公开(公告)号：KR790001341B1

公开(公告)日：1979-09-27

申请号：KR750000705

申请日：1975-04-04

Applicant: HOECHST AG

Inventor： KIRSCH REINHARD ,  LOEWE HEINZ ,  DIETER DUEWEL ,  URBANIETZ JOSEF

Abstract: Title compds. (I; R1 = C1-4 alkyl; R2,R3 = H, oxalic acid, C1-4 alkoxy, halogen, CF3, C1-4 alkyl, carboalkoxy, CN), useful as anthelimintics, were prepd. Thus, O-phenylene diamines(II) were condensed with HN:C(SCH3)NHCO2R1 at pH1-6,NCNHCO2R' at pH 1-6, R1OC (;O)N;C Cl2 at -10-40≦̸C in the presence of base, and R4S(R5S)C:N CO2R1(R4,R5 = same or not C1-4 alkyl, C3-5 alkenyl, cyclohexyl) to give I.

公开(公告)号：US3917635A

公开(公告)日：1975-11-04

申请号：US41764073

申请日：1973-11-20

Applicant: HOECHST AG

Inventor： HORLEIN GERHARD ,  MILDENBERGER HILMAR ,  KRONIGER ARNO ,  HARTEL KURT ,  DUWEL DIETER ,  KIRSCH REINHARD

IPC: A01N47/38 ,  A23L3/3544 ,  C07D235/32

CPC classification number: A23L3/3544 ,  C07D235/32

Abstract: Benzimidazole derivatives of the formula

wherein R1 is alkyl or cycloalkyl and R2 is alkyl, haloalkyl, cycloalkyl or optionally substituted phenyl, benzyl or naphthyl, are valuable fungicides and anthelmintics.

Abstract translation: 式N的苯并咪唑衍生物N ANGLE ANGLE -NH-COOCH 3 N | O = C-NH-SO 2 -N-SO 2 -R 2 | R 1其中R 1是烷基或环烷基，R 2是烷基，卤代烷基，环烷基或任选取代的苯基，苄基或 萘基，是有价值的杀真菌剂和驱虫剂。

公开(公告)号：US3928375A

公开(公告)日：1975-12-23

申请号：US50833774

申请日：1974-09-23

Applicant: HOECHST AG

Inventor： DUWEL DIETER ,  KIRSCH REINHARD ,  LOEWE HEINZ ,  URBANIETZ JOSEF

IPC: C07D235/32

CPC classification number: C07D235/32

Abstract: The invention describes novel 2-carbalkoxy-amino-benzimidazolyl5(6)-amino-phenyl ether of the formula (I)

wherein R1 is alkyl having 1 to 4 carbon atoms, R2, in each case independently from one another, represents hydrogen, alkyl having 1 to 4 carbon atoms, hydroxyl, alkoxy having 1 to 4 carbon atoms, halogen or trifluoromethyl, n represents the integers 0, 1 or 2 and X represents oxygen or sulfur, the salts of such compounds with physiologically tolerable salts and their preparation. These compounds are chemotherapeutics and act particularly against helminths in humans and animals.

Abstract translation: 本发明描述了式（I）的新的2-烷氧基 - 氨基 - 苯并咪唑基-5（6） - 氨基 - 苯基醚，其中R1是具有1至4个碳原子的烷基，R2各自独立地表示氢 ，具有1至4个碳原子的烷基，具有1至4个碳原子的烷氧基，卤素或三氟甲基，n表示整数0,1或2，X表示氧或硫，这些化合物与生理上可耐受的盐的盐及其 制备。 这些化合物是化学治疗剂，特别是针对人类和动物中的蠕虫。

公开(公告)号：US3915983A

公开(公告)日：1975-10-28

申请号：US43635674

申请日：1974-01-24

Applicant: HOECHST AG

Inventor： DRANSCH GUNTER KARL W ,  WIESENHUTTER HEIRESS BY ANNELI ,  FLERSHEIM HEIRESS BY JOHANNA M ,  BOESENBERG HEINZ ,  MILDENBERGER HILMAR ,  HARTEL KURT ,  KIRSCH REINHARD

IPC: C07D235/32

CPC classification number: C07D235/32

Abstract: Benzimidazoles of the formula

WHEREIN R1 is alkyl, R2 is alkyl, cyclo-alkyl, benzyl or phenyl, SR2 being in 2- or 3-position, R3 is hydrogen, alkyl, aliphatic saturated alkanoyl, chlorine, bromine, cyano, methoxy, ethoxy, phenoxy, phenylthio or benzoyl, and R4 is hydrogen, chlorine or methyl are valuable fungicides and anthelminthics.

