公开(公告)号：AT67487T

公开(公告)日：1991-10-15

申请号：AT86112631

申请日：1986-09-12

Applicant: HOECHST AG

Inventor： SIEGEL HERBERT DR ,  KAMPE KLAUS-DIETER DR ,  ALPERMANN HANS GEORG DR ,  GERHARDS HERMANN JOSEF DR ,  USINGER PATRICIA DR ,  SCHACHT ULRICH DR ,  LEVEN MARGRET DR ,  RAETHER WOLFGANG DR ,  DITTMAR WALTER DR ,  SACHSE BURKHARD DR

IPC: A61K31/41 ,  A61K31/415 ,  C07D233/60 ,  C07D249/08

公开(公告)号：GR3000641T3

公开(公告)日：1991-09-27

申请号：GR900400432

申请日：1990-07-12

Applicant: HOECHST AG

Inventor： BOHN MANFRED DR ,  DITTMAR WALTER DR ,  PEIL HEINZ GEORG DR ,  FUTTERER EBERHARD DR ,  KRAEMER KARL DR

IPC: A61K8/00 ,  A61K8/49 ,  A61K31/44 ,  A61Q3/02 ,  C07D213/89 ,  A61K7/043

Abstract: 1. An antimycotic nail varnish containing a) a 1-hydroxy-2-pyridone of the formula I see diagramm : EP0226984,P8,F2 in which R**1 is a saturated hydrocarbon radical having 6-9 carbon atoms, one of the radicals R**2 and R**4 is a hydrogen atom and the other is hydrogen, methyl or ethyl and R**3 is an alkyl radical having one or two carbon atoms, in the free form or in salt form, as the antimycotic substance, b) a water-insoluble film-forming agent, c) a physiologically acceptable solvent, and if appropriate d) additives customary in cosmetics.

公开(公告)号：DE3671699D1

公开(公告)日：1990-07-12

申请号：DE3671699

申请日：1986-12-13

Applicant: HOECHST AG

Inventor： BOHN MANFRED DR ,  DITTMAR WALTER DR ,  PEIL HEINZ GEORG DR ,  FUTTERER EBERHARD DR ,  KRAEMER KARL DR

IPC: A61K8/00 ,  A61K8/49 ,  A61K31/44 ,  A61Q3/02 ,  C07D213/89 ,  A61K7/043

Abstract: 1. An antimycotic nail varnish containing a) a 1-hydroxy-2-pyridone of the formula I see diagramm : EP0226984,P8,F2 in which R**1 is a saturated hydrocarbon radical having 6-9 carbon atoms, one of the radicals R**2 and R**4 is a hydrogen atom and the other is hydrogen, methyl or ethyl and R**3 is an alkyl radical having one or two carbon atoms, in the free form or in salt form, as the antimycotic substance, b) a water-insoluble film-forming agent, c) a physiologically acceptable solvent, and if appropriate d) additives customary in cosmetics.

公开(公告)号：AT53292T

公开(公告)日：1990-06-15

申请号：AT86117377

申请日：1986-12-13

Applicant: HOECHST AG

Inventor： BOHN MANFRED DR ,  DITTMAR WALTER DR ,  PEIL HEINZ GEORG DR ,  FUTTERER EBERHARD DR ,  KRAEMER KARL DR

IPC: A61K8/00 ,  A61K8/49 ,  A61K31/44 ,  A61Q3/02 ,  C07D213/89 ,  A61K7/043

公开(公告)号：DE3613061A1

公开(公告)日：1987-10-22

申请号：DE3613061

申请日：1986-04-18

Applicant: HOECHST AG

Inventor： LOHAUS GERHARD DR ,  DITTMAR WALTER DR ,  HAENEL HEINZ DR ,  RAETHER WOLFGANG DR

IPC: A61K31/44 ,  A61K31/4418 ,  A61K31/445 ,  A61P17/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  C07D213/89 ,  C07D309/38

