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公开(公告)号：CA1146775A
公开(公告)日：1983-05-24
申请号：CA369576
申请日：1981-01-28
Applicant: COULTER ELECTRONICS
Inventor： GINSBERG GUENTER , HODGINS BRUCE J
Abstract: SAMPLE AND STAT FEEDING SYSTEM AND SAMPLE TRAY A sample and stat feeding system for sequentially supplying a renewable supply of cuvettes with aliquots of sample liquids in a continuous processing mode. The sample liquids are contained in a annular sample tray having a plurality of sample vessels molded into the tray. The sample containers form two or more annular rows on the outer edge of the tray in which routine samples are maintained in an ordered sequence. Emergency samples (stats) and controls (standards) are maintained in separate auxiliary locations or arrays of locations which may be molded or separate cups placed in tray cavities. A sample pick up mechanism has a pick up probe which is rotated to define an arc across at least a substantial portion of the tray and at least one stat location. The tray is rotated to align the sample, stat and control cavities with the arc of the probe. Sample aliquots are picked up and dispensed into the cuvettes in a programed operation sequence, with each sample fluid being related to a particular patient and programed for one or more analytical tests such as measuring the chemical reaction resulting from the addition of one or more reagents from a reagent supply. The program sequencing includes inserting a control aliquot in some of the cuvettes at a predetermined frequency to monitor the accuracy of the machine. When a stat test occurs, the stat is inserted in the tray and the programed sequence is interrupted to load the stat into the reaction vessel. The order of sample locations is not disturbed since the stats and controls are maintained in separate locations. The sample tray preferably will be molded of inexpensive material so it may be thrown away after all sample aliquots have been loaded into respective cuvettes for testing.
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公开(公告)号：FR2478318A1
公开(公告)日：1981-09-18
申请号：FR8101501
申请日：1981-01-27
Applicant: COULTER ELECTRONICS
Inventor： GINSBERG GUENTER , HORNE THOMAS
Abstract: System and program for measuring progressively the absorbance changes of a large number of aliquots from a plurality of different samples in a continuous processing mode. A plurality of routine samples are maintained in an ordered sequence in a sample tray which may be moved to a first sample pick up position. Emergency samples (stats) and controls (standards) are positioned in a second plurality of auxiliary positions which may be moved to a second sample position. A first and second plurality of reagents are maintained, moved to respective reagent pick up positions, picked up, moved and dispensed in respective dispensing positions by respective single reagent dispensing arms in a similar manner to the sample operation. The chemical reaction is then monitored by photometer means preferably having a plurality of photometric detectors such that radiation passes through each of the cuvettes and the fluids therein during each cycle of the system. Just prior to the sample dispensing position the cuvette is cleaned and tested to ensure that all the previously added fluids have been removed prior to receiving a new sample. Any one sample may be tested with different reagents or reagent mixtures in different aliquots placed in separate cuvettes at each wavelength as desired. Each sample aliquot and reagent mixture may be measured to determine the rate of the chemical reaction and the equilibrium or end point of the reaction or both, if desired. The array of cuvettes is continuous, because it is replenished at the end of each sequence prior to the addition of the new sample.
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公开(公告)号：AU3286078A
公开(公告)日：1979-08-09
申请号：AU3286078
申请日：1978-01-31
Applicant: COULTER ELECTRONICS
Inventor： SIMPSON RONALD O , STARLING J DAVID , JAMES BOBBY D , GODIN THOMAS JOHN , GINSBERG GUENTER , DRBAL VLADIMIR J , SZULGA ANATOLE
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公开(公告)号：DE2806383A1
公开(公告)日：1978-08-17
申请号：DE2806383
申请日：1978-02-15
Applicant: COULTER ELECTRONICS
Inventor： SIMPSON RONALD O , STARLING J DAVID , JAMES BOBBY D , GODIN THOMAS JOHN , GINSBERG GUENTER , DRBAL VLADIMIR J , SZULGA ANATOLE
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公开(公告)号：DE2435691A1
公开(公告)日：1975-02-06
申请号：DE2435691
申请日：1974-07-24
Applicant: COULTER ELECTRONICS
Inventor： FIGUEROA DAVID RICHARD , GINSBERG GUENTER
Abstract: In an environment where sample origin and test results require correlation, the number of tests per sample is predetermined, yet variable, the samples can step along one path and the test products (aliquots) step along another path with a step ratio dependent upon the number of tests per sample, the sample carrier is subdivided into indicia bearing receivers (one for each sample), and there is established a step count-distance relationship on the one hand between the original position (transfer station) of the sample, the number of tests per sample and a fixed indicator position, and on the other hand between the original position (receiving station) of the aliquot and the testing station; whereby a presettable counter is preset to correspond to the indicia of the sample receiver in the fixed indicator position at the time of start-up and then will automatically progressively step to attain the indicia value for each sample as its aliquots are being tested and ready for test data printout; the counter feeding the printer the sample indicia at the same time that the printer is printing the test data for that sample.