Abstract translation: 苄基或苯基，SR2为2-或3-位，R3为氢，烷基，脂族饱和链烷酰基，氯，溴，氰基，甲氧基，乙氧基 ，苯氧基，苯硫基或苯甲酰基，R4是氢，氯或甲基是有价值的杀真菌剂和anthelminthics。

公开(公告)号：US3928345A

公开(公告)日：1975-12-23

申请号：US48678074

申请日：1974-07-09

Applicant: HOECHST AG

Inventor： ROCHLING HANS ,  HARTEL KURT ,  KIRSCH REINHARD

IPC: C07D487/08 ,  A01N47/16 ,  A23K1/16 ,  C07D519/00 ,  C07D251/72

CPC classification number: C07D519/00

Abstract: AND TO A PROCESS FOR PREPARING THESE COMPOUNDS. The products of the invention are useful as pesticides, especially as fungicides on the plant system and as antiparasites.

The invention relates to bis-triazinobenzimidazoles of the formula

Abstract translation: 本发明涉及下式的双 - 三嗪苯并咪唑和制备这些化合物的方法。 本发明的产品可用作农药，特别是作为植物系统上的杀真菌剂和抗寄生虫剂。

公开(公告)号：NO306296B1

公开(公告)日：1999-10-18

申请号：NO953204

申请日：1995-08-15

Applicant: HOECHST AG

Inventor： KIRSCH REINHARD ,  KLEIM JOERG-PETER ,  RIESS GUENTHER ,  ROESNER MANFRED ,  WINKLER IRVIN

IPC: A61K31/47 ,  A61P31/12 ,  A61P31/18 ,  C07D215/22 ,  C07D215/227 ,  C07D215/24 ,  C07D215/26 ,  C07D215/36 ,  C07D215/38 ,  C07D215/58 ,  C07D221/20 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14

Abstract: 4-Methylene-2-quinolones of formula (I) and their tautomers of formula (Ia) and their isomers, salts and prodrugs are new: n = 0-4; R1 = halo, CF3, OCF3, OH, alkyl, cycloalkyl, alkoxy, alkoxyalkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, NO2, NH2, azido, alkylamino, dialkylamino, piperidino, morpholino, pyrrolidino, acyl, acyloxy, acylamino, CONH2, COOH, alkoxycarbonyl, SO3H, SO2NH2, Ar, OAr, COOAr, SAr, SOAr, SO2Ar, SO3Ar, OSO2Ar, SO2NHAr, NHSO2Ar, COAr, Ar', etc.; Ar,Ar' = phenyl and heteroaryl resp., etc.; X = O, S, Se, NR2 or NOR2; R2 = H; alkyl opt. substd. by halogen, CN, NH2, OH, etc.;R5, R6 = COOH or gps. as defined for R2; or R5+R6 forms a 3-8C carbocyclic ring; R3,R4 = alkyl, alkenyl, cycloalkyl or cycloalkenyl,etc.; or R3+R4 = a 3-8C carbocyclic ring; or R3+R4 = CZ1Z2 gp., where Z1 and Z2 are as defined for R3 and R4 as above; provided that X is not O when R1=R2=R5=R6=H and R3=R4=Me or R3+R4= (CH2)4.

公开(公告)号：HK1011988A1

公开(公告)日：1999-07-23

申请号：HK98113241

申请日：1998-12-12

Applicant: HOECHST AG

Inventor： ROSNER MANFRED ,  BILLHARDT-TROUGHTON UTA-MARIA ,  KIRSCH REINHARD ,  KLEIM JORG-PETER ,  MEICHSNER CHRISTOPH ,  RIESS GUNTHER ,  WINKLER IRVIN

IPC: A61K31/495 ,  A61P31/12 ,  C07D241/44 ,  C07F11/00 ,  C07D ,  A61K

Abstract: Quinoxaline derivs. of formula (I) and tautomers of formula (Ia), and their salts and prodrugs are new: R1 = F, Cl,OH or 1-3C alkoxy; R2 = 1-4C alkyl (opt. substd. by OH, 1-4C alkoxy or 1-4C alkylthio); R3 = 1-6C alkoxy-carbonyl or 2-6C alkenyloxy carbonyl; X = 0, S or Se; n = 0-2.