Abstract: 1-Hydroxy-2-pyridones of the general formula I in which R , R and R , which are identical or different, denote hydrogen or lower alkyl having 1-4 carbon atoms, where R and R are preferably hydrogen and R is preferably methyl, X denotes S or preferably O, Y denotes hydrogen or up to 2 halogen atoms, namely chlorine and/or bromine, Z denotes a single bond or the divalent radicals O, S, -CH2-, -CH2O-, -OCH2-, -CH2S-, -SCH2- or -CH = CH-CH2O-, Ar denotes an aromatic ring system containing up to 2 rings which can be substituted by up to 3 radicals from the group consisting of fluorine, chlorine, bromine, methoxy, C1-C4-alkyl, trifluoromethyl and trifluoromethoxy. The invention further relates to medicaments which contain such compounds and a process for the preparation of those compounds of the formula V in which R , R , R , X, Y and Ar have the abovementioned meaning.

公开(公告)号：DE3609598A1

公开(公告)日：1987-10-01

申请号：DE3609598

申请日：1986-03-21

Applicant: HOECHST AG

Inventor： KAMPE KLAUS-DIETER DR ,  RAETHER WOLFGANG DR ,  DITTMAR WALTER DR ,  HAENEL HEINZ DR

IPC: A61K31/44 ,  A01N43/60 ,  A01N43/653 ,  A61K31/443 ,  A61K31/47 ,  A61P31/04 ,  C07D239/26 ,  C07D239/28 ,  C07D239/34 ,  C07D239/36 ,  C07D317/00 ,  C07D405/12 ,  C07D521/00 ,  C07D405/14 ,  C07D239/30 ,  C07D213/04 ,  C07D215/02 ,  C07D217/02 ,  A01N43/50 ,  A01N43/54

Abstract: Compounds of the formula I in which A equals CH or N, Ar equals phenyl, naphthyl or thienyl, R1 equals alkyl or halogen, and Y is a number of nitrogen-containing heterocyclic rings, have an excellent antimycotic action. The compounds IIIa IIIa are valuable intermediates for the preparation thereof.

公开(公告)号：DE3608792A1

公开(公告)日：1987-09-24

申请号：DE3608792

申请日：1986-03-15

Applicant: HOECHST AG

Inventor： BLUME ERNST DR ,  SCHAPER WOLFGANG DR ,  EHRHARDT HEINZ DR ,  RAETHER WOLFGANG DR ,  DITTMAR WALTER DR ,  HAENEL HEINZ DR ,  SACHSE BURKHARD DR

IPC: C07D247/00 ,  A01N43/50 ,  A01N43/653 ,  C07C41/00 ,  C07C43/18 ,  C07C67/00 ,  C07C201/00 ,  C07C213/00 ,  C07C215/42 ,  C07C217/48 ,  C07C217/74 ,  C07C253/00 ,  C07C255/54 ,  C07C313/00 ,  C07C317/12 ,  C07C317/14 ,  C07C317/18 ,  C07C317/20 ,  C07C323/22 ,  C07D233/56 ,  C07D233/60 ,  C07D233/61 ,  C07D249/08 ,  C07D307/38 ,  C07D333/00 ,  C07D401/12 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D521/00 ,  A61K31/44 ,  A61K31/41 ,  C07D409/06 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06

Abstract: Compounds I I where A equals t-butyl or a large number of (substituted) aromatics; Y equals azolyl; or Y equals -X-R1 where X=oxygen or sulfur and R1 equals (cyclo)alkyl or (heterocyclic) aryl; or Y equals where R2 equals (cyclo)alkyl, acetyl or aryl; or Y equals -NR3R4 where R3/R4 is alkyl; or Y equals several nitrogen-containing heterocyclic rings; Z equals OH, alkylcarbonyloxy, hal, alkoxy or benzyloxy; and the salts thereof are effective antimycotics or fungicides. They are obtained by reaction of II II with (CH3)2 III and further reaction of the compound IV obtained from this with a nucleophile YM (M=hydrogen or a metal equivalent). The compounds I (where Z=OH) resulting from this can be acylated or alkylated, or converted into I where Z=hal.

