公开(公告)号：HUT54144A

公开(公告)日：1991-01-28

申请号：HU360688

申请日：1988-07-08

Applicant: HOECHST AG

Inventor： KESSLER KURT ,  BECK GERHARD ,  BARTMANN WILHELM ,  GRANZER ERNOLD

IPC: A61K31/44 ,  A61K31/365 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/505 ,  A61P3/06 ,  A61P9/10 ,  C07D213/55 ,  C07D239/26 ,  C07D405/06 ,  C07D405/14 ,  C07F7/18 ,  C07D409/14 ,  C07D401/04

Abstract: 3-Desmethylmevalonic acid derivatives of the formula I ( delta -lactone) or II (corresponding dihydroxycarboxylic acid derivative) … … in which A-B, Z, R , R , R and R have the meanings given, are used as medicaments.

公开(公告)号：NO893777A

公开(公告)日：1990-03-26

申请号：NO893777

申请日：1989-09-22

Applicant: HOECHST AG

Inventor： KESSELER KURT ,  BARTMANN WILHELM ,  WESS GUENTHER ,  GRANZER ERNOLD

IPC: A61K31/215 ,  A61K31/34 ,  A61K31/35 ,  A61K31/351 ,  A61K31/365 ,  A61K31/366 ,  A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/496 ,  A61K31/50 ,  A61K31/505 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07C33/48 ,  C07C45/30 ,  C07C47/24 ,  C07C51/367 ,  C07C59/42 ,  C07C59/46 ,  C07C59/48 ,  C07C59/56 ,  C07C67/31 ,  C07C69/732 ,  C07C69/734 ,  C07D207/32 ,  C07D207/333 ,  C07D207/337 ,  C07D213/48 ,  C07D213/55 ,  C07D213/62 ,  C07D213/63 ,  C07D231/12 ,  C07D233/64 ,  C07D237/08 ,  C07D239/26 ,  C07D261/08 ,  C07D275/02 ,  C07D309/30 ,  C07D405/06 ,  C07D

CPC classification number: C07D207/333 ,  C07C33/486 ,  C07C45/305 ,  C07C47/24 ,  C07C59/56 ,  C07D207/337 ,  C07D213/48 ,  C07D213/55 ,  C07D237/08 ,  C07D239/26 ,  C07D309/30 ,  C07D405/06

公开(公告)号：PT91362A

公开(公告)日：1990-03-08

申请号：PT9136289

申请日：1989-08-03

Applicant: HOECHST AG

Inventor： WESS GUENTHER ,  BECK GERHARD ,  GRANZER ERNOLD ,  BARTMANN WILHELM

IPC: A61K31/19 ,  A61K31/215 ,  A61K31/365 ,  A61K31/366 ,  A61K31/40 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/50 ,  A61K31/505 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07C27/00 ,  C07C29/147 ,  C07C33/48 ,  C07C45/56 ,  C07C47/55 ,  C07C59/56 ,  C07C67/00 ,  C07C67/31 ,  C07C67/343 ,  C07C69/65 ,  C07C69/732 ,  C07C69/738 ,  C07D207/32 ,  C07D207/333 ,  C07D207/337 ,  C07D213/30 ,  C07D213/48 ,  C07D213/55 ,  C07D213/79 ,  C07D237/08 ,  C07D239/26 ,  C07D307/54 ,  C07D309/30 ,  C07D333/24 ,  C07D405/06 ,  C07D407/06 ,  C07D409/06 ,  C07C59/00 ,  C07D237/00 ,  C07D239/00 ,  C07D207/00 ,  C07D333/00 ,  C07D307/00 ,  A61K31/38 ,  A61K31/34

Abstract: 6-Fluoro-3,5-dihydroxy carboxylic acid derivatives of the formula I and the corresponding lactones of the formula II in which R1 and R2 have the specified meanings, a process for the preparation of these compounds, the use thereof as medicinal agents and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formula I or formula II are described.

