公开(公告)号：GR3033220T3

公开(公告)日：2000-08-31

申请号：GR20000400911

申请日：2000-04-14

Applicant: HOECHST AG

Inventor： ARETZ WERNER DR ,  SAUBER KLAUS DR

IPC: C07D501/18 ,  C12N9/18 ,  C12P35/00 ,  C12P35/06 ,  C12R1/01 ,  C12R1/465

Abstract: An esterase with a molecular weight of 55 200 +/- 300 Da is suitable for the chemoselective conversion of a compound of the formula II into a compound of the formula I.

公开(公告)号：DK0474211T3

公开(公告)日：1996-05-20

申请号：DK91114933

申请日：1991-09-04

Applicant: HOECHST AG

Inventor： BAYER THOMAS DR ,  SAUBER KLAUS DR

IPC: C07D501/20 ,  C12N9/06 ,  C12N11/08 ,  C12N11/10 ,  C12P35/00 ,  C12P35/06

Abstract: A process for the continuous conversion of cephalosporin derivatives into glutaryl-7-aminocephalosporanic acid derivatives A process for the continuous conversion of cephalosporin derivatives into the corresponding glutaryl-7-aminocephalosporanic acid derivatives in the presence of a catalyst containing D-amino-acid oxidase is described. The product yield can be increased, where appropriate, by addition of hydrogen peroxide.

公开(公告)号：GR3018713T3

公开(公告)日：1996-04-30

申请号：GR950403689

申请日：1996-01-18

Applicant: HOECHST AG

Inventor： BAYER THOMAS DR ,  SAUBER KLAUS DR

IPC: C07D501/20 ,  C12N9/06 ,  C12N11/08 ,  C12N11/10 ,  C12P35/00 ,  C12P35/06

Abstract: A process for the continuous conversion of cephalosporin derivatives into glutaryl-7-aminocephalosporanic acid derivatives A process for the continuous conversion of cephalosporin derivatives into the corresponding glutaryl-7-aminocephalosporanic acid derivatives in the presence of a catalyst containing D-amino-acid oxidase is described. The product yield can be increased, where appropriate, by addition of hydrogen peroxide.

公开(公告)号：CZ279063B6

公开(公告)日：1994-12-15

申请号：CS28588

申请日：1988-01-15

Applicant: HOECHST AG

Inventor： ARETZ WERNER DR ,  SAUBER KLAUS DR

IPC: C12N1/20 ,  C12N9/10 ,  C12P35/00 ,  C12P35/02 ,  C12P35/06 ,  C12R1/06 ,  C12R1/125 ,  C12R1/37 ,  C12R1/38 ,  C12R1/385 ,  C12R1/40

Abstract: Using a gamma -glutamyltranspeptidase which can be prepared by fermentation, it is possible to hydrolyse adipinyl- or glutaryl-monoamino compounds, in particular alpha -keto-adipinyl- or glutaryl-7-aminocephalosporanic acid.

公开(公告)号：ES2058141T3

公开(公告)日：1994-11-01

申请号：ES88100349

申请日：1988-01-13

Applicant: HOECHST AG

Inventor： ARETZ WERNER DR ,  SAUBER KLAUS DR

IPC: C12N1/20 ,  C12N9/10 ,  C12P35/00 ,  C12P35/02 ,  C12P35/06 ,  C12R1/06 ,  C12R1/125 ,  C12R1/37 ,  C12R1/38 ,  C12R1/385 ,  C12R1/40

Abstract: Using a gamma -glutamyltranspeptidase which can be prepared by fermentation, it is possible to hydrolyse adipinyl- or glutaryl-monoamino compounds, in particular alpha -keto-adipinyl- or glutaryl-7-aminocephalosporanic acid.

公开(公告)号：ES2051921T3

公开(公告)日：1994-07-01

申请号：ES89109648

申请日：1989-05-29

Applicant: HOECHST AG

Inventor： SCHULZ ARNO DR ,  BARTSCH KLAUS DR ,  TRIPIER DOMINIQUE DR ,  SAUBER KLAUS DR

IPC: C12N9/10 ,  C12N11/02 ,  C12N11/08 ,  C12P13/00 ,  C12P13/04 ,  C12R1/19

Abstract: Transaminase, the preparation thereof and the use thereof. A transaminase can be isolated from E. coli DH-1 and can be used with great efficiency to prepare L-phosphinothricin and gamma -aminobutyric acid from the appropriate precursor by transfer of the amino group from glutamate.

公开(公告)号：CZ8800285A3

公开(公告)日：1993-04-14

申请号：CS28588

申请日：1988-01-15

Applicant: HOECHST AG

Inventor： ARETZ WERNER DR ,  SAUBER KLAUS DR

IPC: C12N1/20 ,  C12N9/10 ,  C12P35/02 ,  C12P35/06 ,  C12R1/06 ,  C12R1/125 ,  C12R1/37 ,  C12R1/38 ,  C12R1/385 ,  C12R1/40

CPC classification number: C12N9/104 ,  C12P35/02

公开(公告)号：DE3766671D1

公开(公告)日：1991-01-24

申请号：DE3766671

申请日：1987-08-26

Applicant: HOECHST AG

Inventor： MAUZ OTTO DR ,  NOETZEL SIEGFRIED DR ,  SAUBER KLAUS DR

IPC: A61K9/16 ,  A61K39/385 ,  A61K39/44 ,  C08F2/14 ,  C08F16/14 ,  C08F20/26 ,  C08F26/00 ,  C08F216/14 ,  C08F220/28 ,  C08F226/00 ,  C08F226/02 ,  C08F271/02 ,  C12N11/08

Abstract: Crosslinked polymers which are produced from monomers containing glycerol carbonate groups, crosslinking monomers and, where appropriate, other monoethylenically unsaturated monomers are composed of principally spherical porous particles and are very suitable as carrier materials for the immobilization of biologically active substances.

公开(公告)号：DE3910966A1

公开(公告)日：1990-10-11

申请号：DE3910966

申请日：1989-04-05

Applicant: HOECHST AG

Inventor： SAUBER KLAUS DR ,  GERHARDS HERRMANN DR

IPC: C08F8/12 ,  C08F218/04 ,  C12N11/06 ,  C12N11/08 ,  G01N33/545

Abstract: The support material consists of acetylcholine esterase and choline oxidase and a copolymer based on vinyl acylate and/or vinyl alcohol units and units of a crosslinker. A material of this type is stable for at least 6 months. It is used for determining choline and acetylcholine, which are detected via the formation of hydrogen peroxide.

公开(公告)号：DE3171623D1

公开(公告)日：1985-09-05

申请号：DE3171623

申请日：1981-12-16

Applicant: HOECHST AG

Inventor： GRABLEY SUSANNE DR ,  SAUBER KLAUS DR

IPC: C12P7/52 ,  C07B57/00 ,  C07F9/30 ,  C12P13/04 ,  C12P41/00