公开(公告)号：JPH1059851A

公开(公告)日：1998-03-03

申请号：JP25638796

申请日：1996-09-27

Applicant: OTSUKA PHARMA FACTORY INC ,  KAO CORP

Inventor： YONEKAWA MOTOKI ,  YAMAOKA IPPEI ,  HASHIMOTO KINJI ,  SAKASHITA EIJI ,  KORI HIDEAKI ,  KONDO AKIHIRO ,  AMIYA TSUYOSHI

IPC: A61M1/14 ,  A61K31/78 ,  A61M1/36 ,  A61P43/00

Abstract: PROBLEM TO BE SOLVED: To obtain the subject medicine effective for patients with acute and chronic renal insufficiency, receiving hemodialysis and reduced in liver function, having a new action, by using a specific resin as an active ingredient. SOLUTION: This reducing agent comprises an acrylic water-absorbing resin as an active ingredient. An alkaline earth metal acrylate- or methacrylate-based polymer or a self cross-linking type metal acrylate-based polymer is preferable as the acrylic water-absorbing resin. Preferably, these metal salts comprise at least partially a calcium ion (with the proviso that a potassium salt is omitted in the case of a potassium ion adsorbent). The medicine reduces a guanidine compound accumulated in the body of a patient, discharges the compound out of the body together with water accumulated in the body without by hemodialysis and also potassium ion accumulated in the body.

公开(公告)号：JPH09286853A

公开(公告)日：1997-11-04

申请号：JP10087096

申请日：1996-04-23

Applicant: KAO CORP

Inventor： TSUJI MAKOTO ,  NANBU HIROMI ,  AMIYA TSUYOSHI

IPC: C08G65/10 ,  C08G65/02 ,  C08G65/22 ,  C08G65/32

Abstract: PROBLEM TO BE SOLVED: To produce a diblock fluoropolyether having a narrow molecular weight distribution within a short time in high yields by polymerizing an alkylene oxide in the presence of a specified catalyst, polymerizing trifluoropropylene oxide and terminating the polymerization with a terminator. SOLUTION: This fluoropolyether is produced by polymerizing an alkylene oxide represented by formula II (wherein R is hydrogen, a halogen, hydroxyl, amino or the like) in the presence of a polymerization initiator being a metal alkoxide or hydroxide represented by formula I (wherein R is hydrogen, a halogen, hydroxyl, amino or the like; R is a group derived from the polymerization initiator being a metal alkoxide or hydroxide; R is a group derived from the shortstop; and m+n is 2-3,000 on the average), polymerizing trifluoropropylene oxide represented by formula III and terminating the polymerization with a terminator. The alkylene oxide represented by formula II is desirably ethylene oxide or propylene oxide.

公开(公告)号：JPH08176311A

公开(公告)日：1996-07-09

申请号：JP32612794

申请日：1994-12-27

Applicant: KAO CORP

Inventor： IGARASHI TADASHI ,  AMIYA TSUYOSHI

IPC: C08K3/22 ,  C08J3/24 ,  C08L101/00 ,  C08L101/14

Abstract: PURPOSE: To obtain a resin high in water absorption factor with favorably sustainable water-absorbing rate, liquid permeability and gel stability over time after swollen, by blending a hydrous highly water-absorbing resin with a metal compound and a cross-linking agent followed by conducting a reaction. CONSTITUTION: A hydrous highly water-absorbing resin prepared by incorporating 10-100 pts.wt. of water in 100 pts.wt. of a highly water-absorbing resin is blended with 0.005-5 pts.wt., based on 100 pts.wt. of the highly water-absorbing resin, of metal compound having at least two hydrolyzable groups and a cross- linking agent having at least two functional group reactive with the metal compound at the weight ratio of the metal compound to cross-linking agent of 0.1 to 30 to carry out a reaction. The highly water-absorbing resin is a hydrophilic polymer prepared by reversed-phase suspension polymerization of an aqueous solution of a carboxyl- or carboxylate-bearing hydrophilic polymer containing a water-soluble initiator (specifically, acrylic (alkali metal salt) (co)polymer). The metal in the metal compound is e.g. silicon, and the hydrolyzable groups e.g. alkoxyls (specifically, an alkoxytitanium or alkoxysilane). The functional group in the cross-linking agent is e.g. hydroxyl group.

公开(公告)号：JPH0790015A

公开(公告)日：1995-04-04

申请号：JP23940793

申请日：1993-09-27

Applicant: KAO CORP

Inventor： NAKAMURA GENICHI ,  ITO KOJI ,  AMIYA TSUYOSHI

IPC: C08F8/00 ,  C08F110/02

Abstract: PURPOSE:To obtain a new modified polyethylene having a polar and highly reactive functional group near the middle part of the molecule in high purity by performing living polymerization of ethylene using an alkyllithium/t-diamine initiator and reacting the product with a formic acid ester. CONSTITUTION:Ethylene is subjected to living polymerization in the presence of an initiator consisting of a 1-6C straight or a branched alkyllithium (e.g. methyllithium) and a t-diamine (preferably tetramethylethylenediamine, etc.) preferably at 20-80 deg.C generally for 0.1-24hr. The polymerization product is reacted with a formic acid ester preferably by slowly adding the ester little by little to the system to obtain the objective polyethylene having a functional group near the middle part of the molecular chain and expressed by the formula (R) is a 1-6C straight or a branched saturated hydrocarbon chain; (m) and (n) are 10-1,000; A is H or a alkali metal). The living polymerization is preferably carried out by introducing ethylene into a cyclohexane solution containing the initiator under a pressure of 1-100kg/cm .

