公开(公告)号：DE69940785D1

公开(公告)日：2009-06-04

申请号：DE69940785

申请日：1999-11-19

Applicant: FUSO PHARMACEUTICAL IND

Inventor： UEMURA HIDETOSHI ,  OKUI AKIRA ,  KOMINAMI KATSUYA ,  YAMAGUCHI NOZOMI ,  MITSUI SHINICHI

IPC: C12N15/85 ,  C07K14/47 ,  C12N5/10 ,  C12N9/64 ,  C12N15/86 ,  C12P21/02

Abstract: A protein expression vector characterized by containing a secretory signal nucleotide sequence and, in the 3' downstream side thereof, a Tag nucleotide sequence, a cleavable nucleotide sequence and a cloning site, into which a nucleotide sequence encoding a target protein can be inserted, in this order.

公开(公告)号：AT429504T

公开(公告)日：2009-05-15

申请号：AT99972690

申请日：1999-11-19

Applicant: FUSO PHARMACEUTICAL IND

Inventor： UEMURA HIDETOSHI ,  OKUI AKIRA ,  KOMINAMI KATSUYA ,  YAMAGUCHI NOZOMI - ,  MITSUI SHINICHI

IPC: C12N15/85 ,  C07K14/47 ,  C12N5/10 ,  C12N9/64 ,  C12N15/86 ,  C12P21/02

Abstract: A protein expression vector characterized by containing a secretory signal nucleotide sequence and, in the 3' downstream side thereof, a Tag nucleotide sequence, a cleavable nucleotide sequence and a cloning site, into which a nucleotide sequence encoding a target protein can be inserted, in this order.

公开(公告)号：PT1092767E

公开(公告)日：2007-01-31

申请号：PT99926899

申请日：1999-07-02

Applicant: FUSO PHARMACEUTICAL IND

Inventor： KOMINAMI KATSUYA ,  OKUI AKIRA ,  MITSUI SHINICHI ,  YAMAGUCHI NOZOMI

IPC: C12N15/02 ,  A61K39/395 ,  C07K16/40 ,  C12N5/12 ,  C12N5/20 ,  C12P21/08 ,  G01N33/573 ,  G01N33/577 ,  G01N33/68

公开(公告)号：DK1092767T3

公开(公告)日：2006-11-27

申请号：DK99926899

申请日：1999-07-02

Applicant: FUSO PHARMACEUTICAL IND

Inventor： KOMINAMI KATSUYA ,  OKUI AKIRA ,  MITSUI SHINICHI ,  YAMAGUCHI NOZOMI

IPC: C12N15/02 ,  A61K39/395 ,  C07K16/40 ,  C12N5/12 ,  C12N5/20 ,  C12P21/08 ,  G01N33/573 ,  G01N33/577 ,  G01N33/68

Abstract: A monoclonal antibody binding selectively to neurosin obtained from hybridomas, in particular, strain 2B2-6 and strain S2E5 showing stable proliferation ability. These hydridomas are obtained by fusing mouse spleen cells having a high antibody titer against neurosin with mouse-derived myeloma cells, screening fused cells being highly reactive with neurosin, and thus producing an antibody binding specifically to neurosin. By using this antibody, various diseases in which neurosin participates can be diagnosed.

公开(公告)号：DE69933565D1

公开(公告)日：2006-11-23

申请号：DE69933565

申请日：1999-07-02

Applicant: FUSO PHARMACEUTICAL IND

Inventor： KOMINAMI KATSUYA ,  OKUI AKIRA ,  MITSUI SHINICHI ,  YAMAGUCHI NOZOMI

IPC: C12N15/02 ,  A61K39/395 ,  C07K16/40 ,  C12N5/12 ,  C12N5/20 ,  C12P21/08 ,  G01N33/573 ,  G01N33/577 ,  G01N33/68

Abstract: A monoclonal antibody binding selectively to neurosin obtained from hybridomas, in particular, strain 2B2-6 and strain S2E5 showing stable proliferation ability. These hydridomas are obtained by fusing mouse spleen cells having a high antibody titer against neurosin with mouse-derived myeloma cells, screening fused cells being highly reactive with neurosin, and thus producing an antibody binding specifically to neurosin. By using this antibody, various diseases in which neurosin participates can be diagnosed.

