公开(公告)号：US3863507A

公开(公告)日：1975-02-04

申请号：US34216173

申请日：1973-03-16

Applicant: COULTER ELECTRONICS

Inventor： JONES ALAN RICHARDSON ,  GODIN THOMAS J

IPC: G01N1/00 ,  G01N31/00

CPC classification number: G01N35/1097

Abstract: The apparatus includes a sampling head adapted to be mounted at a sample pickup station. The head includes a hollow sample pickup probe adapted to be inserted into a sample container at the sample pickup station for extracting a given amount of fluid sample from the container. The pickup probe is movable between a first or sampling position and a second or retracted position by means of an air cylinder. A valve mechanism connected to the probe is operable on movement of the probe to the sampling position for connecting the probe to a device for withdrawing fluid from the sample container through the probe. The air cylinder not only moves the probe but also, and at the same time, operates the valve mechanism, between first and second valve positions. In the second position the valve mechanism effects fluid connections for mixing a given amount of the fluid sample with another fluid, for simultaneously transferring the mixture to a receptacle and for drawing de-ionized water through the probe for cleaning same. The apparatus also includes a water delivery trough and a mechanism for moving same into position under the raised probe. The air cylinder is operable to lower the probe into the trough with a lost motion mechanism of the sampling head permitting the valve mechanism to remain in the second valve position while the probe is so lowered.

Abstract translation: 该装置包括适于安装在样品拾取站的取样头。 头包括中空的样品拾取探头，其适于插入样品拾取站的样品容器中，用于从容器中提取给定量的流体样品。 拾取探头可借助于气缸在第一或取样位置与第二或缩回位置之间移动。 连接到探头的阀机构可在探头移动到采样位置时操作，用于将探针连接到用于通过探针从样品容器中抽出流体的装置。 气缸不仅使探头移动，而且同时在第一和第二阀位之间操作阀机构。 在第二位置，阀机构实现用于将给定量的流体样品与另一种流体混合的流体连接，用于将混合物同时转移到容器中并用于通过探针吸收去离子水以进行清洁。 该装置还包括输水槽和用于将其移动到升高的探针下方的位置的机构。 气缸可操作以将探头降低到槽中，使得采样头的空动机构允许阀机构在探头如此降低时保持在第二阀位置。

公开(公告)号：US3902115A

公开(公告)日：1975-08-26

申请号：US40098673

申请日：1973-09-26

Applicant: COULTER ELECTRONICS

Inventor： HOGG WALTER R ,  COULTER WALLACE H ,  GINSBERG GUENTER ,  PRONI OSCAR ,  GODIN THOMAS J

IPC: G01N1/38 ,  G01N15/12 ,  G01N27/00

CPC classification number: G01N15/12 ,  G01N1/38 ,  G01N15/1218

Abstract: A two chamber aperture tube for obtaining signals from particles suspended in a fluid which passes through a scanning aperture. The suspension enters an aperture in an inlet chamber and passes thereafter to an outlet chamber in fluid connection with the inlet chamber. The inlet chamber of the tube is connected to a source of clean electrolyte; the outlet chamber is connected to a waste collecting container. A vacuum is applied to the collecting container to cause clean electrolyte to be drawn through the inlet chamber and wash behind the aperture simultaneously with passage of the suspension through the aperture. A restriction in the path of flow of the clean electrolyte causes the flow velocity thereof to increase behind the aperture and ensure that proper signals from all particles in the suspension are obtained.

公开(公告)号：CA1090424A

公开(公告)日：1980-11-25

申请号：CA296820

申请日：1978-02-13

Applicant: COULTER ELECTRONICS

Inventor： SIMPSON RONALD O ,  STARLING J DAVID ,  JAMES BOBBY D ,  GODIN THOMAS J ,  GINSBERG GUENTER ,  DRBAL VLADIMIR J

IPC: G01N15/12 ,  G01N27/02

Abstract: An aperture module for obtaining signals from microscopic particles suspended in a sample blood solution which passes through a scanning aperture. A module housing including an aperture holder is mounted on a container or bath containing a body of the particulate liquid suspension to be tested. The aperture holder with aperture formed therein extends into the vessel to permit passage of the sample through the aperture to an outlet chamber immediately behind the aperture. The chamber is connected to a source of clean electrolyte and has a narrowed or reduced dimension portion positioned immediately behind the aperture. A vacuum is applied to the chamber to cause the sample to be drawn through the aperture for testing thereof. An optical hemoglobinometer is positioned in association with the bath to measure the hemoglobin content of the solution to be tested.

公开(公告)号：CA1053756A

公开(公告)日：1979-05-01

申请号：CA254006

申请日：1976-06-03

Applicant: COULTER ELECTRONICS

Inventor： GODIN THOMAS J

IPC: G01N1/38 ,  G01N15/12 ,  G01N27/02

Abstract: A particle analyzing system of the type having an aperture retaining member for obtaining signals from microscopic particles suspended in a fluid which passes through a scanning aperture. The aperture opens on one side thereof to the fluid suspension and on the opposite side to a passageway in the aperture retaining member; the passageway is connected at an entrance end thereof to a source of clean electrolyte and at an exit end thereof to a waste collecting container or isolator and a vacuum source. A vacuum from the source is applied to the collecting container to cause the clean electrolyte to be drawn through the passageway and wash or sweep behind the aperture simultaneously with passage of the suspension through the aperture. A sealed sweep flow isolator drip chamber or tank is interposed in the fluid conduits between the source of clean electrolyte and the passageway with a respective restriction in the fluid conduit on either side of the tank to enable filling of the tank with clean electrolyte to a predetermined desired level below the sealed top of the tank thereby to prevent electrical connection between the electrolyte supply and the passageway. The waste isolator is provided with a second aperture retaining member disposed in the wall thereof. Sample which has been sensed in the scanning aperture and diluted with the sweep flow clean electrolyte mixed therewith in the passageway is accumulated in the isolator to be tested with low coincidence correction required by passing the same through the second aperture into a secondary isolator. Alternatively, diluted sample present in the fluid conduit between the exit end of the passageway and the waste isolator may itself be forced back through the scanning aperture by applying pressure to the waste isolator; the diluted sample thereby is tested with low coincidence correction required. -ii-

