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公开(公告)号：DE2227864A1
公开(公告)日：1973-01-04
申请号：DE2227864
申请日：1972-06-08
Applicant: COULTER ELECTRONICS
Inventor： HORNE THOMAS , JARMAN GRAHAM ROGER
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公开(公告)号：US3883305A
公开(公告)日：1975-05-13
申请号：US34106973
申请日：1973-03-14
Applicant: COULTER ELECTRONICS
Inventor： HOSKINS DOUGLAS HAIG , HORNE THOMAS , JARMAN GRAHAM ROGER , DUNSMORE ARTHUR WILLIAM
CPC classification number: G01N35/02 , G01N35/021
Abstract: An automatic chemical analysis apparatus having separate closedlooped conveyors for sample and reactant containers. At a fixed location, sample portions from a given sample are transferred to a serial sequence of reactant containers. Colourimetric testing is arranged such that all of the reactant products of the given sample are tested simultaneously. Sample and reactant products identification are obtained at the time the reactant containers are at the colourimeter station, at which time the sample container is at a variably positioned identification station, the position being dictated by the number of sample portions being tested for that given sample.
Abstract translation: 一种具有用于样品和反应物容器的分离的闭环输送机的自动化学分析装置。 在固定位置，将来自给定样品的样品部分转移到反应物容器的串联序列。 布置测色测试，使得给定样品的所有反应物产物同时测试。 样品和反应物产品鉴定是在反应物容器在色度计位置时获得的，此时样品容器处于可变位置的鉴定位置，该位置由对该给定样品进行测试的样品部分的数量决定。
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公开(公告)号：CA1138220A
公开(公告)日：1982-12-28
申请号：CA391038
申请日：1981-11-26
Applicant: COULTER ELECTRONICS
Inventor： GINSBERG GUENTER , HORNE THOMAS , KREISELMAN ROBERT L
IPC: G01N21/75
Abstract: Apparatus for measuring progressively the absorbance changes of a large number of aliquots from a plurality of different samples. The sample introduction, testing instructions, aliquot preparation, reagent dispensing, absorbance measuring and data recording all can be accomplished in a continuous mode of processing. Stat and batch operation also can be accomplished. The aliquots are in an array of cuvettes which is advanced slowly along a circular path. Photometer means, preferably having several photometric detectors, are mounted in fixed orientation on a common support that advances rapidly along a similar circular path, such that radiation passing through each of the cuvettes is monitored many times by a specific photometric detector by the time that cuvette completes one circuit of its path. The photometric detectors can operate at several different wavelengths. Many different chemical reactions can be monitored at the same time The radiant energy passing through each cuvette is received by the continuously moving photometer means, is converted electrically into a digitized value proportional to absorbance and is transmitted digitally from the moving assemblage of photometric detectors, cuvettes and electrical components to a stationary receiver. In one embodiment, the digital transmission is in the form of a pulsed train of light signals. In another embodiment, one or more slip rings transmit electric signals from the moving assemblage to the stationary portion. Suitable drive elements, sample and reagent storage and transfer mechanisms as well as cuvette laundry means may be provided as part of the complete apparatus.
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公开(公告)号：NO782137L
公开(公告)日：1978-12-21
申请号：NO782137
申请日：1978-06-19
Applicant: COULTER ELECTRONICS
Inventor： GINSBERG GUENTER , KREISELMAN ROBERT LEE , HORNE THOMAS
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公开(公告)号：GB2133144B
公开(公告)日：1985-01-09
申请号：GB8325013
申请日：1983-09-19
Applicant: COULTER ELECTRONICS
Inventor： GINSBERG GUENTER , HORNE THOMAS
Abstract: System and program for measuring progressively the absorbance changes of a large number of aliquots from a plurality of different samples in a continuous processing mode. A plurality of routine samples are maintained in an ordered sequence in a sample tray which may be moved to a first sample pick up position. Emergency samples (stats) and controls (standards) are positioned in a second plurality of auxiliary positions which may be moved to a second sample position. A first and second plurality of reagents are maintained, moved to respective reagent pick up positions, picked up, moved and dispensed in respective dispensing positions by respective single reagent dispensing arms in a similar manner to the sample operation. The chemical reaction is then monitored by photometer means preferably having a plurality of photometric detectors such that radiation passes through each of the cuvettes and the fluids therein during each cycle of the system. Just prior to the sample dispensing position the cuvette is cleaned and tested to ensure that all the previously added fluids have been removed prior to receiving a new sample. Any one sample may be tested with different reagents or reagent mixtures in different aliquots placed in separate cuvettes at each wavelength as desired. Each sample aliquot and reagent mixture may be measured to determine the rate of the chemical reaction and the equilibrium or end point of the reaction or both, if desired. The array of cuvettes is continuous, because it is replenished at the end of each sequence prior to the addition of the new sample.
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Patent Agency Ranking
公开(公告)号：FR2478318A1
公开(公告)日：1981-09-18
申请号：FR8101501
申请日：1981-01-27
Applicant: COULTER ELECTRONICS
Inventor： GINSBERG GUENTER , HORNE THOMAS
Abstract: System and program for measuring progressively the absorbance changes of a large number of aliquots from a plurality of different samples in a continuous processing mode. A plurality of routine samples are maintained in an ordered sequence in a sample tray which may be moved to a first sample pick up position. Emergency samples (stats) and controls (standards) are positioned in a second plurality of auxiliary positions which may be moved to a second sample position. A first and second plurality of reagents are maintained, moved to respective reagent pick up positions, picked up, moved and dispensed in respective dispensing positions by respective single reagent dispensing arms in a similar manner to the sample operation. The chemical reaction is then monitored by photometer means preferably having a plurality of photometric detectors such that radiation passes through each of the cuvettes and the fluids therein during each cycle of the system. Just prior to the sample dispensing position the cuvette is cleaned and tested to ensure that all the previously added fluids have been removed prior to receiving a new sample. Any one sample may be tested with different reagents or reagent mixtures in different aliquots placed in separate cuvettes at each wavelength as desired. Each sample aliquot and reagent mixture may be measured to determine the rate of the chemical reaction and the equilibrium or end point of the reaction or both, if desired. The array of cuvettes is continuous, because it is replenished at the end of each sequence prior to the addition of the new sample.
