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公开(公告)号：AU2021203482A1
公开(公告)日：2021-07-01
申请号：AU2021203482
申请日：2021-05-28
Applicant: HOFFMANN LA ROCHE
Inventor： GAVELLE OLIVIER , GRETHER UWE , NETTEKOVEN MATTHIAS , ROEVER STEPHAN , ROGERS-EVANS MARK , ROMBACH DIDIER
IPC: C07D231/12 , A61K31/4245 , A61P29/00 , C07C13/04 , C07D205/04 , C07D207/14 , C07D209/54 , C07D213/61 , C07D271/06 , C07D277/30 , C07D305/06 , C07D331/04 , C07D401/10 , C07D403/10 , C07D413/06 , C07D413/10 , C07D413/12
Abstract: PHENYL DERIVATIVES AS CANNABINOID RECEPTOR 2 AGONISTS Abstract (I) The invention relates to a compound of formula (I) wherein R' to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
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公开(公告)号：NZ715085A
公开(公告)日：2021-05-28
申请号：NZ71508514
申请日：2014-09-03
Applicant: HOFFMANN LA ROCHE
Inventor： ROGERS-EVANS MARK , GRETHER UWE , NETTEKOVEN MATTHIAS , ROEVER STEPHAN , SCHMITT SÉBASTIEN , KIMBARA ATSUSHI
IPC: C07D487/04 , A61K31/519
Abstract: The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
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公开(公告)号：AU2016368475B2
公开(公告)日：2021-03-04
申请号：AU2016368475
申请日：2016-12-06
Applicant: HOFFMANN LA ROCHE
Inventor： GAVELLE OLIVIER , GRETHER UWE , NETTEKOVEN MATTHIAS , ROEVER STEPHAN , ROGERS-EVANS MARK , ROMBACH DIDIER
IPC: C07D231/12 , A61K31/4245 , A61P29/00 , C07C13/04 , C07D205/04 , C07D207/14 , C07D209/54 , C07D213/61 , C07D271/06 , C07D277/30 , C07D305/06 , C07D331/04 , C07D401/10 , C07D403/10 , C07D413/06 , C07D413/10 , C07D413/12
Abstract: The invention relates to a compound of formula (I) wherein R
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公开(公告)号：HUE049656T2
公开(公告)日：2020-10-28
申请号：HUE15716824
申请日：2015-04-20
Applicant: HOFFMANN LA ROCHE
Inventor： HOVES SABINE , KUHN BERND , RICKLIN FABIENNE , ROEVER STEPHAN
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公开(公告)号：ES2787855T3
公开(公告)日：2020-10-19
申请号：ES16805856
申请日：2016-12-06
Applicant: HOFFMANN LA ROCHE
Inventor： GAVELLE OLIVIER , GRETHER UWE , NETTEKOVEN MATTHIAS , ROEVER STEPHAN , ROGERS-EVANS MARK , ROMBACH DIDIER
IPC: C07D231/12 , A61K31/4245 , A61P29/00 , C07C13/04 , C07D205/04 , C07D207/14 , C07D209/54 , C07D213/61 , C07D271/06 , C07D277/30 , C07D305/06 , C07D331/04 , C07D401/10 , C07D403/10 , C07D413/06 , C07D413/10 , C07D413/12
Abstract: Un compuesto de fórmula (I) **(Ver fórmula)** en la que R1 es ciclopropilo, alquilo o haloacetidinilo; R2 es ciclopropilmetoxi, alcoxi, haloalcoxi, halopiridinilo, alquilpirazolilo o halopirrolidinilo; siempre que al menos uno de R1 y R2 sea ciclopropilo o ciclopropilmetoxi; R3 es -C(O)-NH-C(R4R5)-R6, -C(O)-R7 o R8; R4 y R5 se seleccionan independientemente de hidrógeno, alquilo, cicloalquilo, cicloalquilalquilo, alquilsulfonilalquilo y alquiloxetanilo; o R4 y R5 conjuntamente con el átomo de carbono al que están unidos forman oxetanilo o dioxotietanilo; R6 es aminocarbonilo, 5-metil-1,2,4-oxadiazol-3-ilo, hidroxialquilo, tiazolilo, alcoxicarbonilo, carboxi, difluoroacetidinilcarbonilo, 5-amino-1,2,4-oxadiazol-3-ilo, alquilaminocarbonilo o aminocarbonilalquilo; R7 es (aminocarbonil)(difluoro)pirrolidinilo o (aminocarbonil)azaespiro[2.4]heptilo; y R8 es 3-alquil-1,2,4-oxadiazol-5-ilo o 5-alquil-1,2,4-oxadiazol-3-ilo; o una sal o éster farmacéuticamente aceptable del mismo.
