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    26.
    发明专利
    未知

    公开(公告)号：NO911081D0

    公开(公告)日：1991-03-19

    申请号：NO911081

    申请日：1991-03-19

    Applicant: HOECHST AG

    Inventor： JAEHNE GERHARD ,  ROESNER MANFRED ,  WINKLER IRVIN ,  HELSBERG MATTHIAS ,  SCHOLL THOMAS

    IPC: A61K31/52 ,  A61K31/522 ,  A61P31/12 ,  A61P31/22 ,  C07D473/00 ,  C07D473/04 ,  C07D473/16 ,  C07D473/18 ,  C07D473/20 ,  C07D473/22 ,  C07D473/24 ,  C07D473/28 ,  C07D473/32 ,  C07D473/34 ,  C07D473/36 ,  C07D473/40 ,  C07D

    Abstract: Purine derivs. of formula (I) and their salts are new. R1 = H, halo, NH3, OH, 1-6C alkoxy, -O-CH2Ph, -OPh, SH, 1-6C alkylthio, -S-CH2Ph, -SPh, NH2, 1-6C alkylamino, -NH-CH2Ph, -NH-Ph, 2-12C dialkylamino, -N(CH2Ph)2, cyclic dialkylamino, -N(Ph)2, 1-8C acylamino, 2-16C diacylamino, (N-alkyl-2-pyrrolidin-yliden)amino or 2-10C dialkylaminomethylidenamino; R2 = H, halo, N3, OH, SH, NH2, 1-6C alkylamino, 2-12C dialkylamino, -NH-CH2Ph, -N-(CH2Ph)2, cyclic dialkylamino, -NH-Ph, -N(Ph)2, 1-8C acylamino or thioacylamino, 2-16C diacylamino or di(thioacyl)amino; R3 = H, 1-6C alkyl (opt. substd.) or R8, where R8 is a phosphate ester-contg. gp.; R4 = H, 1-6C alkyl, OH, SH, NH2, halo, N3, 1-6C alkoxy, alkylthio or alkylamino, 2-12C dialkylamino, -O-CH2Ph, -S-CH2Ph, -NH-CH2Ph, -N(CH2Ph)2, -NHPh, -N(Ph)2, -OPh, -SPh, 1-8C acyloxy, 1-8C acylthio, 1-8C acylamino, 2-16C diacylamino, -O-(1-4C alkyl)-P(O)(OR6)(OR7) or -O(1-4C alkyl)-P(1-6C alkyl)(=O)(OR6); R5 = H, 1-6C alkyl (opt. substd.). A number of provisos are given in the specification.

    27.
    发明专利
    未知

    公开(公告)号：FI911310A0

    公开(公告)日：1991-03-18

    申请号：FI911310

    申请日：1991-03-18

    Applicant: HOECHST AG

    Inventor： JAEHNE GERHARD ,  ROESNER MANFRED ,  WINKLER IRVIN ,  HELSBERG MATTHIAS ,  SCHOLL THOMAS

    IPC: A61K31/52 ,  A61K31/522 ,  A61P31/12 ,  A61P31/22 ,  C07D473/00 ,  C07D473/04 ,  C07D473/16 ,  C07D473/18 ,  C07D473/20 ,  C07D473/22 ,  C07D473/24 ,  C07D473/28 ,  C07D473/32 ,  C07D473/34 ,  C07D473/36 ,  C07D473/40 ,  C07D

    Abstract: Purine derivs. of formula (I) and their salts are new. R1 = H, halo, NH3, OH, 1-6C alkoxy, -O-CH2Ph, -OPh, SH, 1-6C alkylthio, -S-CH2Ph, -SPh, NH2, 1-6C alkylamino, -NH-CH2Ph, -NH-Ph, 2-12C dialkylamino, -N(CH2Ph)2, cyclic dialkylamino, -N(Ph)2, 1-8C acylamino, 2-16C diacylamino, (N-alkyl-2-pyrrolidin-yliden)amino or 2-10C dialkylaminomethylidenamino; R2 = H, halo, N3, OH, SH, NH2, 1-6C alkylamino, 2-12C dialkylamino, -NH-CH2Ph, -N-(CH2Ph)2, cyclic dialkylamino, -NH-Ph, -N(Ph)2, 1-8C acylamino or thioacylamino, 2-16C diacylamino or di(thioacyl)amino; R3 = H, 1-6C alkyl (opt. substd.) or R8, where R8 is a phosphate ester-contg. gp.; R4 = H, 1-6C alkyl, OH, SH, NH2, halo, N3, 1-6C alkoxy, alkylthio or alkylamino, 2-12C dialkylamino, -O-CH2Ph, -S-CH2Ph, -NH-CH2Ph, -N(CH2Ph)2, -NHPh, -N(Ph)2, -OPh, -SPh, 1-8C acyloxy, 1-8C acylthio, 1-8C acylamino, 2-16C diacylamino, -O-(1-4C alkyl)-P(O)(OR6)(OR7) or -O(1-4C alkyl)-P(1-6C alkyl)(=O)(OR6); R5 = H, 1-6C alkyl (opt. substd.). A number of provisos are given in the specification.