公开(公告)号：NO893167A

公开(公告)日：1990-02-07

申请号：NO893167

申请日：1989-08-04

Applicant: HOECHST AG

Inventor： BECK GERHARD ,  BARTMANN WILHELM ,  WESS GUENTHER ,  GRANZER ERNOLD

IPC: A61K31/19 ,  A61K31/215 ,  A61K31/365 ,  A61K31/366 ,  A61K31/40 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/50 ,  A61K31/505 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07C27/00 ,  C07C29/147 ,  C07C33/48 ,  C07C45/56 ,  C07C47/55 ,  C07C59/56 ,  C07C67/00 ,  C07C67/31 ,  C07C67/343 ,  C07C69/65 ,  C07C69/732 ,  C07C69/738 ,  C07D207/32 ,  C07D207/333 ,  C07D207/337 ,  C07D213/30 ,  C07D213/48 ,  C07D213/55 ,  C07D213/79 ,  C07D237/08 ,  C07D239/26 ,  C07D307/54 ,  C07D309/30 ,  C07D333/24 ,  C07D405/06 ,  C07D407/06 ,  C07D409/06 ,  C07D207/323 ,  C07D213/04 ,  C07D309/10

CPC classification number: C07D207/333 ,  C07C33/486 ,  C07C45/56 ,  C07C47/55 ,  C07D207/337 ,  C07D213/30 ,  C07D213/48 ,  C07D213/55 ,  C07D237/08 ,  C07D239/26 ,  C07D307/54 ,  C07D309/30 ,  C07D333/24 ,  C07D405/06 ,  C07D407/06 ,  C07D409/06

公开(公告)号：AU3471589A

公开(公告)日：1989-12-21

申请号：AU3471589

申请日：1989-05-12

Applicant: HOECHST AG

Inventor： JENDRALLA HEINER ,  BECK GERHARD ,  BARTMANN WILHELM ,  WESS GUNTHER

IPC: A61K31/365 ,  A61K31/185 ,  A61K31/19 ,  A61K31/35 ,  A61K31/366 ,  A61P3/06 ,  C07C39/367 ,  C07C59/64 ,  C07C59/68 ,  C07C323/01 ,  C07C323/09 ,  C07D309/30 ,  C07C39/15 ,  C07C39/17 ,  C07C149/34

Abstract: Compounds of the general formula I and the corresponding open-chain dihydroxy carboxylic acids of the formula II in which X, Y and Z have the stated meanings, and their pharmacologically tolerated salts with bases and their pharmacologically tolerated esters, process for preparing this compound, its use as pharmaceutical and pharmaceutical products are described. Also described are phenols and thiophenols of the formula III in which X, Y and Z have the stated meanings.

公开(公告)号：DK235389A

公开(公告)日：1989-11-14

申请号：DK235389

申请日：1989-05-12

Applicant: HOECHST AG

Inventor： JENDRALLA HEINER ,  WESS GUENTHER ,  BARTMANN WILHELM ,  BECK GERHARD

IPC: A61K31/365 ,  A61K31/185 ,  A61K31/19 ,  A61K31/35 ,  A61K31/366 ,  A61P3/06 ,  C07C39/367 ,  C07C59/64 ,  C07C59/68 ,  C07C323/01 ,  C07C323/09 ,  C07D309/30 ,  C07C59/72 ,  C07C149/40 ,  C07C39/42 ,  C07C149/34

Abstract: Compounds of the general formula I and the corresponding open-chain dihydroxy carboxylic acids of the formula II in which X, Y and Z have the stated meanings, and their pharmacologically tolerated salts with bases and their pharmacologically tolerated esters, process for preparing this compound, its use as pharmaceutical and pharmaceutical products are described. Also described are phenols and thiophenols of the formula III in which X, Y and Z have the stated meanings.

公开(公告)号：PT87929A

公开(公告)日：1989-06-30

申请号：PT8792988

申请日：1988-07-07

Applicant: HOECHST AG

Inventor： KEBELER KURT ,  BECK GERHARD ,  GRANZER ERNOLD ,  BARTMANN WILHELM

IPC: A61K31/44 ,  A61K31/365 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/505 ,  A61P3/06 ,  A61P9/10 ,  C07D213/55 ,  C07D239/26 ,  C07D405/06 ,  C07D405/14 ,  C07F7/18 ,  C07D405/00 ,  C07D213/00 ,  C07D237/00 ,  A61K31/35 ,  A61K31/50

Abstract: 3-Desmethylmevalonic acid derivatives of the formula I ( delta -lactone) or II (corresponding dihydroxycarboxylic acid derivative) … … in which A-B, Z, R , R , R and R have the meanings given, are used as medicaments.

