公开(公告)号：JPS6440498A

公开(公告)日：1989-02-10

申请号：JP19629687

申请日：1987-08-07

Applicant: TOSOH CORP

Inventor： KURAUCHI YASUHIRO ,  AKAZAWA MICHIHIRO ,  HARADA TSUNEO ,  KOYAMA KIYOTAKA ,  TOKUDA AKIRA

IPC: C07K5/037 ,  B01D61/00 ,  B01D61/44 ,  B01D61/54 ,  C07K1/00 ,  C07K1/14 ,  C07K1/24 ,  C07K5/06 ,  C07K5/072 ,  C07K5/075 ,  C08J5/22 ,  C09K5/06 ,  C25B3/00

Abstract: PURPOSE:To purify the titled compound in high efficiency, suppressing the decomposition of the compound, by supplying an aqueous solution of a dipeptide ester containing an inorganic acid into a middle chamber of an electrolytic cell partitioned with anion exchange membranes, charging a base and an electrolyte to a cathode chamber and an anode chamber, respectively, and transferring the inorganic acid from the middle chamber to the anode chamber. CONSTITUTION:An aqueous solution of a dipeptide ester (e.g. alpha-aspartyl-L-phenylalanine methyl ester) containing an inorganic acid is supplied to a middle chamber 7 between anion exchange chambers 2, 3 of an electrolytic cell 1 partitioned with plural anion exchange membranes 2, 3. The cathode chamber 8 and the anode chamber 6 are supplied with an aqueous solution containing a basic substance and an aqueous solution of an electrolyte, respectively. A potential is applied between the anode 4 and the cathode 5 to transfer hydroxyl ion from the cathode chamber 8 through the anion exchange membrane 3 into the middle chamber 7 to neutralize the aqueous solution of dipeptide ester containing inorganic acid and, at the same time, the anion of the inorganic acid in the aqueous solution is transferred through the anion exchange membrane 2 into the anode chamber 6 to obtain the objective compound in purified state.

公开(公告)号：JP2503529B2

公开(公告)日：1996-06-05

申请号：JP22049987

申请日：1987-09-04

Applicant: TOSOH CORP

Inventor： HARADA TSUNEO ,  TOKUDA AKIRA ,  KOYAMA KYOTAKA

IPC: C07C271/54 ,  C07C67/00 ,  C07C239/00 ,  C07C269/04 ,  C07C271/22

公开(公告)号：JPS6345297A

公开(公告)日：1988-02-26

申请号：JP18866286

申请日：1986-08-13

Applicant: TOSOH CORP

Inventor： WAKAMATSU HIDETOSHI ,  IRINO SHIGEAKI ,  HARADA TSUNEO ,  TOKUDA AKIRA ,  KOYAMA KIYOTAKA

IPC: A23L27/30 ,  C07K1/14 ,  C07K5/06 ,  C07K5/075

Abstract: PURPOSE:To obtain aspartame having excellent storage stability and useful as a sweetener, without using high-temperature drying and redrying processes, by drying wet aspartame crystal in air containing more than a specific amount of water. CONSTITUTION:Wet crystal of alpha-L-aspartyl-L-phenylalanine methyl ester is optionally granulated to a granule having a diameter of 1.0-4.0mm and dried in air having an absolute humidity of >=0.015kg/kg to obtain the objective substance. The drying is preferably carried out with an aeration dryer or a fluidizing dryer at

公开(公告)号：JPS6344592A

公开(公告)日：1988-02-25

申请号：JP18775786

申请日：1986-08-12

Applicant: TOSOH CORP

Inventor： WAKAMATSU HIDETOSHI ,  IRINO SHIGEAKI ,  HARADA TSUNEO ,  TOKUDA AKIRA ,  KOYAMA KIYOTAKA

IPC: A23L27/30 ,  C07K1/14 ,  C07K5/072 ,  C07K5/075

Abstract: PURPOSE:To suppress formation of type II crystals by drying and obtain the titled compound useful as sweeteners, etc., by granulating wet crystals of alpha-L- aspartyl-L-phenylalanine methyl ester under specific condition and drying the resultant granulated crystals. CONSTITUTION:Wet crystals of alpha-L-aspartyl-L-phenyalanine methyl ester are initially granulated to give >=4m /g specific surface area after drying and the resultant granulated crystals are dried, preferably at =4m /g.