公开(公告)号：WO2011106493A2

公开(公告)日：2011-09-01

申请号：PCT/US2011/026019

申请日：2011-02-24

Applicant: COLGATE-PALMOLIVE COMPANY ,  YANG, Ying ,  PILLAI, Shyamala ,  FEI, Lin ,  SUBRAMANYAM, Ravi ,  XU, Guofeng

Inventor： YANG, Ying ,  PILLAI, Shyamala ,  FEI, Lin ,  SUBRAMANYAM, Ravi ,  XU, Guofeng

IPC: A61Q11/00

CPC classification number: A61Q11/00 ,  A61K8/347 ,  A61K8/39 ,  A61K8/86 ,  A61K2800/49

Abstract: Disclosed herein are methods of enhancing the solubility and delivery of one or more active ingredients found in magnolia extract, or a synthetic analogue thereof, in an oral composition.

Abstract translation: 本文公开了在口腔组合物中增强在木兰提取物或其合成类似物中发现的一种或多种活性成分的溶解度和递送的方法。

公开(公告)号：WO2010115034A2

公开(公告)日：2010-10-07

申请号：PCT/US2010/029674

申请日：2010-04-01

Applicant: COLGATE-PALMOLIVE COMPANY ,  TRIVEDI, Harsh M. ,  XU, Tao ,  YANG, Ying

Inventor： TRIVEDI, Harsh M. ,  XU, Tao ,  YANG, Ying

IPC: G01N33/50

CPC classification number: G01N33/56955 ,  G01N2333/96486 ,  G01N2800/60

Abstract: Methods for identifying compounds useful for treating diseases or conditions of the oral cavity are described herein.

Abstract translation: 本文描述了鉴定可用于治疗口腔疾病或病症的化合物的方法。

公开(公告)号：WO2022188083A1

公开(公告)日：2022-09-15

申请号：PCT/CN2021/080127

申请日：2021-03-11

Applicant: COLGATE-PALMOLIVE COMPANY ,  XU, Shaopeng

Inventor： YANG, Ying ,  XU, Guofeng ,  TRIVEDI, Harsh Mahendra ,  MASTERS, James ,  CHEN, Dandan ,  WON, Betty

IPC: A61K8/27 ,  A61K8/44 ,  A61K8/365 ,  A61P1/02 ,  A61Q11/00 ,  A61K8/21

Abstract: Methods of increasing sIgA levels in an individual's oral cavity are disclosed. The methods comprise applying effective amounts of zinc oxide, zinc citrate, and arginine. Methods of increasing the concentration of sIgA in the individual's mucosa pellicle in the oral cavity are disclosed. Methods of increasing phagocytotic activity of phagocytotic cells in the individual's oral cavity are also disclosed. In addition, methods of increasing levels of β-Defensin 1 in the individual's oral cavity are disclosed.

公开(公告)号：WO2020139633A1

公开(公告)日：2020-07-02

申请号：PCT/US2019/066926

申请日：2019-12-17

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： CHEN, Dandan ,  TRIVEDI, Harsh Mahendra ,  YANG, Ying ,  MASTERS, James

IPC: A61K8/19 ,  A61K8/21 ,  A61K8/24 ,  A61K8/27 ,  A61Q11/00 ,  A61P1/02

Abstract: Methods of increasing sIgA and mucin 5B levels in an individual's oral cavity are disclosed. The methods comprise applying to the individuals oral cavity in an amount effective to increase sIgA and mucin 5B levels in the individuals oral cavity, an oral care composition comprising: zinc phosphate, stannous fluoride and optionally, an organic acid buffer system.

公开(公告)号：WO2014098814A1

公开(公告)日：2014-06-26

申请号：PCT/US2012/070492

申请日：2012-12-19

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： PAN, Long ,  MATTAI, Jairajh ,  ANSARI, Shamim ,  QIU, Jianhong ,  MASTERS, James, G. ,  YANG, Ying

IPC: A61K8/27 ,  A61K8/44 ,  A61Q15/00

CPC classification number: A61K8/27 ,  A61K8/20 ,  A61K8/44 ,  A61K2800/58 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q15/00 ,  A61Q17/005 ,  A61Q19/00 ,  A61Q19/10

Abstract: A personal care composition for application to the skin or hair comprising a cosmetically acceptable carrier and zinc X halide precursors wherein the precursors are a zinc ion source, an X source, and a halide source, wherein the halide source can be part of the zinc ion source, the X source, or a halogen acid, wherein the precursors can complex into the zinc X halide when the composition is applied to the skin or hair, wherein X is an amino acid or trimethylglycine. Methods of making and using the compositions are also provided. When the precursors complex into a zinc X halide, the complex can be used to deliver zinc salts to block perspiration and provide antibacterial effects.