公开(公告)号：AU767187B2

公开(公告)日：2003-11-06

申请号：AU1184200

申请日：1999-11-19

Applicant: FUSO PHARMACEUTICAL IND

Inventor： UEMURA HIDETOSHI ,  OKUI AKIRA ,  KOMINAMI KATSUYA ,  YAMAGUCHI NOZOMI ,  MITSUI SHINICHI

IPC: C12N1/21 ,  C12N9/64 ,  C12N15/12 ,  C12P21/08 ,  A01K67/027 ,  C07K16/40 ,  C12N5/06 ,  G01N33/543

Abstract: There are provided proteins having the amino acid sequences represented by SEQ ID NOS: 2, 4 and 6; proteins having amino acid sequences derived from these amino acid sequences by deletion, substitution or addition of one to several amino acids; and nucleotide sequences encoding the same; transgenic non-human animals with altered expression level of a serine protease BSSP6; an antibody against BSSP6; and a method for detecting BSSP6 in a specimen by using the antibody.

公开(公告)号：CA2616940A1

公开(公告)日：2000-06-02

申请号：CA2616940

申请日：1999-11-19

Applicant: FUSO PHARMACEUTICAL IND

Inventor： OKUI AKIRA ,  YAMAGUCHI NOZOMI ,  KOMINAMI KATSUYA ,  MITSUI SHINICHI ,  UEMURA HIDETOSHI

IPC: C12N15/57 ,  C07K16/40 ,  C12N5/10 ,  C12N9/64 ,  C12P21/02 ,  C12P21/08 ,  G01N33/573

Abstract: There are provided proteins having amino acid sequences represented by SEQ ID NOS: 2, 4, 6, 8 and 10; proteins having amino acid sequences derived from these amino acid sequences by deletion, substitution or addition of one to several amino acids; and nucleotide sequences encoding the same; transgenic non-human animals with altered expression level of a serine protease BSSP2; an antibody against BSSP2; and a method for detecting BSSP2 in a specimen by using the antibody.

公开(公告)号：CA2350165A1

公开(公告)日：2000-06-02

申请号：CA2350165

申请日：1999-11-19

Applicant: FUSO PHARMACEUTICAL IND

Inventor： UEMURA HIDETOSHI ,  OKUI AKIRA ,  KOMINAMI KATSUYA ,  YAMAGUCHI NOZOMI ,  MITSUI SHINICHI

IPC: C12N1/21 ,  C12N9/64 ,  C12N15/12 ,  C12P21/08 ,  A01K67/027 ,  C12N5/06 ,  C07K16/40 ,  G01N33/543

Abstract: Proteins having the amino acid sequences represented by SEQ ID NOS: 2, 4 and 6 and proteins derived from these proteins by deletion, substitution or additi on of one or several amino acids in these amino acid sequences; base sequences encoding these proteins; a transgenic non-human animal having an altered BSS P6 expression level; an antibody against BSSP6; and a method for detecting BSSP 6 in a specimen by using this antibody.

公开(公告)号：CA2350080A1

公开(公告)日：2000-06-02

申请号：CA2350080

申请日：1999-11-19

Applicant: FUSO PHARMACEUTICAL IND

Inventor： MITSUI SHINICHI ,  OKUI AKIRA ,  UEMURA HIDETOSHI ,  KOMINAMI KATSUYA ,  YAMAGUCHI NOZOMI

IPC: C12N1/21 ,  C12N9/64 ,  C12P21/08 ,  C12N15/52 ,  C12P21/02 ,  A01K67/027 ,  C12N5/10 ,  C07K16/40 ,  G01N33/53 ,  C12Q1/68

Abstract: Proteins having the amino acid sequences represented by SEQ ID NOS: 2, 4, 6, 8 and 10; proteins having amino acid sequences derived from these amino acid sequences by deletion, substitution or addition of one to several amino acid s; and base sequences encoding the same. Transgenic non-human animals with altered expression level of a serine protease BSSP2; an antibody against BSSP2; and a method for detecting BSSP2 in a specimen by using the antibody.

公开(公告)号：CA2348971C

公开(公告)日：2012-02-07

申请号：CA2348971

申请日：1999-11-19

Applicant: FUSO PHARMACEUTICAL IND

Inventor： UEMURA HIDETOSHI ,  OKUI AKIRA ,  KOMINAMI KATSUYA ,  YAMAGUCHI NOZOMI ,  MITSUI SHINICHI

IPC: C12N15/57 ,  A01K67/027 ,  C07K14/47 ,  C07K16/40 ,  C12N9/50 ,  C12N9/64 ,  C12P21/02 ,  G01N33/53

Abstract: The present invention teaches proteins having amino acid sequences represented by SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14, 16, 18 and 20; proteins having amino acid sequences derived from these amino acid sequences by deletion, substitution or addition of one to several amino acids; and nucleotide sequences encoding the same; transgenic non-human animals with altered expression level of a serine protease BSSP4; an antibody against BSSP4; and a method for detecting BSSP4 in a specimen using the antibody.