公开(公告)号：HU192984B

公开(公告)日：1987-08-28

申请号：HU170384

申请日：1984-05-02

Applicant: HOECHST AG

Inventor： KIRRSTETTER REINER ,  DUERCKHEIMER WALTER ,  LATTRELL RUDOLF ,  SCHWAB WILFRIED

IPC: A61K31/425 ,  A61K31/545 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/06 ,  C07D501/38 ,  C07D501/46 ,  C07D501/56 ,  C07D501/57 ,  C07D519/00

Abstract: Process for the preparation of cephem compounds of the formula wherein R is optionally substituted aminothiazolyl or amino-1,2,4-thiadiazolyl, A is optionally substituted pyridinium, R1 is hydrogen or methoxy and R2 are special aliphatic substituents, by a nucleophilic replacement in the substituent in 3-position in the presence of tri-C1C4-alkyl iodosilane.

公开(公告)号：DK68987A

公开(公告)日：1987-08-13

申请号：DK68987

申请日：1987-02-11

Applicant: HOECHST AG

Inventor： KOLLER KLAUS-PETER ,  SCHWAB WILFRIED

IPC: C01F17/00 ,  C01B11/18 ,  C01D17/00 ,  C12P19/34

Abstract: Cesium chloride is recovered from used density gradient solutions by extraction of lipophilic and coloring components using a lipophilic solvent, subsequent extraction with a polar protic organic solvent, adding perchlorate ions to the extraction residue, and converting the precipitated cesium perchlorate into cesium chloride.

公开(公告)号：CA1224458A

公开(公告)日：1987-07-21

申请号：CA453604

申请日：1984-05-04

Applicant: HOECHST AG

Inventor： KIRRSTETTER REINER ,  DUERCKHEIMER WALTER ,  LATTRELL RUDOLF ,  SCHWAB WILFRIED

IPC: A61K31/425 ,  A61K31/545 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/06 ,  C07D501/38 ,  C07D501/46 ,  C07D501/56 ,  C07D501/57 ,  C07D519/00

Abstract: of the disclosure: Process for the preparation of cephem compounds of the formula Compounds of this formula in which R represents a 2-amino-thiazol-4-yl radical and their physiologically acceptable salts have antibacterial activity.

公开(公告)号：CA1219857A

公开(公告)日：1987-03-31

申请号：CA422765

申请日：1983-03-03

Applicant: HOECHST AG

Inventor： LATTRELL RUDOLF ,  KIRRSTETTER REINER ,  SCHWAB WILFRIED ,  DUERCKHEIMER WALTER ,  SEIBERT GERHARD

IPC: C07D501/36 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/20 ,  C07D501/34 ,  C07D501/46 ,  C07D501/56

Abstract: of the disclosure: The invention relates to cephem derivatives of the general formula I and their physiologically acceptable acid addition salts, to pharmaceutical formulations active against bacterial infections, to processes for preparing the compounds and formulations, and to the use of the compounds for combating bacterial infections.

公开(公告)号：DK68987D0

公开(公告)日：1987-02-11

申请号：DK68987

申请日：1987-02-11

Applicant: HOECHST AG

Inventor： KOLLER KLAUS-PETER ,  SCHWAB WILFRIED

IPC: C01F17/00 ,  C01B11/18 ,  C01D17/00 ,  C12P19/34

Abstract: Cesium chloride is recovered from used density gradient solutions by extraction of lipophilic and coloring components using a lipophilic solvent, subsequent extraction with a polar protic organic solvent, adding perchlorate ions to the extraction residue, and converting the precipitated cesium perchlorate into cesium chloride.

公开(公告)号：HUT37152A

公开(公告)日：1985-11-28

申请号：HU372684

申请日：1984-10-02

Applicant: HOECHST AG

Inventor： FLEISCHMANN KLAUS ,  DUERKHEIMER WALTER ,  LATTRELL RUDOLF ,  SCHWAB WILFRIED ,  SEEGER KARL

IPC: C07D501/46 ,  A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/00 ,  C07D501/56 ,  C07D501/57

Abstract: Cephalosporin derivatives of the formula pharmaceutical preparations active against bacterial infections and which contain cephem derivatives of this type, process for the preparation of the cephem derivatives and the pharmaceutical preparations and use of the cephem derivatives for combating bacterial infections.

公开(公告)号：DK479984A

公开(公告)日：1985-04-09

申请号：DK479984

申请日：1984-10-05

Applicant: HOECHST AG

Inventor： LATTRELL RUDOLF ,  BLUMBACH JUERGEN ,  DUERCKHEIMER WALTER ,  SCHWAB WILFRIED ,  SEIBERT GERHARD

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/38 ,  C07D501/46 ,  C07D501/56 ,  C07D501/57 ,  C07D

公开(公告)号：NO841792L

公开(公告)日：1984-11-08

申请号：NO841792

申请日：1984-05-04

Applicant: HOECHST AG

Inventor： LATTRELL RUDOLF ,  DUERKHEIMER WALTER ,  KIRRSTETTER REINER ,  SCHWAB WILFRIED

IPC: C07D501/04 ,  A61K31/425 ,  A61K31/545 ,  C07D20060101 ,  C07D501/00 ,  C07D501/06 ,  C07D501/38 ,  C07D501/46 ,  C07D501/56 ,  C07D501/57 ,  C07D

Abstract: Process for the preparation of cephem compounds of the formula

公开(公告)号：FI841764A

公开(公告)日：1984-11-08

申请号：FI841764

申请日：1984-05-03

Applicant: HOECHST AG

Inventor： SCHWAB WILFRIED ,  DUERCKHEIMER WALTER ,  KIRRSTETTER REINER ,  LATTRELL RUDOLF

IPC: C07D501/04 ,  A61K31/425 ,  A61K31/545 ,  C07D20060101 ,  C07D501/00 ,  C07D501/06 ,  C07D501/38 ,  C07D501/46 ,  C07D501/56 ,  C07D501/57 ,  C07D

Abstract: Process for the preparation of cephem compounds of the formula

公开(公告)号：DK479684D0

公开(公告)日：1984-10-05

申请号：DK479684

申请日：1984-10-05

Applicant: HOECHST AG

Inventor： FLEISCHMANN KLAUS ,  DUERCKHEIMER WALTER ,  LATTRELL RUDOLF ,  SCHWAB WILFRIED ,  SEEGER KARL

IPC: C07D501/46 ,  A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/00 ,  C07D501/56 ,  C07D501/57 ,  C07D

Abstract: Cephalosporin derivatives of the formula pharmaceutical preparations active against bacterial infections and which contain cephem derivatives of this type, process for the preparation of the cephem derivatives and the pharmaceutical preparations and use of the cephem derivatives for combating bacterial infections.