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公开(公告)号：WO2013089720A1
公开(公告)日：2013-06-20
申请号：PCT/US2011/065022
申请日：2011-12-15
Applicant: COLGATE-PALMOLIVE COMPANY , HOURIGAN, Regina , MATTAI, Jairajh , MASTERS, James
Inventor： HOURIGAN, Regina , MATTAI, Jairajh , MASTERS, James
CPC classification number: A61K8/87 , A61Q17/005 , A61Q19/10
Abstract: A cleansing composition comprising a cleansing effective amount of surfactant and polyurethane-34. The polyurethane-34 can deposit on skin during cleansing and form a barrier that reduces bacterial attachment to skin.
Abstract translation: 一种清洁组合物，其包含清洁有效量的表面活性剂和聚氨酯-34。 在清洁过程中，聚氨酯-34可以沉积在皮肤上，并形成一种可以减少细菌附着于皮肤的屏障。
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公开(公告)号：WO2013089719A1
公开(公告)日：2013-06-20
申请号：PCT/US2011/065021
申请日：2011-12-15
Applicant: COLGATE-PALMOLIVE COMPANY , HOURIGAN, Regina , MASTRULL, Jeffrey , MATTAI, Jairajh , MASTERS, James
Inventor： HOURIGAN, Regina , MASTRULL, Jeffrey , MATTAI, Jairajh , MASTERS, James
CPC classification number: A01N31/08 , A01N25/02 , A61K8/347 , A61K8/4973 , A61K8/4993 , A61K8/86 , A61K2800/49 , A61Q11/00 , A61Q11/02 , A61Q19/10
Abstract: A composition comprising a solubilized magnolol analog comprising at least one magnolol analog chosen from propyl magnolol, isopropyl magnolol, butyl magnolol, and isobutyl magnolol and a sorbitan ester. These solubilized analogs are useful in personal care, oral care, and home care compositions to provide anti -bacterial activity and reducing the expression of pro - inflammatory mediators. If isopropyl is selected, then the sorbitan ester is at least one of polyoxyethylene 20 sorbitan monooleate, and a proviso that if isobutyl magnolol is selected, then the sorbitan ester is poloxyethylene 20 sorbitan monooleate.
Abstract translation: 包含溶解的厚朴酚类似物的组合物包含至少一种厚朴酚类似物，其选自丙基厚朴酚，异丙基厚朴酚，丁基木洛洛尔和异丁基木洛洛尔和脱水山梨糖醇酯。 这些溶解的类似物可用于个人护理，口腔护理和家庭护理组合物以提供抗细菌活性并减少促炎介质的表达。 如果选择异丙基，则脱水山梨糖醇酯是聚氧乙烯20脱水山梨糖醇单油酸酯中的至少一种，条件是如果选择异丁基木兰醇，则脱水山梨醇酯是脱水山梨糖醇单油酸酯。
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23.发明申请ORAL CARE OR CLEANSER COMPOSITION COMPRISING SOLUBILIZED MAGNOLOL ANALOGS AND PPG-1 - PEG-9 LAURYL GLYCOL ETHER 审中-公开包含溶解的魔力霉素和PPG-1-PEG-9 LAURYL GLYCOL醚的口腔护理或清洁组合物
公开(公告)号：WO2013089718A1
公开(公告)日：2013-06-20
申请号：PCT/US2011/065020
申请日：2011-12-15
Applicant: COLGATE-PALMOLIVE COMPANY , HOURIGAN, Regina , MASTRULL, Jeffrey , MATTAI, Jairajh , MASTERS, James
Inventor： HOURIGAN, Regina , MASTRULL, Jeffrey , MATTAI, Jairajh , MASTERS, James
CPC classification number: A61K8/86 , A61K8/21 , A61K8/25 , A61K8/29 , A61K8/347 , A61K8/39 , A61K8/416 , A61K8/463 , A61K8/602 , A61K8/84 , A61K36/575 , A61K2800/10 , A61K2800/49 , A61K2800/74 , A61Q11/00 , A61Q19/10
Abstract: A composition comprising a solubilized magnolol analog comprising at least one magnolol analog chosen from propyl magnolol, isopropyl magnolol, butyl magnolol, and isobutyl magnolol, and PPG-1-PEG-9 lauryl glycol ether. These solubilized analogs are useful in personal care, oral care, and home care compositions to provide anti-bacterial activity and reducing the expression of pro-inflammatory mediators.
Abstract translation: 一种包含溶解的厚朴酚类似物的组合物，其包含至少一种选自丙基厚朴酚，异丙基厚朴酚，丁基厚朴酚和异丁基木洛酚的厚朴酚类似物，以及PPG-1-PEG-9月桂基二醇醚。 这些溶解的类似物可用于个人护理，口腔护理和家庭护理组合物中以提供抗细菌活性并减少促炎介质的表达。
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公开(公告)号：WO2013039489A1
公开(公告)日：2013-03-21
申请号：PCT/US2011/051478
申请日：2011-09-14
Applicant: COLGATE-PALMOLIVE COMPANY , WU, Qiang , MASTERS, James
Inventor： WU, Qiang , MASTERS, James
CPC classification number: G01N21/65 , A61B5/222 , A61B5/4266 , G01J3/44
Abstract: A method to assess perspiration reduction of a composition comprising obtaining an amount of water in stratum corneum in a first area of skin on an individual using confocal Raman spectroscopy, applying a composition to the first area of skin on the individual, having the individual perform an activity to cause the individual to perspire, and obtaining an amount of water in stratum corneum in the first area of skin on the individual after the activity using confocal Raman spectroscopy.
