公开(公告)号：DE3009229A1

公开(公告)日：1981-10-15

申请号：DE3009229

申请日：1980-03-11

Applicant: HOECHST AG

Inventor： STURM KARL DIPL CHEM DR ,  MUSCHAWECK ROMAN DR

IPC: A61K31/18 ,  A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/63 ,  A61P7/10 ,  C07C67/00 ,  C07C301/00 ,  C07C303/32 ,  C07C303/40 ,  C07C311/39 ,  C07D307/52 ,  C07D333/20 ,  C07C143/80 ,  A61K31/255

Abstract: The present invention relates to compounds of the formula I wherein R is furyl, thienyl or phenyl, to physiologically acceptable salts thereof, to a process for their manufacture, to a composition comprising said compounds and to their use as a medicament.

公开(公告)号：DE2517183A1

公开(公告)日：1976-10-28

申请号：DE2517183

申请日：1975-04-18

Applicant: HOECHST AG

Inventor： STURM KARL DIPL CHEM DR ,  STAREAY FRANZ DR

IPC: C07D295/14 ,  C07D295/155 ,  C07D295/18 ,  C07D295/22 ,  C07D295/12 ,  C07D413/12

公开(公告)号：DE3006686A1

公开(公告)日：1981-08-27

申请号：DE3006686

申请日：1980-02-22

Applicant: HOECHST AG

Inventor： STURM KARL DIPL CHEM DR ,  MUSCHAWECK ROMAN DR

IPC: A61K31/18 ,  A61K31/63 ,  A61P13/02 ,  A61P15/00 ,  C07C67/00 ,  C07C313/00 ,  C07C315/02 ,  C07C317/36 ,  C07D307/52 ,  C07D333/20 ,  C07C147/12 ,  A61K31/38 ,  A61K31/34

Abstract: What are disclosed are compounds of the formula I in which R denotes alkyl, alkenyl, cycloalkyl or cycloalkylalkyl, each of which has up to 10 C atoms, or phenyl and Ar denotes phenyl, thienyl or furyl and salts thereof, the preparation of these compounds and their use as medicaments and also medicaments of this type as such.

公开(公告)号：DE3041812A1

公开(公告)日：1982-06-16

申请号：DE3041812

申请日：1980-11-06

Applicant: HOECHST AG

Inventor： STURM KARL DIPL CHEM DR ,  MUSCHAWECK ROMAN DR ,  HROPOT MAX DR

IPC: C07D251/18 ,  A61K31/41 ,  A61P7/10 ,  C07D257/04 ,  C07D307/52 ,  C07D333/20 ,  C07D405/12 ,  C07D409/12 ,  A61K31/635

Abstract: What are disclosed are salidiuretic compounds of the formula and physiologically acceptable salts thereof, wherein R is phenyl, furyl or thienyl, intermediates of said compounds, methods for making said compounds, salidiuretic pharmaceutical preparations containing said compounds or salts, and methods for treating humans and other mammals with such compounds or salts.

公开(公告)号：DE3034880A1

公开(公告)日：1982-04-29

申请号：DE3034880

申请日：1980-09-16

Applicant: HOECHST AG

Inventor： STURM KARL DIPL CHEM DR

IPC: C07D307/52 ,  C07C143/80

Abstract: 1. A process for the preparation of 5-sulfamoyl-orthanilic acids of the formula I see diagramm : EP0047973,P5,F1 in which R denotes N-methylanilino, phenylsulfonyl, phenoxy, which is optionally substituted by Cl, CH3 or OCH3 , or alkyl sulfonyl or cycloalkylsulfonyl or cycloalkylalkylsulfonyl having up to 10 carbon atoms in each case, and Ar denotes phenyl or furyl, in the form of their salts, which comprises hydrogenating an aryl ester of the formula II see diagramm : EP0047973,P5,F2 in which Z denotes aryl, in a solvent which is stable to hydrogenation and with the addition of at least one equivalent of a base, in the presence of a palladium catalyst, until one mol equivalent of hydrogen has been absorbed.

公开(公告)号：DE3101960A1

公开(公告)日：1982-09-02

申请号：DE3101960

申请日：1981-01-22

Applicant: HOECHST AG

Inventor： STURM KARL DIPL CHEM DR ,  MUSCHAWECK ROMAN DR ,  HROPOT MAX DR

IPC: A61K31/63 ,  A61K31/635 ,  A61P7/10 ,  C07C67/00 ,  C07C301/00 ,  C07C303/40 ,  C07C311/39 ,  C07D307/52 ,  C07D333/20 ,  C07C143/80 ,  A61K31/195

Abstract: The invention relates to base-substituted anthranilic acids of the formula I in which R denotes furyl, thienyl or phenyl, and to physiologically acceptable salts thereof, and also to a process for their preparation, to an agent containing these and to their use as medicaments.

公开(公告)号：DE2718871A1

公开(公告)日：1978-11-09

申请号：DE2718871

申请日：1977-04-28

Applicant: HOECHST AG

Inventor： STURM KARL DIPL CHEM DR ,  MUSCHAWECK ROMAN DR

IPC: A61K31/635 ,  A61P7/10 ,  C07D307/52 ,  C07D333/20 ,  A61K31/63 ,  C07C143/80 ,  C07C149/453 ,  C07D317/54

公开(公告)号：DE2239846A1

公开(公告)日：1974-02-14

申请号：DE2239846

申请日：1972-08-12

Applicant: HOECHST AG

Inventor： STURM KARL DIPL CHEM DR ,  STAREY FRANZ DR

IPC: A61K20060101 ,  C07D20060101 ,  C07D51/70

Abstract: Cmpds. of formula (I) and their acid salts are new: (where R is lower alkyl or aralkyl; R' and R2 are H, Me or Et; R3 is H or lower alkyl; and R4 is H, lower alkyl, is not >8 C cycloalkyl or cycloalkylalkyl, or aralkyl opt. substd. in the aromatic ring by 1 or 2 halogen atoms or alkyl or alkoxy residues; or NR3R4 is pyrrolidino, piperidino, hexamethyleneimino, morpholino or 4-alkyl-1-piperazinyl). (I) have marked hypotensive activity accompanied by weak coronary dilating activity and positive inotropic activity. Other pharmacological activity is absent and toxicity is low, so that (I) are useful for treating hypertension, esp. essential hypertension.