公开(公告)号：JPS61212590A

公开(公告)日：1986-09-20

申请号：JP5159586

申请日：1986-03-11

Applicant: HOECHST AG

Inventor： SCHEUNEMANN KARL-HEINZ ,  DUERCKHEIMER WALTER ,  BLUMBACH JUERGEN ,  LIMBERT MICHAEL ,  SCHORLEMMER HANS-ULRICH ,  DICKNEITE GERHARD ,  SEDLACEK HANS-HARALD

IPC: A61K31/33 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61K31/433 ,  A61K31/455 ,  A61K31/465 ,  A61K31/53 ,  A61P31/04 ,  A61P35/00 ,  A61P37/00 ,  A61P37/04 ,  A61P43/00 ,  C07D211/54 ,  C07D211/84 ,  C07D213/80 ,  C07D231/18 ,  C07D235/28 ,  C07D237/18 ,  C07D239/38 ,  C07D241/18 ,  C07D249/12 ,  C07D253/06 ,  C07D253/07 ,  C07D277/20 ,  C07D277/32 ,  C07D277/36 ,  C07D277/46 ,  C07D277/56 ,  C07D277/70 ,  C07D277/74 ,  C07D285/12 ,  C07D285/125 ,  C07D521/00

公开(公告)号：BR9505132A

公开(公告)日：1997-09-09

申请号：BR9505132

申请日：1995-11-09

Applicant: HOECHST AG

Inventor： LATTRELL RUDOLF ,  DUERCKHEIMER WALTER ,  SCHMID PETER

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07B63/00 ,  C07C59/52 ,  C07C65/03 ,  C07C65/05 ,  C07C65/10 ,  C07C65/11 ,  C07C235/52 ,  C07D501/00 ,  C07D501/46 ,  C07D501/56 ,  C07C59/48

Abstract: Cephem addn. salts of formula (I) are new: n = 1 or 2; m = 0.4-2.6; X = anion of phenolic carboxylic acid of formula (IIa) or (IIb) etc: X can be X/2 when the acid is diprotic.

公开(公告)号：CA1339421C

公开(公告)日：1997-09-02

申请号：CA591261

申请日：1989-02-16

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  MENCKE BURGHARD ,  BLUMBACH JUERGEN ,  ISERT DIETER ,  SEIBERT GERHARD ,  FISCHER GERD ,  DUERCKHEIMER WALTER

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/00 ,  C07D501/32 ,  C07D501/34

Abstract: Cephemcarboxylic acid esters of the general formula pharmaceutical preparations which are active against bacterial infections, which contain such cephem derivatives, a process for the preparation of the cephem derivatives and the pharmaceutical preparations, and also the use of the cephem derivatives for combating bacterial infections.

公开(公告)号：HRP940734A2

公开(公告)日：1997-06-30

申请号：HRP940734

申请日：1994-10-24

Applicant: HOECHST AG ,  RUHRCHEMIE AG

Inventor： KIRRSTEITER REINER ,  DUERCKHEIMER WALTER ,  LATTRELL RUDOLF ,  SCHWAB WILFRIED

IPC: C07D501/46

公开(公告)号：FI96424C

公开(公告)日：1996-06-25

申请号：FI902900

申请日：1990-06-11

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  DUERCKHEIMER WALTER ,  MENCKE BURKHARD ,  ISERT DIETER

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/00 ,  C07D501/34 ,  C07D501/56

公开(公告)号：ZA9509510B

公开(公告)日：1996-05-28

申请号：ZA9509510

申请日：1995-11-09

Applicant: HOECHST AG

Inventor： LATTRELL RUDOLF ,  DUERCKHEIMER WALTER ,  SCHMID PETER

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07B63/00 ,  C07C59/52 ,  C07C65/03 ,  C07C65/05 ,  C07C65/10 ,  C07C65/11 ,  C07C235/52 ,  C07D501/00 ,  C07D501/46 ,  C07D501/56 ,  C07D ,  A61K ,  C07C

CPC classification number: C07D501/00

公开(公告)号：HU9503213D0

公开(公告)日：1996-01-29

申请号：HU9503213

申请日：1995-11-09

Applicant: HOECHST AG

Inventor： LATTRELL RUDOLF ,  DUERCKHEIMER WALTER ,  SCHMID PETER

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07B63/00 ,  C07C59/52 ,  C07C65/03 ,  C07C65/05 ,  C07C65/10 ,  C07C65/11 ,  C07C235/52 ,  C07D501/00 ,  C07D501/46 ,  C07D501/56

Abstract: Cephem addn. salts of formula (I) are new: n = 1 or 2; m = 0.4-2.6; X = anion of phenolic carboxylic acid of formula (IIa) or (IIb) etc: X can be X/2 when the acid is diprotic.

