公开(公告)号：ES2187501T3

公开(公告)日：2003-06-16

申请号：ES93103301

申请日：1993-03-02

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  WAGNER ADALBERT DR ,  GERHARDS HERMANN DR ,  BECKER REINHARD DR ,  SCHOLKENS BERNWARD PROF DR

IPC: A61K31/4164 ,  A61K31/64 ,  A61P9/10 ,  A61P9/12 ,  A61K31/415 ,  C07D233/84 ,  C07D233/86 ,  C07D233/90

Abstract: Compounds of the formula (I) in which R is, for example, ethyl, R is, for example, methyl, n is, for example, zero, R is, for example, COOH and R is, for example, SO2NHCONHCH3 are highly active antagonists of angiotensin II receptors.

公开(公告)号：DK0795547T3

公开(公告)日：2000-09-18

申请号：DK97103163

申请日：1997-02-27

Applicant: HOECHST AG

Inventor： SCHOELKENS BERNWARD PROF DR ,  HEITSCH HOLGER DR ,  WAGNER ADALBERT DR ,  WIRTH KLAUS DR ,  NOELKEN GERHARD DR

IPC: C07D215/48 ,  A61K31/47 ,  A61P43/00 ,  C07D215/26

Abstract: 8-(3-(Aminoalkoxy)-benzyloxy)-quinoline compounds of formula (I) and their salts are new. R1-R3 = H, halo, CHO, COOH, 1-5C alkyl, 6-10C aryl, 1-3C alkyl-(6-10C) aryl, 3-8C cycloalkyl or 1-3C alkoxycarbonyl; R4, R5 = H, halo, NO2, CN, 1-3C alkoxy or 1-3C alkylthio; R6 = H, 1-3C alkyl, 3-5C alkylalkenyl (sic) or 1-3C alkyl-6-10C aryl; R7 = H, 1-6C alkanoyl, alkanoyl (substituted by 1-3C alkoxy, alkylcarbamoyl or aryl), 3-7C alkenoyl, 3-8C cycloalkylcarbonyl, 5-7C cycloalkenylcarbonyl, 1-3C alkoxycarbonyl, aryloxycarbonyl, 6-12C aroyl (optionally substituted by 1-3C alkoxy or halo), alkenoyl (substituted by aryl (optionally substituted by 1-3C alkoxy, 1-3C alkylenedioxy, NO2, CN, halo, 1-3C haloalkyl, hetero-3-8C cycloalkyl (sic), NH2, 1-4C alkylamino, 6-12C heteroaryl-alkanoylamino, aroylamino, 6-12C heteroarylcarbonylamino, 1-5C alkylsulphonylamino, 1-5C alkylureido, alkanoyl, 1-5C alkoxycarbonyl, 1-5C alkylcarbamoyl or arylcarbamoyl), 2-5C acylamino-arylcinnamoyl, 1-3C alkoxycarbonylamino-arylcinnamoyl, 1-4C alkylaminocarbonylaminocinnamoyl, aryl-1-5C alkoxycarbonyl, 1-5C alkylcarbamoyl, arylcarbamoyl, aroylcarbamoyl, alkylsulphonyl, arylsulphonyl, aryl-alkylsulphonyl or phthaloyl (for R6=R7(sic)); n = 1-8; alkyl has 1-6C, aryl has 6-12C, alkanoyl has 2-6C, and alkenoyl has 3-6C unless specified other wise.

公开(公告)号：ES2114874T3

公开(公告)日：1998-06-16

申请号：ES91122406

申请日：1992-01-01

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  ENGLERT HEINRICH DR ,  KLEEMANN HEINZ-WERNER DR ,  GERHARDS HERMANN DR ,  SCHOLKENS BERNWARD PROF DR ,  BECKER REINHARD DR

IPC: A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K31/64 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D207/34 ,  C07D207/36 ,  C07D233/54 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D249/02 ,  C07D255/02 ,  C07D257/02 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D521/00

Abstract: Azole derivative of the general formula (I) in which A, L, O, R , X, Y, Z and q have the meanings given, a process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the formula I where the symbols have, for example, the following meanings: R = (C2-C10)-alkyl Z = nitrogen X and Y = independently of one another CR L = -CH2- q = zero or 1 A = biphenyl radical which is substituted, for example, by R R = halogen or hydrogen R = SO2-NH-CO-OR and R = phenyl, are highly active antagonists of angiotensin II receptors.

