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公开(公告)号：JP2012122871A
公开(公告)日：2012-06-28
申请号：JP2010274370
申请日：2010-12-09
Applicant: Shimadzu Corp , 株式会社島津製作所
Inventor： IWAMOTO SHINICHI , TANAKA KOICHI , KAJIWARA SHIGEKI
Abstract: PROBLEM TO BE SOLVED: To improve reliability of compound identification by database retrieval by preventing a peak not derived from a target compound from being mixed with an ion peak observed on an MSspectrum.SOLUTION: A precursor ion is selected under a predetermined selection condition on a mass spectrum obtained by performing mass analysis of peptide and MSanalysis is executed (S1 to S3). If an ion peak other than Mp-17 or Mp-18 exists in a range between a precursor ion peak m/z (Mp) and m/z (Mp-57) lower than the m/z(Mp) by 57 [Da] on an acquired MSspectrum (S5, S6), the selection condition is changed so that a part of an isotope peak cluster is excluded, and then the precursor ion is selected and the MSanalysis is executed again (S8, S2-S3). Consequently, an admixture peak overlapped to the isotope peak cluster can be excluded from the precursor ion and the MSspectrum having high purity can be acquired.
Abstract translation: 要解决的问题：为了通过防止从目标化合物得到的峰不与MS
2观察到的离子峰进行混合，提高数据库检索的化合物鉴定的可靠性 >谱。 解决方案：在通过进行肽的质量分析获得的质谱上，在预定的选择条件下选择前体离子，进行分析（S1〜S3）。 如果除Mp-17或Mp-18之外的离子峰存在于比m / z（Mp）低于57 [Da]的前体离子峰m / z（Mp）和m / z（Mp-57） ]在获得的MS 2 频谱（S5，S6）中，改变选择条件以排除部分同位素峰簇，然后选择前体离子， 再次执行MS 2 分析（S8，S2-S3）。 因此，可以从前体离子中排除与同位素峰簇重叠的混合峰，可以获得高纯度的MS。 版权所有（C）2012，JPO＆INPIT -
公开(公告)号：JP2011174887A
公开(公告)日：2011-09-08
申请号：JP2010040923
申请日：2010-02-25
Applicant: Shimadzu Corp , 株式会社島津製作所
Inventor： FUKUYAMA HIROKO , IWAMOTO SHINICHI
Abstract: PROBLEM TO BE SOLVED: To form a sample/matrix mixture having the uniformity and the high ionization durability on a sample plate.
SOLUTION: A CHCA_B as a liquid matrix and a sample liquid containing a material to be analyzed are dropped, and mixed on the sample plate 10. A droplet integration liquid contains a methanol or an acetonitrile, and is dropped on it. The sample/matrix mixture divided into a plurality of small droplets on the sample plate 10 can be integrated into one droplet. The material to be analyzed can be in a uniform state macroscopically. The high ionization durability can be achieved by using the liquid matrix as a matrix in comparison with a conventional method using a solid matrix. As a result from the above, the sufficient analysis accuracy can be achieved by a laser irradiation at several points only. An analysis time can be greatly reduced in a MALDI-MS.
COPYRIGHT: (C)2011,JPO&INPITAbstract translation: 要解决的问题：在样品板上形成具有均匀性和高电离耐久性的样品/基质混合物。 解决方案：将作为液体基质的CHCA_B和含有待分析材料的样品液体滴落并在样品板10上混合。液滴积分液体含有甲醇或乙腈，并滴在其上。 在样品板10上分成多个小液滴的样品/基质混合物可以整合成一个液滴。 待分析的材料可以在宏观上处于统一的状态。 与使用固体基质的常规方法相比，可以通过使用液体基质作为基质来实现高电离耐久性。 作为上述的结果，可以通过几点的激光照射来实现足够的分析精度。 在MALDI-MS中可以大大降低分析时间。 版权所有（C）2011，JPO＆INPIT
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公开(公告)号：JP2011003481A
公开(公告)日：2011-01-06
申请号：JP2009147198
申请日：2009-06-22
Applicant: Shimadzu Corp , 株式会社島津製作所
Inventor： IWAMOTO SHINICHI , KODERA KEI
Abstract: PROBLEM TO BE SOLVED: To improve mass resolution by making a resonance exciting condition close to an ideal condition in the case of discharging ion with resonance excitation by applying the rectangular waveform voltage to an end cap electrode.SOLUTION: Before performing the resonance excitation discharge, an excitation resonance voltage direct current potential computing section 71 computes the direct current potential shifted amount, at which the time average potential becomes zero, by using a cycle, a pulse duration and a voltage value of the rectangular waveform voltage generated in a pulse voltage generating section 51. In execution of the resonance excitation discharge, a variable direct current voltage generating section 52 generates the direct current voltage corresponding to the direct current potential shifted amount, and the rectangular waveform voltage is shifted by the direct current voltage by voltage overlapped parts 53 and 54. With this structure, the time average potential of the rectangular waveform voltage to be applied to each end cap electrode 22 and 24 become zero together, and a direct current potential gradient in a direction along the central axis inside of an ion trap 2 space is eliminated. As a result, the orbit center of the caught ion coincides with the geometric center of the trap 2, and the resonance exciting condition close to the ideal can be obtained.
