Abstract:
An optoacoustic system comprises an optoacoustic transducer (10) including a first array of acoustic transducers (10C, 10D) and a second array of optical fibers (10A, 10B); an acoustic subsystem (18, 20, 30, 34) for controllably exciting at least a first subset of the acoustic transducers to generate acoustic pulses with a prescribed pulse width, and for forming a first image based on return acoustic pulses reflected from a patient; an optical subsystem (14, 20, 22, 24, 26, 30, 32) for controllably generating optical pulses to be transmitted through at least a first subset of the optical fibers toward the patient, and for forming a second image based on light reflected from the patient; and image correlation means (16, 20, 17) for correlating the first and second images. The first and second arrays may take various forms, including the form of an annular array in which the acoustic transducers are arranged coaxially and the optical fibers are disposed around an outer periphery of the first array. The first and second arrays may also take the form of linear arrays.
Abstract:
Novel stabilized suspensions of a gas as diagnostic contrast agents, including computed tomography (CT) and magnetic resonance (MR) contrast agents. In preferred embodiments, the suspensions comprise stabilized gas-filled microspheres. Also in some preferred embodiments, at least a portion of the gas is derived from a gaseous precursor.
Abstract:
The invention provides contrast media for diagnostic imaging comprising a substantially homogeneous aqueous suspension of gas-filled microspheres, wherein the microspheres are filled with a perfluorocarbon gas. The microspheres are preferably formed from biocompatible synthetic polymers or copolymers.
Abstract:
Compositions comprising, in an aqueous carrier, a lipid and a material which is capable of stabilizing the composition. The stabilizing material is associated non-covalently with said lipid and is present in an amount sufficient to coat the lipid but insufficient to raise the viscosity of the composition. The compositions are particularly suitable for use in diagnostic applications, including ultrasound. The compositions can take the form of vesicular compositions, such as micelles and liposomes.