Abstract translation: 一种用于皮肤或毛发的个人护理组合物，其包含美容上可接受的载体和锌X卤化物前体，其中前体是锌离子源，X源和卤化物源，其中卤化物源可以是锌离子的一部分 源，X源或卤素酸，其中当将组合物施用于皮肤或毛发时，前体可以复合成锌X卤化物，其中X是氨基酸或三甲基甘氨酸。 还提供了制备和使用组合物的方法。 当前体复合成锌X卤化物时，该配合物可用于递送锌盐以阻止汗水并提供抗菌效果。

公开(公告)号：WO2012064319A1

公开(公告)日：2012-05-18

申请号：PCT/US2010/055764

申请日：2010-11-08

Applicant: COLGATE-PALMOLIVE COMPANY ,  MILLER, Steven ,  XU, Guofeng ,  FEI, Lin ,  YANG, Ying ,  JARACZ, Stanislav

Inventor： MILLER, Steven ,  XU, Guofeng ,  FEI, Lin ,  YANG, Ying ,  JARACZ, Stanislav

IPC: A61K8/04 ,  A61K8/27 ,  A61K8/49 ,  A61K8/73 ,  A61K8/86 ,  A61Q11/00

CPC classification number: A61K8/11 ,  A61K8/0275 ,  A61K8/27 ,  A61K8/4993 ,  A61K8/731 ,  A61K8/86 ,  A61K2800/412 ,  A61Q11/00

Abstract: The invention relates to a composite and oral care compositions for use in the mouth to retard the accumulation of dental plaque and/or calculus. The composite is a microaggregate comprising polymer coated, surfactant stabilized particles of a substantially insoluble metal, metal salt or metal oxide, for example zinc oxide. Also methods for retarding the accumulation of dental plaque and/or calculus are provided.

Abstract translation: 本发明涉及一种用于口腔的复合和口腔护理组合物，以阻止牙菌斑和/或结石的积聚。 该复合物是包含聚合物涂覆的表面活性剂稳定的基本上不溶的金属，金属盐或金属氧化物的颗粒，例如氧化锌的微粒聚集体。 还提供了用于延缓牙斑和/或结石积聚的方法。

公开(公告)号：WO2012015408A1

公开(公告)日：2012-02-02

申请号：PCT/US2010/043645

申请日：2010-07-29

Applicant: COLGATE-PALMOLIVE COMPANY ,  MIRAJKAR, Yelloji-Rao K ,  XU, Guofeng ,  YANG, Ying ,  BOYD, Thomas ,  PRENCIPE, Michael

Inventor： MIRAJKAR, Yelloji-Rao K ,  XU, Guofeng ,  YANG, Ying ,  BOYD, Thomas ,  PRENCIPE, Michael

IPC: A61K8/27 ,  A61K8/34 ,  A61K8/97 ,  A61Q11/00

CPC classification number: A61K31/05 ,  A61K8/27 ,  A61K8/97 ,  A61K36/575 ,  A61K2300/00 ,  A61Q11/00

Abstract: An oral care composition for treating or preventing calculus comprising an anticalculus agent and an antibacterial agent comprising a biphenol compound obtainable from Magnolia officinalis , wherein the composition is free of phosphate-containing anticalculus agents.

Abstract translation: 一种用于治疗或预防结石的口腔护理组合物，其包含抗结石剂和抗菌剂，其包含可从木兰木兰获得的联苯酚化合物，其中所述组合物不含磷酸盐抗牙垢剂。

公开(公告)号：EP3883528A1

公开(公告)日：2021-09-29

申请号：EP19839524.6

申请日：2019-12-17

Applicant: Colgate-Palmolive Company

Inventor： CHEN, Dandan ,  TRIVEDI, Harsh Mahendra ,  YANG, Ying ,  MASTERS, James

IPC: A61K8/19 ,  A61K8/21 ,  A61K8/24 ,  A61K8/27 ,  A61Q11/00 ,  A61P1/02

公开(公告)号：EP3454824A1

公开(公告)日：2019-03-20

申请号：EP17734620.2

申请日：2017-06-21

Applicant: Colgate-Palmolive Company

Inventor： YANG, Ying ,  CHEN, Dandan ,  D'AMBROGIO, Robert ,  THOMSON, Paul ,  TRIVEDI, Harsh Mahendra ,  PRENCIPE, Michael ,  MASTERS, James Gerard ,  JARACZ, Stanislav

IPC: A61K8/27 ,  A61K8/34 ,  A61K8/35 ,  A61K8/365 ,  A61Q11/00 ,  A61K8/21 ,  A61Q17/00

Abstract: This invention relates to oral care compositions comprising zingerone, bisabolol, a stannous ion source, zinc oxide, and zinc citrate, as well as to methods of using and of making these compositions.

公开(公告)号：EP2934440B1

公开(公告)日：2018-02-21

申请号：EP12809988.4

申请日：2012-12-19

Applicant: Colgate-Palmolive Company

Inventor： HAO, Zhigang ,  YANG, Ying ,  LIU, Zhiqiang ,  XU, Guofeng ,  VINCENTI, Paul Joseph

IPC: A61K8/55 ,  A61K8/58 ,  A61K8/67 ,  A61K33/30 ,  A61Q11/00 ,  A61K8/27

CPC classification number: A61K8/58 ,  A61K8/27 ,  A61K8/55 ,  A61K8/676 ,  A61K33/30 ,  A61K2800/58 ,  A61Q11/00

Abstract: Provided herein is an oral care composition comprising an orally-acceptable aqueous vehicle and an antimicrobial ingredient, wherein the antimicrobial ingredient comprises a zinc ascorbylphosphate and methods for treating or preventing a disease or disorder of the oral cavity using the oral care compositions disclosed herein.