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    1.
    发明专利
    未知

    公开(公告)号：FR2753966B1

    公开(公告)日：2003-10-31

    申请号：FR9712024

    申请日：1997-09-26

    Applicant: TOSOH CORP

    Inventor： KATSUURA KIMIO ,  IRINO SHIGEAKI ,  TOKUDA AKIRA

    IPC: C07C227/34 ,  C07C227/40 ,  C07C227/42 ,  C07C229/36

    Abstract: A method for producing an optically active amino acid or derivative thereof having a high optical purity from an optically active amino acid comprising optical isomers or derivative thereof, which comprises any one of processes (A), (B), and (C), wherein the process (A) comprises the steps: (1) previously preparing an optically active amino acid or derivative thereof having an optical purity higher than a convergent value of a mutual solubility of the optical isomers and (2) crystallizing the optically active amino acid or the derivative thereof that exists in excess, said convergent value being a ratio of the desired optical isomer in the optical isomers dissolved in a mother liquor in which crystals of a racemate and an optically active compound coexist at equilibrium (the optical purity in a mother liquor). The processes (B) and (C) are described in the specification.

    2.
    发明专利
    未知

    公开(公告)号：DE3870754D1

    公开(公告)日：1992-06-11

    申请号：DE3870754

    申请日：1988-08-03

    Applicant: TOSOH CORP

    Inventor： KURAUCHI YASUHIRO ,  AKAZAWA MICHIHIRO ,  HARADA TSUNEO ,  OYAMA KIYOTAKA ,  TOKUDA AKIRA

    IPC: C07K5/037 ,  B01D61/00 ,  B01D61/44 ,  B01D61/54 ,  C07K1/00 ,  C07K1/14 ,  C07K1/24 ,  C07K5/06 ,  C07K5/072 ,  C07K5/075 ,  C08J5/22 ,  C09K5/06 ,  C25B3/00

    Abstract: A method for purifying a dipeptide ester by electrolysis in an electrolytic cell comprising an anode compartment, a cathode compartment and a central compartment partitioned by anion exchange membranes, which comprises supplying an aqueous dipeptide ester solution containing an inorganic acid to the central compartment defined by said anion exchange membranes, an aqueous solution containing a basic substance or an aqueous electrolyte solution containing a basic substance to the cathode compartment and an aqueous electrolyte solution to the anode compartment, supplying hydroxyl ions from the cathode compartment to the central compartment through the anion exchange membrane to neutralize the aqueous dipeptide ester solution containing the inorganic acid and removing anions of the inorganic acid in the aqueous dipeptide ester solution from the central compartment to the anode compartment through the anion exchange membrane.

    Optically pure aminoacid preparation
    3.
    发明专利
    Optically pure aminoacid preparation 未知

    公开(公告)号：FR2753966A1

    公开(公告)日：1998-04-03

    申请号：FR9712024

    申请日：1997-09-26

    Applicant: TOSOH CORP

    Inventor： KATSUURA KIMIO ,  IRINO SHIGEAKI ,  TOKUDA AKIRA

    IPC: C07C227/34 ,  C07C227/40 ,  C07C227/42 ,  C07C229/36

    Abstract: Three methods (A)-(C) are claimed for preparing aminoacids (AA) and their hydrochlorides in optically pure form. Method (A) involves preparing AA having an optical purity above the convergence value (CV) of the mutual solubility of the optical isomers, where CV is the fraction of the desired optical isomer in the mixture of isomers in a mother liquor in which racemate and optical isomers co-exist in equilibrium. The optical isomer of the AA in excess above CV is then crystallised out. Method (B) involves crystallising an optically active AA at a pH around the isoelectric point, reducing the pH of the mother liquor to 1 or less and recovering the resulting crystals. Method (C) involves: mixing an optically active AA ester in aqueous solution with an N-substituted - alpha -L-aspartyl-L-phenyl alanine alkyl ester of formula (I); extracting the addition product with a water-immiscible organic solvent; washing the organic solution is with an aqueous acid; and decomposing the organic solution with an acid to isolate the pure D-AA in aqueous acid solution. R1 = optionally substituted phenyl; R2 = aliphatic oxycarbonyl or optionally substituted benzyloxycarbonyl; R3 = alkyl.

    8.
    发明专利
    未知

    公开(公告)号：NL1007126A1

    公开(公告)日：1998-03-31

    申请号：NL1007126

    申请日：1997-09-26

    Applicant: TOSOH CORP

    Inventor： KATSUURA KIMIO ,  IRINO SHIGEAKI ,  TOKUDA AKIRA

    IPC: C07C227/34 ,  C07C227/40 ,  C07C227/42 ,  C07C229/36 ,  C07C227/30

    Abstract: A method for producing an optically active amino acid or derivative thereof having a high optical purity from an optically active amino acid comprising optical isomers or derivative thereof, which comprises any one of processes (A), (B), and (C), wherein the process (A) comprises the steps: (1) previously preparing an optically active amino acid or derivative thereof having an optical purity higher than a convergent value of a mutual solubility of the optical isomers and (2) crystallizing the optically active amino acid or the derivative thereof that exists in excess, said convergent value being a ratio of the desired optical isomer in the optical isomers dissolved in a mother liquor in which crystals of a racemate and an optically active compound coexist at equilibrium (the optical purity in a mother liquor). The processes (B) and (C) are described in the specification.

    9.
    发明专利
    未知

    公开(公告)号：AT75765T

    公开(公告)日：1992-05-15

    申请号：AT88112652

    申请日：1988-08-03

    Applicant: TOSOH CORP

    Inventor： KURAUCHI YASUHIRO ,  AKAZAWA MICHIHIRO ,  HARADA TSUNEO ,  OYAMA KIYOTAKA ,  TOKUDA AKIRA

    IPC: C07K5/037 ,  B01D61/00 ,  B01D61/44 ,  B01D61/54 ,  C07K1/00 ,  C07K1/14 ,  C07K1/24 ,  C07K5/06 ,  C07K5/072 ,  C07K5/075 ,  C08J5/22 ,  C09K5/06 ,  C25B3/00

    Abstract: A method for purifying a dipeptide ester by electrolysis in an electrolytic cell comprising an anode compartment, a cathode compartment and a central compartment partitioned by anion exchange membranes, which comprises supplying an aqueous dipeptide ester solution containing an inorganic acid to the central compartment defined by said anion exchange membranes, an aqueous solution containing a basic substance or an aqueous electrolyte solution containing a basic substance to the cathode compartment and an aqueous electrolyte solution to the anode compartment, supplying hydroxyl ions from the cathode compartment to the central compartment through the anion exchange membrane to neutralize the aqueous dipeptide ester solution containing the inorganic acid and removing anions of the inorganic acid in the aqueous dipeptide ester solution from the central compartment to the anode compartment through the anion exchange membrane.

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