公开(公告)号：NO300173B1

公开(公告)日：1997-04-21

申请号：NO940600

申请日：1994-02-22

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH ,  MANIA DIETER ,  HARTUNG JENS ,  GOEGELEIN HEINZ ,  KAISER JOACHIM ,  LINZ WOLFGANG ,  WETTLAUFER DAVID

IPC: A61K31/64 ,  A61P9/00 ,  A61K31/18 ,  A61P9/04 ,  A61P9/10 ,  C07C303/40 ,  C07C311/46 ,  C07C311/58 ,  C07C323/67 ,  C07C335/42

Abstract: There are described benzenesulphonylureas and -thioureas of the formula I where R(1) is H, (fluoro)methyl, R(2) is H, Hal, (fluoro)(mercapto) alkyl(oxy), E is O, S; Y is -[CR(3)2]n- where R(3) = H or alkyl and n = 1 - 4, X is H, Hal, alkyl, Z is Hal, NO2, alkyl(oxy). The compounds (I) are used for the treatment of cardiac arrhythmias and for the prevention of sudden heart death due to arrhythmias and can therefore be used as antiarrhythmics. They are particularly suitable for those cases in which arrhythmias are the result of constriction of a coronary vessel, such as in angina pectoris or in acute cardiac infarct.

公开(公告)号：HU9603450D0

公开(公告)日：1997-02-28

申请号：HU9603450

申请日：1996-12-13

Applicant: HOECHST AG

Inventor： CRAUSE PETER ,  ENGLERT HEINRICH CHRISTIAN ,  GERLACH UWE ,  GOEGELEIN HEINZ ,  KLAUS ERIK ,  LINZ WOLFGANG ,  MANIA DIETER

IPC: C07D311/58 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/4025 ,  A61K31/4412 ,  A61K31/443 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  C07D311/64 ,  C07D311/70 ,  C07D405/12

Abstract: N-(4-Amidoalkyl-chroman-5-yl-sulphonyl)-urea or -thiourea derivatives of formula (I) and their salts are new. R1 = H, alkyl, alkoxy, F, Cl, Br, I, CF3, NH2, mono- or dialkylamino or alkylthio; R2a = H, Me or Et; R2b, R2d = H, Me or Et; or phenyl or benzyl (both optionally ring-substituted by 1-3 of halogen, Me, Et, OMe and OEt); R2c,R2e = H, Me or Et; R3 = H, alkyl, cycloalkyl, cycloalkylmethyl or CF3; n = 1 or 2; Z = O or S; A = phenyl (optionally substituted by 1-3 of halogen, Me, OMe, Et or OEt), a lactam residue of formula (a), 1-oxo-1,2,3,4-tetrahydroisoquinolin-2-yl, 1-oxo-per-hydro-isoquinolin-2-yl, 1-oxo-1,2-dihydro-iso-indol-2-yl or 1-oxo-per-hydro-iso-indol-2-yl; B = 3-6C alkylene or 3-6C alkenylene (both optionally substituted by 1-3 alkyl); unless specified otherwise alkyl moieties have 1-4C and cycloalkyl moieties 3-6C.

公开(公告)号：HRP940767A2

公开(公告)日：1997-02-28

申请号：HRP940767

申请日：1994-10-25

Applicant: HOECHST AG ,  RUHRCHEMIE AG

Inventor： WAGNER ADALBERT ,  ENGLERT HEINRICH ,  KLEEMANN HEINZ-WERNER ,  GERHARDS HERMAN ,  SCHOELKENS BERNWARD ,  BECKER REINHARD ,  LINZ WOLFGANG ,  CAILLE M JEAN-CLOUDE ,  VEVERT M JEAN-PAUL

IPC: A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K31/64 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D207/34 ,  C07D207/36 ,  C07D233/54 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D249/02 ,  C07D255/02 ,  C07D257/02 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D521/00

Abstract: Azole derivative of the general formula (I) in which A, L, O, R , X, Y, Z and q have the meanings given, a process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the formula I where the symbols have, for example, the following meanings: R = (C2-C10)-alkyl Z = nitrogen X and Y = independently of one another CR L = -CH2- q = zero or 1 A = biphenyl radical which is substituted, for example, by R R = halogen or hydrogen R = SO2-NH-CO-OR and R = phenyl, are highly active antagonists of angiotensin II receptors.