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Patent Agency Ranking
公开(公告)号：NZ710052A
公开(公告)日：2020-09-25
申请号：NZ71005214
申请日：2014-03-04
Applicant: HOFFMANN LA ROCHE
Inventor： ROGERS-EVANS MARK , KIMBARA ATSUSHI , GRETHER UWE , NETTEKOVEN MATTHIAS , ROEVER STEPHAN , SCHULZ-GASCH TANJA , RICKLIN FABIENNE
IPC: C07D471/04 , C07D473/04 , C07D487/04
Abstract: The invention relates to a compound of formula (I) wherein A1 and A2 are each carbon or nitrogen, R3 is phenyl or a heterocyclic group, and the remaining substituents are as defined in the specification. The compound of formula (I) is a cannabinoid receptor type 2 agonist.
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公开(公告)号：HUE048865T2
公开(公告)日：2020-08-28
申请号：HUE16805856
申请日：2016-12-06
Applicant: HOFFMANN LA ROCHE
Inventor： GAVELLE OLIVIER , GRETHER UWE , NETTEKOVEN MATTHIAS , ROEVER STEPHAN , ROGERS-EVANS MARK , ROMBACH DIDIER
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公开(公告)号：HRP20200606T1
公开(公告)日：2020-07-10
申请号：HRP20200606
申请日：2020-04-16
Applicant: HOFFMANN LA ROCHE
Inventor： GAVELLE OLIVIER , GRETHER UWE , NETTEKOVEN MATTHIAS , ROEVER STEPHAN , ROGERS-EVANS MARK , ROMBACH DIDIER
IPC: C07D231/12 , A61K31/4245 , A61P29/00 , C07C13/04 , C07D205/04 , C07D207/14 , C07D209/54 , C07D213/61 , C07D271/06 , C07D277/30 , C07D305/06 , C07D331/04 , C07D401/10 , C07D403/10 , C07D413/06 , C07D413/10 , C07D413/12
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公开(公告)号：MA43400B1
公开(公告)日：2020-05-29
申请号：MA43400
申请日：2016-12-06
Applicant: HOFFMANN LA ROCHE
Inventor： ROMBACH DIDIER , ROGERS-EVANS MARK , GAVELLE OLIVIER , GRETHER UWE , NETTEKOVEN MATTHIAS , ROEVER STEPHAN
IPC: A61K31/4245 , A61P29/00 , C07C13/04 , C07D205/04 , C07D207/14 , C07D209/54 , C07D213/61 , C07D231/12 , C07D271/06 , C07D277/30 , C07D305/06 , C07D331/04 , C07D401/10 , C07D403/10 , C07D413/06 , C07D413/10 , C07D413/12
Abstract: L'invention porte sur un composé de formule (i) dans laquelle r1 à r3 sont tels que définis dans la description et dans les revendications. Le composé de formule (i) peut être utilisé comme médicament.
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公开(公告)号：LT3386951T
公开(公告)日：2020-05-11
申请号：LT16805856
申请日：2016-12-06
Applicant: HOFFMANN LA ROCHE
Inventor： GAVELLE OLIVIER , GRETHER UWE , NETTEKOVEN MATTHIAS , ROEVER STEPHAN , ROGERS-EVANS MARK , ROMBACH DIDIER
IPC: C07D231/12 , A61K31/4245 , A61P29/00 , C07C13/04 , C07D205/04 , C07D207/14 , C07D209/54 , C07D213/61 , C07D271/06 , C07D277/30 , C07D305/06 , C07D331/04 , C07D401/10 , C07D403/10 , C07D413/06 , C07D413/10 , C07D413/12
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