公开(公告)号：WO2015195117A1

公开(公告)日：2015-12-23

申请号：PCT/US2014/042947

申请日：2014-06-18

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： FITZGERALD, Michael ,  CONVERY, Joseph ,  MANUS, Lisa ,  TRIVEDI, Harsh

IPC: C07F3/00

CPC classification number: C07F3/06 ,  C07B2200/13 ,  C07F3/003

Abstract: The disclosure provides an improved synthesis for a zinc-lysine complex having the formula [Zn(C 6 H 14 N 2 O 2 ) 2 Cl] + Cl - , in which a zinc compound selected from ZnO and ZnCl 2 , is reacted with a lysine compound selected from lysine and lysine•HCl, in aqueous acid. The disclosure also provides oral care and personal care compositions comprising the complex prepared by the synthesis, and methods of using these complexes and compositions.

Abstract translation: 本公开提供了具有式[Zn（C 6 H 14 N 2 O 2）2 Cl] + Cl-的锌 - 赖氨酸复合物的改进合成，其中选自ZnO和ZnCl 2的锌化合物与选自赖氨酸和赖氨酸的赖氨酸化合物反应•HCl ，在酸性水溶液中。 本公开还提供了包含通过合成制备的络合物的口腔护理和个人护理组合物，以及使用这些复合物和组合物的方法。

公开(公告)号：WO2019103751A1

公开(公告)日：2019-05-31

申请号：PCT/US2017/063266

申请日：2017-11-27

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： SAMBANTHAMOORTHY, Karthik ,  TRIVEDI, Harsh

IPC: A61K8/49 ,  A61Q11/00 ,  A61K31/35 ,  A61P31/04 ,  A61K8/9783

Abstract: An oral care composition including rottlerin in an amount sufficient to reduce a growth of gram-positive bacteria in a mouth treated with the oral care composition.

公开(公告)号：WO2019083554A1

公开(公告)日：2019-05-02

申请号：PCT/US2017/067407

申请日：2017-12-19

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： CHENG, Shujiang ,  NABI, Zeenat ,  DU-THUMM, Laurence D. ,  WU, Qiang ,  ONG, Jane ,  SIOMYK, Halyna ,  TRIVEDI, Harsh ,  MASTERS, James ,  CHENG, Chi-Yuan ,  WU, Donghui

IPC: A61K8/27 ,  A61K8/49 ,  A61Q11/00 ,  A61Q19/02 ,  A61Q19/08

Abstract: Personal care compositions including a naringin:zinc complex and methods for preparing and using the same are provided. The personal care compositions may include a carrier and a naringin:zinc complex having a 2:1 naringin to zinc molar ratio.

公开(公告)号：WO2018212771A1

公开(公告)日：2018-11-22

申请号：PCT/US2017/033087

申请日：2017-05-17

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： ANSARI, Shamim ,  TRIVEDI, Harsh ,  MASTERS, James G.

IPC: A61Q11/00 ,  A61K8/92 ,  A61K8/34 ,  A61K8/73 ,  A61K8/9794 ,  A61K36/185 ,  A61K36/886

Abstract: Disclosed herein are oral care compositions comprising hemp seed oil and caprylyl glycol. In certain embodiments, the oral care composition optionally further comprises one or more ingredients selected from hyaluronic acid and aloe vera. Methods of making and using the compositions are also provided.

公开(公告)号：WO2007051098A1

公开(公告)日：2007-05-03

申请号：PCT/US2006/060175

申请日：2006-10-24

Applicant: COLGATE-PALMOLIVE COMPANY ,  CAMERON, Ryan, B. ,  SUBRAMANYAM, Ravi ,  TRIVEDI, Harsh ,  WORRELL, Cortney

Inventor： CAMERON, Ryan, B. ,  SUBRAMANYAM, Ravi ,  TRIVEDI, Harsh ,  WORRELL, Cortney

IPC: A61K8/49 ,  A61Q11/00

CPC classification number: A61K8/498 ,  A61K2800/522 ,  A61Q11/00

Abstract: The present invention relates to an oral composition useful to reduce inflammatory processes. More specifically, the invention relates to a composition consisting essentially of an anti-oxidative effective amount of morin and a water-humectant phase, and to a composition comprising an anti-oxidative effective amount of morin, one or more anti-bacterial agents and a water-humectant phase. In an embodiment, the composition is used in a method of preventing or treating inflammatory dental diseases such as gingivitis and periodontitis.