公开(公告)号：DE3544983A1

公开(公告)日：1987-06-25

申请号：DE3544983

申请日：1985-12-19

Applicant: HOECHST AG

Inventor： BOHN MANFRED DR ,  DITTMAR WALTER DR ,  PEIL HEINZ GEORG DR ,  FUTTERER EBERHARD DR ,  KRAEMER KARL DR

IPC: A61K8/00 ,  A61K8/49 ,  A61K31/44 ,  A61Q3/02 ,  C07D213/89 ,  A61K31/435 ,  A61K7/043

Abstract: 1. An antimycotic nail varnish containing a) a 1-hydroxy-2-pyridone of the formula I see diagramm : EP0226984,P8,F2 in which R**1 is a saturated hydrocarbon radical having 6-9 carbon atoms, one of the radicals R**2 and R**4 is a hydrogen atom and the other is hydrogen, methyl or ethyl and R**3 is an alkyl radical having one or two carbon atoms, in the free form or in salt form, as the antimycotic substance, b) a water-insoluble film-forming agent, c) a physiologically acceptable solvent, and if appropriate d) additives customary in cosmetics.

公开(公告)号：DE2214608A1

公开(公告)日：1973-10-04

申请号：DE2214608

申请日：1972-03-25

Applicant: HOECHST AG

Inventor： LOHAUS GERHARD DR ,  DITTMAR WALTER DR

IPC: C07D221/04 ,  A61K31/4412 ,  A61P31/04 ,  C07D213/64 ,  C07D213/89 ,  C07D221/10 ,  C07D221/20 ,  C07D405/04 ,  C07D405/06 ,  C07D29/42

Abstract: 1416397 Process for 1-hydroxy-2-pyridones HOECHST AG 21 March 1973 [25 March 1972] 13587/73 Heading C2C The invention comprises making compounds in which R 1 represents an alkyl radical of 1 to 17 carbon atoms which may be branched; an alkenyl radical of 2 to 17 carbon atoms; a cycloalkyl radical of 3 to 8 carbon atoms; a cyclohexylalkyl radical; a phenyl, phenylalkyl, phenylalkenyl, benzhydryl, phenoxymethyl; phenylmercaptomethyl or phenyl-sulphonylmethyl radical which may be substituted in the aromatic nucleus by one or more alkyl, alkoxy, amino, nitro, alkoxycarbonyl or cyano groups or halogen atoms; or a furyl or furylalkenyl radical; R 2 represents a hydrogen atom or an alkyl, alkenyl or alkynyl radical or a benzyl group or R 2 together with R 1 or R 3 forms a 5- or 6- membered carbocyclic ring; R 3 represents a hydrogen atom, an alkyl radical or a phenyl group and R 4 represents a hydrogen atom, an alkyl or alkenyl radical, a methoxymethyl or benzyl radical, or a chlorine or bromine atom, by reacting a 2-pyrone of the general Formula (II) with NH 2 OH or its salt in the presence of an optionally substituted aminopyridine or imidazole. Pharmaceutical preparations showing antibacterial and antimycotic actions contain (I) as active ingredient.

公开(公告)号：DE2134358A1

公开(公告)日：1973-01-25

申请号：DE2134358

申请日：1971-07-09

Applicant: HOECHST AG

Inventor： DOERFELT CHRISTOPHER DR ,  FISCHER KLAUS ,  DITTMAR WALTER DR

IPC: C07F7/22

Abstract: 1399748 Organotin compounds HOECHST AG 7 July 1972 [9 July 1971] 31945/72 Heading C2J Compounds of general formula where R 1 -R 4 are alkyl, aryl or alkaryl groups and R 4 may additionally be H, and R 5 is H or methyl are prepared by condensing a bisorganotin oxide (R 1 R 2 R 3 Sn) 2 O with a carboxylic acid at elevated temperature, usually in benzene, toluene or xylene as solvent. The compounds have fungistatic and bacteriostatic properties and are used in the antimicrobial finishing of fibrous materials (many specified). The compounds may be applied as solutions, especially in iso-propanol/water mixtures or in dimethyloldihydroxy-ethylene-urea containing MgCl 2 , dispersions or emulsions and may be incorporated into pastes, pigment mixtures and plastics dispersions such as polyacrylate, polyurethane, butadiene copolymer, polyvinylacetate, or natural latex and especially an aqueous dispersion of a copolymer of butyl acrylate, acrylonitrile, styrene and acrylamide.