公开(公告)号：DE3870754D1

公开(公告)日：1992-06-11

申请号：DE3870754

申请日：1988-08-03

Applicant: TOSOH CORP

Inventor： KURAUCHI YASUHIRO ,  AKAZAWA MICHIHIRO ,  HARADA TSUNEO ,  OYAMA KIYOTAKA ,  TOKUDA AKIRA

IPC: C07K5/037 ,  B01D61/00 ,  B01D61/44 ,  B01D61/54 ,  C07K1/00 ,  C07K1/14 ,  C07K1/24 ,  C07K5/06 ,  C07K5/072 ,  C07K5/075 ,  C08J5/22 ,  C09K5/06 ,  C25B3/00

Abstract: A method for purifying a dipeptide ester by electrolysis in an electrolytic cell comprising an anode compartment, a cathode compartment and a central compartment partitioned by anion exchange membranes, which comprises supplying an aqueous dipeptide ester solution containing an inorganic acid to the central compartment defined by said anion exchange membranes, an aqueous solution containing a basic substance or an aqueous electrolyte solution containing a basic substance to the cathode compartment and an aqueous electrolyte solution to the anode compartment, supplying hydroxyl ions from the cathode compartment to the central compartment through the anion exchange membrane to neutralize the aqueous dipeptide ester solution containing the inorganic acid and removing anions of the inorganic acid in the aqueous dipeptide ester solution from the central compartment to the anode compartment through the anion exchange membrane.

公开(公告)号：AU606071B2

公开(公告)日：1991-01-31

申请号：AU7681887

申请日：1987-08-12

Applicant: TOSOH CORP

Inventor： WAKAMATSU HIDETOSHI ,  IRINO SHIGEAKI ,  HARADA TSUNEO ,  TOKUDA AKIRA ,  OYAMA KIYOTAKA

IPC: C07K5/072 ,  C07K5/075 ,  C07K5/06

Abstract: A process for producing dry alpha -L-aspartyl-L-phenylalanine methyl ester, which comprises drying wet crystals of alpha -L-aspartyl-L-phenylalanine methyl ester by means of an air having an absolute humidity of at least 0.0l5 kg/kg or at most 0.0l kg/kg.

公开(公告)号：CA1331361C

公开(公告)日：1994-08-09

申请号：CA581240

申请日：1988-10-25

Applicant: TOSOH CORP

Inventor： HARADA TSUNEO ,  FUKUDA KEN-ICHI ,  SHIMIZU HIROSHI ,  TOKUDA AKIRA ,  OYAMA KIYOTAKA

IPC: C07K1/14 ,  C07K1/24 ,  C07K5/06 ,  C07K5/072 ,  C07K5/075 ,  C25B9/19 ,  C25D3/00

Abstract: A method for purifying a dipeptide ester by electrolysis in an electrolytic cell comprising an anode compartment, a cathode compartment and a central compartment partitioned by ion exchange membranes, which comprises supplying an aqueous dipeptide ester solution containing organic acids to the central compartment defined by anion and cation exchange membranes or by anion exchange membranes and an aqueous electrolyte solution to the cathode and anode compartments, and electrically removing the organic acids from the central compartment to the anode compartment through the anion exchange membrane.

公开(公告)号：AU598565B2

公开(公告)日：1990-06-28

申请号：AU7614787

申请日：1987-07-27

Applicant: TOSOH CORP

Inventor： WAKAMATSU HIDETOSHI ,  IRINO SHIGEAKI ,  HARADA TSUNEO ,  TOKUDA AKIRA ,  OYAMA KIYOTAKA

IPC: A23L27/30 ,  C07K1/00 ,  C07K5/072 ,  C07K5/075 ,  C07K5/06 ,  C07K3/12

Abstract: A process for producing dry alpha -L-aspartyl-L-phenylalanine methyl ester having an improved solubility from wet crystals of alpha -L-aspartyl-L-phenylalanine methyl ester having a water content of at least 20% by weight, which comprises drying the wet crystals at a temperature of higher than 50 DEG C to obtain moist crystals having a water content of less than 20 and more than l5% by weight, then drying the moist crystals at a temperature of not higher than 50 DEG C to obtain semi-dry crystals having a water content of less than 5% by weight, and further drying the semi-dry crystals at a temperature of higher than 50 DEG C to obtain dry crystals of alpha -L-aspartyl-L-phenylalanine methyl ester.