公开(公告)号：SI9500260A

公开(公告)日：1996-02-29

申请号：SI9500260

申请日：1995-08-16

Applicant: HOECHST AG

Inventor： KIRSCH REINHARD ,  KLEIM JOERG-PETER ,  RIESS GUENTHER ,  ROESNER MANFRED ,  WINKLER IRVIN

IPC: A61K31/47 ,  A61P31/12 ,  A61P31/18 ,  C07D215/22 ,  C07D215/227 ,  C07D215/24 ,  C07D215/26 ,  C07D215/36 ,  C07D215/38 ,  C07D215/58 ,  C07D221/20 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D215/18 ,  C07D401/00

Abstract: 4-Methylene-2-quinolones of formula (I) and their tautomers of formula (Ia) and their isomers, salts and prodrugs are new: n = 0-4; R1 = halo, CF3, OCF3, OH, alkyl, cycloalkyl, alkoxy, alkoxyalkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, NO2, NH2, azido, alkylamino, dialkylamino, piperidino, morpholino, pyrrolidino, acyl, acyloxy, acylamino, CONH2, COOH, alkoxycarbonyl, SO3H, SO2NH2, Ar, OAr, COOAr, SAr, SOAr, SO2Ar, SO3Ar, OSO2Ar, SO2NHAr, NHSO2Ar, COAr, Ar', etc.; Ar,Ar' = phenyl and heteroaryl resp., etc.; X = O, S, Se, NR2 or NOR2; R2 = H; alkyl opt. substd. by halogen, CN, NH2, OH, etc.;R5, R6 = COOH or gps. as defined for R2; or R5+R6 forms a 3-8C carbocyclic ring; R3,R4 = alkyl, alkenyl, cycloalkyl or cycloalkenyl,etc.; or R3+R4 = a 3-8C carbocyclic ring; or R3+R4 = CZ1Z2 gp., where Z1 and Z2 are as defined for R3 and R4 as above; provided that X is not O when R1=R2=R5=R6=H and R3=R4=Me or R3+R4= (CH2)4.

公开(公告)号：CA2156128A1

公开(公告)日：1996-02-17

申请号：CA2156128

申请日：1995-08-15

Applicant: HOECHST AG

Inventor： KIRSCH REINHARD ,  KLEIM JOERG-PETER ,  RIEBETA GUENTHER ,  ROESNER MANFRED ,  WINKLER IRVIN

IPC: A61K31/47 ,  A61P31/12 ,  A61P31/18 ,  C07D215/22 ,  C07D215/227 ,  C07D215/24 ,  C07D215/26 ,  C07D215/36 ,  C07D215/38 ,  C07D215/58 ,  C07D221/20 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D215/16 ,  C07D401/00 ,  C07D405/00 ,  C07D409/00 ,  C07D413/00 ,  C07D417/00 ,  A61K31/505 ,  A61K31/535

Abstract: Compounds of the formula I, (I) and also their tautomeric forms of the formula Ia, (Ia) in which the substituents R1 to R6 and X have said meanings, exhibit antiviral activity.

公开(公告)号：HU9502403D0

公开(公告)日：1995-10-30

申请号：HU9502403

申请日：1995-08-15

Applicant: HOECHST AG

Inventor： KIRSCH REINHARD ,  KLEIM JOERG-PETER ,  RIESS GUENTHER ,  ROESNER MANFRED ,  WINKLER IRVIN

IPC: A61K31/47 ,  A61P31/12 ,  A61P31/18 ,  C07D215/22 ,  C07D215/227 ,  C07D215/24 ,  C07D215/26 ,  C07D215/36 ,  C07D215/38 ,  C07D215/58 ,  C07D221/20 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14

Abstract: 4-Methylene-2-quinolones of formula (I) and their tautomers of formula (Ia) and their isomers, salts and prodrugs are new: n = 0-4; R1 = halo, CF3, OCF3, OH, alkyl, cycloalkyl, alkoxy, alkoxyalkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, NO2, NH2, azido, alkylamino, dialkylamino, piperidino, morpholino, pyrrolidino, acyl, acyloxy, acylamino, CONH2, COOH, alkoxycarbonyl, SO3H, SO2NH2, Ar, OAr, COOAr, SAr, SOAr, SO2Ar, SO3Ar, OSO2Ar, SO2NHAr, NHSO2Ar, COAr, Ar', etc.; Ar,Ar' = phenyl and heteroaryl resp., etc.; X = O, S, Se, NR2 or NOR2; R2 = H; alkyl opt. substd. by halogen, CN, NH2, OH, etc.;R5, R6 = COOH or gps. as defined for R2; or R5+R6 forms a 3-8C carbocyclic ring; R3,R4 = alkyl, alkenyl, cycloalkyl or cycloalkenyl,etc.; or R3+R4 = a 3-8C carbocyclic ring; or R3+R4 = CZ1Z2 gp., where Z1 and Z2 are as defined for R3 and R4 as above; provided that X is not O when R1=R2=R5=R6=H and R3=R4=Me or R3+R4= (CH2)4.