公开(公告)号：DK236585D0
公开(公告)日：1985-05-28
申请号：DK236585
申请日：1985-05-28
Applicant: CIBA GEIGY AG
Inventor： BASCHANG GERHARD , HARTMANN ALBERT , WACKER OSKAR
Abstract: There are described sugar derivatives of the formula I (I) that have immuno-stimulating action and that contain as inventive element at least one radical A1 or A2. These radicals A1 and A2, which may be constituents of the radicals R1, R2, R4, R6, R9, R10 or R12 according to formula I, are defined as follows: A1 represents lower alkanoyl that is substituted by aryl, heteroaryl or heteroarylthio and that may be additionally substituted by an ethylene radical which, with the above-mentioned aryl or heteroaryl substituent, forms a five-membered ring or represents ortho- or ortho/meta-substituted aroyl. A2 represents lower alkoxy substituted by aryl, heteroaryl or heteroarylthio. Also described are processes for the manufacture of the compounds of the formula I and novel intermediates.
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公开(公告)号：NO151325B
公开(公告)日：1984-12-10
申请号：NO810500
申请日：1981-02-13
Applicant: CIBA GEIGY AG
Inventor： HARTMANN ALBERT , BASCHANG GERHARD , WACKER OSKAR , STANEK JAROSLAV
IPC: C07H1/00 , A23K1/16 , A61K31/70 , A61P37/04 , C07H15/00 , C07K1/113 , C07K5/00 , C07K9/00 , C07K14/52 , C07K14/53 , C07K14/535 , C07H15/12 , C07C103/52
Abstract: Described are derivatives of pyranoses of the formula I, manufacturing processes and intermediates, and their use as medicaments. (I) The pyranose moiety in the compounds of the formula I is derived especially from D-glucose, but alternatively from D-galactose or D-mannose. Characteristic of the compounds of the formula I is the lower alkyl or phenyl-lower alkyl radical R8, which carries an oxycarbonyl, mercaptocarbonyl or aminocarbonyl group, which is bonded to an aliphatic, cycloaliphaticaliphatic, cycloaliphatic or aromatic hydrocarbon radical R0, each of which is optionally substituted and which may be interrupted by oxycarbonyl, mercaptocarbonyl and/or iminocarbonyl and which, like the remaining radicals of the formula I, is defined in patent claim 1.
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公开(公告)号：ZA8400521B
公开(公告)日：1984-09-26
申请号：ZA8400521
申请日：1984-01-24
Applicant: CIBA GEIGY AG
Inventor： BASCHANG GERHARD , HARTMANN ALBERT , WACKER OSKAR
IPC: A61K38/00 , A61P31/04 , A61P31/12 , A61P37/04 , C07K1/02 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/08 , C07K5/083 , C07K5/10 , C07K5/103 , C07K7/02 , C07K7/06 , C07K9/00 , C07C , A61K
CPC classification number: C07K7/06 , A61K38/00 , C07K5/0606 , C07K5/081 , C07K5/1013 , C07K9/005
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