公开(公告)号：LT3373B

公开(公告)日：1995-08-25

申请号：LTIP716

申请日：1993-06-25

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  ENGLERT HEINRICH ,  KLEEMANN HEINZ-WERNER ,  GERHARDS HERMANN ,  SCHOELKENS BERNWARD ,  BECKER REINHARD ,  LINZ WOLFGANG

IPC: A61K20060101 ,  A61K31/40 ,  A61K31/425 ,  C07D20060101 ,  C07D207/30 ,  C07D257/04 ,  C09F20060101

Abstract: Azole derivatives, which have a general formula (I): where A, Z, O, R1, X, Y, Z and q have indicated meanings, their extraction method, pharmaceutical preparations and the use of these compounds, as medical substances. The azole derivatives, which have a formula (I), in which the symbols, for example, have these meanings:R - (C2-C10)-alkyl,Z - azote,X, Y - independently from one another, CR ,Z - -CH2-,q - 0 or 1,A - biphenyl residue, in which there is a substitute, for example, R ,R - halogen or hydrate,R - SO2-NH-CO-R andR - phenylare very effective antagonists of angiotensin-II-receptors.

公开(公告)号：NZ245896A

公开(公告)日：1995-04-27

申请号：NZ24589693

申请日：1993-02-12

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH ,  MANIA DIETER ,  LANG HANS-JOCHEN ,  SCHOLZ WOLFGANG ,  LINZ WOLFGANG ,  ALBUS UDO

IPC: A61K31/155 ,  A61K31/165 ,  A61K31/445 ,  A61P1/16 ,  A61P3/08 ,  A61P3/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  C07C279/22 ,  C07D213/65 ,  C07D295/14 ,  C07D295/155 ,  A61K31/40

Abstract: There are described benzoylguanidines of the formula I in which R(1) or R(2) is an amino group -NR(3)R(4), where R(3) and R(4) are equal to H, (cyclo)alkyl or R(3) is equal to phenyl-(CH2)p- where p = 0, 1, 2, 3 or 4, or phenyl, or R(3) and R(4) together can also be a methylene chain, and in which the other substituent R(1) or R(2) in each case is H, F, Cl, alkyl, alkoxy, CF3, CmF2m+1-CH2-, benzyl or phenoxy, and their pharmaceutically tolerable salts. The compounds according to the invention have very good antiarrhythmic properties, such as they show, for example, in the case of oxygen deficiency symptoms. The compounds are used as antiarrhythmic medicaments having a cardioprotective component for infarct prophylaxis and infarct treatment and also for the treatment of angina pectoris, where they preventively inhibit or strongly decrease the pathophysiological processes during the formation of ischaemically induced damage, in particular during the induction of ischaemically induced cardiac arrhythmias.

公开(公告)号：AU658261B2

公开(公告)日：1995-04-06

申请号：AU3301393

申请日：1993-02-12

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH ,  MANIA DIETER ,  LANG HANS-JOCHEN ,  SCHOLZ WOLFGANG ,  LINZ WOLFGANG ,  ALBUS UDO

IPC: A61K31/155 ,  A61K31/165 ,  A61K31/445 ,  A61P1/16 ,  A61P3/08 ,  A61P3/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  C07C279/22 ,  C07D213/65 ,  C07D295/14 ,  C07D295/155 ,  C07D295/06