公开(公告)号：ZA885337B

公开(公告)日：1989-03-29

申请号：ZA885337

申请日：1988-07-22

Applicant: HOECHST AG

Inventor： WESS GUENTER ,  GUENTER WESS ,  ANAGNOSTOPULOS HIRISTO ,  BARTMANN WILHELM ,  WILHELM BARTMANN ,  BECK GERHARD ,  HIRISTO ANAGNOSTOPULOS ,  GERHARD BECK

IPC: A61K31/085 ,  A61K31/10 ,  A61K31/12 ,  A61K31/38 ,  A61K31/165 ,  A61K31/19 ,  A61K31/215 ,  A61K31/22 ,  A61K31/34 ,  A61K31/381 ,  A61K31/395 ,  A61K31/41 ,  A61K31/44 ,  A61K31/535 ,  A61K31/5375 ,  A61P1/04 ,  A61P11/00 ,  A61P17/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07C41/00 ,  C07C43/00 ,  C07C43/178 ,  C07C43/20 ,  C07C43/235 ,  C07C43/263 ,  C07C45/00 ,  C07C47/52 ,  C07C49/84 ,  C07C51/00 ,  C07C59/125 ,  C07C65/21 ,  C07C67/00 ,  C07C69/007 ,  C07C69/025 ,  C07C69/675 ,  C07C69/92 ,  C07C201/00 ,  C07C235/06 ,  C07C235/16 ,  C07C239/00 ,  C07C239/14 ,  C07C313/00 ,  C07C317/00 ,  C07C317/04 ,  C07C317/18 ,  C07C317/22 ,  C07C317/24 ,  C07C317/44 ,  C07C317/46 ,  C07C323/00 ,  C07C323/16 ,  C07C323/19 ,  C07C323/22 ,  C07C323/52 ,  C07C323/56 ,  C07C323/60 ,  C07C323/65 ,  C07D213/30 ,  C07D257/04 ,  C07D295/18 ,  C07D317/36 ,  C07D317/38 ,  C07D333/16 ,  C07C ,  A61K ,  C07D

Abstract: Leukotriene antagonists, a process for the preparation thereof, and the use thereof for the treatment of diseases (I) in which R1, R2, R3, R4, R5 and X have the indicated meanings, a process for the preparation of these compounds, the use thereof as pharmaceuticals, and pharmaceutical products based on these compounds, are described.

公开(公告)号：NO883074L

公开(公告)日：1989-01-11

申请号：NO883074

申请日：1988-07-08

Applicant: HOECHST AG

Inventor： BERGMANN ANDREAS ,  BARTMANN WILHELM ,  BECK GERHARD ,  LAU HANS-HERMANN

IPC: C07D213/30 ,  A61K31/365 ,  A61K31/366 ,  A61K31/38 ,  A61K31/40 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/50 ,  A61P3/06 ,  A61P9/10 ,  C07C45/68 ,  C07C47/55 ,  C07C51/00 ,  C07C51/09 ,  C07C59/00 ,  C07C59/125 ,  C07C59/48 ,  C07C59/68 ,  C07C59/72 ,  C07C59/90 ,  C07C67/00 ,  C07C313/00 ,  C07C323/52 ,  C07C333/04 ,  C07D213/55 ,  C07D239/26 ,  C07D309/10 ,  C07D309/30 ,  C07D405/06 ,  C07D405/10 ,  C07D405/12 ,  C07D407/06 ,  C07D407/12 ,  C07D409/06 ,  C07D409/12 ,  C07D493/04 ,  C07D493/14 ,  C07F7/18 ,  C07H15/18 ,  C07D309/00

Abstract: 3-Desmethyl-4-fluoromevalonic acid derivatives of the formula I and the corresponding dihydroxycarboxylic acid derivatives of the formula II … … in which R, X and Y have the meanings given, processes for the preparation of these compounds, their use as medicaments and pharmaceutical preparations are described. Novel intermediates for the preparation of the compounds of the formula I or formula II are additionally described.

公开(公告)号：NO883073A

公开(公告)日：1989-01-11

申请号：NO883073

申请日：1988-07-08

Applicant: HOECHST AG

Inventor： KESSELER KURT ,  BECK GERHARD ,  BARTMANN WILHELM ,  GRANZER ERNOLD

IPC: A61K31/44 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/505 ,  A61P3/06 ,  A61P9/10 ,  C07D213/55 ,  C07D239/26 ,  C07D405/06 ,  C07F7/18 ,  C07D405/00

CPC classification number: C07D239/26 ,  C07D213/55 ,  C07D405/06 ,  C07F7/1856