公开(公告)号：JPH1067772A

公开(公告)日：1998-03-10

申请号：JP13798497

申请日：1997-05-14

Applicant: HOECHST AG

Inventor： LANG HANS JOCHEN DR ,  GERLACH UWE DR ,  BRENDEL JOACHIM DR ,  ENGLERT HEINRICH CHRISTIAN DR ,  GOEGELEIN HEINZ DR ,  HROPOT MAX DR ,  BOHN HELMUT DR ,  HERLING ANDREAS DR ,  BUSCH ANDREAS PROF DR ,  GREGER RAINER PROF DR

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/44 ,  A61K31/443 ,  A61P1/00 ,  A61P1/04 ,  A61P9/00 ,  A61P9/06 ,  C07D311/68 ,  C07D311/70 ,  C07D311/72 ,  C07D311/96 ,  C07D405/12

Abstract: PROBLEM TO BE SOLVED: To obtain the subject new compound opened by cyclic adenosine- phosphoric acid (CAMP), exhibiting strong and specific blocking action in K channel different from K (ATP) channel and useful as an agent, etc., for treating tumor of stomach and intestinal canal. SOLUTION: This chroman is represented by formula I R(1) or R(2) are each independently H, a 1-6C alkyl, etc.; R(3) is a group of R(9)-Cn H2n [NR(11)] [R(9) is H or a 3-8C cycloalkyl; (n) is an integer of 0-10; R(11) and R(9) together form a 1-8C alkylene]; R(4) is a group of R(12)-Cr H2r [R(12) is H, a 3-8C cycloalkyl, etc.; (r) is an integer of 1-20]; R(5) to R(8) are each independently H, F, Cl, Br, I, a 1-4C alkyl, etc.} or its physiologically permissible salt, e.g. a compound of formula II. The compound of the formula is obtained by alkylation, etc., of sulfonamide by a chroman derivative having alkylation action.

公开(公告)号：CZ149497A3

公开(公告)日：1997-12-17

申请号：CZ149497

申请日：1997-05-14

Applicant: HOECHST AG

Inventor： LANG HANS JOCHEN DR ,  GERLACH UWE DR ,  BRENDEL JOACHIM DR ,  ENGLERT HEINRICH CHRISTIAN DR ,  GOGELEIN HEINZ DR ,  HROPOT MAX DR ,  BOHN HELMUT DR ,  HERLING ANDREAS DR ,  BUSCH ANDREAS PROF DR ,  GREGER RAINER PROF DR

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/44 ,  A61K31/443 ,  A61P1/00 ,  A61P1/04 ,  A61P9/00 ,  A61P9/06 ,  C07D311/68 ,  C07D311/70 ,  C07D311/72 ,  C07D311/96 ,  C07D405/12

公开(公告)号：DE3783657D1

公开(公告)日：1993-03-04

申请号：DE3783657

申请日：1987-06-05

Applicant: HOECHST AG

Inventor： KOENIG WOLFGANG DR ,  BREIPOHL GERHARD DR ,  GEIGER ROLF PROF DR ,  KNOLLE JOCHEN DR ,  HROPOT MAX DR

IPC: C07K5/10 ,  A61K38/00 ,  A61P7/10 ,  C07K1/06 ,  C07K5/02 ,  C07K5/083 ,  C07K5/11 ,  C07K5/117 ,  C07K7/06 ,  C07K7/64 ,  C07K14/58 ,  A61K37/02

Abstract: Peptide derivs. of formula (I) and their salts are new: R2 = H or NH(A)nR; R3 = NH2, guanidino or mono- or di(1-3C alkyl)amino; m = 1-6; A = NH-CR4R5-CO; R = H, 1-6C alkanoyl, 7-11C aroyl (opt. mono- or disubstd. by 1-4C alkyl, 1-4C alkoxy, 1-4C alkylthio, halogen, CONH2, 2-5C alkoxycarbonyl and/or SO2NH2 or monosubstd. by methylenedioxy), (5-7C)cycloalkyl(1-3C)alkanoyl or (6-14C)aryl(1-3C)alkanoyl, where one CH2 gp. in R may be replaced by O or S; n = 0 or 1; R4 and R5 = H, 1-6C alkyl or 7-11C aralkanoyl; L = Pro, D-Pro or NHCH(R6)CO; R6= (a) 1-6C alkyl opt. monosubstd. by OH, 1-6C alkoxy, 2-7C alkoxycarbonyl, CONH2 or NHR, provided that R is not H, (b) 7-11C aralkyl opt. monosubstd. in the ring by 1-6C alkoxy, or (c) indol-3-ylmethyl; M = Pro, D-Pro or NHCH(R7)CO; R7 is as defined for R6; B = NHCH((CH2)mR3)CO; R8, R6 in which any CH, CH2 or CH3 gps. beta to NH are opt. monohydroxylated; R9 = H; or R8+R9 = (CH2)3 or (CH2)4; R1 = H, OH, 1-6C alkoxy, COOR10 or CONR10R11; or R1+R = CO; R10 and R11 = H, 1-6C alkyl or 7-11C aralkyl, or NR10R11 = pyrrolidino, piperidino or morpholino.

