公开(公告)号：JP2006138860A

公开(公告)日：2006-06-01

申请号：JP2005345332

申请日：2005-11-30

Applicant: Medispectra Inc ,  メディスペクトラ・インコーポレーテッドMedispectra,Inc.

Inventor： MODELL MARK ,  DEBARYSHE GREGORY ,  HED A ZE EV

IPC: G01N21/27 ,  G01N21/64 ,  A61B1/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B10/00 ,  G01N21/47

CPC classification number: A61B5/0084 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  G01N21/4795

Abstract: PROBLEM TO BE SOLVED: To provide a method and a device for analyzing samples by spatially limiting responses observed in a small volume element. SOLUTION: This device includes: a radiating section 12 for generating radiation; a 1st light-limiting section 14; and a directivity (objective) optical system 16 (these are collectively referred to as "irradiation optical systems"), where the beam that has passed through the light-limiting section and formed will be irradiated on a sample 18. A collecting optical system 20 collects and detects radiation from the irradiated sample 18, which will pass through the 2nd light-limiting section 22. The device also includes a limiting section 26, connected to the irradiation and collecting optical system or its part, to adjust the position where the radiation has been directed, and collecting responses from selected volume elements. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：提供用于通过空间限制在小体积元件中观察到的响应来分析样品的方法和装置。 解决方案：该装置包括：用于产生辐射的辐射部分12; 第一限光部分14; 以及定向性（物镜）光学系统16（这些统称为“照射光学系统”），其中已经通过限定部分并形成的光束将照射在样本18上。收集光学系统20 收集和检测来自被照射的样品18的辐射，其将通过第二限光部分22.该装置还包括限制部分26，其连接到照射和收集光学系统或其部分，以调节放射线 已被引导，并收集所选卷元素的响应。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：MX9800874A

公开(公告)日：1998-09-30

申请号：MX9800874

申请日：1998-01-30

Applicant: MEDISPECTRA INC

Inventor： MODELL MARK ,  DEBARYSHE GREGORY ,  HED A ZE EV

IPC: G01N21/64 ,  A61B1/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/27 ,  G01N21/47 ,  A61B05/00

Abstract: Una sonda optica recolecta luz que emana de un espécimen que representa en forma selectiva y preferencial un elemento de volumen localizado dentro de una muestra, con intensidad de iluminacion y eficacia de recoleccion que se retiran ambas del elemento de volumen localizado, para limitar la contribucion integrada desde fuera del elemento. Por ejemplo, los componentes opticos proporcionan alta iluminacion de pico y alta eficiencia de recoleccion, que ambas se traslapan en elementos de volumen de un tamaño limitado que corresponde a una estructura o proceso del espécimen. La señal recolectada resultante comprende uno o más segmentos espectrales se correlaciona altamente con características opticas tales como absorbencia, dispersion o características de fluorescencia del material en pequeños elementos de volumen. Un procesador puede aplicar una transformada de matriz o vector previamente derivado a las respuestas recolectadas, para producir una salida. Los espectros recolectados u otras respuestas tienen alta intensidad de señal y representan efectos opticos pequeños o de otra forma inaccesibles o enmascarados presentes en la muestra, de manera tal que se correlacionen fácilmente a condiciones de interés.

公开(公告)号：AU6645796A

公开(公告)日：1997-02-26

申请号：AU6645796

申请日：1996-08-01

Applicant: MEDISPECTRA INC

Inventor： MODELL MARK ,  DEBARYSHE GREGORY ,  HED A ZE EV

IPC: G01N21/64 ,  A61B1/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/27 ,  G01N21/47

公开(公告)号：CA2228308A1

公开(公告)日：1997-02-13

申请号：CA2228308

申请日：1996-08-01

Applicant: MEDISPECTRA INC

Inventor： DEBARYSHE GREGORY ,  MODELL MARK ,  HED A ZE EV

IPC: G01N21/64 ,  A61B1/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/27 ,  G01N21/47 ,  G01N21/00 ,  A61B10/00

Abstract: An optical probe collects light emanating from a specimen that selectively and preferentially represents a localized volume element within the sample, with illumination intensity and collection efficacy both dropping off away from the localized volume element to limit the integrated contribution from outside the element. For example, the optics provide high peak illumination and high collection efficiency which both overlap in volume elements of a limited size corresponding to a structure or process of the specimen. The resulting collected signal comprising one or more spectral segments is highly correlated with optical characteristics, such as absorbance, scattering or fluorescence characteristics of material in the small volume elements. A processor may apply a previously-derived vector or matrix transform to the collected responses to produce an output. The collected spectra or other responses have high signal strength and represent small or otherwise inaccessible or masked optical effects present in the sample, so that they are readily correlated to conditions of interest.