公开(公告)号：DE3208189A1

公开(公告)日：1983-09-08

申请号：DE3208189

申请日：1982-03-06

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  MANIA DIETER DR ,  MUSCHAWECK ROMAN DR ,  HROPOT MAX DR

IPC: A61K31/18 ,  A61K31/40 ,  A61P3/00 ,  A61P7/10 ,  A61P9/12 ,  C07C67/00 ,  C07C301/00 ,  C07C303/02 ,  C07C303/38 ,  C07C303/40 ,  C07C311/15 ,  C07C311/37 ,  C07D295/22 ,  C07D295/26 ,  C07C143/80 ,  C07C143/78

Abstract: The invention relates to 2-aminomethylphenols of the formula I in which R1 and R2 represent hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl or benzyl which is optionally substituted by alkyl, alkoxy or halogen, R3 and R5 denote hydrogen, halogen, alkyl or alkoxy, R4 denotes halogen, alkyl or cycloalkyl and R6 and R7 represent hydrogen or alkyl, it being possible for the radicals R1 and R2, R6 R7 and/or two of the radicals R3, R4 and R5 to form an alkylene chain which is optionally substituted by methyl groups and which, in the case of the radicals R1, R2, R6 and R7, can also be interrupted by oxygen atoms, sulfur atoms and/or imino groups, and to physiologically acceptable salts thereof, a process for their preparation, and their use and to pharmaceutical formulations based on these compounds.

公开(公告)号：DE2964850D1

公开(公告)日：1983-03-24

申请号：DE2964850

申请日：1979-11-13

Applicant: HOECHST AG

Inventor： MERKEL WULF DR ,  BORMANN DIETER DR ,  MANIA DIETER DR ,  MUSCHAWECK ROMAN DR

IPC: A61K31/38 ,  A61K31/381 ,  A61P7/10 ,  A61P9/12 ,  C07D333/20 ,  C07D333/24 ,  C07D333/28 ,  C07D409/12

公开(公告)号：CH632996A5

公开(公告)日：1982-11-15

申请号：CH1580477

申请日：1977-12-21

Applicant: HOECHST AG

Inventor： MERKEL WULF DR ,  BORMANN DIETER DR ,  MANIA DIETER DR ,  MUSCHAWECK ROMAN DR

IPC: A61K31/40 ,  A61P7/10 ,  C07D207/32 ,  C07D207/327 ,  C07D295/155 ,  C07D317/64

公开(公告)号：DE3041812A1

公开(公告)日：1982-06-16

申请号：DE3041812

申请日：1980-11-06

Applicant: HOECHST AG

Inventor： STURM KARL DIPL CHEM DR ,  MUSCHAWECK ROMAN DR ,  HROPOT MAX DR

IPC: C07D251/18 ,  A61K31/41 ,  A61P7/10 ,  C07D257/04 ,  C07D307/52 ,  C07D333/20 ,  C07D405/12 ,  C07D409/12 ,  A61K31/635

Abstract: What are disclosed are salidiuretic compounds of the formula and physiologically acceptable salts thereof, wherein R is phenyl, furyl or thienyl, intermediates of said compounds, methods for making said compounds, salidiuretic pharmaceutical preparations containing said compounds or salts, and methods for treating humans and other mammals with such compounds or salts.

公开(公告)号：CH616923A5

公开(公告)日：1980-04-30

申请号：CH181479

申请日：1979-02-23

Applicant: HOECHST AG

Inventor： BORMANN DIETER DR ,  MERKEL WULF DR ,  MUSCHAWECK ROMAN DR ,  MANIA DIETER DR

IPC: C07D207/04 ,  A61K20060101 ,  A61K31/125 ,  A61K31/18 ,  A61K31/33 ,  A61K31/395 ,  A61K31/397 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/402 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/445 ,  A61K31/45 ,  A61K31/635 ,  A61P7/10 ,  C07C20060101 ,  C07D20060101 ,  C07D205/04 ,  C07D205/10 ,  C07D207/02 ,  C07D207/06 ,  C07D207/08 ,  C07D207/10 ,  C07D207/18 ,  C07D207/20 ,  C07D207/32 ,  C07D207/327 ,  C07D207/40 ,  C07D207/404 ,  C07D207/44 ,  C07D207/452 ,  C07D209/00 ,  C07D209/44 ,  C07D209/48 ,  C07D209/52 ,  C07D209/94 ,  C07D211/04 ,  C07D211/14 ,  C07D211/18 ,  C07D211/30 ,  C07D211/32 ,  C07D211/34 ,  C07D211/38 ,  C07D211/70 ,  C07D211/88 ,  C07D265/32 ,  C07D265/33 ,  C07D295/00 ,  C07D295/02 ,  C07D295/04 ,  C07D295/08 ,  C07D295/10 ,  C07D295/116 ,  C07D295/12 ,  C07D295/14 ,  C07D295/155 ,  C07D295/18 ,  C07D295/192 ,  C07D317/00 ,  C07D403/10 ,  C07D405/10 ,  C07D407/10 ,  C07D413/10 ,  C07D211/06

