公开(公告)号：DE59309902D1

公开(公告)日：2000-01-20

申请号：DE59309902

申请日：1993-09-16

Applicant: HOECHST AG

Inventor： BILLHARDT-TROUGHTON UTA-MARIA ,  ROESNER MANFRED ,  BENDER RUDOLF ,  MEICHSNER CHRISTOPH

IPC: A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  A61P31/12 ,  C07D213/02 ,  C07D239/24 ,  C07D241/18 ,  C07D471/04 ,  C07D475/00 ,  C07D487/04

Abstract: Compounds of the formula I and their tautomeric form of the formula Ia, in which the substituents R to R and V, W, Y and Z have the meanings mentioned, have an action against viruses.

公开(公告)号：AT184003T

公开(公告)日：1999-09-15

申请号：AT93109965

申请日：1993-06-22

Applicant: HOECHST AG

Inventor： BILLHARDT-TROUGHTON UTA-MARIA ,  ROESNER MANFRED ,  BENDER RUDOLF ,  MEICHSNER CHRISTOPH

IPC: A61K31/47 ,  A61P31/12 ,  A61P31/18 ,  C07D215/22 ,  C07D215/42 ,  C07D401/06 ,  C07D401/12

Abstract: Compounds of the formula I and their tautomeric forms, of the general formula Ia Ib and Ic in which the substituents R -R and X and Y have the meanings mentioned, have an antiviral activity.

公开(公告)号：ZA949785B

公开(公告)日：1995-07-12

申请号：ZA949785

申请日：1994-12-08

Applicant: HOECHST AG

Inventor： MEICHSNER CHRISTOPH ,  RIESS GUENTHER ,  KLEIM JOERG-PETER ,  ROESNER MANFRED ,  PAESSENS ARNO ,  BLUNCK MARTIN

IPC: A61K31/495 ,  A61K20060101 ,  A61K31/498 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K31/70 ,  A61P31/12 ,  A61P31/18 ,  C08G61/12 ,  A61K

Abstract: A combination product containing at least one nucleoside and a compound of the formulae I and/or Ia, or the physiologically tolerated salts thereof, where the symbols X and n, and the substituents R -R , have the stated meanings, display antiviral activity.

公开(公告)号：NO174834C

公开(公告)日：1994-07-20

申请号：NO883375

申请日：1988-07-29

Applicant: HOECHST AG

Inventor： SCHRINNER ELMAR ,  WINKLER IRVIN ,  MEICHSNER CHRISTOPH ,  HELSBERG MATTHIAS

IPC: C07D473/06 ,  A61K20060101 ,  A61K31/52 ,  A61K31/70 ,  A61K31/715 ,  A61P31/12 ,  C07D20060101 ,  C07D473/04 ,  C08B20060101 ,  C08B37/00 ,  A61K31/725

Abstract: The preparation contains or consists of… a) at least one sulphated polysaccharide and… b) at least one xanthine derivative. The preparation is suitable for the control and prophylaxis of viral diseases, especially those caused by retroviruses.

公开(公告)号：ZA934576B

公开(公告)日：1994-01-31

申请号：ZA934576

申请日：1993-06-25

Applicant: HOECHST AG

Inventor： BILLHARDT-TROUGHTON UTA-MARIA ,  ROESNER MANFRED ,  BENDER RUDOLF ,  MEICHSNER CHRISTOPH

IPC: A61K31/47 ,  A61P31/12 ,  A61P31/18 ,  C07D215/22 ,  C07D215/42 ,  C07D401/06 ,  C07D401/12 ,  C07D ,  A61K

Abstract: Compounds of the formula I and their tautomeric forms, of the general formula Ia Ib and Ic in which the substituents R -R and X and Y have the meanings mentioned, have an antiviral activity.

公开(公告)号：HU9301875D0

公开(公告)日：1993-09-28

申请号：HU9301875

申请日：1993-06-25

Applicant: HOECHST AG

Inventor： BILLHARDT-TROUGHTON UTA-MARIA ,  ROESNER MANFRED ,  BENDER RUDOLF ,  MEICHSNER CHRISTOPH

IPC: A61K31/47 ,  A61P31/12 ,  A61P31/18 ,  C07D215/22 ,  C07D215/42 ,  C07D401/06 ,  C07D401/12

Abstract: Compounds of the formula I and their tautomeric forms, of the general formula Ia Ib and Ic in which the substituents R -R and X and Y have the meanings mentioned, have an antiviral activity.