公开(公告)号：JPH0657010A

公开(公告)日：1994-03-01

申请号：JP8967993

申请日：1993-04-16

Applicant: KAO CORP

Inventor： AMIYA TSUYOSHI ,  NOUSHIRO RIYUUICHI ,  NANBU HIROMI ,  KOBAYASHI TAKATOSHI ,  NAKANISHI HIROFUMI

IPC: B01J20/26 ,  C08F8/00 ,  C08J3/24

Abstract: PURPOSE:To provide a highly absorptive polymer which has a high initial absorption rate, when it meets a large amount of aqueous liquid such as humor excluded from human bodies mainly urine, causes no reduction in its absorptive power even after swelling and can sufficiently develop the absorptive power of the absorptive polymer. CONSTITUTION:In an absorptive polymer particles which comprises a water- insoluble, hydrophilic and crosslinked polymer bearing carboxyl groups or carboxylate groups, the crosslinking density is increased on the particle surface to give the following absorptive power to the crosslinked polymer particles: i) more than 40g/g polymer equilibratory swelling absorption of physiological saline solution, ii) more than 3ml absorption, when 0.3g of the polymer is swollen with physiological solution for 10 seconds.

公开(公告)号：JPH04310720A

公开(公告)日：1992-11-02

申请号：JP7758191

申请日：1991-04-10

Applicant: KAO CORP

Inventor： HOSOKAWA YASUTOKU ,  SUZUKI FUMITO ,  AMIYA TSUYOSHI ,  YASUDA YUTAKA

IPC: B29B11/08 ,  B29C49/00 ,  B29C49/06 ,  B29C49/08 ,  B29C49/22 ,  B29C49/64 ,  B29K23/00 ,  B29K67/00 ,  B29K105/32 ,  B29L22/00 ,  B65D65/40

Abstract: PURPOSE:To use suitably a plastic container particularly as a food packaging container by manufacturing the plastic container having transparency, superior barrier properties against water vapor and against UV rays. CONSTITUTION:A preform composed at least of two layers consisting of a mixed polyester layer (layer A) composed of thermoplastic polyester (a) containing 80mol% or more of ethylene terephthalate and/or ethylene isophthalate unit as repeating unit and thermoplatic polyester (b) containing 20mol% or more of ethylene naphthalate unit as repeating unit and a polyolefin layer (layer B) is injection molded, and further stretch blown at least in a monoaxial direction in a temperature range of 110 deg.C-140 deg.C to manufacture a plastic multi-layer container.

公开(公告)号：JPH04310719A

公开(公告)日：1992-11-02

申请号：JP7758091

申请日：1991-04-10

Applicant: KAO CORP

Inventor： HOSOKAWA YASUTOKU ,  SUZUKI FUMITO ,  AMIYA TSUYOSHI ,  YASUDA YUTAKA

IPC: B29B11/08 ,  B29C49/08 ,  B29C49/22 ,  B29C49/64 ,  B29K23/00 ,  B29K67/00 ,  B29K105/32 ,  B29L22/00 ,  B65D65/40

Abstract: PURPOSE:To use suitably a plastic container particularly as a food packaging container by manufacturing the plastic container having transparency, superior barrier properties against water vapor and against UV rays. CONSTITUTION:A peform composed of at least two layers consisting of a thermoplastic polyester layer (layer A) containing 1mol% or more to less than 80mol% of etylene naphthalate unit as repeating unit and a polyolefin layer (layer B) is injected and molded, and further stretch-blown at least in an monoaxial direction in a temperature range of 110 deg.C-140 deg.C to manufacture a multi-layer plastic container.