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Patent Agency Ranking
公开(公告)号：GB2133144A
公开(公告)日：1984-07-18
申请号：GB8325013
申请日：1983-09-19
Applicant: COULTER ELECTRONICS
Inventor： GINSBERG GUENTER , HORNE THOMAS
Abstract: System and program for measuring progressively the absorbance changes of a large number of aliquots from a plurality of different samples in a continuous processing mode. A plurality of routine samples are maintained in an ordered sequence in a sample tray which may be moved to a first sample pick up position. Emergency samples (stats) and controls (standards) are positioned in a second plurality of auxiliary positions which may be moved to a second sample position. A first and second plurality of reagents are maintained, moved to respective reagent pick up positions, picked up, moved and dispensed in respective dispensing positions by respective single reagent dispensing arms in a similar manner to the sample operation. The chemical reaction is then monitored by photometer means preferably having a plurality of photometric detectors such that radiation passes through each of the cuvettes and the fluids therein during each cycle of the system. Just prior to the sample dispensing position the cuvette is cleaned and tested to ensure that all the previously added fluids have been removed prior to receiving a new sample. Any one sample may be tested with different reagents or reagent mixtures in different aliquots placed in separate cuvettes at each wavelength as desired. Each sample aliquot and reagent mixture may be measured to determine the rate of the chemical reaction and the equilibrium or end point of the reaction or both, if desired. The array of cuvettes is continuous, because it is replenished at the end of each sequence prior to the addition of the new sample.
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公开(公告)号：CH637766A5
公开(公告)日：1983-08-15
申请号：CH663978
申请日：1978-06-19
Applicant: COULTER ELECTRONICS
Inventor： GINSBERG GUENTER , HORNE THOMAS , KREISELMAN ROBERT LEE
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公开(公告)号：GB2000284B
公开(公告)日：1982-03-31
申请号：GB7827285
申请日：1978-06-19
Applicant: COULTER ELECTRONICS
Inventor： GINSBERG GUENTER , HORNE THOMAS , KREISELMAN ROBERT LEE
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公开(公告)号：DE3102754A1
公开(公告)日：1981-12-17
申请号：DE3102754
申请日：1981-01-28
Applicant: COULTER ELECTRONICS
Inventor： GINSBERG GUENTER , HORNE THOMAS
Abstract: System and program for measuring progressively the absorbance changes of a large number of aliquots from a plurality of different samples in a continuous processing mode. A plurality of routine samples are maintained in an ordered sequence in a sample tray which may be moved to a first sample pick up position. Emergency samples (stats) and controls (standards) are positioned in a second plurality of auxiliary positions which may be moved to a second sample position. A first and second plurality of reagents are maintained, moved to respective reagent pick up positions, picked up, moved and dispensed in respective dispensing positions by respective single reagent dispensing arms in a similar manner to the sample operation. The chemical reaction is then monitored by photometer means preferably having a plurality of photometric detectors such that radiation passes through each of the cuvettes and the fluids therein during each cycle of the system. Just prior to the sample dispensing position the cuvette is cleaned and tested to ensure that all the previously added fluids have been removed prior to receiving a new sample. Any one sample may be tested with different reagents or reagent mixtures in different aliquots placed in separate cuvettes at each wavelength as desired. Each sample aliquot and reagent mixture may be measured to determine the rate of the chemical reaction and the equilibrium or end point of the reaction or both, if desired. The array of cuvettes is continuous, because it is replenished at the end of each sequence prior to the addition of the new sample.
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公开(公告)号：CA1090424A
公开(公告)日：1980-11-25
申请号：CA296820
申请日：1978-02-13
Applicant: COULTER ELECTRONICS
Inventor： SIMPSON RONALD O , STARLING J DAVID , JAMES BOBBY D , GODIN THOMAS J , GINSBERG GUENTER , DRBAL VLADIMIR J
Abstract: An aperture module for obtaining signals from microscopic particles suspended in a sample blood solution which passes through a scanning aperture. A module housing including an aperture holder is mounted on a container or bath containing a body of the particulate liquid suspension to be tested. The aperture holder with aperture formed therein extends into the vessel to permit passage of the sample through the aperture to an outlet chamber immediately behind the aperture. The chamber is connected to a source of clean electrolyte and has a narrowed or reduced dimension portion positioned immediately behind the aperture. A vacuum is applied to the chamber to cause the sample to be drawn through the aperture for testing thereof. An optical hemoglobinometer is positioned in association with the bath to measure the hemoglobin content of the solution to be tested.
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