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    21.
    发明专利
    未知

    公开(公告)号：DK581075A

    公开(公告)日：1976-06-22

    申请号：DK581075

    申请日：1975-12-19

    Applicant: HOECHST AG

    Inventor： BECK G ,  LERCH U ,  SEEGER K ,  TEUFEL H

    IPC: C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D307/935 ,  C07D309/12 ,  C07F9/38 ,  C07F9/40 ,  C07C

    Abstract: Prostaglandin analogues of formula (I) in the natural, optically active configuration or as racemic cpds.: (where R1 + R2 is O, or one of R1 and R2 is H and the other is OH; one of R3 and R4 is H and the other is OH; is 1-5C straight or branched alkyl, or phenyl or benzyl opt. mono- di- or tri-substd. in the nucleus by halogen, CF3, OH, 1-4C alkyl and/or 1-4C alkoxy; R5, when X is 1-5C alkyl, is a diphenyl ether gp. opt. mono- di- or tri-substd. in either or both nuclei by halogen, CF3, OH, 1-4C alkyl and/or 1-4C alkoxy or a phenoxy-(2-5 C straight chain or 3-6C branched chain alkyl) opt. mono-di- or tri-substd. in the nucleus by halogen, CF3, OH, 1-4C alkyl and/or 1-4C alkoxy, or, when X is opt. substd. phenyl, a benzyl residue opt. mono- di- or tri-substd. in the nucleus by halogen, CF3, OH, 1-4C alkyl and/or 1-4C alkoxy, or, when X is opt. substd. benzyl, a phenyl residue opt. mono-, di- or tri-substd. by halogen, CF3, OH, 1-4C alkyl and/or 1-4C alkoxy; and the C-atoms in the 5- and 6-positions and the 13- and 14-positions are all linked by single bonds or all linked by double bonds), e.g. 9-oxo-11 alpha, 15-dihydroxy-16-methyl-16-(3-chloro-4-(4-chlorophenoxy)-phenoxy)-- 5-cis-13-trans-tetranorprostadienoci acid, their physiologically tolerable salts with organic and inorganic bases, and their esters with 1-8C aliphatic, cycloaliphatic and araliphatic alcohols are new. (I) can be used as pharmaceuticals with hypotensive, diuretic, antithrombotic labour-inducing, abortifacient, contraceptive, gastric secretion inhibiting, antiulcer and antiasthmatic activity. They are particularly useful as contraceptives for use in humans and as agents for synchronising oestrus in various animal species. They are more potent and longer-acting than natural prostaglandins.

    22.
    发明专利
    未知

    公开(公告)号：DK496775A

    公开(公告)日：1976-05-07

    申请号：DK496775

    申请日：1975-11-05

    Applicant: HOECHST AG

    Inventor： KYHLEIN K ,  REUSCHLING D-B ,  BABEJ M ,  BARTMANN W ,  BECK G

    IPC: C07D207/26 ,  C07D207/277 ,  C07D

    Abstract: The present invention relates to pyrrolidone derivatives which are analogous to natural prostaglandins and to a process for preparing the same. The compounds according to the present invention have prostaglandin-like properties and may be used as pharmaceuticals.

    30.
    发明专利
    未知

    公开(公告)号：DK205882A

    公开(公告)日：1982-11-08

    申请号：DK205882

    申请日：1982-05-06

    Applicant: HOECHST AG

    Inventor： BECK G ,  BARTMANN W ,  KNOLLE J ,  RUPP R H

    IPC: A61K31/40 ,  A61K31/4025 ,  A61P43/00 ,  C07D207/24 ,  C07D409/12 ,  C07D

    Abstract: The present invention relates to DELTA 1-pyrroline thiolactim ethers of the general formula I I which have a more specific action and/or a longer-lasting action than PGI2, and to a process for their preparation. The compounds are distinguished by a platelet aggregation-inhibiting action and a blood vessel-relaxing and hypotensive action, and can therefore be used as medicaments.

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