Abstract translation: 要解决的问题：通过将矩形波形电压施加到端盖电极，通过使谐振激励条件接近理想条件来提高质量分辨率。在执行谐振励磁放电之前， 励磁谐振电压直流电位计算部71通过使用在脉冲电压产生中产生的矩形波形电压的周期，脉冲持续时间和电压值来计算时间平均电位变为零的直流电位移动量 在执行共振励磁放电时，可变直流电压产生部分52产生对应于直流电位移动量的直流电压，并且矩形波形电压通过电压重叠部分53的直流电压偏移 有了这个结构，时间平均就可以了 要施加到每个端盖电极22和24的矩形波形电压的电位变为零，并且消除沿着离子阱2空间的中心轴线的方向上的直流电势梯度。 结果，捕获离子的轨道中心与捕获器2的几何中心重合，并且可以获得接近理想的共振激励条件。
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Patent Agency Ranking
公开(公告)号：JP2007121178A
公开(公告)日：2007-05-17
申请号：JP2005315964
申请日：2005-10-31
Applicant: Shimadzu Corp , 株式会社島津製作所
Inventor： FURUHASHI OSAMU , OGAWA KIYOSHI , IZUMI HIDEAKI , IWAMOTO SHINICHI
IPC: G01N27/62
Abstract: PROBLEM TO BE SOLVED: To provide a mass analyzer capable of enhancing the analyzing sensitivity or precision of target product ions by enhancing the selectivity of precursor ions.
SOLUTION: When a CID gas is introduced into an ion trap, the frequency of an exciting signal is determined in consideration of that the secular vibration frequency of the ions trapped by the collision with the CID gas lowers slightly. That is, the gas pressure in a vacuum chamber 1 in which the ion trap is mounted is detected by a pressure sensor 4 and a control part 20 corrects the frequency of the exciting signal on the basis of the frequency shift quantity data calculated corresponding to this gas pressure. Then, when the secular vibration frequency of the ions in the ion trap 10 lowers by an increase in the introducing amount of the CID gas, the detected gas pressure rises and the frequency of the exciting signal is lowered. Accordingly, target ions are accurately excited to cause dissociation with high frequency.
COPYRIGHT: (C)2007,JPO&INPITAbstract translation: 要解决的问题：提供能够通过提高前体离子的选择性来提高目标产物离子的分析灵敏度或精度的质量分析器。 解决方案：当将CID气体引入离子阱中时，考虑到与CID气体碰撞捕获的离子的长期振动频率稍微降低，确定了激发信号的频率。 也就是说，通过压力传感器4检测其中安装有离子阱的真空室1中的气体压力，并且控制部分20基于相应于此计算的频移量数据来校正激励信号的频率 气压。 然后，当离子阱10中的离子的长期振动频率由于CID气体的引入量的增加而降低时，检测到的气体压力升高，并且激励信号的频率降低。 因此，目标离子被精确激发以引起高频离解。 版权所有（C）2007，JPO＆INPIT
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公开(公告)号：JP2005292093A
公开(公告)日：2005-10-20
申请号：JP2004111619
申请日：2004-04-05
Applicant: Shimadzu Corp , 株式会社島津製作所
Inventor： FUKUYAMA HIROKO , IWAMOTO SHINICHI
IPC: G01N27/62
Abstract: PROBLEM TO BE SOLVED: To provide a mass calibration method having a wide application range, capable of calibrating a mass accurately and simply.
SOLUTION: In this mass calibration method for mass, a combination of a plurality of kinds of sugar chains different each other in the numbers of constitutive sugars, using one or a plurality of kinds of monosaccharides having the same molecular weight, as the constitutive sugars, is used as a standard substance for the mass calibration. Preferably, the plurality of kinds of sugar chains are used as a mixture; each of the sugar chains is a cyclic sugar chain, the number of the constitutive sugars is different by one among the plurality of kinds of respective sugar chains; and all the constitutive sugars of the sugar chains are the same kinds of monosaccharides.