公开(公告)号：EP3117901A4

公开(公告)日：2017-11-01

申请号：EP15761960

申请日：2015-03-10

Applicant: TOSOH CORP

Inventor： KAWABE SHOU ,  HARADA TSUNEO ,  FUJIWARA TOMIYOSHI

IPC: B01J23/80 ,  B01J35/10 ,  B01J37/03 ,  C07B61/00 ,  C07C209/36 ,  C07C211/46

CPC classification number: B01J23/80 ,  B01J21/04 ,  B01J21/08 ,  B01J35/0026 ,  B01J35/023 ,  B01J35/1014 ,  B01J37/0063 ,  B01J37/038 ,  B01J2523/00 ,  C07C209/36 ,  C07C211/46 ,  B01J2523/17 ,  B01J2523/23 ,  B01J2523/27 ,  B01J2523/41 ,  B01J2523/31 ,  B01J2523/22

公开(公告)号：EP2517789A4

公开(公告)日：2014-05-21

申请号：EP10839583

申请日：2010-12-24

Applicant: TOSOH CORP

Inventor： HARADA TSUNEO ,  KAWABE SHOU

IPC: B01J23/78 ,  B01J37/18 ,  C07B61/00 ,  C07C209/36 ,  C07C211/46

CPC classification number: C07C209/36 ,  B01J21/16 ,  B01J23/72 ,  B01J23/78 ,  B01J35/1014 ,  B01J37/18 ,  C07C211/46

Abstract: To provide a hydrogenation catalyst which does not contain chromium oxide, unlike conventional copper/chromium oxide catalysts, and therefore does not cause any environmental contamination or health hazard, and which shows an activity, selectivity and durability at equivalent or higher levels to or than those of conventional copper/chromium oxide catalysts. A hydrogenation catalyst which comprises, as the main components, (1) copper and (2) at least one member selected from the group consisting of silicon oxide, calcium oxide and calcium silicate, wherein the content of the copper is from 20 to 60 wt% based on the entire amount of the hydrogenation catalyst, and in the calcium silicate, the molar ratio of calcium oxide (CaO) to silicon oxide (SiO 2 ) is less than 1.

公开(公告)号：AT75765T

公开(公告)日：1992-05-15

申请号：AT88112652

申请日：1988-08-03

Applicant: TOSOH CORP

Inventor： KURAUCHI YASUHIRO ,  AKAZAWA MICHIHIRO ,  HARADA TSUNEO ,  OYAMA KIYOTAKA ,  TOKUDA AKIRA

IPC: C07K5/037 ,  B01D61/00 ,  B01D61/44 ,  B01D61/54 ,  C07K1/00 ,  C07K1/14 ,  C07K1/24 ,  C07K5/06 ,  C07K5/072 ,  C07K5/075 ,  C08J5/22 ,  C09K5/06 ,  C25B3/00

Abstract: A method for purifying a dipeptide ester by electrolysis in an electrolytic cell comprising an anode compartment, a cathode compartment and a central compartment partitioned by anion exchange membranes, which comprises supplying an aqueous dipeptide ester solution containing an inorganic acid to the central compartment defined by said anion exchange membranes, an aqueous solution containing a basic substance or an aqueous electrolyte solution containing a basic substance to the cathode compartment and an aqueous electrolyte solution to the anode compartment, supplying hydroxyl ions from the cathode compartment to the central compartment through the anion exchange membrane to neutralize the aqueous dipeptide ester solution containing the inorganic acid and removing anions of the inorganic acid in the aqueous dipeptide ester solution from the central compartment to the anode compartment through the anion exchange membrane.

公开(公告)号：AU603122B2

公开(公告)日：1990-11-08

申请号：AU7682087

申请日：1987-08-12

Applicant: TOSOH CORP

Inventor： WAKAMATSU HIDETOSHI ,  IRINO SHIGEAKI ,  HARADA TSUNEO ,  TOKUDA AKIRA ,  OYAMA KIYOTAKA

IPC: A23L27/30 ,  C07K1/14 ,  C07K5/072 ,  C07K5/075 ,  C07K5/06

Abstract: A process for producing stable alpha -L-aspartyl-L-phenylalanine methyl ester, which comprises heat-treating crystals of alpha -L-aspartyl-L-phenylalanine methyl ester having a water content of from 5 to l5% by weight based on wet crystals, at a temperature of higher than 50 DEG C and lower than 80 DEG C for at least 30 minutes.

公开(公告)号：AU590439B2

公开(公告)日：1989-11-02

申请号：AU7681987

申请日：1987-08-12

Applicant: TOSOH CORP

Inventor： WAKAMATSU HIDETOSHI ,  IRINO SHIGEAKI ,  HARADA TSUNEO ,  OYAMA KIYOTAKA ,  TOKUDA AKIRA

IPC: A23L27/30 ,  C07K1/14 ,  C07K5/072 ,  C07K5/075 ,  C07K5/06

Abstract: A process for producing dry alpha -L-aspartyl-L-phenylalanine methyl ester having an improved solubility by drying wet crystals of alpha -L-aspartyl-L-phenylalanine methyl ester, characterized in that the wet crystals of alpha -L-aspartyl-L-phenylalanine methyl ester are granulated so that the specific surface area during the drying operation is at least 4 m /g, followed by drying.

公开(公告)号：JP2503529B2

公开(公告)日：1996-06-05

申请号：JP22049987

申请日：1987-09-04

Applicant: TOSOH CORP

Inventor： HARADA TSUNEO ,  TOKUDA AKIRA ,  KOYAMA KYOTAKA

IPC: C07C271/54 ,  C07C67/00 ,  C07C239/00 ,  C07C269/04 ,  C07C271/22