公开(公告)号：PH30954A

公开(公告)日：1997-12-23

申请号：PH43726

申请日：1992-01-02

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  ENGLERT HEINRICH DR ,  KLEEMANN HEINZ-WERNER DR ,  GERHARDS HERMANN DR ,  SCHOLKENS BERNWARD PROF DR ,  BECKER REINHARD DR ,  LINZ WOLFGANG DR ,  JEAN-PAUL VEVERT ,  JOHN-CLAUDE CAILLE

IPC: A61K31/415 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/40 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K31/64 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D207/34 ,  C07D207/36 ,  C07D233/54 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D249/02 ,  C07D255/02 ,  C07D257/02 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D521/00 ,  A61K31/41

Abstract: Azole derivative of the general formula (I) in which A, L, O, R , X, Y, Z and q have the meanings given, a process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the formula I where the symbols have, for example, the following meanings: R = (C2-C10)-alkyl Z = nitrogen X and Y = independently of one another CR L = -CH2- q = zero or 1 A = biphenyl radical which is substituted, for example, by R R = halogen or hydrogen R = SO2-NH-CO-OR and R = phenyl, are highly active antagonists of angiotensin II receptors.

公开(公告)号：CZ9700766A3

公开(公告)日：1997-10-15

申请号：CZ76697

申请日：1997-03-12

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  WAGNER ADALBERT DR ,  WIRTH KLAUS DR ,  SCHOLKENS BERNWARD PROF DR ,  NOLKEN GERHARD DR

IPC: C07D215/48 ,  A61K31/47 ,  A61P43/00 ,  C07D215/26

CPC classification number: C07D215/26

公开(公告)号：DE19610784A1

公开(公告)日：1997-09-25

申请号：DE19610784

申请日：1996-03-19

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  HEITSCH HOLGER DR ,  NOELKEN GERHARD DR ,  WIRTH KLAUS DR ,  SCHOELKENS BERNWARD PROF DR

IPC: C07D237/28 ,  A61K31/345 ,  A61K31/47 ,  A61K31/495 ,  A61K31/53 ,  A61P43/00 ,  C07D215/04 ,  C07D215/26 ,  C07D239/72 ,  C07D239/74 ,  C07D241/36 ,  C07D241/44 ,  C07D253/04 ,  C07D253/065 ,  C07D257/10 ,  C07D237/30 ,  C07D241/40 ,  C07D253/10 ,  C07D257/12 ,  C07C205/07

Abstract: Fluoroalkyl- and fluoroalkoxy-substituted benzyloxy-azaheterocyclic compounds of formula (I) and their salts are new: X1-X3 = N or CR ; R , R = H or halo; R , R = H, halo, 1-5C alkyl or 2-5C alkenyl; R = 2-5C alkenediyl, halo, OR , SR , NHR , -COOR or COOH; 1-6C alkyl, 6-12C aryl or 6-12C aryl-1-3C alkyl (all optionally substituted by e.g. OR , SR , NO2, CN, NHR or halo); R , R = H, 1-5C alkyl, 3-5C alkenyl or 6-12C aryl-1-3C alkyl; R = 1-5C alkyl or 1-5C alkoxy (both substituted by 1 or more F or Cl); B = amino acid; D = 2-5C alkanediyl, 1-5C alkanediyl or -(CH2)n-Yp-(CH2)m-; E = O or S; Y = O, S or NR ; n, m = 0-3; o = 1-3; and p = 0 or 1.