Abstract translation: 一种评估组合物的排汗减少的方法，其包括使用共聚焦拉曼光谱法获得个体皮肤第一区域中的角质层中的水量，将组合物施用于个体的皮肤第一区域，其具有个体进行 导致个体出汗的活动，并且在使用共聚焦拉曼光谱法的活动之后，在个体的皮肤的第一区域中获得角质层中的水量。
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公开(公告)号：WO2022188083A1
公开(公告)日：2022-09-15
申请号：PCT/CN2021/080127
申请日：2021-03-11
Applicant: COLGATE-PALMOLIVE COMPANY , XU, Shaopeng
Inventor： YANG, Ying , XU, Guofeng , TRIVEDI, Harsh Mahendra , MASTERS, James , CHEN, Dandan , WON, Betty
Abstract: Methods of increasing sIgA levels in an individual's oral cavity are disclosed. The methods comprise applying effective amounts of zinc oxide, zinc citrate, and arginine. Methods of increasing the concentration of sIgA in the individual's mucosa pellicle in the oral cavity are disclosed. Methods of increasing phagocytotic activity of phagocytotic cells in the individual's oral cavity are also disclosed. In addition, methods of increasing levels of β-Defensin 1 in the individual's oral cavity are disclosed.
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Patent Agency Ranking
公开(公告)号：WO2022178003A1
公开(公告)日：2022-08-25
申请号：PCT/US2022/016617
申请日：2022-02-16
Inventor： TEUGHELS, Wim , VERSPECHT, Tim , BERNAERTS, Kristel , QUIRYNEN, Marc , BOON, Nico , DAEP, Carlo , MASTERS, James
Abstract: The disclosure relates to methods of enhancing beneficial oral bacteria and decreasing harmful oral bacteria comprising administering oral care compositions comprising a saccharide prebiotic, e.g., selected from D-mannose, N-acetyl-D-mannosamine and mixtures thereof; and oral care compositions for use in such methods. The disclosure also relates to methods of using prebiotic oral care compositions, methods of screening, and methods of manufacture.
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公开(公告)号：WO2022173884A1
公开(公告)日：2022-08-18
申请号：PCT/US2022/015892
申请日：2022-02-10
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： CHEN, Dandan , TRIVEDI, Harsh Mahendra , MASTERS, James , DARVEAU, Richard P. , MCLEAN, Jeffrey S.
IPC: G01N33/68
Abstract: Methods of identifying an individual as being a slow gingivitis responder or a high gingivitis responder are disclosed. Some methods are based on IL-1β levels in the individual's GCF at the site of inflammation. Some methods are based on MIF and/or CCL-1 levels in the individual's GCF in healthy tissue distant from the site of inflammation. Some disclosed methods are based on temporal differences in IL-8, IL-6 and/or TNFα levels in the individual's GCF in healthy tissue distant from the site of inflammation during the development of plaque induced inflammation. Methods of treating an individual who has gingivitis and methods of preventing gingivitis are also provided. The treatment and prevention methods comprise determining if individual is a slow gingivitis responder or a high gingivitis responder and applying oral care compositions to the individual's oral cavity.
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公开(公告)号：WO2020139633A1
公开(公告)日：2020-07-02
申请号：PCT/US2019/066926
申请日：2019-12-17
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： CHEN, Dandan , TRIVEDI, Harsh Mahendra , YANG, Ying , MASTERS, James
Abstract: Methods of increasing sIgA and mucin 5B levels in an individual's oral cavity are disclosed. The methods comprise applying to the individuals oral cavity in an amount effective to increase sIgA and mucin 5B levels in the individuals oral cavity, an oral care composition comprising: zinc phosphate, stannous fluoride and optionally, an organic acid buffer system.
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公开(公告)号：WO2020139628A1
公开(公告)日：2020-07-02
申请号：PCT/US2019/066866
申请日：2019-12-17
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： ZENOBIA, Camille , DAEP, Carlo , CHEN, Dandan , TRIVEDI, Harsh Mahendra , MASTERS, James
Abstract: Methods of increasing proteins that reduce signals associated with neutrophil recruitment and reducing proteins that induce neutrophil recruitment within an individual's gingival crevice are disclosed. The methods comprise applying to the individual's oral cavity in an amount effective to increase proteins that reduce signals associated with neutrophil recruitment and reduce proteins that induce neutrophil recruitment within an individual's gingival crevice, an oral care composition comprising: zinc phosphate, stannous fluoride and optionally, an organic acid buffer system.
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公开(公告)号：WO2016106071A1
公开(公告)日：2016-06-30
申请号：PCT/US2015/066323
申请日：2015-12-17
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： CHEN, Dandan , TRIVEDI, Harsh , HILLIARD, Peter R., Jr. , MASTERS, James
IPC: A61Q11/00
Abstract: Provided herein is an oral care composition comprising taurine or a salt thereof in an amount of from 0.001 weight % to 0.008 weight % by total weight of the composition, and an orally acceptable carrier. The composition is effective in accelerating HSP 27 production in damaged tissues of the oral cavity and enhances repair of the damaged tissue.
Abstract translation: 本文提供的是含有组合物总重量的0.001重量％至0.008重量％的牛磺酸或其盐的口腔护理组合物和口服可接受的载体。 该组合物有效促进口腔损伤组织中的HSP27生产，并增强损伤组织的修复。
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