公开(公告)号：CA984767A

公开(公告)日：1976-03-02

申请号：CA149743

申请日：1972-08-18

Applicant: COULTER ELECTRONICS

Inventor： GODIN THOMAS J

IPC: B01D29/01 ,  B01D35/02 ,  B01D46/00 ,  B01D46/10

Abstract: A fluid filter to be used for inline installation or in systems which are not to be disturbed when it is desired to clean or replace the filter member. An enclosed body has a lateral slot and the filter element is carried by a removable carrier member which is engaged in the slot into filtering position. Seals are provided to prevent leakage when the carrier member is in operative position.

公开(公告)号：DE2445411A1

公开(公告)日：1975-05-07

申请号：DE2445411

申请日：1974-09-23

Applicant: COULTER ELECTRONICS

Inventor： HOGG WALTER ROBERT ,  COULTER WALLACE HENRY ,  GINSBERG GUENTER ,  PRONI OSCAR ,  GODIN THOMAS J

IPC: G01N1/38 ,  G01N15/12 ,  G01N15/00

Abstract: 1479901 Electro-physical measurement; particle analysis COULTER ELECTRONICS Ltd 23 Sept 1974 [26 Sept 1973] 41368/74 Heading G1N(C) In a Coulter type particle analyzer, a "twochamber" tube is provided whereby clean electrolyte can be flowed past the aperture to waste, in a manner similar to that disclosed in Specification 1341336 and a constriction in the flow-path is arranged to increase the velocity behind the aperture. OVERALL SYSTEM FIG. 1. A double tube 13 is sealed into a coupling block 19 attached by screws 59 to the head-block 58, for easy interchange. The electrolyte system is electrically isolated from waste 42 and supply reservoir 52 by drip feed tanks 24, 29. The sample and electrolyte are moved through the apparatus by vacuum applied to the waste drip tank 24. The clean electrolyte flow is regulated by a constriction 27. Several variations of double tube construction are disclosed with reference to Figs. 2 ... 13 which are substantially self explanatory. Figs. 2, 5, 6, 7 only are shown as typical.

公开(公告)号：CA1021758A

公开(公告)日：1977-11-29

申请号：CA205637

申请日：1974-07-25

Applicant: COULTER ELECTRONICS

Inventor： GINSBERG GUENTER ,  GODIN THOMAS J ,  SIMPSON RONALD O

IPC: F04B7/02 ,  F04B9/12 ,  F16K7/06 ,  F16K11/02 ,  G01F11/02 ,  G01F15/00

Abstract: A pneumatically controlled liquid transfer system for delivering a liquid from a source to a delivery location, said liquid source being provided with a pneumatic cylinder for driving the liquid from said source, a pneumatically operated pinch valve of the make-before-break type and flexible conduit paths leading through the valve to the delivery location. The make-before-break pinch valve comprises a valve shell having two pistons movable laterally therein. The shell has a window. One piston has a yoke, each arm thereof having a passageway, one aligned with the other. A stop extends between the arms of the yoke. One of the flexible conduits is arranged through the window between the first piston and the yoke and the other flexible conduit is arranged also through the window but within the aligned passageways and between the piston and post. The second piston is spring biased to bear against the second conduit to place same in a normally closed condition. The first conduit is normally open. The first piston is acted upon by an external force such as air pressure to move same to a first condition wherein the piston pinches the first flexible conduit against the yoke, closing said conduit without overcoming the bias of the second piston to open the second conduit. Continued force exercised upon said first piston causes the same to move laterally within the housing to a second condition overcoming the spring bias of the second piston, to open the second conduit while the first conduit is retained in closed position. The second piston by virtue of its spring bias, will force the yoke back into its first position once the pressure on the first piston is relaxed. A manual override is provided operative upon the second piston to lock the same in open condition so that both conduits are open. This last mentioned position is utilized during down time of the apparatus concerned.

公开(公告)号：DE2412635A1

公开(公告)日：1974-10-03

申请号：DE2412635

申请日：1974-03-15

Applicant: COULTER ELECTRONICS

Inventor： JONES ALAN RICHARDSON ,  GODIN THOMAS J

IPC: G01N1/00 ,  G01N1/14 ,  B08B3/04

Abstract: The apparatus includes a sampling head adapted to be mounted at a sample pickup station. The head includes a hollow sample pickup probe adapted to be inserted into a sample container at the sample pickup station for extracting a given amount of fluid sample from the container. The pickup probe is movable between a first or sampling position and a second or retracted position by means of an air cylinder. A valve mechanism connected to the probe is operable on movement of the probe to the sampling position for connecting the probe to a device for withdrawing fluid from the sample container through the probe. The air cylinder not only moves the probe but also, and at the same time, operates the valve mechanism, between first and second valve positions. In the second position the valve mechanism effects fluid connections for mixing a given amount of the fluid sample with another fluid, for simultaneously transferring the mixture to a receptacle and for drawing de-ionized water through the probe for cleaning same. The apparatus also includes a water delivery trough and a mechanism for moving same into position under the raised probe. The air cylinder is operable to lower the probe into the trough with a lost motion mechanism of the sampling head permitting the valve mechanism to remain in the second valve position while the probe is so lowered.