公开(公告)号：JPS6134004A

公开(公告)日：1986-02-18

申请号：JP15443684

申请日：1984-07-25

Applicant: Kao Corp

Inventor： AMIYA TSUYOSHI ,  TSUSHIMA RIKIO

IPC: A61K8/00 ,  A61K8/72 ,  A61K8/73 ,  A61Q5/00 ,  C08B37/08

Abstract: PURPOSE: A water-soluble cationized chitin suitable for use in cosmetics, perfumes, toiletries, etc., prepared by replacing the reactive hydrogen atoms of chitin by quat. nitrogen-containing groups and cleaving its intermolecular hydrogen bonds.
CONSTITUTION: A cationized chitin prepared by replacing the reactive hydrogen atoms in a chitin molecule by quat. nitrogen-containing groups represented by formula I (wherein R is methyl or ethyl and X is a halogen) and cleaving the intermolecular hydrogen bonds. Said modified chitin is produced by reacting 100pts.wt. chitin with at least about 30pts.wt. cationizing agent [e.g., a compound of formula II or III (glycidyltrialkylammonium or 3-chloro-2-hydroxypropyl- trialkylammonium salt)] in the presence of an alkali in an aqueous solvent (water and/or an alcohol), neutralizing and washing the product and dissolving it in, e.g., an aqueous chloride solution (≥about 1N) to cleave the intermolecular hydrogen bonds.
COPYRIGHT: (C)1986,JPO&Japio

Abstract translation: 目的：适用于化妆品，香水，化妆品等的水溶性阳离子化壳多糖，通过用几何替代几丁质的反应性氢原子制备。 含氮基团并裂解其分子间氢键。 构成：通过用几何替代几丁质分子中的反应性氢原子制备的阳离子化几丁质。 由式I表示的含氮基团（其中R是甲基或乙基，X是卤素）并切断分子间氢键。 所述改性几丁质是通过使100pts.wt。 甲壳素至少约30pts.wt。 阳离子化剂[例如式II或III的化合物（缩水甘油基三烷基铵或3-氯-2-羟丙基 - 三烷基铵盐）]在碱存在下，在水溶剂（水和/或醇）中，中和并洗涤 产物并将其溶解在例如氯化氢水溶液（> =约1N）中以切割分子间氢键。

公开(公告)号：JPS5723631A

公开(公告)日：1982-02-06

申请号：JP9825680

申请日：1980-07-18

Applicant: Kao Corp

Inventor： MIYAMOTO TAKEAKI ,  AMIYA TSUYOSHI ,  TSUSHIMA RIKIO

IPC: C08H1/00

Abstract: PURPOSE: To obtain the titled keratin readily soluble in water and aqueous solvents, by readucing a Keratinous substance to cleave sulfhydryl groups, and reacting a cationic agent having a quaternary nitrogen atom and an epoxy group with the reduction product.
CONSTITUTION: A keratinous substance, e.g. wool, feather, hair or nail, is reduced with a reducing agent, e.g. 2-mercaptoethanol, in water or its mixture with an organic solvent, e.g. methanol, acetone or dioxane, to convert disulfide bonds into sulfhydryl bonds. The resultant product is then reacted with a cationic agent, e.g. glycidyltrimethylammonium chloride, having a group of formula I, II or III and a quaternary nitrogen atom in one molecule to give the aimed modified keratinous protein. Perferably, the reducing reaction is carried out at pH 6W11 and if necessary under heating for 2W3hr.
COPYRIGHT: (C)1982,JPO&Japio

Abstract translation: 目的：获得容易溶于水和水性溶剂的标题角蛋白，通过读取角质物质以切割巯基，并使具有季氮原子和环氧基的阳离子剂与还原产物反应。 构成：角质物质，例如 羊毛，羽毛，头发或指甲，用还原剂还原。 2-巯基乙醇，在水中或其与有机溶剂的混合物，例如 甲醇，丙酮或二恶烷，将二硫键转化为巯基。 然后将所得产物与阳离子试剂反应，例如 缩水甘油基三甲基氯化铵，具有式I，II或III的基团和一个分子中的季氮原子，得到目标修饰的角质蛋白。 优选地，还原反应在pH6-11下进行，如果需要，加热2-3小时。

公开(公告)号：JP2000273017A

公开(公告)日：2000-10-03

申请号：JP7980799

申请日：1999-03-24

Applicant: KAO CORP

Inventor： OSUMI TAKAHIRO ,  YOSHIMURA TADANORI ,  IGARASHI TADASHI ,  AMIYA TSUYOSHI

IPC: A61K8/02 ,  A61K8/81 ,  A61Q19/00 ,  A61Q19/10 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To obtain a keratotic plug remover which keeps high film strength even under high humidity and can certainly remove keratotic plug clogging pores in the skin by including a copolymer containing a vinyl monomer bearing salt-forming groups and a hydrophobic vinyl monomer as essential monomers. SOLUTION: This keratotic plug remover is obtained by including a copolymer, which contains at least (A) vinyl monomer [e.g. maleic acid, dimethylaminoethyl (meth)acrylate or the like] bearing salt-forming groups (e.g. carboxyl, acid anhydride, phosphonic acid and the like) and (B) hydrophobic vinyl monomer, e.g. an alkyl (meth)acrylate, an alkyl (meth)acrylamide or the like as essential monomers, as an active ingredient. The components A and B are preferably blended in proportions of 20-95 mol% and 5-80 mol%, respectively, based on the whole monomer used in the above copolymerization. Further, the above copolymerization can be carried out by all means of bulk polymerization, solution polymerization, suspension polymerization, emulsion polymerization and the like in the presence of a radical polymerization initiator.