Abstract: There are described benzoylguanidines of the formula I in which R(1) or R(2) is an amino group -NR(3)R(4), where R(3) and R(4) are equal to H, (cyclo)alkyl or R(3) is equal to phenyl-(CH2)p- where p = 0, 1, 2, 3 or 4, or phenyl, or R(3) and R(4) together can also be a methylene chain, and in which the other substituent R(1) or R(2) in each case is H, F, Cl, alkyl, alkoxy, CF3, CmF2m+1-CH2-, benzyl or phenoxy, and their pharmaceutically tolerable salts. The compounds according to the invention have very good antiarrhythmic properties, such as they show, for example, in the case of oxygen deficiency symptoms. The compounds are used as antiarrhythmic medicaments having a cardioprotective component for infarct prophylaxis and infarct treatment and also for the treatment of angina pectoris, where they preventively inhibit or strongly decrease the pathophysiological processes during the formation of ischaemically induced damage, in particular during the induction of ischaemically induced cardiac arrhythmias.

公开(公告)号：NO941562A

公开(公告)日：1994-10-31

申请号：NO941562

申请日：1994-04-28

Applicant: HOECHST AG

Inventor： LINZ WOLFGANG ,  WIRTH KLAUS ,  SCHOLKENS BERNWARD ,  BREIPOHL GERHARD ,  HENKE STEPHAN ,  KNOLLE JOCHEN

IPC: A61K38/00 ,  A61K38/04 ,  A61P9/10 ,  A61K37/64 ,  C07K7/00 ,  C07K7/06

CPC classification number: A61K38/043

公开(公告)号：AU653760B2

公开(公告)日：1994-10-13

申请号：AU9011091

申请日：1991-12-31

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  VEVERT JEAN-PAUL ,  CAILLE JEAN-CLAUDE ,  ENGLERT HEINRICH ,  KLEEMANN HEINZ-WERNER ,  GERHARDS HERMANN ,  SCHOLKENS BERNWARD ,  BECKER REINHARD ,  LINZ WOLFGANG

IPC: A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K31/64 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D207/34 ,  C07D207/36 ,  C07D233/54 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D249/02 ,  C07D255/02 ,  C07D257/02 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D521/00 ,  A61K31/41 ,  A61K31/495

Abstract: Azole derivative of the general formula (I) in which A, L, O, R , X, Y, Z and q have the meanings given, a process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the formula I where the symbols have, for example, the following meanings: R = (C2-C10)-alkyl Z = nitrogen X and Y = independently of one another CR L = -CH2- q = zero or 1 A = biphenyl radical which is substituted, for example, by R R = halogen or hydrogen R = SO2-NH-CO-OR and R = phenyl, are highly active antagonists of angiotensin II receptors.

公开(公告)号：HU9401226D0

公开(公告)日：1994-08-29

申请号：HU9401226

申请日：1994-04-28

Applicant: HOECHST AG

Inventor： LINZ WOLFGANG ,  WIRTH KLAUS ,  KNOLLE JOSHEN ,  HENKE STEPHAN ,  BREIPOHL GERHARD ,  SCHOELKENS BERNWARD

IPC: A61K38/00 ,  A61K38/04 ,  A61P9/10

公开(公告)号：NO940600L

公开(公告)日：1994-08-24

申请号：NO940600

申请日：1994-02-22

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN ,  MANIA DIETER ,  HARTUNG JENS ,  GOEGELEIN HEINZ ,  KAISER JOACHIM ,  LINZ WOLFGANG ,  WETTLAUFER DAVID

IPC: A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61K31/18 ,  A61P9/10 ,  C07C303/40 ,  C07C311/46 ,  C07C311/58 ,  C07C323/67 ,  C07C335/42

Abstract: There are described benzenesulphonylureas and -thioureas of the formula I where R(1) is H, (fluoro)methyl, R(2) is H, Hal, (fluoro)(mercapto) alkyl(oxy), E is O, S; Y is -[CR(3)2]n- where R(3) = H or alkyl and n = 1 - 4, X is H, Hal, alkyl, Z is Hal, NO2, alkyl(oxy). The compounds (I) are used for the treatment of cardiac arrhythmias and for the prevention of sudden heart death due to arrhythmias and can therefore be used as antiarrhythmics. They are particularly suitable for those cases in which arrhythmias are the result of constriction of a coronary vessel, such as in angina pectoris or in acute cardiac infarct.