公开(公告)号：AT22284T

公开(公告)日：1986-10-15

申请号：AT83102004

申请日：1983-03-02

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN DR ,  MANIA DIETER DR ,  MUSCHAWECK ROMAN DR ,  HROPOT MAX DR

IPC: A61K31/18 ,  A61K31/40 ,  A61P3/00 ,  A61P7/10 ,  A61P9/12 ,  C07C67/00 ,  C07C301/00 ,  C07C303/02 ,  C07C303/38 ,  C07C303/40 ,  C07C311/15 ,  C07C311/37 ,  C07D295/22 ,  C07D295/26 ,  C07C143/78

公开(公告)号：DE3232922A1

公开(公告)日：1984-03-08

申请号：DE3232922

申请日：1982-09-04

Applicant: HOECHST AG

Inventor： SEURING BERNHARD DR ,  LANG HANS-JOCHEN DR ,  HROPOT MAX DR ,  MUSCHAWECK ROMAN DR

IPC: A61K31/255 ,  A61K20060101 ,  A61K31/18 ,  A61K31/19 ,  A61K31/215 ,  A61K31/41 ,  A61P3/00 ,  A61P3/12 ,  A61P19/06 ,  C07C20060101 ,  C07C67/00 ,  C07C301/00 ,  C07C303/40 ,  C07C311/29 ,  C07F13/00 ,  C07C143/78

Abstract: Compounds of the formula in which R , R and R are identical or different and represent hydrogen, halogen, alkyl having 1 to 4 C atoms or alkoxy having 1 to 4 C atoms, in which however R and R cannot denote simultaneously hydrogen and in which R and R together can also denote a bridge comprising two to 5 methylene groups or methylenedioxy, R and R are identical or different and represent hydrogen or alkyl having 1 to 4 C atoms or are part of a 3- to 7-membered saturated carbocyclic ring and R represents hydrogen, alkyl having 1 to 4 C atoms which are unsubstituted or substituted by hydroxyl or alkoxy having 1 to 3 C atoms, or denotes aralkyl having 7 to 9 C atoms and their physiologically acceptable salts have uricosuric and salidiuretic effects.

公开(公告)号：CH624678A5

公开(公告)日：1981-08-14

申请号：CH1079879

申请日：1979-12-05

Applicant: HOECHST AG

Inventor： LANG HANS-JOCHEN DR ,  MUSCHAWECK ROMAN DR

IPC: A61K31/165 ,  A61K31/425 ,  A61K31/426 ,  A61K31/44 ,  A61K31/505 ,  A61P7/10 ,  C07C67/00 ,  C07C301/00 ,  C07C303/22 ,  C07C303/38 ,  C07C303/40 ,  C07C311/16 ,  C07C325/00 ,  C07C335/30 ,  C07C335/32 ,  C07D277/18 ,  C07D295/26 ,  C07D417/12 ,  C07D513/04

Abstract: The invention relates to thiazolidine derivatives having in 4-position a hydroxy group and a 3'-sulphamyl-phenyl substituent, in 2-position an imino group and in 1-position an aliphatic or cycloaliphatic substituent. Said thiazolidines have diuretic activity.

公开(公告)号：DE2860471D1

公开(公告)日：1981-03-26

申请号：DE2860471

申请日：1978-08-07

Applicant: HOECHST AG

Inventor： LANG HANS-JOCHEN DR ,  MUSCHAWECK ROMAN DR ,  HROPOT MAX DR

IPC: A61K31/18 ,  A61K31/40 ,  A61K31/4015 ,  A61P9/12 ,  C07C205/56 ,  C07D207/26 ,  C07D207/273 ,  C07D295/22 ,  C07D295/26 ,  C07D307/33 ,  C07D307/58 ,  C07D317/28 ,  C07D319/06 ,  C07D405/12 ,  C07C143/78

公开(公告)号：DE2917997A1

公开(公告)日：1980-11-20

申请号：DE2917997

申请日：1979-05-04

Applicant: HOECHST AG

Inventor： MERKEL WULF DIPL CHEM DR ,  BORMANN DIETER DIPL CHEM DR ,  MUSCHAWECK ROMAN DR

IPC: C07D207/06 ,  A61K31/40 ,  A61K31/4025 ,  A61P7/10 ,  C07D207/20 ,  C07D207/32 ,  C07D207/327 ,  C07D213/65 ,  C07D295/02 ,  C07D295/033 ,  C07D333/24 ,  C07D401/12 ,  C07D409/10 ,  A61K31/18 ,  C07D401/02