公开(公告)号：HUT68577A

公开(公告)日：1995-06-28

申请号：HU9402831

申请日：1994-10-03

Applicant: HOECHST AG

Inventor： BOHN MANFRED ,  STACHE ULRICH ,  ALPERMANN HANS-GEORG ,  DUERCKHEIMER WALTER

IPC: A61K31/57 ,  A61K31/56 ,  A61K31/573 ,  A61K31/58 ,  A61P17/00 ,  A61P29/00 ,  C07J5/00 ,  C07J17/00 ,  C07J31/00 ,  C07J33/00 ,  C07J41/00 ,  C07J43/00 ,  C07J75/00

Abstract: Corticoid 17,21-dicarboxylic esters and corticoid 17-carboxylic esters 21-carbonic esters of the formula I with A equal to CHOH and CHClm CH2, C=0, 9(11) double bond; Y equal to H, F, Cl; Z equal to H, F, methyl, R(1) equal to aryl, hetaryl; R(2) equal to alkyl, R(3) equal to H, methyl are described. They are obtained, inter alia, by reacting a compound of the formula II in which R(5) is equal to OH, with an activated carboxylic acid of the formula III They have very high local and topical antiinflammatory activity and show a very good ratio of local to systemic antiinflammatory effect. They are used inter alia as agents for treating inflammatory dermatoses.

公开(公告)号：FI944599A0

公开(公告)日：1994-10-03

申请号：FI944599

申请日：1994-10-03

Applicant: HOECHST AG

Inventor： STACHE ULRICH ,  ALPERMANN HANS-GEORG ,  DUERCKHEIMER WALTER ,  BOHN MANFRED

IPC: A61K31/57 ,  A61K31/56 ,  A61K31/573 ,  A61K31/58 ,  A61P17/00 ,  A61P29/00 ,  C07J5/00 ,  C07J17/00 ,  C07J31/00 ,  C07J33/00 ,  C07J41/00 ,  C07J43/00 ,  C07J75/00 ,  C07J

Abstract: Corticoid 17,21-dicarboxylic esters and corticoid 17-carboxylic esters 21-carbonic esters of the formula I with A equal to CHOH and CHClm CH2, C=0, 9(11) double bond; Y equal to H, F, Cl; Z equal to H, F, methyl, R(1) equal to aryl, hetaryl; R(2) equal to alkyl, R(3) equal to H, methyl are described. They are obtained, inter alia, by reacting a compound of the formula II in which R(5) is equal to OH, with an activated carboxylic acid of the formula III They have very high local and topical antiinflammatory activity and show a very good ratio of local to systemic antiinflammatory effect. They are used inter alia as agents for treating inflammatory dermatoses.

公开(公告)号：FI943902A0

公开(公告)日：1994-08-25

申请号：FI943902

申请日：1994-08-25

Applicant: HOECHST AG

Inventor： STACHE ULRICH ,  ALPERMANN HANS-GEORG ,  DUERCKHEIMER WALTER ,  BOHN MANFRED

IPC: A61K31/57 ,  A61P17/00 ,  A61P29/00 ,  C07J5/00 ,  C07J17/00 ,  C07J31/00 ,  C07J33/00 ,  C07J41/00 ,  C07J43/00 ,  C07J

Abstract: There are described 17-alkyl carbonate-21-carbonic/carboxylic acid esters of corticosteroids of the formula I where A is CHOH or CHCl, CH2, C = O, a 9(11) double bond; Y is H, F, Cl; Z is H, F, CH3; R(1) is aryl, hetaryl; n and m are zero or 1; R(2) is alkyl, -(CH2)2-OCH3; R(3) is H, methyl. They are obtained by reacting a compound of the formula II in which R(5) is OH, with an activated carboxylic acid of the formula III R(6)-CO-(O)n-[(C1-C4)-alkyl]m-R(1) III The compounds I have very potent local and topical anti-inflammatory activity and show a very good ratio of local to systemic anti-inflammatory action, which is often clearly superior compared with analogous corticoid 17-alkyl carbonate 21-esters which do not carry an aryl or hetaryl group in the 21 ester radical.