公开(公告)号：PT98167A

公开(公告)日：1993-08-31

申请号：PT9816791

申请日：1991-07-01

Applicant: HOECHST AG

Inventor： UHLMANN EUGEN ,  MEICHSNER CHRISTOPH ,  PEYMAN ANUSCHIRWAN ,  WINKLER IRVIN ,  HELSBERG MATTHIAS

IPC: A61K31/505 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7064 ,  A61K31/7068 ,  A61K31/7072 ,  A61P31/12 ,  A61P31/22 ,  C07D239/36 ,  C07D239/47 ,  C07D239/52 ,  C07D239/54 ,  C07D239/553 ,  C07D405/04 ,  C07D409/04 ,  C07H19/06

公开(公告)号：AU617115B2

公开(公告)日：1991-11-21

申请号：AU2017988

申请日：1988-07-29

Applicant: HOECHST AG

Inventor： SCHRINNER ELMAR ,  WINKLER IRVIN ,  MEICHSNER CHRISTOPH ,  HELSBERG MATTHIAS

IPC: C07D473/06 ,  A61K20060101 ,  A61K31/52 ,  A61K31/70 ,  A61K31/715 ,  A61P31/12 ,  C07D20060101 ,  C07D473/04 ,  C08B20060101 ,  C08B37/00 ,  A61K31/735

Abstract: The preparation contains or consists of… a) at least one sulphated polysaccharide and… b) at least one xanthine derivative. The preparation is suitable for the control and prophylaxis of viral diseases, especially those caused by retroviruses.

公开(公告)号：IE904625A1

公开(公告)日：1991-07-17

申请号：IE462590

申请日：1990-12-20

Applicant: HOECHST AG

Inventor： PEYMAN ANUSCHIRWAN ,  UHLMANN EUGEN ,  WINKLER IRVIN ,  HELSBERG MATTHIAS ,  MEICHSNER CHRISTOPH

IPC: A61K31/66 ,  A61K31/662 ,  A61K31/675 ,  A61K31/685 ,  A61P31/12 ,  A61P31/18 ,  C07F9/38 ,  C07F9/40 ,  C07F9/58 ,  C07F9/653 ,  C07F9/6539 ,  C07F9/6558 ,  C07F9/6571

Abstract: The compound of the formula I in which R represents an aldehyde group or a group which can be converted into an aldehyde, R and R represent alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, hydrogen, sodium, potassium, calcium, magnesium, aluminium, lithium, ammonium or triethylammonium or R and R together form a cyclic diester, R and R represent alkyl, alkenyl, alkynyl, cycloalkyl, hydrogen, alkoxy or halogen, R and R represent alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, alkoxy, phenyl, cyanide, hydroxyl or hydrogen, X, Y or Z represent oxygen or sulphur, or prodrug forms of the compound of the formula I can be used for treatment of diseases caused by viruses. The preparation of these compounds and pharmaceutical preparations which contain them and also their use are described.

公开(公告)号：HU906244D0

公开(公告)日：1991-03-28

申请号：HU624490

申请日：1990-09-27

Applicant: HOECHST AG

Inventor： BUDT KARL-HEINZ ,  STOWASSER BERND ,  RUPPERT DIETER ,  MEICHSNER CHRISTOPH ,  PAESSENS ARNOLD ,  HANSEN JUTTA ,  KNOLLE JOCHEN

IPC: A61K38/55 ,  A61K31/13 ,  A61K31/16 ,  A61K31/27 ,  A61K38/00 ,  A61K38/04 ,  A61P31/12 ,  C07C211/20 ,  C07C211/27 ,  C07C215/18 ,  C07C237/10 ,  C07C237/22 ,  C07C271/10 ,  C07C271/20 ,  C07C271/22 ,  C07C317/28 ,  C07C317/44 ,  C07C323/58 ,  C07C323/60 ,  C07D211/58 ,  C07D211/96 ,  C07D213/34 ,  C07D213/40 ,  C07D213/50 ,  C07D213/56 ,  C07D213/70 ,  C07D213/89 ,  C07D215/48 ,  C07D217/26 ,  C07D317/50 ,  C07D333/22 ,  C07D333/24 ,  C07D521/00 ,  C07F7/18 ,  C07K1/113 ,  C07K5/00 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/078 ,  C07K5/08 ,  C07K5/083 ,  C07K5/10 ,  C07K7/06 ,  C07K9/00 ,  C07K14/81

Abstract: The present invention relates to a compound of the formula I in which A, Y, R , R , R , R , R , l, m and the corresponding radicals with are defined as indicated in the description, a process for the preparation thereof, and the use thereof for inhibiting retroviral proteases.