公开(公告)号：CZ280248B6

公开(公告)日：1995-12-13

申请号：CS90691

申请日：1991-04-02

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  HENNING RAINER DR ,  GERHARDS HERMANN DR ,  SCHOLKENS BERNHARD DR ,  CAILLE JEAN-CLAUDE ,  VEVERT JEAN-PAUL

IPC: A61K31/415 ,  A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4164 ,  A61K31/423 ,  A61K31/437 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/495 ,  A61K31/505 ,  A61K31/519 ,  A61P9/12 ,  A61P29/00 ,  A61P43/00 ,  C07D233/64 ,  C07D233/84 ,  C07D233/90 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D471/04 ,  C07D487/04

Abstract: The invention relates to compounds of the formula in which X, Y and Z are identical or different and are N or CR , R and R are as defined in the description, L is an alkylene radical, q = 0 or 1, and A is the radical of a fused heterobicycle. The invention furthermore relates to a method for the preparation of the abovementioned compounds, to compositions containing them, and to their use.

公开(公告)号：ES2076395T3

公开(公告)日：1995-11-01

申请号：ES91105178

申请日：1991-04-02

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  HENNING RAINER DR ,  GERHARDS HERMANN DR ,  SCHOLKENS BERNWARD DR ,  JEAN-CLAUDE CAILLE ,  JEAN-PAUL VEVERT

IPC: A61K31/415 ,  A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4164 ,  A61K31/423 ,  A61K31/437 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/495 ,  A61K31/505 ,  A61K31/519 ,  A61P9/12 ,  A61P29/00 ,  A61P43/00 ,  C07D233/64 ,  C07D233/84 ,  C07D233/90 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D471/04 ,  C07D487/04

Abstract: The invention relates to compounds of the formula in which X, Y and Z are identical or different and are N or CR , R and R are as defined in the description, L is an alkylene radical, q = 0 or 1, and A is the radical of a fused heterobicycle. The invention furthermore relates to a method for the preparation of the abovementioned compounds, to compositions containing them, and to their use.

公开(公告)号：AT124696T

公开(公告)日：1995-07-15

申请号：AT91105178

申请日：1991-04-02

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  HENNING RAINER DR ,  GERHARDS HERMANN DR ,  SCHOELKENS BERNWARD DR ,  JEAN-CLAUDE CAILLE ,  JEAN-PAUL VEVERT

IPC: A61K31/415 ,  A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4164 ,  A61K31/423 ,  A61K31/437 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/495 ,  A61K31/505 ,  A61K31/519 ,  A61P9/12 ,  A61P29/00 ,  A61P43/00 ,  C07D233/64 ,  C07D233/84 ,  C07D233/90 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D471/04 ,  C07D487/04

Abstract: The invention relates to compounds of the formula in which X, Y and Z are identical or different and are N or CR , R and R are as defined in the description, L is an alkylene radical, q = 0 or 1, and A is the radical of a fused heterobicycle. The invention furthermore relates to a method for the preparation of the abovementioned compounds, to compositions containing them, and to their use.

公开(公告)号：CZ1494A3

公开(公告)日：1994-08-17

申请号：CZ1494

申请日：1994-01-04

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  BHATNAGAR NEERJA DR ,  BUENDIA JEAN DR ,  GRIFFOUL CHRISTINE DR

IPC: B01J23/44 ,  A61K31/235 ,  A61K31/41 ,  C07B37/04 ,  C07B61/00 ,  C07C41/48 ,  C07C45/61 ,  C07C45/71 ,  C07C47/546 ,  C07C67/30 ,  C07C67/343 ,  C07C69/76 ,  C07C69/767 ,  C07C253/30 ,  C07C255/37 ,  C07C255/40 ,  C07C255/56 ,  C07C303/40 ,  C07C311/09 ,  C07C311/48 ,  C07C311/51 ,  C07C311/52 ,  C07C311/53 ,  C07C311/54 ,  C07C311/57 ,  C07C311/58 ,  C07D257/04

Abstract: The invention relates to a method for the preparation of a compound of the general formula (I) in which X represents an optionally protected formyl group and R denotes a group which is itself inert to the reaction conditions of the synthesis, for example -CN, characterised in that a compound of the general formula (II) where X is as defined above, is reacted with a substituted phenyl halogen compound of the formula (III) where Hal denotes e.g. bromine. The compounds are useful intermediates for pharmaceutical synthesis.