公开(公告)号：US20240272074A1

公开(公告)日：2024-08-15

申请号：US18582748

申请日：2024-02-21

Applicant: Trustees of Boston University

Inventor： Ji-Xin Cheng ,  Jian Zhao ,  Lei Tian ,  Alex Matlock

IPC: G01N21/63 ,  G01N21/65

CPC classification number: G01N21/636 ,  G01N2021/637 ,  G01N2021/655

Abstract: An example microscope includes a pump laser for providing a first illumination to a sample. A laser array provides a second illumination to the sample. The laser array may include a plurality of laser elements, each providing oblique illuminations to the sample. An illumination collecting source collects the first illumination and the second illumination from the sample. The illumination collecting source may capture transient 3D refractive index (RI) variations in the sample due to the first illumination and second illumination.

公开(公告)号：US20230285063A1

公开(公告)日：2023-09-14

申请号：US18196698

申请日：2023-05-12

Applicant: Trustees of Boston University

Inventor： Chen Yang ,  Ji-Xin Cheng ,  Nan Zheng ,  Yueming Li ,  Ying Jiang ,  Lu Lan ,  Linli Shi

IPC: A61B18/04 ,  B01J19/10 ,  B82Y40/00 ,  B82Y30/00 ,  A61B5/00 ,  A61B18/26

CPC classification number: A61B18/04 ,  B01J19/10 ,  B82Y40/00 ,  B82Y30/00 ,  A61B5/0095 ,  A61B18/26 ,  A61B5/0035 ,  A61B5/0059 ,  A61B8/4416

Abstract: A tapered fiber optoacoustic emitter includes a nanosecond laser configured to emit laser pulses and an optic fiber. The optic fiber includes a tip configured to guide the laser pulses. The tip has a coating including a diffusion layer and a thermal expansion layer, wherein the diffusion layer includes epoxy and zinc oxide nanoparticles configured to diffuse the light while restricting localized heating. The thermal expansion layer includes carbon nanotubes (CNTs) and Polydimethylsiloxane (PDMS) configured to convert the laser pulses to generate ultrasound. The frequency of the ultrasound is tuned with a thickness of the diffusion layer and a CNT concentration of the expansion layer.

公开(公告)号：US11709352B2

公开(公告)日：2023-07-25

申请号：US17704896

申请日：2022-03-25

Applicant: Trustees of Boston University

Inventor： Ji-Xin Cheng ,  Celalettin Yurdakul ,  Haonan Zong ,  M. Selim Ünlü

IPC: G02B21/16 ,  G02B21/02 ,  G02B21/36

CPC classification number: G02B21/16 ,  G02B21/025 ,  G02B21/361

Abstract: Microscopic analysis of a sample includes a system using dark-field illumination. A mid-IR optical source generates a mid-infrared beam, which is directed onto the sample to induce a temperature change by absorption of the mid-infrared beam. A visible light source generates a light illuminating the sample on a substrate and creating a scattered field and a reflected field along a collection path of the system. A pupil mask is positioned along the collection path to block the reflected field while allowing the scattered field to pass therethrough. A camera is positioned at an end of the collection path to collect the scattered field and generate a dark-field image of the sample.

公开(公告)号：US20230140692A1

公开(公告)日：2023-05-04

申请号：US18089122

申请日：2022-12-27

Applicant: Trustees of Boston University

Inventor： Chen Yang ,  Ji-Xin Cheng ,  Nan Zheng ,  Yueming Li ,  Ying Jiang ,  Lu Lan ,  Carolyn Marar

IPC: A61B18/18 ,  H01P7/08

Abstract: A system for neuromodulation includes a split-ring resonator (SRR) comprising a resonance circuit, the SRR being implantable in a cranial target site and a source of microwave signals, wherein the microwave signals are deliverable wirelessly to couple with the SRR to produce a localized electrical field, wherein the localized electrical field inhibits one or more neurons at the cranial target site with submillimeter spatial precision.

公开(公告)号：US11199453B2

公开(公告)日：2021-12-14

申请号：US17067345

申请日：2020-10-09

Applicant: Trustees of Boston University ,  Purdue Research Foundation

Inventor： Ji-Xin Cheng ,  Delong Zhang ,  Lu Lan

IPC: G01J5/08 ,  G02F1/125 ,  H01S3/094 ,  G01J5/00

Abstract: A method includes directing a first plurality of probe laser pulses through a sample, dividing each of the first plurality of probe laser pulses to generate a first interferogram, and generating first image data reproducible as a first phase image of the sample. A plurality of pump laser bursts are directed onto the sample to heat the sample. A second plurality of probe laser pulses are directed through the sample at a predetermined time delay. Each of the second plurality of probe laser pulses are divided to generate a second interferogram. Second image data is generated that is reproducible as a second phase image of the sample. A transient phase shift is determined in the second phase image relative to the first phase image. A vibrational spectroscopy property is determined of the sample based on the transient phase shift, thereby allowing an identification of chemical bond information of within the sample.