公开(公告)号：DE3608726A1

公开(公告)日：1987-09-17

申请号：DE3608726

申请日：1986-03-15

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN DR ,  HROPOT MAX DR ,  LANG HANS JOCHEN DR ,  GREGER RAINER PROF DR

IPC: A61K31/195 ,  A61K31/245 ,  A61K31/395 ,  A61K31/40 ,  A61K31/445 ,  A61K31/55 ,  A61P1/12 ,  C07C67/00 ,  C07C227/00 ,  C07C229/56 ,  C07D207/32 ,  C07D207/327 ,  A61K31/24

Abstract: There is described the use of amino-substituted benzoic acid derivatives of the formula I … … in which:… R and R represent hydrogen, (cyclo)alkyl, unsubstituted or substituted phenyl or naphthyl, or… R and R together represent a chain -(CH2)m- where m = 3 to 6, or together represent a chain -(CH=CH)n- where n is 2 or 3; R represents hydrogen, halogen or alkyl; R represents hydrogen or NO2; R represents hydrogen or a radical which can be eliminated under physiological conditions;… for preparing a medicament against diarrhoea.

公开(公告)号：AT22284T

公开(公告)日：1986-10-15

申请号：AT83102004

申请日：1983-03-02

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN DR ,  MANIA DIETER DR ,  MUSCHAWECK ROMAN DR ,  HROPOT MAX DR

IPC: A61K31/18 ,  A61K31/40 ,  A61P3/00 ,  A61P7/10 ,  A61P9/12 ,  C07C67/00 ,  C07C301/00 ,  C07C303/02 ,  C07C303/38 ,  C07C303/40 ,  C07C311/15 ,  C07C311/37 ,  C07D295/22 ,  C07D295/26 ,  C07C143/78

公开(公告)号：DE3232922A1

公开(公告)日：1984-03-08

申请号：DE3232922

申请日：1982-09-04

Applicant: HOECHST AG

Inventor： SEURING BERNHARD DR ,  LANG HANS-JOCHEN DR ,  HROPOT MAX DR ,  MUSCHAWECK ROMAN DR

IPC: A61K31/255 ,  A61K20060101 ,  A61K31/18 ,  A61K31/19 ,  A61K31/215 ,  A61K31/41 ,  A61P3/00 ,  A61P3/12 ,  A61P19/06 ,  C07C20060101 ,  C07C67/00 ,  C07C301/00 ,  C07C303/40 ,  C07C311/29 ,  C07F13/00 ,  C07C143/78

Abstract: Compounds of the formula in which R , R and R are identical or different and represent hydrogen, halogen, alkyl having 1 to 4 C atoms or alkoxy having 1 to 4 C atoms, in which however R and R cannot denote simultaneously hydrogen and in which R and R together can also denote a bridge comprising two to 5 methylene groups or methylenedioxy, R and R are identical or different and represent hydrogen or alkyl having 1 to 4 C atoms or are part of a 3- to 7-membered saturated carbocyclic ring and R represents hydrogen, alkyl having 1 to 4 C atoms which are unsubstituted or substituted by hydroxyl or alkoxy having 1 to 3 C atoms, or denotes aralkyl having 7 to 9 C atoms and their physiologically acceptable salts have uricosuric and salidiuretic effects.

公开(公告)号：DE2860471D1

公开(公告)日：1981-03-26

申请号：DE2860471

申请日：1978-08-07

Applicant: HOECHST AG

Inventor： LANG HANS-JOCHEN DR ,  MUSCHAWECK ROMAN DR ,  HROPOT MAX DR

IPC: A61K31/18 ,  A61K31/40 ,  A61K31/4015 ,  A61P9/12 ,  C07C205/56 ,  C07D207/26 ,  C07D207/273 ,  C07D295/22 ,  C07D295/26 ,  C07D307/33 ,  C07D307/58 ,  C07D317/28 ,  C07D319/06 ,  C07D405/12 ,  C07C143/78

公开(公告)号：AT68785T

公开(公告)日：1991-11-15

申请号：AT86110027

申请日：1986-07-22

Applicant: HOECHST AG

Inventor： GREGER RAINER PROF DR ,  ENGLERT HEINRICH CHRISTIAN DR ,  LANG HANS-JOCHEN DR ,  HROPOT MAX DR

IPC: A61K31/195 ,  A61K31/34 ,  C07C205/57 ,  C07C229/56 ,  C07D307/52

公开(公告)号：DE3608725A1

公开(公告)日：1987-09-17

申请号：DE3608725

申请日：1986-03-15

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN DR ,  HROPOT MAX DR ,  LANG HANS-JOCHEN DR ,  GREGER RAINER PROF DR

IPC: A61K31/195 ,  A61K31/22 ,  A61P1/12 ,  C07C67/00 ,  C07C227/00 ,  C07C227/08 ,  C07C227/16 ,  C07C227/22 ,  C07C229/18 ,  C07C229/34 ,  C07D205/08 ,  C07D207/26 ,  C07D211/74 ,  C07D227/04 ,  C07C101/34

Abstract: A process for preparing a compound of the formula I … … in which:… R , R , R (identical or different) represent H, alkyl having 1-2 C-atoms and F, Cl, Br or I;… R represents H or alkyl having 1-4 C-atoms,… n represents the numbers 2-5 and… R represents a radical which can be removed under physiological conditions or hydrogen, and their physiologically tolerable salts. … They are effective medicines against diarrhoea.

公开(公告)号：DE3528048A1

公开(公告)日：1987-02-05

申请号：DE3528048

申请日：1985-08-05

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH C DR ,  GREGER RAINER PROF DR ,  HROPOT MAX DR ,  LANG HANS-JOCHEN DR

IPC: C07D307/52 ,  C07C101/52 ,  A61K31/19 ,  A61K31/34 ,  A61K31/395

Abstract: Compounds I where R is equal to hydrogen or alkyl, X is equal to alkylene and Ar is equal to aromatic, show an excellent detumescent action on cerebral oedemas, as well as intestinal action.