Abstract translation: 本发明涉及可用于减少炎症过程的口服组合物。 更具体地，本发明涉及基本上由抗氧化有效量的莽草酮和水 - 保湿剂相组成的组合物，以及包含抗氧化有效量的莽草酮，一种或多种抗菌剂和 水保湿阶段。 在一个实施方案中，组合物用于预防或治疗诸如牙龈炎和牙周炎的炎症性牙科疾病的方法。

公开(公告)号：WO2017014723A1

公开(公告)日：2017-01-26

申请号：PCT/US2015/040927

申请日：2015-07-17

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： KINSCHERF, Kevin ,  SCHAEFFER-KORBYLO, Lyndsay ,  SZEWCZYK, Gregory ,  MYERS, Carl ,  TRIVEDI, Harsh

IPC: A61K8/27 ,  A61K8/30 ,  A61K8/46 ,  A61Q11/00 ,  A61K33/30

CPC classification number: A61Q11/00 ,  A61K8/27 ,  A61K8/30 ,  A61K8/463 ,  A61K9/08 ,  A61K33/00 ,  A61K33/30 ,  A61K45/06 ,  A61K47/34 ,  A61K2300/00

Abstract: An oral care composition comprising a surfactant having formula [R(OC 2 H 4 ) x OSO 3 ] 2 M wherein R is a saturated or unsaturated alkyl group with an alkyl chain length of 8 to 30 carbon atoms; x is from 0 to 10; and M is a divalent metal cation selected from zinc cations, copper cations and stannous cations is provided.

Abstract translation: 一种含有式[R（OC 2 H 4）x OSO 3] 2M表面活性剂的口腔护理组合物，其中R是烷基链长度为8-30个碳原子的饱和或不饱和烷基; x为0〜10; 并且M是选自锌阳离子，铜阳离子和亚锡阳离子的二价金属阳离子。

公开(公告)号：WO2016106069A1

公开(公告)日：2016-06-30

申请号：PCT/US2015/066318

申请日：2015-12-17

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： CHEN, Dandan ,  TRIVEDI, Harsh ,  HILLIARD, JR., Peter R. ,  MASTERS, James

IPC: A61K8/41 ,  A61Q11/00

CPC classification number: A61Q11/00 ,  A61K8/21 ,  A61K8/24 ,  A61K8/44

Abstract: Provided herein is an oral care composition comprising a basic amino acid or a salt thereof in an amount of from 0.001 weight % to 0.08 weight % by total weight of the composition, and an orally acceptable carrier. The composition is effective in accelerating HSP 27 production in damaged tissues of the oral cavity and enhances repair of the damaged tissue.

Abstract translation: 本文提供的是包含碱性氨基酸或其盐的口服护理组合物，其量为组合物总重量的0.001重量％至0.08重量％，和口腔可接受的载体。 该组合物有效促进口腔损伤组织中的HSP27生产，并增强损伤组织的修复。

公开(公告)号：WO2017066560A1

公开(公告)日：2017-04-20

申请号：PCT/US2016/057028

申请日：2016-10-14

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： JOHANSSON, Patrik ,  TRIVEDI, Harsh ,  HOHLBEIN, Douglas J.

IPC: A46B15/00 ,  A61C17/22 ,  A61N1/05

CPC classification number: A61N1/0548 ,  A46B15/0022 ,  A61C17/16 ,  A61C17/222 ,  A61N1/205 ,  A61N1/26 ,  A61N1/322 ,  A61N1/326 ,  C25B1/26 ,  C25B1/28 ,  C25B1/285 ,  C25B9/06

Abstract: In some embodiments, an oral care implement includes a housing, a power source, and a plurality of conductive protrusions extending from a surface of the housing. Also disclosed are methods of using the oral care implement, for example, for treating conditions in the oral cavity.

Abstract translation: 在一些实施例中，口腔护理器具包括壳体，电源以及从壳体的表面延伸的多个导电突起。 还公开了使用口腔护理用具例如用于治疗口腔疾病的方法。

公开(公告)号：WO2016106071A1

公开(公告)日：2016-06-30

申请号：PCT/US2015/066323

申请日：2015-12-17

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： CHEN, Dandan ,  TRIVEDI, Harsh ,  HILLIARD, Peter R., Jr. ,  MASTERS, James

IPC: A61Q11/00

CPC classification number: A61K8/466 ,  A61Q11/00

Abstract: Provided herein is an oral care composition comprising taurine or a salt thereof in an amount of from 0.001 weight % to 0.008 weight % by total weight of the composition, and an orally acceptable carrier. The composition is effective in accelerating HSP 27 production in damaged tissues of the oral cavity and enhances repair of the damaged tissue.

Abstract translation: 本文提供的是含有组合物总重量的0.001重量％至0.008重量％的牛磺酸或其盐的口腔护理组合物和口服可接受的载体。 该组合物有效促进口腔损伤组织中的HSP27生产，并增强损伤组织的修复。

公开(公告)号：EP3215230A1

公开(公告)日：2017-09-13

申请号：EP15820782.9

申请日：2015-12-17

Applicant: Colgate-Palmolive Company

Inventor： CHEN, Dandan ,  TRIVEDI, Harsh ,  HILLIARD, Peter R., Jr. ,  MASTERS, James

IPC: A61Q11/00

CPC classification number: A61K8/466 ,  A61Q11/00

Abstract: Provided herein is an oral care composition comprising taurine or a salt thereof in an amount of from 0.001 weight % to 0.008 weight % by total weight of the composition, and an orally acceptable carrier. The composition is effective in accelerating HSP 27 production in damaged tissues of the oral cavity and enhances repair of the damaged tissue.

Abstract translation: 本文提供口腔护理组合物，其包含占组合物总重量的0.001重量％至0.008重量％的牛磺酸或其盐以及口腔可接受的载体。 该组合物有效加速口腔受损组织中HSP27的生成并增强受损组织的修复。