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    PROCESS FOR THE PREPARATION OF CYCLOPENTANE DERIVATIVES
    1.
    发明授权
    PROCESS FOR THE PREPARATION OF CYCLOPENTANE DERIVATIVES 失效

    公开(公告)号：KR790001979B1

    公开(公告)日：1979-12-30

    申请号：KR790002417

    申请日：1979-09-20

    Applicant: HOECHST AG

    Inventor： BARTMANN W ,  MILOS BABEJ ,  BECK G

    IPC: C07C177/00

    Abstract: Prostaglandin analogues and their intermediates (I; R1 and R2 are different, H or hydroxyl group, R3 = C1-5 alkyl, R4 = C1-5 alkyl, R5 = tetrahydropyranyl of H,U = (CH2)m, m = 0-5, R6 and R7 are same or not, H or C1-5 alkyl group, V = C1-5 alkyl, W =C1-5 alkyl, X = (CH2) m, m = 0-5). The compds, had strong antiprostaglandin activity. Thus, compd. II was reacted with hydrated metal complex to give I.

    PROCESS FOR THE MANUFACTURE OF NOVEL PROSTAGLANDIN ANALOGS
    2.
    发明授权
    PROCESS FOR THE MANUFACTURE OF NOVEL PROSTAGLANDIN ANALOGS 失效

    公开(公告)号：KR820001258B1

    公开(公告)日：1982-07-14

    申请号：KR770003102

    申请日：1977-12-30

    Applicant: HOECHST AG

    Inventor： BARTMANN W ,  BECK G ,  LERCH U ,  TEUFEL H ,  SCHOELKENS B

    IPC: C07C177/00

    Abstract: Title compds. I(R1,R2 = O, H, HO; R3 = H, C1-8 alip. or Cycloalip. group, C7-9 aralip., substituted ammonium ion; R4 = C1-10 alip. hydrocarbon, C3-7 cycloalip. hydrocarbon; R5 = H, alkyl, alkenyl, alkynyl; R6 = H, alkyl; A = trans -CH=CH- or -CH2-CH2-), useful hypertensives, were prepd. by reacting compd. II with acylating agent contg. C2-11 carboxylic group. Thus, 9-keto-15α--hydroxy-16,16-dimethyl-18- oxa -prosta-2,13-dienic acid methyl ester was dissolved in anhydrous dimethoxy ethane and added to a mixt. of dimethoxy ethane, pyridine and acetyl chloride to give 9-keto-15α-acetoxy-16,16-dimethyl-18-oxa-prosta-2,13-dienic acid methyl ester.

    PROCESS FOR PREPARING ISOQUINOLINE DERIVATIVES
    7.
    发明授权
    PROCESS FOR PREPARING ISOQUINOLINE DERIVATIVES 失效

    公开(公告)号：KR820002385B1

    公开(公告)日：1982-12-29

    申请号：KR790001318

    申请日：1979-04-25

    Applicant: HOECHST AG

    Inventor： BARTMANN W ,  KONZ E ,  GEYER H

    IPC: C07D217/22

    Abstract: Isoquinolines I(R1 = amino group -N(R4)(R5); R4, R5 = alky1 and make 5-8 membered cycle with N; R2 = halogen, OH, nitro, amino, substituted amino, mono- or di-substituted pheny1, pyridy1 or thieny1; R3 = H, OH, halogen, C1-6 alky1, alkoxy, NO2, amino, ethylenedioxy; m = 1,2), exhibiting effective activities for melancholia, were prepd. by reacting compds. II (X = H, carboxy1; Y = cl, Br) with amines (III). Thus, 3-chloro-1-pheny1-isoquinoline-4-carboxylic acid was heated to 150oC in N-methy1-piperazine and maintained for 6 hr to give 3-N-methy1piperazino-1-pheny1-isoquinoline.

    PROCESS FOR THE PREPARATION OF 2,4-11-DEOXYPGE SERIES PROSTAGLANDIN
    8.
    发明授权
    PROCESS FOR THE PREPARATION OF 2,4-11-DEOXYPGE SERIES PROSTAGLANDIN 失效

    公开(公告)号：KR820000509B1

    公开(公告)日：1982-04-10

    申请号：KR780003626

    申请日：1978-11-30

    Applicant: HOECHST AG

    Inventor： BICKEL M ,  BARTMANN W ,  BECK G ,  LERCH U

    IPC: C07C177/00

    Abstract: Title compds.(I; R1 = H, C1-10 hydrocarbon, ammonium ion; R2 = C1-6 aliphatic hydrocarbon) were prepd. by the hydrolysis of IV(R3 = protecting group; Z = CH2 or -C(CH3)2 group) obtained from the reaction of II and III (R4 = C1-4 alkyl or phenyl). Thus, 111.2 g 3-carbomethoxy-2-propenyl-2-triphenyl-phosphonium bromide and 71.6 g methyl-γ-bromo-crotonate were stirred at 26oC for 1.5 hr to give I.

    BASICALLY SUBSTITUTED INDOLE DERIVATIVES
    9.
    发明授权
    BASICALLY SUBSTITUTED INDOLE DERIVATIVES 失效

    公开(公告)号：KR800001398B1

    公开(公告)日：1980-12-02

    申请号：KR760003232

    申请日：1976-12-30

    Applicant: HOECHST AG

    Inventor： KAISER J ,  LATRELL R ,  BARTMANN W

    IPC: A61K31/40 ,  C07D209/12

    Abstract: The indole derivs. (I; R1 = pyrrolidino, piperidino, 4-hexamethyleneimino, morphorino, 4-hydroxypiperidino, 4-carbethoxy-piperidino, 1-piperaziny1; R2 = H, pyrrolidino, hexamethylene-imino, 4-hydroxypiperidino, morpholino, 1-piperazinyl; R3 = H, 6-methoxy; m= 1-2; R4 = H, Me, Ph, benzyl, alkoxypheny1), useful as hypotensive and antiarrhythmics, were prepd. by reaction of II(R = Cl, Br) and HNR5R6(R5, R6 = C1-6 alkyl). Thus, 51.2g II(R = Cl) was refluxed with 172g anhydrous piperazine in 500ml dioxane to give 46g 1-pheny1-2-piperazino-3-indole carbaldehyde.

    PROCESS FOR THE PREPARATION OF PROST ANOIC ACID
    10.
    发明授权
    PROCESS FOR THE PREPARATION OF PROST ANOIC ACID 失效

    公开(公告)号：KR790001860B1

    公开(公告)日：1979-12-26

    申请号：KR740003673

    申请日：1974-09-23

    Applicant: HOECHST AG

    Inventor： LEROH U ,  BARTMANN W ,  MILOS BABEJ

    IPC: C07C51/00

    Abstract: Prostanoic acid [I; u= (CH2)m, m = 0-5, - R3CCR4-, (R3 = / ≠ R4 = H, C1-C5 alkyl, but when X is (CH2)1-3, R3,R4 ≠ H at the same time), V= single bond, O, W = R5CR6 (R5 = / ≠ R6 = 0), C1-C5 alkyl) and its acid salts useful as anticonvulsive, were prepd. by retro-Dieckmann condensation of II to give III, followed by alkali safonification of III, decarboxylating, and then isolating ethers from III.

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