COPYRIGHT: (C)2006,JPO&NCIPIAbstract translation: 要解决的问题：提供具有广泛应用范围的质量校准方法，能够准确且简单地校准质量。 解决方案：在这种质量的质量校准方法中，使用一种或多种具有相同分子量的单糖，组成型糖的数量彼此不同的多种糖链的组合，如 组成型糖被用作质量校准的标准物质。 优选使用多种糖链作为混合物; 每个糖链是环状糖链，组成型糖的数量在多种各自的糖链中是不同的; 糖链的所有组成型糖都是相同种类的单糖。 版权所有（C）2006，JPO＆NCIPI
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公开(公告)号：JPH1080417A
公开(公告)日：1998-03-31
申请号：JP23774796
申请日：1996-09-09
Applicant: SHIMADZU CORP
Inventor： IWAMOTO SHINICHI
Abstract: PROBLEM TO BE SOLVED: To provide a vital function measuring instrument capable of making measurement without requiring an operator. SOLUTION: The instrument for measuring the vital function of the testee accompanying kinetic load has a kinetic loading device 2 which imposes the kinetic load on the testee 7, a measuring instrument 3 which measures the testee's vital function, an instruction device 4 which gives the testee an instruction and an arithmetic unit 5 which computes a prescribed measurement item in accordance with the instruction signal to this instruction device and the measurement signal from the measuring instrument. The instruction device makes measurement without requiring the operator by automatically changing the instruction contents, such as motion start, stop, resting, the change of the kinetic load and the end of the measurement.
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公开(公告)号：JPH08184593A
公开(公告)日：1996-07-16
申请号：JP33920194
申请日：1994-12-29
Applicant: SHIMADZU CORP
Inventor： TSUNASAWA YOSHIO , EDA HIDEO , IWAMOTO SHINICHI , KATSUTA NOBUYUKI , YAMAGUCHI TAKESHI , TSUNEISHI SHOICHI , TAMURA TOMOMI
IPC: G01N33/483 , A61B5/145 , A61B5/1455 , A61B10/00
Abstract: PURPOSE: To obtain an optical probe device whose optical intensity is large and which is disposable. CONSTITUTION: A prism 12 as a light-sending part and a photodiode 13 which is in a position at distance of 3cm from it are installed at a probe 11 so as to be capable of coming into contact with a living body 6. In order to guide light with a plurality of wavelengths to the prism 12, one end of a plastic fibercord 16 as a transmission line is coupled to the prism 12, and the cross-sectional area of the optical fiber 16 is larger than the cross-sectional area of an optical fiber bundle 20 which has bundled quartz fiber cords 20-1 to 20-4. An optical connector part 18 in which both edges are opposed to each other and brought into contact with each other so that the edge of the optical fiber bundle 20 is positioned inside the edge of the optical fiber 16 and which is connected so as to be attachable/detachable is installed at the other end of the optical fiber 16. A signal cable 17 which guides a detection signal to a somatometry apparatus body 40 is connected to the detector 13, and a signal connector part 19 which is connected to the somatometry apparatus body 40 so as to be attachable/detachable is installed at the tip of the signal cable 17.
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公开(公告)号：JPH08150135A
公开(公告)日：1996-06-11
申请号：JP32370594
申请日：1994-11-30
Applicant: SHIMADZU CORP
Inventor： WADA YUKIHISA , TSUNASAWA YOSHIO , IWAMOTO SHINICHI
Abstract: PURPOSE: To enable light absorption coefficient and scattering coefficient to be adjusted independently, and also, to enable both to be set accurately, changing the scattering coefficient and the absorption efficient freely, by circulating light absorbing liquid within many tubes, and light scattering liquid outside the tubes, respectively, and passing them measuring sections. CONSTITUTION: A light absorbing liquid supply part 6, a gas exchange part 8 for adjusting the saturation of the oxygen of the light absorber, and a measuring section 10, where the measurement is made by an organism measuring device, are arranged in order along the passage 4 equipped with liquid feed pumps 2a and 2b. And, by adjusting the flow of the pumps 2a and 2b in the light absorbing liquid supply part 6, the concentration of the light absorber of the light absorbing liquid supplied to the passage 4 is adjusted. Moreover, the gas exchange part 8 consists of a gas exchange vessel 30 and a bundle of thin porous pipes 32 which pass therein and allow liquid to pass but do not allow gas to pass through themselves, and light absorbing liquid is circulating in the fine pipe 32, and it is adjusted to light absorbing liquid in desired oxygen saturation by contacting with the gas being adjusted to specified oxygen partial pressure within the gas exchange vessel 30.
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