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    24.
    发明专利
    未知

    公开(公告)号：DE3344912A1

    公开(公告)日：1985-06-20

    申请号：DE3344912

    申请日：1983-12-13

    Applicant: HOECHST AG

    Inventor： MAUZ OTTO DR ,  NOETZEL SIEGFRIED DR ,  NEUMANN BERNHARD DR

    IPC: A61K38/46 ,  A61K39/00 ,  A61K39/44 ,  A61K47/00 ,  A61K47/32 ,  B01D15/08 ,  B01J20/26 ,  B01J20/281 ,  B01J20/285 ,  C08F2/00 ,  C08F2/18 ,  C08F8/00 ,  C08F8/12 ,  C08F16/02 ,  C08F16/32 ,  C08F18/02 ,  C08F22/18 ,  C08F26/00 ,  C08F26/10 ,  C08F216/06 ,  C08F216/12 ,  C08F218/00 ,  C08F218/02 ,  C08F218/04 ,  C08F218/08 ,  C08F226/06 ,  C08J9/224 ,  C12N11/08 ,  G01N30/88 ,  G01N33/543

    Abstract: For the contracting states : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE 1. A crosslinked polymer in the form of beads which substantially comprises vinyl acylate units and units of a crosslinking agent which has the formulae see diagramm : EP0150350,P12,F1 and/or see diagramm : EP0150350,P12,F2 where R1 and R2 in the formula (I) can be identical or different and each denotes vinyl-, 1-acyloxyvinyl, allyl- or 2-acyloxyallyl, A represents a divalent hydrocarbon radical of 2 to 8 carbon atoms, B in the formula (II) stands for a divalent hydrocarbon radical of 1 to 8 carbon atoms and X denotes acyloxy, the amount of theses crosslinking agent units accounting for 1 to 60 % by weight of the polymer, the acyloxy groups of the vinyl acylate units being present as such or having been partially or completely replaced by hydroxyl groups, and the average particle size of the beads being 20 to 800 mu m and the mean pore diameter being 2 to 10,000 nm. For the contracting state AT 1. A process for preparing a crosslinked polymer in the form of beads by copolymerizing vinyl acylate with a crosslinking agent and, if propriate, a further monomer copolymerizable with the vinyl acylate in ther presence of a dispersion medium and if desired partially or completely hydrolyzing the resulting polymer, wherein the crosslinking agent has the formulae see diagramm : EP0150350,P12,F1 and/or see diagramm : EP0150350,P12,F2 where R1 and R2 in the formula (I) can be identical or different and each denotes vinyl-, 1-acyloxyvinyl, allyl- or 2-acyloxyallyl, A represents a divalent hydrocarbon radical of 2 to 8 carbon atoms, B in the formula (II) stands for a divalent hydrocarbon radical of 1 to 8 carbon atoms and X denotes acyloxy, and the beads obtained have an average particle size of 10 to 800 mu m and an average pore diameter of 2 to 10,000 nm.

    25.
    发明专利
    未知

    公开(公告)号：GR81579B

    公开(公告)日：1984-12-11

    申请号：GR840174829

    申请日：1984-05-25

    Applicant: HOECHST AG

    Inventor： NOETZEL SIEGFRIED DR ,  MAUZ OTTO DR ,  SAUBER KLAUS DR

    IPC: A61K47/48 ,  B01D15/08 ,  B01J20/26 ,  C08F20/54 ,  C08F220/54 ,  C12N11/08

    Abstract: The invention relates to bead polymers based on monomers of the formula (I) in which X is hydrogen or methyl, R denotes an aliphatic hydrocarbon radical having 1 to 12 carbon atoms, and Y denotes OH or NH2, which have been prepared using a special dispersion stabilizer. They are particularly distinguished by high porosity and are very suitable as carrier materials for biologically active substances.

    26.
    发明专利
    未知

    公开(公告)号：GR81288B

    公开(公告)日：1984-12-11

    申请号：GR830173046

    申请日：1983-11-23

    Applicant: HOECHST AG

    Inventor： MAUZ OTTO DR ,  SAUBER KLAUS DR ,  NOETZEL SIEGFRIED DR

    IPC: C08F34/00 ,  A61K39/00 ,  C07K1/22 ,  C07K17/08 ,  C08F34/02 ,  C12N11/08

    Abstract: The invention relates to bead polymers based on vinylene carbonate which are distinguished, in particular, by high porosity and which are well suited as carrier materials for biologically active substances. The preparation of these bead polymers is carried out, according to the invention, in the presence of certain dispersion stabilizers.

    28.
    发明专利
    未知

    公开(公告)号：DE2228448A1

    公开(公告)日：1973-12-13

    申请号：DE2228448

    申请日：1972-06-10

    Applicant: HOECHST AG

    Inventor： MAUZ OTTO DR ,  GRANZER ERNOLD DR DR

    IPC: C07C59/52 ,  C07C65/00

    Abstract: Pharmaceutical compositions acting on the metabolism which contain as active substance bis(4-hydroxy-phenyl)alkanoic acids corresponding to the formulae I and II wherein R1 and R2 wich may be identical or different, each stands for a hydrogen or halogen atom or an alkyl group having 1 to 4 carbon atoms, R3 stands for a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, R4 stands for hydroxy, alkoxy having 1 to 18 carbon atoms, phenyl-alkoxy having 1 to 4 alkyl carbon atoms, cycloalkoxy having 5 to 8 carbon atoms or a group of the formula in which Z and Z', which may be identical or different, each stands for hydrogen, alkyl of 1 to 18 carbon atoms, phenyl or cycloalkyl of 5 to 8 carbon atoms, or both together with the nitrogen atom may form a heterocyclic ring, R6 stands for an alkylene radical having 2 to 12 atoms and n stands for zero or an integer of 1 to 6, and process for preparing them.

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