公开(公告)号：DE2658766A1

公开(公告)日：1978-07-06

申请号：DE2658766

申请日：1976-12-24

Applicant: HOECHST AG

Inventor： MERKEL WULF DIPL CHEM DR ,  BORMANN DIETER DIPL CHEM DR ,  MANIA DIETER DIPL CHEM DR ,  MUSCHAWECK ROMAN DR

IPC: A61K31/40 ,  A61P7/10 ,  C07D207/32 ,  C07D207/327 ,  C07D295/155 ,  C07D317/64

Abstract: Pyrrolo-benzoic acid derivs. of formula (I) and their salts with bases and acids are new, as are pyrrolo-benzoic acid derivs. of formula (IV) and their salts with bases. In the formula R is H or 1-4C alkyl; R1 and R1' are each H, halo, CF3, 1-4C alkyl, 1-4C alkoxy, hydroxy or amino or together = 3,4-methylene-dioxy; R2,R3 and R4 are each lower alkyl, R2 may also be H and/or two of the groups may be joined to form a ring; R5 and R6 are each H or 1-2C alkyl; X= O,S,NH or CH2; and R1" is CH3 or Cl. (IV) are diuretics and saluretics which have superior activity to the unsubstd. cpd. i.e. R1=H. They are administered orally or parenterally in doses of 0.5-100 mg. opt. with other active cpds.

公开(公告)号：DE2361058A1

公开(公告)日：1975-06-19

申请号：DE2361058

申请日：1973-12-07

Applicant: HOECHST AG

Inventor： SIEGEMUND GUENTER DR ,  MUSCHAWECK ROMAN DR

IPC: C07C43/12 ,  A61K31/08

Abstract: chlorofluoromethyl ether (I) of the formula: CF3-CHF-3-CHF-Cl is a new cpd. which may be prepd. by (a) subjecting an ether of the formula: CF3-nClnCHF1-mClm-O-CH3 (II) (where n is 0, 1, 2 or 3 and m is 0 or 1) to partial photochlorination to give an ether of the formula: CF3-nCln-CHF1-mClm-O-CH2Cl (III), fluorinating (III) to give the other of the formula: CH3-CHF-O-CH2F (IV), again chlorinating (IV), and isolating (I) from the chlorination mixt. by conventional procedures, or (b) converting (II; n = m = 0) by partial photochlorination into the ether of the formula: CF3-CHF-O-CHCl2 (VI), partially fluorinating (VI), and isolating (I) from the fluorination mixt. in a conventional manner. (I) is of use as an inhalation anaesthetic. Due to its relatively low b. pt. (51.5 degrees C/-760 mm.) it can be readily and controllably admixed with respiration mixts. contg. sufficient oxygen to maintain life.

公开(公告)号：DE1643325A1

公开(公告)日：1971-03-25

申请号：DEF0052885

申请日：1967-07-07

Applicant: HOECHST AG

Inventor： RUSCHIG HEINRICH PROF DIPL-CHE ,  SCHORR MANFRED DIPL-CHEM DR ,  MUSCHAWECK ROMAN DR ,  DR RIPPEL ROBERT DIPL-CHEM

IPC: C07D333/36 ,  C07D333/38 ,  A61K27/00

公开(公告)号：DE3163418D1

公开(公告)日：1984-06-07

申请号：DE3163418

申请日：1981-10-29

Applicant: HOECHST AG

Inventor： STURM KARL DR ,  MUSCHAWECK ROMAN DR ,  HROPOT MAX DR

IPC: C07D251/18 ,  A61K31/41 ,  A61P7/10 ,  C07D257/04 ,  C07D307/52 ,  C07D333/20 ,  C07D405/12 ,  C07D409/12

Abstract: What are disclosed are salidiuretic compounds of the formula and physiologically acceptable salts thereof, wherein R is phenyl, furyl or thienyl, intermediates of said compounds, methods for making said compounds, salidiuretic pharmaceutical preparations containing said compounds or salts, and methods for treating humans and other mammals with such compounds or salts.

公开(公告)号：DE3006686A1

公开(公告)日：1981-08-27

申请号：DE3006686

申请日：1980-02-22

Applicant: HOECHST AG

Inventor： STURM KARL DIPL CHEM DR ,  MUSCHAWECK ROMAN DR

IPC: A61K31/18 ,  A61K31/63 ,  A61P13/02 ,  A61P15/00 ,  C07C67/00 ,  C07C313/00 ,  C07C315/02 ,  C07C317/36 ,  C07D307/52 ,  C07D333/20 ,  C07C147/12 ,  A61K31/38 ,  A61K31/34

Abstract: What are disclosed are compounds of the formula I in which R denotes alkyl, alkenyl, cycloalkyl or cycloalkylalkyl, each of which has up to 10 C atoms, or phenyl and Ar denotes phenyl, thienyl or furyl and salts thereof, the preparation of these compounds and their use as medicaments and also medicaments of this type as such.