公开(公告)号：US20210108968A1

公开(公告)日：2021-04-15

申请号：US17067345

申请日：2020-10-09

Applicant: Trustees of Boston University ,  Purdue Research Foundation

Inventor： Ji-Xin Cheng ,  Delong Zhang ,  Lu Lan

IPC: G01J5/08 ,  G02F1/125 ,  H01S3/094

Abstract: A method includes directing a first plurality of probe laser pulses through a sample, dividing each of the first plurality of probe laser pulses to generate a first interferogram, and generating first image data reproducible as a first phase image of the sample. A plurality of pump laser bursts are directed onto the sample to heat the sample. A second plurality of probe laser pulses are directed through the sample at a predetermined time delay. Each of the second plurality of probe laser pulses are divided to generate a second interferogram. Second image data is generated that is reproducible as a second phase image of the sample. A transient phase shift is determined in the second phase image relative to the first phase image. A vibrational spectroscopy property is determined of the sample based on the transient phase shift, thereby allowing an identification of chemical bond information of within the sample.

公开(公告)号：US20240255419A1

公开(公告)日：2024-08-01

申请号：US18424524

申请日：2024-01-26

Applicant: Trustees of Boston University

Inventor： Ji-Xin Cheng ,  Hongjian He

IPC: G01N21/35 ,  G01N33/50 ,  G01N33/58

CPC classification number: G01N21/35 ,  G01N33/5005 ,  G01N33/581

Abstract: A system and method for characterizing biological activity in a live cell using a mid-infrared photothermal system and at least one molecular probe. A mid-infrared optical source generates a mid-infrared beam, the mid-infrared beam being directed at the sample to induce a thermal effect. A visible light source generates a light, the light illuminating the sample on the substrate. An optical detector collects the light after interaction with the sample. Biological activity in the sample is characterized based on a spectral shift. Each molecular probe includes an substrate and a chemical functional group.

公开(公告)号：US11994687B2

公开(公告)日：2024-05-28

申请号：US17308905

申请日：2021-05-05

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  TRUSTEES OF BOSTON UNIVERSITY

Inventor： Zhaoyi Li ,  Yao-Wei Huang ,  Peng Lin ,  Ji-Xin Cheng ,  Federico Capasso

IPC: G02B27/01 ,  G02B1/00 ,  G02B27/14 ,  G02B27/42 ,  G06T19/00

CPC classification number: G02B27/141 ,  G02B27/4227 ,  G06T19/006

Abstract: A display system includes an optical device configured according to constructive interference for a plurality of wavelengths at a focal length. The display system includes a fiber. The display system includes a controller configured to scan the fiber using a Lissajous scanning method to generate a display. The display can be disposed within a focal plane of the optical device. The controller is configured to modulate light intensity from the fiber. The controller can be configured to form a display image that passes through the optical device. The display system can include an optical combiner configured to reflect the display image from the optical device and form a virtual image. The optical device can be configured to magnify a display image from the display and form a virtual image.

公开(公告)号：US20240053264A1

公开(公告)日：2024-02-15

申请号：US18234195

申请日：2023-08-15

Applicant: Trustees of Boston University

Inventor： Ji-Xin Cheng ,  Lu Lan ,  Jiaze Yin

IPC: G01N21/359 ,  G01N21/64 ,  G01N21/65

CPC classification number: G01N21/359 ,  G01N21/6458 ,  G01N21/65

Abstract: A mid-infrared photothermal microscopy system images a sample. A mid-infrared optical source generates a mid-infrared beam which is directed along a first optical path to reach the substrate on a first side and heat the sample. A probe light source generates a probe light which is directed along a second optical path to reach the substrate on a second side and illuminate the sample. A first laser scanner is positioned along the first optical path and configured to rotate to redirect light and scan the sample with the mid-infrared beam. A second laser scanner is positioned along the second optical path and configured to rotate to redirect light and scan the sample with the probe light. The laser scanners each include at least one mirror driven to rotate such that the mid-infrared beam and the probe light scan the sample synchronously.

公开(公告)号：US20240019369A1

公开(公告)日：2024-01-18

申请号：US18100347

申请日：2023-01-23

Applicant: Trustees of Boston University

Inventor： Ji-Xin Cheng ,  Jian Zhao ,  Lei Tian ,  Alex Matlock

IPC: G01N21/63

CPC classification number: G01N21/636 ,  G01N2021/655

Abstract: An example microscope includes a pump laser for providing a first illumination to a sample. A laser array provides a second illumination to the sample. The laser array may include a plurality of laser elements, each providing oblique illuminations to the sample. An illumination collecting source collects the first illumination and the second illumination from the sample. The illumination collecting source may capture transient 3D refractive index (RI) variations in the sample due to the first illumination and second illumination.