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公开(公告)号：CA1027836A
公开(公告)日：1978-03-14
申请号：CA166440
申请日：1973-03-19
Applicant: COULTER ELECTRONICS
Inventor： HOSKINS DOUGLAS H , HORNE THOMAS , JARMAN GRAHAM R , DUNSMORE ARTHUR W
Abstract: An automatic chemical analysis apparatus having separate closed-looped conveyors for sample and reactant containers. At a fixed location, sample portions from a given sample are transferred to a serial sequence of reactant containers. Colourimetric testing is arranged such that all of the reactant products of the given sample are tested simultaneously. Sample and reactant products identification are obtained at the time the reactant containers are at the colourimeter station, at which time the sample container is at a variably positioned identification station, the position being dictated by the number of sample portions being tested for that given sample.
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公开(公告)号：CA1175672A
公开(公告)日：1984-10-09
申请号：CA405223
申请日：1982-06-15
Applicant: COULTER ELECTRONICS
Inventor： HORNE THOMAS
Abstract: APPARATUS FOR MONITORING CHEMICAL REACTIONS Apparatus for monitoring chemical reactions occurring on a slide, cartridge or other reflective carrier in which the nature of the reaction is determined quantitatively by means of a change in color. The reaction products are illuminated by radiant energy of a known wavelength and the reaction is detected and/or monitored by the reflection of the radiant energy from the sample where the reaction is occurring. A plurality of samples carried on such slides is disposed in alignment in a circle or a line and a rotor or carriage carrying plural photometers or a single photometer producing plural beams at different wavelengths is moved relative to the samples, the beams being directed at the samples. Each sample is scanned at least once as the carriage moves or the rotor rotates and the reflected radiant energy is captured by photo-responsive devices and channeled to a computer where the data is processed and information acquired concerning the respective samples with regard to end points and kinetic characteristics of their reactions.
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公开(公告)号：CA1138221A
公开(公告)日：1982-12-28
申请号：CA391039
申请日：1981-11-26
Applicant: COULTER ELECTRONICS
Inventor： GINSBERG GUENTER , HORNE THOMAS , KREISELMAN ROBERT L
IPC: G01N35/04
Abstract: Apparatus for measuring progressively the absorbance changes of a large number of aliquots from a plurality of different samples. The sample introduction, testing instructions, aliquot preparation, reagent dispensing, absorbance measuring and data recording all can be accomplished in a continuous mode of processing. Stat and batch operation also can be accomplished. The aliquots are in an array of cuvettes which is advanced slowly along a circular path. Photometer means, preferably having several photometric detectors, are mounted in fixed orientation on a common support that advances rapidly along a similar circular path, such that radiation passing through each of the cuvettes is monitored many times by a specific photometric detector by the time that cuvette completes one circuit of its path. The photometric detectors can operate at several different wavelengths. Many different chemical reactions can be monitored at the same time, The radiant energy passing through each cuvette is received by the continuously moving photometer means, is converted electrically into a digitized value proportional to absorbance and is transmitted digitally from the moving assemblage of photometric detectors, cuvettes and electrical components to a stationary receiver. In one embodiment, the digital transmission is in the form of a pulsed train of light signals. In another embodiment, one or more slip rings transmit electric signals from the moving assemblage to the stationary portion. Suitable drive elements, sample and reagent storage and transfer mechanisms as well as cuvette laundry means may be provided as part of the complete apparatus.
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公开(公告)号：CA1116430A
公开(公告)日：1982-01-19
申请号：CA305783
申请日：1978-06-19
Applicant: COULTER ELECTRONICS
Inventor： GINSBERG GUENTER , HORNE THOMAS , KREISELMAN ROBERT L
Abstract: Apparatus for measuring progressively the absorbance changes of a large number of aliquots from a plurality of different samples. The sample introduction, testing instructions, aliquot preparation, reagent dispensing, absorbance measuring and data recording all can be accomplished in a continuous mode of processing. Stat and batch operation also can be accomplished. The aliquots are in an array of cuvettes which is advanced slowly along a circular path. Photometer means, preferably having several photometric detectors, are mounted in fixed orientation on a common support that advances rapidly along a similar circular path, such that radiation passing through each of the cuvettes is monitored many times by a specific photometric detector by the time that cuvette completes one circuit of its path. The photometric detectors can operate at several different wavelengths. Many different chemical reactions can be monitored at the same time. The radiant energy passing through each cuvette is received by the continuously moving photometer means, is converted electrically into a digitized value proportional to absorbance and is transmitted digitally from the moving assemblage of photometric detectors, cuvettes and electrical components to a stationary receiver. In one embodiment, the digital transmission is in the form of a pulsed train of light signals. In another embodiment, one or more slip rings transmit electric signals from the moving assemblage to the stationary portion. Suitable drive elements, sample and reagent storage and transfer mechanisms as well as cuvette laundry means may be provided as part of the complete apparatus.
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