公开(公告)号：CA2375168A1

公开(公告)日：2000-12-14

申请号：CA2375168

申请日：2000-06-09

Applicant: MEDISPECTRA INC

Inventor： EMANS MATTHEW ,  KWO JENNIE ,  HED ZE EV ,  MODELL MARK ,  BEE DAVID ,  NORDSTROM ROBERT

IPC: A61B1/00 ,  A61B19/00 ,  A61B5/00

Abstract: The present invention recognizes that optical probes function both as medica l access devices and as instruments which collect complex optical data. The invention provides an optical probe accessory device which can access lumina l spaces within the body of a patient without sacrificing the quality of optic al data obtained. The accessory device further comprises either, singly, or in combination, selectable features or options which optimize light transmissio n, maximize patient comfort, and provide single-use capabilities.

公开(公告)号：AU2723600A

公开(公告)日：2000-08-01

申请号：AU2723600

申请日：2000-01-11

Applicant: MEDISPECTRA INC

Inventor： MODELL MARK ,  HED ZE EV A ,  BEE DAVID ,  NORDSTROM ROBERT ,  KWO JENNIE ,  EMANS MATTHEW ,  LIPSON DAVID

IPC: G01N21/64 ,  A61B1/00 ,  A61B5/00 ,  G01N21/47

公开(公告)号：AU2715300A

公开(公告)日：2000-07-12

申请号：AU2715300

申请日：1999-12-22

Applicant: MEDISPECTRA INC

Inventor： NORDSTROM ROBERT ,  MODELL MARK ,  ZELENCHUK ALEXANDER

IPC: G01N21/64 ,  A61B1/04 ,  A61B5/00 ,  A61B6/00 ,  A61B10/00 ,  G01N20060101 ,  G01N21/17 ,  G01N21/27 ,  G01N21/33 ,  G01N21/47

Abstract: The present invention relates to systems and methods for examining a sample using a substantially monostatic, substantially confocal optical system comprising transmitting optics that focus an illuminating light upon the sample and receiving optics that collect light emitted from the sample following illumination thereof. In certain embodiments, the receiving optics may be arranged circumferentially around the light path traversed by the illuminating light. In certain embodiments, video apparatus may be included to produce images or to align the system in proximity to the target tissue. The systems and methods of the present invention may be directed towards the examination of a body tissue to provide a medical diagnosis.

公开(公告)号：CA2356195A1

公开(公告)日：2000-06-29

申请号：CA2356195

申请日：1999-12-23

Applicant: MEDISPECTRA INC

Inventor： MODELL MARK ,  NORDSTROM ROBERT

IPC: G01N21/64 ,  A61B5/00 ,  A61B10/00 ,  G01N21/27 ,  G01N21/35

Abstract: A method and a system is provided for discriminating between healthy cervica l tissue and pathologic cervical tissue based on the fluorescence response of the tissue to laser excitation (LIF) and the backscatter response to illumination by white light (in the spectral range of 360 to 750 nm). Combining LIF and white light responses, as well as evaluating a spatial correlation between proximate cervical tissue sites in conjunction with a statistically significant "distance" algorithm, such as the Mahalanobis distance between data sets, can improve the discrimination between normal an d abnormal tissue. The results may be displayed in the form of a map of the cervix representing the suspected pathology.

公开(公告)号：CA2277095A1

公开(公告)日：1998-07-16

申请号：CA2277095

申请日：1998-01-09

Applicant: MEDISPECTRA INC

Inventor： MODELL MARK ,  HED A ZE EV

IPC: G01N21/64 ,  A61B1/00 ,  A61B5/00 ,  A61B10/00 ,  G01N21/27 ,  G01N21/47

Abstract: Methods and apparatus are provided for determining a characteristic of a sample of a material by the interaction of electromagnetic radiation with the sample. The apparatus includes a source of electromagnetic radiation, an optical assembly and a detector. The optical assembly sequentially illuminates a plurality of volume elements in the sample with an intensity distribution in the sample that drops off substantially monotonically from a first region in a first optical path and collects electromagnetic radiation emanating from each of the volume elements. The optical assembly collects the electromagnetic radiation emanating from each of the volume elements with a collected distribution that drops off substantially monotonically from a second region in a second optical path. The first and second regions at least partially overlap in each of the volume elements. The detector detects the collected electromagnetic radiation emanating from each of the sequentially illuminated volume elements to produce responses representative of the characteristic in each of the volume elements.

公开(公告)号：AU6645796A

公开(公告)日：1997-02-26

申请号：AU6645796

申请日：1996-08-01

Applicant: MEDISPECTRA INC

Inventor： MODELL MARK ,  DEBARYSHE GREGORY ,  HED A ZE EV

IPC: G01N21/64 ,  A61B1/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/27 ,  G01N21/47

公开(公告)号：CA2228308A1

公开(公告)日：1997-02-13

申请号：CA2228308

申请日：1996-08-01

Applicant: MEDISPECTRA INC

Inventor： DEBARYSHE GREGORY ,  MODELL MARK ,  HED A ZE EV

IPC: G01N21/64 ,  A61B1/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/27 ,  G01N21/47 ,  G01N21/00 ,  A61B10/00

Abstract: An optical probe collects light emanating from a specimen that selectively and preferentially represents a localized volume element within the sample, with illumination intensity and collection efficacy both dropping off away from the localized volume element to limit the integrated contribution from outside the element. For example, the optics provide high peak illumination and high collection efficiency which both overlap in volume elements of a limited size corresponding to a structure or process of the specimen. The resulting collected signal comprising one or more spectral segments is highly correlated with optical characteristics, such as absorbance, scattering or fluorescence characteristics of material in the small volume elements. A processor may apply a previously-derived vector or matrix transform to the collected responses to produce an output. The collected spectra or other responses have high signal strength and represent small or otherwise inaccessible or masked optical effects present in the sample, so that they are readily correlated to conditions of interest.