Abstract: 1504505 Sulphonamides HOECHST AG 25 April 1975 [25 April 1974 27 Dec 1974] 17337/75 Heading C2C The invention comprises novel compounds (I) (including salts thereof) in which R 1 and R 2 , which may be identical or different, each represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms, and, if R 1 represents a hydrogen atom, R 2 may also represent an alkoxymethyl group having from 1 to 4 carbon atoms in the alkoxy radical, a phenoxymethyl group or a phenylthiomethyl group, R 3 represents a hydrogen atom, a straight or branched chain alkyl group having from 1 to 4 carbon atoms, a cycloalkyl group, having 5 or 6 ring members, one of which may be replaced by an oxygen or sulphur atom, a phenyl or benzyl group which may be substituted in the phenyl nucleus by one or more substituents selected from nitro groups, alkyl groups having from 1 to 3 carbon atoms, alkoxy groups having from 1 to 5 carbon atoms and halogen atoms, or represents a benzhydryl group or an alkanoyloxymethyl group having 2 to 4 carbon atoms in the alkanoyl part, X represents a halogen atom, a CF 3 or CCl 3 group, a straight or branched chain, saturated or unsaturated alkyl group having from 1 to 6 carbon atoms, a benzyl group which may be substituted in the phenyl nucleus by one or more substituents selected from halogen atoms, hydroxy and amino groups, and alkyl and alkoxy groups, or represents one of the groups -O-R 4 , -S-R 4 , SO-R 4 , SO 2 -R 4 and NR 4 R 5 , in which R 4 represents a phenyl group which may be substituted by one or more substituents selected from halogen atoms, CF 3 , OH and amino groups, alkyl and alkoxy groups having from 1 to 4 carbon atoms, and SO 2 NH 2 groups, or represents a straight or branched chain alkyl group having from 1 to 4 carbon atoms which may be substituted by a phenyl, pyridyl, furyl or thienyl group, and R 5 represents a hydrogen atom, a straight or branched chain alkyl group having from 1 to 4 carbon atoms, and the group NR 4 R 5 may represent a saturated, heterocyclic, 5- or 6-membered ring which may be interrupted by an O-, N- or S- atom, A represents a single bond, or an alkylene chain of 1 to 3 carbon atoms which may be unsaturated, interrupted by O-, N- or S-atoms or substituted by halogen atoms and/or substituted by alkyl, aralkyl, aryl groups or by mono-nuclear hetero-aromatic rings, or A represents an ortho-phenylene radical or the grouping in which Y represents a single bond or an alkylene group having from 1 to 4 carbon atoms, and R 6 and R 7 , which may be identical or different, each represents a hydrogen or halogen atom or an alkyl group having from 1 to 4 carbon atoms. They are made by standard methods. Pharmaceutical preparations having diuretic and saluretic action contain (I) as active ingredient. Administration is enterally or parenterally.

公开(公告)号：DE2727802A1

公开(公告)日：1979-04-19

申请号：DE2727802

申请日：1977-06-21

Applicant: HOECHST AG

Inventor： LANG HANS-JOCHEN DIPL CHEM DR ,  MUSIL JOSEF DR ,  MUSCHAWECK ROMAN DR

IPC: A61K31/34 ,  A61K31/343 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61P7/10 ,  A61P19/06 ,  C07D209/12 ,  C07D307/80 ,  C07D333/56 ,  C07D209/10 ,  A61K31/475

Abstract: Heterocyclic sulfamoyl-aryl-ketones wherein the heterocyclic component consists of a benzofuran, indole or benzothiophene radical and the sulfamoyl-aryl moiety is ortho-substituted by halogen, methyl or trifluoromethyl having uricosuric, hypouricemic and salidiuretic action and a process for their manufacture.

公开(公告)号：DE2546165A1

公开(公告)日：1977-04-28

申请号：DE2546165

申请日：1975-10-15

Applicant: HOECHST AG

Inventor： LANG HANS-JOCHEN DIPL CHEM DR ,  MUSCHAWECK ROMAN DR

IPC: A61K31/425 ,  A61K31/426 ,  A61P7/10 ,  C07C311/58 ,  C07C311/59 ,  C07D277/18 ,  C07D295/215 ,  C07D513/04

Abstract: Diuretically active thiazolidine compounds and methods for making the same are disclosed, said compounds having an alkyl or alkenyl substituent in the 1-position, an imino group in the 2-position, and an hydroxy group and an N-acylated 3'-sulfamoylphenyl substituent in the 4-position, i.e.

公开(公告)号：DE2409355A1

公开(公告)日：1975-09-04

申请号：DE2409355

申请日：1974-02-27

Applicant: HOECHST AG

Inventor： OTTO EBERHARD DR ,  DUERCKHEIMER WALTER DR ,  MUSCHAWECK ROMAN DR

IPC: C07D285/36 ,  C07D255/00

Abstract: Novel thiatriazepinone derivs. of formula (I) (where R1 is not 4 C alkyl, phenyl or benzyl, opt. substd. in the benzene ring by is not >4 C alkyl, is not >4 C alkoxy, 1-2 C alkylenedioxy, halogen and/or di(is not >4C alkyl)amino; and R2 is H, or both R2 are linked to form a fused benzene ring), e.g. 1,5-dimethyl-1,3-dihydro-2,1,3,5-benzothiatriazepin-4(5H)-one 2,2-dioxide, and their salts with bases, are carbonic anhydrase inhibitors with diuretic activity. On account of their reactive hydrogen (I) are also useful as inters, for other therapeutically active substances.

公开(公告)号：CH507937A

公开(公告)日：1971-05-31

申请号：CH1127369

申请日：1969-07-23

Applicant: HOECHST AG

Inventor： GEIGER ROLF DR ,  KOENIG WOLFGANG DR ,  PROF SIEDEL WALTER DR ,  MUSCHAWECK ROMAN DR

IPC: C07D295/13 ,  C07D27/04 ,  C07D29/28

公开(公告)号：CH505128A

公开(公告)日：1971-03-31

申请号：CH1196770

申请日：1968-07-04

Applicant: HOECHST AG

Inventor： PROF RUSCHIG HEINRICH DR ,  SCHORR MANFRED DR ,  MUSCHAWECK ROMAN DR ,  RIPPEL ROBERT DR

IPC: C07D333/36 ,  C07D333/38 ,  C07D63/12