公开(公告)号：NO760561L

公开(公告)日：1976-08-24

申请号：NO760561

申请日：1976-02-20

Applicant: HOFFMANN LA ROCHE

Inventor： BERNAUER K ,  PFOERTNER K ,  SCHNEIDER F ,  SCHMID H

IPC: C07D213/50 ,  C07D401/04 ,  C07D

Abstract: Compounds represented by the formula +q,10 WHEREIN R1 is a pyridyl, R2 is hydrogen or lower alkyl, R3 is hydrogen, lower alkyl or benzyl and R4 is phenyl or phenyl substituted at one or more carbon atoms with one or more of halogen, lower alkyl, lower alkoxy, nitro or amino AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, HAVING ANALGESIC ACTIVITY ARE DISCLOSED.

公开(公告)号：BR7207906D0

公开(公告)日：1973-08-30

申请号：BR790672

申请日：1972-11-10

Applicant: HOFFMANN LA ROCHE

Inventor： GREUTER H ,  FRATER G ,  SCHMID H

IPC: C07C49/643 ,  C11B9/00 ,  C07C13/54 ,  C07D5/16 ,  C07D7/26

公开(公告)号：BR7207875D0

公开(公告)日：1973-08-30

申请号：BR787572

申请日：1972-11-09

Applicant: HOFFMANN LA ROCHE

Inventor： GREUTER H ,  FRATER G ,  SCHMID H

IPC: C07C49/385 ,  A61K8/35 ,  A61Q13/00 ,  C07C45/00 ,  C07C49/453 ,  C07C49/587 ,  C07C49/613 ,  C07C49/617 ,  C07C49/643 ,  C07C67/00 ,  C11B9/00 ,  C07C45/04

Abstract: 1346977 Tricyclic ketones F HOFFMANNLA ROCHE & CO AG 10 Nov 1972 [12 Nov 1971] 52025/72 Heading C2C [Also in Division A5] The invention comprises compounds of general Formula Ia or Ib wherein R 1 , R 7 , and R 8 are hydrogen, C 1 -C 6 alkyl or C 1 -C 6 alkoxy groups; R 2 is hydrogen, C 1 -C 6 alkyl or C 2 -C 6 alkenyl; R 3 and R 4 are hydrogen or C 1 -C 6 alkyl, R 5 and R 6 are C 1 -C 6 alkyl and the bonds indicated # may be single or double bonds. The compounds of the invention may be prepared by (a) heating a compound of the general Formula II or by (b) for the manufacture of tricyclic ketones in which at least one of the ring situated double bonds is hydrogenated, hydrogenating a tricyclic ketone of Formula Ia or Ib which contains at least one ring situated double bond, in the presence of a noble-metal catalyst. Compounds of Formula II are prepared by reacting the sodium salt of a phenol of general Formula III with a compound of general Formula IV in which X is a leaving group, e.g. Cl, Br, I, arylsulphonyloxy or alkylsulphonyloxy.

公开(公告)号：NZ184691A

公开(公告)日：1980-05-08

申请号：NZ18469177

申请日：1977-07-20

Applicant: HOFFMANN LA ROCHE

Inventor： BERNAUER K ,  PFOERTNER K ,  SCHMID H ,  SCHNEIDER F

IPC: C07D207/08

公开(公告)号：NZ179859A

公开(公告)日：1978-07-10

申请号：NZ17985976

申请日：1976-01-29

Applicant: HOFFMANN LA ROCHE

Inventor： SCHMID H ,  BERNAUER K ,  SCHNEIDER F ,  PFOERTNER K

IPC: C07D213/50 ,  C07D401/04

Abstract: Compounds represented by the formula +q,10 WHEREIN R1 is a pyridyl, R2 is hydrogen or lower alkyl, R3 is hydrogen, lower alkyl or benzyl and R4 is phenyl or phenyl substituted at one or more carbon atoms with one or more of halogen, lower alkyl, lower alkoxy, nitro or amino AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, HAVING ANALGESIC ACTIVITY ARE DISCLOSED.

公开(公告)号：ZA774345B

公开(公告)日：1978-06-28

申请号：ZA774345

申请日：1977-07-19

Applicant: HOFFMANN LA ROCHE

Inventor： SCHMID H ,  BERNAUER K ,  PFOERTNER K ,  SCHNEIDER F

IPC: C07D207/08 ,  C07C ,  C07D

公开(公告)号：MC1158A1

公开(公告)日：1978-04-17

申请号：MC1253

申请日：1977-07-21

Applicant: HOFFMANN LA ROCHE

Inventor： SCHMID H ,  PFOERTNER K ,  BERNAUER K ,  SCHNEIDER F

IPC: C07D207/08 ,  C07B ,  C07D