    29.
    发明专利
    未知

    公开(公告)号：NO900736D0

    公开(公告)日：1990-02-15

    申请号：NO900736

    申请日：1990-02-15

    Applicant: HOECHST AG

    Inventor： MEHLHORN HEINZ ,  TARASCHEWSKI HORST ,  SCHMAHL GUENTHER ,  RAETHER WOLFGANG ,  ROESNER MANFRED

    IPC: A61K31/53 ,  A61K31/535 ,  A01N43/707 ,  A61K31/54 ,  A01N

    Abstract: Compounds of the general formula (I) in which R together with R is a chemical bond or hydrogen, alkyl, cycloalkyl, benzyl which can be substituted in the phenyl ring by halogen and alkyl, or alkanoyl which can be substituted by halogen, or benzoyl which can be substituted by halogen and alkyl, R together with R is a chemical bond or hydrogen, R is hydrogen, alkyl or cycloalkyl, R is hydrogen, alkyl, cycloalkyl, benzyl which can be substituted by halogen and alkyl, X , X , Y , Y and Z are, independently of one another, a) hydrogen, halogen, trifluoromethyl, alkyl, cycloalkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, benzylthio, benzylsulphinyl, benzylsulphonyl, nitro, cyano, amino, alkylamino, dialkylamino, N-alkylaminoethyl, N,N-dialkylaminomethyl, piperidino, morpholino, thiomorpholino, 1-pyrrolidinyl, 4-methyl-1-piperazinyl or acylamino or b) a phenoxy, phenylthio, phenylsulphinyl, phenylsulphonyl, benzoyl, benzoylamino, phenylamino, N,N-phenylalkylamino, 1-cyano-1-phenylmethyl, 1-cyano-1,1-diphenylmethyl, 1-cyano-1-phenyl-1-(C1-C6-alkyl)methyl, 1-cyano-1-phenyl-1-(C3-C6-cycloalkyl)methyl, thienyl or naphthyl radical which is unsubstituted in the phenyl ring or substituted a total of 1, 2 or 3 times by radicals mentioned under a), or in the case R = H also the physiologically tolerated salts thereof, are suitable even at low doses for controlling a wide spectrum of endo- and ectoparasites in fish or insects.

    30.
    发明专利
    未知

    公开(公告)号：BG45552A3

    公开(公告)日：1989-06-15

    申请号：BG7634286

    申请日：1986-09-02

    Applicant: HOECHST AG

    Inventor： ROESNER MANFRED ,  RAETHER WOLFGANG

    IPC: A23K1/16 ,  A61K31/53 ,  A61P31/00 ,  A61P33/02 ,  C07D253/06 ,  C07D253/075

    Abstract: Compounds of the formula I (I) with n=1-3, R=H, Hal, CF3, alkyl, cycloalkyl, alkyloxy, alkylthio, alkylsulfinyl, alkylsulfonyl, benzylsulfinyl, benzylsulfonyl, nitro, cyano, amino, alkylamino, dialkylamino, piperidino, morpholino, pyrrolidinyl, 4-methyl-1-piperazinyl, acylamino or substituted phenoxy, phenylthio, phenylsulfinyl, phenylsulfonyl, benzoyl, benzoylamino or anilino, with R2=H, alkyl, cycloalkyl, optionally substituted benzyl, alkanoyl or benzoyl and R3=H, alkyl, cycloalkyl or optionally substituted benzyl, at least R2 or R3 not being H, are obtained by alkylation or acylation of a compound II (II) in which R1 is as defined above, with compounds R3X (X=leaving group) or R2Y (Y=leaving group), R2 and R3 being defined as indicated. Compounds I are coccidiostatics.

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